Mechanism of inhibition of cathepsin K by potent, selective 1,5- diacylcarbohydrazides: A new class of mechanism-based inhibitors of thiol proteases

Biochemistry

Volumn 38, Issue 48, 1999, Pages 15893-15902

  Bossard, Mary J ^a   Tomaszek, Thaddeus A ^a   Levy, Mark A ^a   Ijames, Carl F ^a,b   Huddleston, Michael J ^a   Briand, Jacques ^a   Thompson, Scott ^a   Halpert, Stacie ^a   Veber, Daniel F ^a   Carr, Steven A ^a   Meek, Thomas D ^a   Tew, David G ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b Polychip Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN K; CYSTEINE PROTEINASE INHIBITOR; HYDRAZIDE DERIVATIVE; PAPAIN;

ACYLATION; ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME STABILITY; HYDROLYSIS; OSTEOCLAST; PRIORITY JOURNAL;

BINDING SITES; CATHEPSINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME REACTIVATORS; HYDRAZINES; KINETICS; LEUCINE; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; PAPAIN; PROTEASE INHIBITORS; SPECTROPHOTOMETRY;

EID: 0033619723     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi991193+     Document Type: Article

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