T cell receptor complementarity determining region 3 length analysis reveals the absence of a characteristic public T cell repertoire in neonatal tolerance: The response in the 'tolerant' mouse within the residual repertoire is quantitatively similar but qualitatively different

Journal of Experimental Medicine

Volumn 191, Issue 4, 2000, Pages 695-702

  Maverakis, Emanual ^a   Beech, Jonathan T ^a   Wilson, Stephen S ^a   Quinn, Anthony ^a   Pedersen, Brian ^a   Sercarz, Eli E ^a  

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

Author keywords

Deletion anergy; HEL; Nasal instillation; Neonatal tolerance; T cell repertoire

Indexed keywords

ANTIGEN; CYTOKINE; FREUND ADJUVANT; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; LYSOZYME; T LYMPHOCYTE RECEPTOR;

ADOLESCENT; ANIMAL CELL; ARTICLE; CLONAL ANERGY; CONTROLLED STUDY; IMMUNE RESPONSE; LYMPHATIC DRAINAGE; LYMPHOCYTE CLONE; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TH2 CELL;

ADMINISTRATION, INTRANASAL; ANIMALS; ANIMALS, NEWBORN; CELLS, CULTURED; CHICKENS; EPITOPES; FEMALE; GENES, T-CELL RECEPTOR; IMMUNE TOLERANCE; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MURAMIDASE; RECEPTORS, ANTIGEN, T-CELL; SPLEEN; T-LYMPHOCYTES;

EID: 0034695876     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.191.4.695     Document Type: Article

References (36)

1. T-cell apoptosis detected in situ during positive and negative selection in the thymus
2. Actively acquired tolerance of foreign cells
3. Induction of TH1 and TH2 immunity in neonatal mice
4. Neonatal peptide exposure can prime T cells and, upon subsequent immunization, induce their immune deviation: Implications for antibody vs. T cell-mediated autoimmunity
5. Vaccination against autoimmune encephalomyelitis with T-lymphocyte line cells reactive against myelin basic protein
6. Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis
7. Vaccination against experimental allergic encephalomyelitis with T cell receptor peptides
8. Control of experimental autoimmune encephalomyelitis by T cells responding to activated T cells
9. + T cells in recovery from antigen-induced autoimmune disease
10. The distinctive specificity of antigen-specific suppressor T cells
11. Neonatal T-cell tolerance to minimal immunogenic peptides is caused by clonal inactivation
12. T cell tolerance by clonal elimination in the thymus
13. Induction of protective CTL responses in newborn mice by a murine retrovirus
14. Peptide-specific prevention of experimental allergic encephalomyelitis. Neonatal tolerance induced to the dominant T cell determinant of myelin basic protein
15. Induction of tolerance to one determinant on a synthetic peptide does not affect the response to a second linked determinant. Implications for the mechanism of neonatal tolerance induction
16. Major histocompatibility complex binding affinity of an antigenic determinant is crucial for the differential secretion of interleukin 4/5 or interferon gamma by T cells
17. + T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model
18. + T cells
19. T cell determinant structure: Cores and determinant envelopes in three mouse major histocompatibility complex haplotypes
20. Public and private V beta T cell receptor repertoires against hen egg white lysozyme (HEL) in nontransgenic versus HEL transgenic mice
21. A single intramuscular injection with an adenovirus-expressing IL-12 protects BALB/c mice against Leishmania major infection, while treatment with an IL-4-expressing vector increases disease susceptibility in B10.D2 mice
22. The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments
23. Hierarchy in the ability of T cell epitopes to induce peripheral tolerance to antigens from myelin
24. Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents routine insulin-dependent diabetes
25. Immune deviation during the induction of tolerance by way of nasal installation: Nasal installation itself can induce Th-2 responses and exacerbation of disease
26. Intramolecular mimicry. Identification and analysis of two cross-reactive T cell epitopes within a single protein
27. Degenerate recognition of a dissimilar antigenic peptide by myelin basic protein-reactive T cells. Implications for thymic education and autoimmunity
28. Homeostasis and self-tolerance in the immune system: Turning lymphocytes off
29. Peptide dose, affinity, and time of differentiation can contribute to the Th1/Th2 cytokine balance
30. + T cells into Th1 and Tb2 subsets
31. How some T cells escape tolerance induction
32. Tolerance to a self-protein involves its immunodominant but does not involve its subdominant determinants
33. Complexes generated by the binding of free peptides to class II MHC molecules are antigenically diverse compared with those generated by intracellular processing
34. + T cell responses: The alternative approaches
35. Specific inhibition of antibody formation during immunological paralysis and unresponsiveness
36. Immunogenetic consequences of vascular anastomoses between bovine twins