Mechanisms of amyloid β protein-induced modification in ion transport systems: Implications for neurodegenerative diseases

Cellular and Molecular Neurobiology

Volumn 21, Issue 3, 2001, Pages 173-213

  Kourie, Joseph I ^a  

^a AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

Author keywords

Alzheimer's disease; Beta amyloid; Ion channel diseases; Membrane physiology; Neurodegeneration; Neurofibrillary tangles; Protein aggregation; Senile plaques

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATE; AMYLOID BETA PROTEIN; CALCIUM CHANNEL; CALCIUM ION; CHLORIDE CHANNEL; CHLORIDE ION; POTASSIUM CHANNEL; POTASSIUM ION; REACTIVE OXYGEN METABOLITE; SODIUM CHANNEL; SODIUM ION;

ALZHEIMER DISEASE; CALCIUM HOMEOSTASIS; CELL MEMBRANE PERMEABILITY; CELL PH; DEGENERATIVE DISEASE; ENZYME ACTIVITY; HUMAN; ION TRANSPORT; NEUROFIBRILLARY TANGLE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN DEGRADATION; REVIEW; SENILE PLAQUE; TRANSPORT KINETICS;

AMYLOID BETA-PROTEIN; ANIMALS; HUMANS; ION CHANNELS; NEURODEGENERATIVE DISEASES;

EID: 0034858202     PISSN: 02724340     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1010932603406     Document Type: Review

References (141)

