The role of interleukin-4 in the induction phase of allogeneic neonatal tolerance

Transplantation

Volumn 62, Issue 12, 1996, Pages 1847-1854

  Gao, Qinglin ^a   Chen, Naixi ^a   Rouse, Todd M ^b   Field, Elizabeth H ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 4;

ANIMAL EXPERIMENT; CELL MATURATION; CONFERENCE PAPER; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTE ACTIVATION; MOUSE; NEWBORN; NONHUMAN; ORGAN TRANSPLANTATION; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; ANTIBODIES, MONOCLONAL; CD4-POSITIVE T-LYMPHOCYTES; FEMALE; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNE TOLERANCE; INTERLEUKIN-4; MICE; MICE, INBRED A; MICE, INBRED BALB C; MICE, INBRED C57BL; PREGNANCY; SKIN TRANSPLANTATION; TH1 CELLS; TH2 CELLS; TRANSPLANTATION CONDITIONING; TRANSPLANTATION IMMUNOLOGY; TRANSPLANTATION, HOMOLOGOUS;

EID: 0030470416     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199612270-00029     Document Type: Conference Paper

References (53)

1. Billingham RE, Brent L, Medawar PB. Actively acquired tolerance of foreign cells. Nature 1953; 172: 603.
2. Brent L, Brooks GG, Medawar PB, Simpson E. Transplantation tolerance. Br Med Bull 1976; 32: 101.
3. Nossal GJV, Pike BL. Functional clonal deletion in immunological tolerance to major histocompatibility complex antigens. Proc Natl Acad Sci USA 1981; 78: 3844.
4. 1 spleen cells into parental mice. J Immunol 1983; 131: 2165.
5. Dorsch S, Roser B. Recirculating suppressor T cells in transplantation tolerance. J Exp Med 1977; 145: 1144.
6. Streilein JW, Gruchalla RS. Analysis of neonatally induced tolerance of H-2 alloantigens. I. Adoptive transfer indicates that tolerance of class I and class II antigens is maintained by distinct mechanisms. Immunogenetics 1981; 12: 161.
7. Powell TJ, Streilein JW. In vitro suppression of cytotoxic T cell generation by lymphocytes from mice rendered neonatally tolerant of class II MHC alloantigens. Transplantation 1991; 52: 383.
8. Matriano JA, Socarras S, Streilein JW. Cellular mechanisms that maintain neonatally induced tolerance of class II alloantigens: evidence that factor-mediated suppression silences cytotoxic T cell activity. J Immunol 1994; 153: 1505.
9. Matriano JA, Socarras S, Streilein JW. Cellular mechanisms that maintain neonatally induced tolerance of class II alloantigens: evidence that precursor cytotoxic T cells are present but silenced. J Immunol 1994; 153: 1515.
10. Streilein JW, Levy RB, Ruiz P, Matriano J, Socarras S. Multiple mechanisms induce and maintain neonatal transplantation tolerance. Transplant Sci 1993; 3: 11.
11. Chen N, Field EH. Enhanced type 2 and diminished type 1 cytokines in neonatal tolerance. Transplantation 1995; 59: 933.
12. Chen N, Gao Q, Field EH. Expansion of memory Th2 cells over Th1 cells in neonatal primed mice. Transplantation 1995; 60: 1187.
13. Powell TJ, Streilein JW. Neonatal tolerance induction by class II alloantigens activates IL-4-secreting, tolerogen-responsive T cells. J Immunol 1990; 144: 854.
14. Abramowicz D, Doutrelepont JM, Lambert P, Van der Vorst P, Bruyns C, Goldman M. Increased expression of Ia antigens on B cells after neonatal induction of lymphoid chimerism in mice: role of interleukin 4. Eur J Immunol 1990; 20: 469.
15. Abramowicz D, Van der Vorst P, Bruyns C, Doutrelepont JM, Vandenabeele P, Goldman M. Persistence of anti-donor allohelper T cells after neonatal induction of allotolerance in mice. Eur J Immunol 1990; 20: 1647.
16. Wood PJ, Cossens IA. Loss of Th1-associated function in peripheral T cells but not thymocytes in tolerance to major histocompatibility complex alloantigen. Immunology 1993; 79: 556.
17. + T lymphocytes in mice neonatally tolerized to alloantigens. Eur J Immunol 1993; 23: 2551.
18. Donckier V, Abramowicz D, Bruyns C, et al. IFN-γ prevents Th2 cell-mediated pathology after neonatal injection of semiallogenic spleen cells in mice. J Immunol 1994; 153: 2361.
19. Donckier V, Wissing M, Bruyns C, et al. Critical role of interleukin 4 in the induction of neonatal transplantation tolerance. Transplantation 1995; 59: 1571.
20. Gao Q, Chen N, Field EH. CD4 Th2 cells do not functionally suppress CTL generation in neonatal tolerant mice. Transplantation 1995; 60: 1260.
21. Adkins B, Hamilton K. Freshly isolated, murine neonatal T cells produce IL-4 in response to anti-CD3 stimulation. J Immunol 1992; 149: 3448.
22. Adkins B, Ghanei A, Hamilton K. Developmental regulation of IL-4, IL-2 and IFN-γ production by murine peripheral T lymphocytes. J Immunol 1993; 151: 6617.
