Impact of apoE deficiency on oxidative insults and antioxidant levels in the brain

Molecular Brain Research

Volumn 86, Issue 1-2, 2001, Pages 76-83

  Ramassamy, Charles ^a,b   Krzywkowski, Pascale ^a   Averill, Diana ^c   Lussier Cacan, Suzanne ^d   Theroux, Louise ^a   Christen, Yves ^e   Davignon, Jean ^d   Poirier, Judes ^a,f  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITÉ DU QUÉBEC À TROIS RIVIÈRES   (Canada)

^c UNIVERSITÉ DU QUÉBEC À MONTRÉAL   (Canada)

^d CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^e IPSEN   (France)

^f MCGILL UNIVERSITY   (Canada)

Author keywords

Tocopherol; Alzheimer's disease; Glutathione; Glutathione peroxidase; Lipid oxidation; Superoxide dismutase

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; APOLIPOPROTEIN E; OXIDIZING AGENT; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ADOLESCENT; ALLELE; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN LEVEL; CONTROLLED STUDY; FRONTAL CORTEX; GENOTYPE; HIPPOCAMPUS; HYPERLIPOPROTEINEMIA TYPE 3; LIPID OXIDATION; MALE; MOUSE; NONHUMAN; OXIDATION; PATHOGENESIS; PRIORITY JOURNAL;

ALZHEIMER DISEASE; ANIMALS; ANTIOXIDANTS; APOLIPOPROTEINS E; FRONTAL LOBE; GLUTATHIONE; HIPPOCAMPUS; LIPID PEROXIDATION; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OXIDATIVE STRESS; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCES; VITAMIN E;

EID: 0035977715     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(00)00268-0     Document Type: Article

References (49)

1. Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: Studies in humans and in atherosclerotic apolipoprotein E-deficient mice
2. Behavioural, phsysiological and morphological analysis of a line of apolipoprotein E knockout mouse
3. Plastic neuronal remodeling is impaired in patients with Alzheimer's disease carrying apolipoprotein e4 allele
4. Superoxide dismutase: Improved assays and an assay applicable to acrylamide gels
5. Apoliprotein E and β-amyloid levels in the hippocampus and frontal cortex of Alzheimer's disease-related and APOE genotype dependent
6. Association of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer's disease
7. Transgenic mouse models of lipoprotein metabolism and atherosclerosis
8. Protein measurement using bicinchoninic acid: Elimination of interfering substances
9. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
10. Chemistry and biochemistry of 4-hydroxy-2-nonenal, malonaldehyde and related aldehydes
11. Evidence for normal aging of the septo-hippocampal cholinergic system on apoE-(-/-) mice but impaired clearance of axonal degeneration products following injury
12. Age-related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in the brain
13. Licorice extract and its major polyphenol glabridin protect low-density lipoprotein against lipid peroxidation: In vitro and ex vivo studies in humans and in atheroslerotic apolipoprotein E-deficient mice
14. Copper/Zinc superoxide dismutase transgenic brain accumulates hydrogen peroxide after perinatal hypoxia ischemia
15. Memory deficit and cholinergic impairments in apolipoprotein E-deficient mice
16. Increased plasma lipoprotein lipid peroxidation in apoE-deficient mice
17. Transbilayer distribution of cholesterol is modified in brain synaptic plasma membranes of knockout mice deficient in the low-density lipoprotein receptor, apoliproptein E, or both proteins
18. Amyloid beta-peptide effects on synaptosomes from apolipoprotein E-deficient mice
19. Cholinergic systems and long-term potentiation in memory-impaired apoliprotein E-deficient mice
20. Apolipoprotein E-deficient mice have increased susceptibility to focal cerebral ischemia
21. Michaelson. Reduced levels of antioxidants in brains of apoE-deficient mice following closed head injury
22. Antioxidant mechanisms in apolipoprotein E deficient mice prior to and following head injury
23. Neurodegeneration in the central nervous system of apoE-deficient mice
24. Neurodegeneration and cognitive impairment in apoE-deficient mice ameliorated by infusion of recombinant apoE
25. Increased 3-nitrotyrosine in brains of ApoE-deficient mice
26. Apolipoprotein E allele-specific antioxidant activity and effects on cyotoxicity insults and β-amyloid peptides
27. 4-Hydroxy-2-nonenal pyrrole adducts in human neurodegenerative disease
28. Immunohistochemical detection of 4-hydroxy-2-nonenal adducts in Alzheimer's disease is associated with inheritance of apoE4
29. Increased cerebral cortical lipid peroxidation and abnormal phospholipids in aged homozygous apoE-deficient C57BL/6J
30. Radical-induced lipoprotein and plasma lipid oxidation in normal and apolipoprotein E gene knockout (apoE-/-) mice: apoE-/- mouse as a model for testing the role of tocopherol-mediated peroxidation in atherogenesis
31. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
32. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase
33. ApoE-deficient mice are a model of lipoprotein oxidation in atherogenesis
34. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombinant in ES cells
35. Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral infarction in mutant that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency
36. Requirement for superoxide in excitotoxic cell death
37. Apolipoprotein E polymorphism and Alzheimer's disease
38. 2-isoprostanes, in vivo markers of lipid peroxidation
39. Vitamin E suppresses isoprotane generation in vivo and reduces atherosclerosis in ApoE-deficient mice
40. Oxidative damage and protection by antioxidants in frontal cortex of Alzheimer's disease is related to the apolipoprotein E genotype
41. Oxidative insults are associated with apolipoprotein E genotype in Alzheimer's disease
42. Apolipoprotein E epsilon 4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases
43. Apolipoprotein E isoform-specific differences in outcome from focal ischemia in transgenic mice
44. Effect of the antioxidant N,N′-diphenyl 1,4-phenylenediamine (DPPD) on atherosclerosis in ApoE-deficient mice
45. Concurrent liquid chromatographic assay of retinol, alpha-tocopherol, beta-carotene, lycopene and beta cryptoxanthin in plasma with tocopherol acetate as internal standard
46. Genetics of the apolipoprotein E system in man
47. Age-related differences in synaptosomal peroxidative damage and membrane properties
48. Neural membrane phospholipids in Alzheimer's disease