1. Learning and memory
2. Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein [AβP-(1-40)] in bilayer membranes
3. 2+-channel hypothesis for neuronal death in Alzheimer disease
4. 2+ interaction with Alzheimer amyloid beta protein calcium channels
5. Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: Blockade by tromethamine and aluminum
6. The secreted form of the Alzheimer's β-amyloid precursor protein stimulates a membrane-associated guanylate cyclase
7. Solution conformations and aggregational properties of synthetic amyloid beta-peptides of Alzheimer's disease. Analysis of circular dichroism spectra
8. Solution structures of beta peptide and its constituent fragments: Relation to amyloid deposition
9. Vitamin E protects nerve cells from amyloid beta protein toxicity
10. Hydrogen peroxide mediates amyloid β protein toxicity
11. Amyloid beta-peptide induces cell monolayer albumin permeability, impairs glucose transport, and induces apoptosis in vascular endothelial cells
12. The amyloid precursor protein fragment His 657-Lys 676 inhibits noradrenaline- and enkephaline-induced suppression of voltage sensitive calcium currents in NG108-15 hybrid cells
13. +-ATPase: Tissue slices versus primary cultures
14. Effects of ischemia and reperfusion on calcium exchange and mechanical function in isolated rabbit myocardium
15. Beta-amyloid peptides are cytotoxic to astrocytes in culture: A role for oxidative stress
16. 2+ influx induced by beta-amyloid peptide 25-35 in cultured hippocampal neurons results from network excitation
17. Modulation of A beta adhesiveness and secretase site cleavage by zinc
18. Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner
19. Electrophysiological effects of 25-35 amyloid-beta-protein on guinea-pig lateral septal neurons
20. Amylin-mediated inhibition of insulin-stimulated glucose transport in skeletal muscle
21. Aging modulates nitric oxide synthesis and cGMP levels in hippocampus and cerebellum. Effects of amyloid beta peptide
22. Caspase and calpain substrates: Roles in synaptic plasticity and cell death
23. Na/K-ATPase mRNA levels and plaque load in Alzheimer's disease
24. Impairment of hippocampal long-term potentiation by Alzheimer amyloid beta-peptides
25. + channel openers on beta-amyloid induced cerebrovascular endothelial dysfunction
26. Oxidative stress and Alzheimer disease
27. 2+-exchange current in cardiac myocytes: Mediation by sulfhydryl groups?
28. + currents of human T-lymphocytes are unaffected by Alzheimer's disease and amyloid beta protein
29. Role of potassium channels in amyloid-induced cell death
30. Barium influx mediated by the cardiac sodium exchanger in transfected Chinese hamster ovary cells
31. Oxidative stress, glutamate, and neurodegenerative disorders
32. Amyloid beta-peptide (AβP) potentiates a nimodipine-sensitive L-type barium conductance in N1E-115 neuroblastoma cells
33. Theoretical models of the ion channel structure of amyloid beta-protein
34. Beta-amyloid-induced calcium influx induces apoptosis in culture by oxidative stress rather than tau phosphorylation
35. Activation of the L voltage-sensitive calcium channel by mitogen-activated protein (MAP) kinase following exposure of neuronal cells to beta-amyloid. MAP kinase mediates beta-amyloid-induced neurodegeneration
36. Molecular mechanisms of memory and the pathophysiology of Alzheimer's disease
37. + channels
38. Amyloid deposits inside myocardial fibers in transthyretin-Met30 familial amyloidotic polyneuropathy. A histological and biochemical study
39. Effects of sulfate ions on Alzheimer beta/A4 peptide assemblies: Implications for amyloid fibril-proteoglycan interactions
40. Membrane currents induced in Xenopus oocytes by the C-terminal fragment of the beta-amyloid precursor protein
41. Amyloid beta protein-induced irreversible current in rat cortical neurones
42. + channels and suppression of neuronal activity by secreted beta-amyloid-precursor protein
43. High affinity glutamate transporters: Regulation of expression and activity
44. Processing of the amyloid protein precursor to potentially amyloidogenic derivatives
45. 2+ exchange in ventricular myocytes
46. 2+ and excitability in a modeled neuron
47. + current in rat hippocampal neurons
48. + channel openers protect hippocampal neurons against oxidative injury and amyloid beta-peptide toxicity
49. ALS-linked Cu/Zn-SOD mutation impairs cerebral synaptic glucose and glutamate transport and exacerbates ischemic brain injury
50. Neurotrophic factors protect cortical synaptic terminals against amyloid and oxidative stress-induced impairment of glucose transport, glutamate transport and mitochondrial function
51. Targeting of cell-surface beta-amyloid precursor protein to lysosomes: Alternative processing into amyloid-bearing fragments
52. Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide
53. Amyloid deposition as the central event in the aetiology of Alzheimer's disease
54. +-dependent glutamate uptake in rat hippocampal as cultures
55. + channel openers prevent global ischemia-induced expression of c-fos, c-jun, heat shock protein, and amyloid beta-protein precursor genes and neuronal death in rat hippocampus
56. Human and rodent sequence analogs of Alzheimer's amyloid beta A4 share similar properties and can be solubilized in buffers of pH 7.4
57. Aggregation and secondary structure of synthetic amyloid beta A4 peptides of Alzheimer's disease
58. Channel formation in the pathogenesis of Alzheimer's disease and other amyloidoses
59. Alzheimer amyloid Aβ1-42 channels: Effects of solvent, pH, and congo red
60. Membrane perturbation by the neurotoxic Alzheimer amyloid fragment b25-35 requires aggregation and β-sheet formation
61. Amyloid peptide channels: Blockade by zinc and inhibition by congo red
62. The effect of amylin and calcitonin generelated peptide on insulin-stimulated glucose transport in the diaphragm
63. Role of intercellular and intracellular communication by nitric oxide in coupling of muscarinic receptors to activation of guanylate cyclase in neuronal cells
64. Beta-amyloid 25-35 activates nitric oxide synthase in a neuronal clone
65. Structure of beta-crystallite assemblies formed by Alzheimer beta-amyloid protein analogues: Analysis by x-ray diffraction
66. Calcium mobilization evoked by amyloid beta-protein involves inositol 1,4,5-triphosphate production in human platelets
67. - channel activity in rat cortical astrocytes
68. +-ATPase activity in skeletal muscle by epinephrine or amylin
69. Amyloid fibril formation requires a chemically discriminating nucleation event: Studies of an amyloidogenic sequence from the bacterial protein OsmB
70. 2+-sensitive, cation-selective channels across excised membrane patches from hypothalamic neurons
