Contribution of peptide bonds to inhibitor-protease binding: Crystal structures of the Turkey ovomucoid third domain backbone variants OMTKY3-Pro181 and OMTKY3-ψ[COO]-Leu181 in complex with Streptomyces griseus proteinase B (SGPB) and the structure of the free inhibitor, OMTKY3-ψ[CH2NH2+]-Asp191

Journal of Molecular Biology

Volumn 305, Issue 4, 2001, Pages 839-849

  Bateman, Katherine S ^a   Huang, Kui ^a   Anderson, Stephen ^b   Lu, Wuyuan ^c   Qasim, M A ^d   Laskowski Jr , Michael ^d   James, Michael N G ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b RUTGERS UNIVERSITY   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

^d PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; OVOMUCOID; PROTEINASE; PROTEINASE B; PROTEINASE INHIBITOR; TURKEY OVOMUCOID THIRD DOMAIN; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL BOND; ENZYME INHIBITOR INTERACTION; NONHUMAN; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN STRUCTURE; PROTEIN VARIANT; STREPTOMYCES GRISEUS; TURKEY (BIRD);

BACTERIA (MICROORGANISMS); STREPTOMYCES GRISEUS;

EID: 0035951311     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.4343     Document Type: Article

References (56)

1. Natural protein proteinase inhibitors and their interactions with proteinases
2. Hydrogen bonding and biological specificity analysed by protein engineering
3. Contribution of hydrogen bonding to the conformational stability of ribonuclease T1
4. The hydrogen bond in molecular recognition
5. Procheck: A program to check the stereochemical quality of protein structure
6. Structure of the complex of Streptomyces griseus protease B and the third domain of the turkey ovomucoid inhibitor at 1.8 Å resolution
7. Refined crystal structure of the molecular complex of Streptomyces griseus protease B, a serine protease, with the third domain of the ovomucoid inhibitor from turkey
8. Water molecules participate in proteinase-inhibitor interactions: Crystal structures of Leu18, Ala18, Gly18 variants of turkey ovomucoid inhibitor third domain with Streptomyces griseus proteinase B
9. Deleterious effects of β-branched residues in the S1 specificity pocket of Streptomyces griseus proteinase B: Cystal structures of the turkey ovomucoid third domain variants Ile18I, Val18I, Thr18I and Ser18I in complex with SGPB
10. Binding of amino acid side-chains to S1 cavities of serine proteinases
11. Crystal and molecular structures of the complex of α-chymotrypsin with its inhibitor turkey ovomucoid third domain at 1.8 Å resolution
12. X-ray crystal structure of the complex of human leukocyte elastase PMN elastase and the third domain of the turkey ovomucoid inhibitor
13. Probing intermolecular main-chain hydrogen bonding in serine proteinase-protein inhibitor complexes: Chemical synthesis of backbone-engineered turkey ovomucoid third domain
14. Ovomucoid third domains from 100 avian species: Isolation, sequences and hypervariability of enzyme-inhibitor contact residues
15. AMoRe: An automated package for molecular replacement
16. Comparison of the accuracy of protein solution structures derived from conventional and network-edited NOSEY data
17. BPTI backbone variants and implications for inhibitory activity
18. Structures of two thermolysin-inhibitor complexes that differ by a single hydrogen bond
19. Calculation of the relative change in binding free energy of a protein-inhibitor complex
20. Evaluation of intrinsic binding energy from a hydrogen bonding group in an enzyme inhibitor
21. Binding energetics of phosphorus-containing inhibitors of thermolysin
22. General and theoretical aspects of the COOH and COOR groups
23. Accurate bond and angle parameters for X-ray protein structure refinement
24. Geometrical reaction coordinates. II Nucleophilic addition to a carbonyl group
25. High resolution X-ray analyses of renin inhibitor-aspartic proteinase complexes
26. Binding of a reduced peptide inhibitor to the aspartic proteinase from Rhizopus chinensis: Implications for a mechanism of action
27. Structure of complex of synthetic HIV-1 protease with a substrate-based inhibitor at 23 Å resolution
28. Molecular structure of an aspartic proteinase zymogen, porcine pepsinogen, at 1.8 Å resolution
29. Refined structure of porcine pepsinogen at 1.8 Å resolution
30. The high-resolution crystal structure of porcine pepsinogen
31. Crystal and molecular structures of human progastricsin at 1.62 Å resolution
32. Crystal structure of human pepsinogen A
33. Molecular mechanisms for the conversion of zymogens to active proteolytic enzymes
34. Amino acid sequence of Streptomyces griseus protease B, a major component of pronase
35. Synthesis of proteins by positive chemical ligation
36. Seeding techniques
37. Multiwire area X-ray diffractometers
38. Use of the multiwire area detector diffractometer as a national resource for protein crystallography
39. Software for a diffractometer with multiwire area detector
40. Processing of X-ray diffraction data collected in oscillation mode
41. Appendix B: Xtalview users' guide. A software system for protein crystallography
42. Improved methods for building protein models in electron density maps and the location of errors in these models
43. Conjugate-direction minimization: An improved method for the refinement of macromolecules
44. Crystallographic analysis of transition-state mimics bound to penicillopepsin: Phosphorus-containing peptide analogues
45. Structural studies of a bacteriochlorophyll-containing protein
46. The Free-R value: A novel statistical quality for assessing the accuracy of crystal structures
47. Homology modeling, model software evaluation: Three related resources
48. The protein data bank: A computer based archival file for macromolecular structures
49. A fast algorithm for rendering space-filling molecule pictures
50. Traitement statistique des erreurs dans la determination des structures cristallines
51. Improved fourier coefficients for maps using phases from partial structures with errors
52. Crystallographic refinement of Japanese quail ovomucoid, a Kazal-type inhibitor, and model building studies of complexes with serine proteases
53. The crystal and molecular structure of the third domain of silver pheasant ovomucoid OMSVP3