Use of papain as a model for the structure-based design of cathepsin K inhibitors: Crystal structures of two papain-inhibitor complexes demonstrate binding to S'-subsites

Journal of Medicinal Chemistry

Volumn 41, Issue 23, 1998, Pages 4567-4576

  LaLonde, Judith M ^a   Zhao, Baoguang ^a   Smith, Ward W ^a   Janson, Cheryl A ^a   DesJarlais, Renee L ^a   Tomaszek, Thaddeus A ^a   Carr, Thomas J ^a   Thompson, Scott K ^a   Oh, Hye Ja ^a   Yamashita, Dennis S ^a   Veber, Daniel F ^a   Abdel Meguid, Sherin S ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOBENZYLOXYLEUCINYLLEUCINYLLEUCINAL; CARBOBENZYLOXYLEUCINYLLEUCINYLMETHOXYMETHYLKETONE; CATHEPSIN; PAPAIN; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; DRUG CONFORMATION; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITOR INTERACTION; ENZYME SPECIFICITY; OSTEOCLAST; OSTEOLYSIS; PROTEINASE INHIBITION; STRUCTURE ANALYSIS;

BINDING SITES; CATHEPSINS; CRYSTALLOGRAPHY, X-RAY; CYSTEINE PROTEINASE INHIBITORS; DIPEPTIDES; DRUG DESIGN; LEUPEPTINS; MODELS, MOLECULAR; PAPAIN; PROTEIN STRUCTURE, TERTIARY;

EID: 15444360805     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980249f     Document Type: Article

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