71. +-ATPase activity, glucose transport, and glutamate transport induced by amyloid beta-peptide and iron
72. Impairment of glucose and glutamate transport and induction of mitochondrial oxidative stress and dysfunction in synaptosomes by amyloid beta-peptide - Role of the lipid peroxidation product 4-hydroxynonenal
73. Alzheimer and beta-amyloid-treated fibroblasts demonstrate a decrease in a memory-associated GTP-binding protein, Cp20
74. C-terminal fragment of Alzheimer's amyloid precursor protein inhibits sodium/calcium exchanger activity in SK-N-SH cell
75. 2+ ATPase
76. Cation selective channels formed by a C-terminal fragment of beta-amyloid precursor protein
77. - channels
78. Interaction of reactive oxygen species with ion transport mechanisms
79. Hydrogen peroxide inhibits chloride channels of the sarcoplasmic reticulum of skeletal muscle
80. Synthetic C-type natriuretic peptide forms large cation selective channels
81. Characterisation of a C-type natriuretic peptide CNP-39-formed cation-selective channel from platypus Ornithrorhynchus anatinus venom
82. + channel
83. Prion fragment PrP[106-126] forms distinct channel types
84. The role of natriuretic peptides in ion transport mechanisms
85. Properties of cytotoxic peptide-formed ion channels
86. Amylin and CGRP induce insulin resistance via a receptor distinct from cAMP-coupled CGRP receptor
87. Suppression of an amyloid beta peptide-mediated calcium channel response by a secreted beta amyloid precursor protein
88. Glutamate transporter alterations in Alzheimer disease are possibly associated with abnormal APP expression
89. 2+-sensitive channel in reconstituted lipid vesicles
90. Protection against amyloid beta peptide toxicity by zinc
91. 2+ channel activity by beta-amyloid-(1-40) in rat cortical synaptosomes and cultured cortical neurons. Modulation by the proinflammatory cytokine interleukin-1beta
92. 2+ homeostasis and cell death
93. +-ATPase activity in hippocampal neurons
94. A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide
95. Amyloid beta-peptide impairs glucose transport in hippocampal and cortical neurons: Involvement of membrane lipid peroxidation
96. Deficient glutamate transport is associated with neurodegeneration in Alzheimer's disease
97. Abnormal glutamate transport function in mutant amyloid precursor protein transgenic mice
98. Caspase dependent DNA fragmentation might be associated with excitotoxicity in Alzheimer disease
99. X-ray diffraction analysis of brain lipid membrane structure in Alzheimer's disease and beta-amyloid peptide interactions
100. Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives
101. Impairment of membrane transport and signal transduction systems by amyloidogenic proteins
102. Aβ25-35 induces rapid lysis of red blood cells: Contrast with Aβ1-42 and examination of underlying mechanisms
103. Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer's disease
104. Effects of APP derivatives and oxidative stress on basal forebrain cholinergic systems in Alzheimer's disease
105. Cellular and molecular mechanisms underlying perturbed energy metabolism and neuronal degeneration in Alzheimer's and Parkinson's diseases
106. Vascular nitric oxide may lessen Alzheimer's risk
107. Channel formation in planar lipid bilayers by a neurotoxic fragment of the beta-amyloid peptide
108. A beta peptides and calcium influence secretion of the amyloid protein precursor from chick sympathetic neurons in culture
109. Novel domain-specific actions of amyloid precursor protein on developing synapses
110. Gamma-secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length
111. Presenilin 1 regulates pharmacologically distinct gamma-secretase activities. Implications for the role of presenilin in gamma-secretase cleavage
112. Release of amyloid β-protein precursor derivatives by electrical depolarization of rat hippocampal slices
113. Glutamate release from microglia via glutamate transporter is enhanced by amyloid-beta peptide
114. Inhibition of Alzheimer's beta-amyloid induced vasoactivity and proinflammatory response in microglia by a cGMP-dependent mechanism
115. Neurodegeneration induced by beta-amyloid peptides in vitro: The role of peptide assembly state
116. In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity
117. Aggregation-related toxicity of synthetic beta-amyloid protein in hippocampal cultures
118. Amylin and epinephrine have no direct effect on glucose transport in isolated rat soleus muscle
119. Ion channel hypothesis for Alzheimer amyloid peptide neurotoxicity
120. A new hypothesis for the mechanism of amyloid toxicity, based on the calcium channel activity of amyloid beta protein (AβP) in phospholipid bilayer membranes
121. 2+ currents in rat cerebellar granule neurones
122. 2+-sensitive channel
123. Aggregates of a beta-amyloid peptide are required to induce calcium currents in neuron-like human teratocarcinoma cells: Relation to Alzheimer's disease
124. - current in identified Aplysia neurons
125. Amyloid peptides are toxic via a common oxidative mechanism
126. + pump current in isolated rabbit ventricular myocytes using the whole-cell voltage-clamp technique. Inhibition of the pump by oxidant stress
127. Activation of microglial cells by PrP and beta-amyloid fragments raises intracellular calcium through L-type voltage sensitive calcium channels
128. Amyloid β peptides act directly on single neurons
129. Amyloidosis
130. Molecular genetics of Alzheimer's disease
131. Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder
132. Amyloid beta peptide 25-35 modulates hydrolysis of phosphoinositides by membrane phospholipase(s) C of adult brain cortex
133. Amyloid beta-peptide-induced inhibition of MTT reduction in PC12h and C1300 neuroblastoma cells: Effect of nitroprusside
134. Displacement currents associated with the insertion of Alzheimer disease amyloid beta-peptide into planar bilayer membranes
135. 2+ channels: A possible involvement of free radicals
136. 2+ channel blockers attenuate beta-amyloid peptide toxicity to cortical neurons in culture
137. Neurotoxicity of Aβ amyloid protein in vitro is not altered by calcium channel blockade
138. Beta-amyloid selectively augments NMDA receptor-mediated synaptic transmission in rat hippocampus
139. Enhancement of outward potassium current may participate in beta-amyloid peptide-induced cortical neuronal death
140. Actions of neurotoxic beta-amyloid on calcium homeostasis and viability of PC12 cells are blocked by antioxidants but not by calcium channel antagonists
141. Human islet amyloid polypeptide at pharmacological levels inhibits insulin and phorbol ester-stimulated glucose transport in in vitro incubated human muscle strips