23. Adkins B, Ghanei A, Hamilton K. Up-regulation of murine neonatal T helper cell responses by accessory cell factors. J Immunol 1994; 153: 3378.
24. Swain SL, Weinberg AD, English M, Huston G. IL-4 directs the development of Th2-like helper effectors. J Immunol 1990; 145: 3796.
25. + subsets during murine Leishmania major infection. Res Immunol 1991; 142: 28.
26. Chatelain R, Varkila K, Coffman RL. IL-4 induces a Th2 response in Leishmania major-infected mice. J Immunol 1992; 148: 1182.
27. Fiorentino DF, Bond MW, Mosmann TR. Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med 1989; 170: 2081.
28. H2 murine helper T lymphocyte clones using recombinant IL-2 and recombinant IFN-γ. J Immunol 1989; 143: 15.
29. Chen N, Gao Q, Field EH. Prevention of Th1 responses is critical for tolerance. Transplantation 1996; 61: 1076.
30. Field EH, Rouse TM. Alloantigen priming after total lymphoid irradiation alters alloimmune cytokine responses. Transplantation 1995; 60: 695.
31. Hosono M, Kurozumi M, Inaba M, Ideyama S, Tomana M, Katsura Y. Neonatal tolerance induction in the thymus to MHC-class-II-associated antigens. IV. Significance of intrathymic chimerism of blood-born Ia+ cells in Mls tolerance. Cell Immunol 1991; 136: 373.
32. Hosono M, Kurozumi M, Ideyama S, Katsura Y. Neonatal tolerance induction in the thymus to MHC-class-II-associated antigens. V. Thymus medulla and site for deletional signaling achievement in Mls tolerance. Thymus 1992; 20: 31.
33. Ruiz P, Streilein JW. Evidence that I-E-negative mice resistant to neonatal H-2 tolerance induction display ubiquitous thymic clonal deletion of donor-reactive T cells. Transplantation 1993; 55: 321.
34. Ruiz P, Nassiri M, Viciana AL, Padmanabhan J, Streilein JW. Characterization of donor chimerism, alloreactive host T cells and memory cells development in thymi from mice resistant to neonatal transplantation tolerance. J Immunol 1995; 154: 633.
35. Bishop DK, Chan S, Li W, Ensley RD, Xu S, Eichwald EJ. CD4-positive helper T lymphocytes mediate mouse cardiac allograft rejection independent of donor alloantigen specific cytotoxic T lymphocytes. Transplantation 1993; 56: 892.
36. Lowry RP, Marghesco DM, Blackburn JH. Immune mechanisms in organ allograft rejection. VI. Delayed-type hypersensitivity and lymphotoxin in experimental renal allograft rejection. Transplantation 1985; 40: 183.
37. b mutant. Immunogenetics 1984; 20: 475.
38. Rosenberg AS, Singer A. Cellular basis of skin allograft rejection: an in vivo model of immune-mediated tissue destruction. Annu Rev Immunol 1993; 10: 333.
39. + T cells. Transplantation 1992; 54: 278.
40. Sprent J, Schaefer M, Lo D, Korngold R. Properties of purified T cell subsets. II. In vivo responses to class I vs. class II H-2 differences. J Exp Med 1986; 163: 998.
41. + cells in vitro and in vivo. Immunol Rev 1986; 91: 195.
42. b mutant skin allografts differing at class I MHC. Nature 1986; 322: 829.
43. Rosenberg AS, Mizuochi T, Sharrow SO, Singer A. Phenotype, specificity, and function of T cell subsets and T cell interactions involved in skin allograft rejection. J Exp Med 1987; 165: 1296.
44. O'Garra A, Murphy K. Role of cytokines in determining T-lymphocyte function. Curr Opin Immunol 1994; 6: 458.
45. + T cells into IL-4-secreting cells. J Immunol 1994; 152: 5180.
46. Schurmans S, Heusser CH, Qin HY, Merino J, Brighouse G, Lambert PH. In vivo effects of anti-IL-4 monoclonal antibody on neonatal induction of tolerance and on an associated autoimmune syndrome. J Immunol 1990; 145: 2465.
47. H2 cytokines and help B cells. Science 1993; 260: 1802.
48. Croft M, Carter L, Swain SL, Dutton RW. Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles. J Exp Med 1994; 180: 1715.
49. + T cell. Immunol Today 1994; 15: 107.
50. + T cells results in Th2 cytokine production and alternate mechanisms of allograft rejection. Transplantation 1995; 53: 1155.
51. Sato S, Iwata H, Kitagawa S, et al. The lymphoid cell populations required for induction of tolerance of different subsets of alloantigen-reactive T cells. Transplantation 1991; 52: 862.
52. Scully R, Qin S, Cobbold S, Waldmann H. Mechanisms in anti-CD4 antibody-mediated transplantation tolerance: kinetics of induction, antigen dependency and role of regulatory T cells. Eur J Immunol 1994; 24: 2383.
53. Bushell A, Pearson TC, Morris PJ, Wood KJ. Donor-recipient microchimerism is not required for tolerance induction following recipient pretreatment with donor-specific transfusion and anti-CD4 antibody. Transplantation 1995; 59: 1367.