Structural basis for specificity of retroviral proteases

Biochemistry

Volumn 37, Issue 13, 1998, Pages 4518-4526

  Wu, Jin ^a   Adomat, Jill M ^a   Ridky, Todd W ^b   Louis, John M ^c   Leis, Jonathan ^b   Harrison, Robert W ^a   Weber, Irene T ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINASE;

ARTICLE; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME STRUCTURE; NONHUMAN; PRIORITY JOURNAL; RETROVIRUS; STRUCTURE ACTIVITY RELATION;

ASPARTIC ENDOPEPTIDASES; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; HIV PROTEASE; HIV PROTEASE INHIBITORS; HUMANS; HYDROGEN BONDING; HYDROLYSIS; KINETICS; MODELS, MOLECULAR; MUTATION; OLIGOPEPTIDES; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION; RECOMBINANT PROTEINS;

AVES; HUMAN IMMUNODEFICIENCY VIRUS 1; RICE STRIPE VIRUS; ROUS SARCOMA VIRUS; UNIDENTIFIED RETROVIRUS;

EID: 0032584293     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi972183g     Document Type: Article

References (28)

1. Miller, M., Jaskólski, M., Mohana Rao, J. K., Leis, J., and Wlodawer, A. (1989) Nature 337, 576-579.
2. Jaskólski, M., Miller, M., Mohana Rao, J. K., Leis, J., and Wlodawer, A. (1990) Biochemistry 29, 5889-5898.
3. Wlodawer, A., and Erickson, J. W. (1993) Annu. Rev. Biochem. 62, 543-585.
4. Grinde, B., Cameron, C. E., Leis, J., Weber, I., Wlodawer, A., Burstein, H., Bizub, D., and Skalka, A.-M. (1992) J. Biol. Chem. 267, 9491-9498.
5. Cameron, C., Grinde, B., Jentoft, J., Leis, J., Weber, I., Copeland, T., and Wlodawer, A. (1992) J. Biol. Chem. 267, 23735-23741.
6. Cameron, C. E., Ridky, T. W., Shulenin, S., Leis, J., Weber, I. T., Copeland, T., Wlodawer, A., Burstein, H., Bizub-Bender, D., and Skalka, A. M. (1994) J. Biol. Chem. 269, 11170-11177.
7. Ridky, T. W., Bizub-Bender, D., Cameron, C., Weber, I. T., Wlodawer, A., Copeland, T., Skalka, A. M., and Leis, J. (1996) J. Biol. Chem. 271, 10538-10544.
8. Aiyar, A., Xiang, Y., and Leis, J. (1995) in Methods in Molecular Biology (Trower, M., Ed.) Vol. 57, pp 177-191, Humana Press Inc., Totoua, NJ.
9. Mildner, A. M., Rothrock, D. J., Leone, J. W., Bannow, C. A., Lull, J. M., Reardon, I. M., Sarcich, J. L., Howe, W. J., Tomich, C.-S. C., Smith, C. W., Heinrickson, R. L., and Tomasselli, A. G. (1994) Biochemistry 33, 9405-9413.
10. Wondrak, E. M., and Louis, J. M. (1996) Biochemistry 35, 12957-12962.
11. Tozser, J., Weber, I. T., Gustchina, A., Blaha, I., Copeland, T. D., Louis, J. M., and Oroszlan, S. (1992) Biochemistry 31, 4793-4800.
12. Dixon, M. (1953) Biochem. J. 55, 170-171.
13. Maibaum, J., and Rich, D. (1988) J. Med. Chem. 31, 625-629.
14. Bhat, T. N., Baldwin, E. T., Liu, B., Cheng, Y.-S., and Erickson, J. W. (1994) Nat. Struct. Biol. 1, 552-556.
15. Weber, I. T., Wu, J., Adomat, J., Harrison, R. W., Kimmel, A. R., Wondrak, E. M., and Louis, J. M. (1997) Eur. J. Biochem. 249, 523-530.
16. Brunger, A. T. (1992) X-PLOR version 3.1, Yale University Press, New Haven, CT.
17. Jones, T. A. (1985) Methods Enzymol. 115, 157-171.
18. Wlodawer, A., Nachman, J., Gilliland, G. L., Gallagher, W., and Woodward, C. (1987) J. Mol. Biol. 198, 469-480.
19. Zegers, I., Maes, D., Dao-Thi, M.-H., Poortmans, F., Palmer, R., and Wyns, L. (1994) Protein Sci. 3, 2322-2339.
20. Miller, M., Schneider, J., Sathyanarayana, B. K., Toth, M. V., Marshall, G. R., Clawson, L., Selk, L., Kent, S., and Wlodawer, A. (1989) Science 246, 1149-1152.
21. Weber, I. T. (1990) J. Biol. Chem. 265, 10492-10496.
22. Gustchina, A., Sansom, C., Prevost, M., Richelle, J., Wodak, S. Y., Wlodawer, A., and Weber, I. T. (1994) Protein Eng. 7, 309-317.
23. Barrie, K. A., Perez, E. E., Lamers, S. L., Farmerie, W. G., Dunn, B. M., Sleasman, J. W., and Goodenow, M. M. (1996) Virology 219, 407-416.
24. Grinde, B., Cameron, C., Weber, I., Wlodawer, A., Burstein, H., Bizub, D., Skalka, A. M., and Leis, J. (1992) J. Biol. Chem. 267, 9481-9490.
25. Tozser, J., Yin, F. H., Cheng, Y.-S. E., Bagossi, P., Weber, I. T., Harrison, R. W., and Oroszlan, S. (1997) Eur. J. Biochem. 244, 235-241.
26. Shao, W., Everitt, L., Manchester, M., Loeb, D., Hutchinson, C., III, and Swanstrom, R. (1997) Proc. Natl. Acad. Sci. U.S.A. 94, 2243-2248.
27. Cameron, C. E., Grinde, B., Jacques, P., Jentoft, J., Leis, J., Wlodawer, A., and Weber, I. (1993) J. Biol. Chem. 268, 11711-11720.
28. Schinazi, R. F., Larder, B. A., and Mellors, J. W. (1996) Int. Antiviral News 4, 95-107.