How microarrays can improve our understanding of immune responses and vaccine development

Annals of the New York Academy of Sciences

Volumn 975, Issue , 2002, Pages 1-23

  Aujame, Luc ^a   Burdin, Nicolas ^a   Vicari, Marissa ^a  

^a Campus Mérieux ^*  (France)

Author keywords

Cancer; Gene profiling; Host pathogen interaction; Immune response; Transcriptome; Vaccine

Indexed keywords

BACTERIAL VACCINE; CANCER VACCINE; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CHEMOKINE; CYTOKINE; DNA; FC RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; RANTES; T LYMPHOCYTE RECEPTOR; VIRUS VACCINE;

ANTIGEN PRESENTING CELL; AUTOIMMUNE DISEASE; B LYMPHOCYTE; BORDETELLA PERTUSSIS; BORRELIA BURGDORFERI; BREAST CANCER; CANCER; CANDIDA ALBICANS; CHLAMYDOPHILA PNEUMONIAE; CONFERENCE PAPER; COXSACKIE VIRUS B3; CYTOMEGALOVIRUS; DENDRITIC CELL; DNA FINGERPRINTING; DNA MICROARRAY; DNA SEQUENCE; ESCHERICHIA COLI; GENETIC TRANSCRIPTION; GENOMICS; HELICOBACTER PYLORI; HERPES SIMPLEX VIRUS 1; HOST PATHOGEN INTERACTION; HUMAN; HUMAN HERPESVIRUS 8; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNE DEFICIENCY; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; IMMUNOPATHOLOGY; INFECTION; INFLAMMATORY DISEASE; INFLUENZA VIRUS; MACROPHAGE; MEASLES VIRUS; MONOCYTE; NEISSERIA MENINGITIDIS; NONHUMAN; PROSTATE CARCINOMA; PSEUDOMONAS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SALMONELLA; STAPHYLOCOCCUS AUREUS; T LYMPHOCYTE; TOXOPLASMA GONDII; TRYPANOSOMA CRUZI; WART VIRUS;

BACTERIA (MICROORGANISMS); BORDETELLA; BORDETELLA PERTUSSIS; BORRELIA; BORRELIA BURGDORFERI; CANDIDA; CANDIDA ALBICANS; CHLAMYDOPHILA; CHLAMYDOPHILA PNEUMONIAE; COXSACKIEVIRUS; CYTOMEGALOVIRUS; ESCHERICHIA COLI; HELICOBACTER; HELICOBACTER PYLORI; HERPESVIRIDAE; HUMAN HERPESVIRUS 1; HUMAN HERPESVIRUS 8; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN PAPILLOMAVIRUS TYPES; INFLUENZA VIRUS; MEASLES VIRUS; NEISSERIA; NEISSERIA MENINGITIDIS; PSEUDOMONAS; SALMONELLA; SIMPLEXVIRUS; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS; TOXOPLASMA GONDII; TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 0036960288     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2002.tb05937.x     Document Type: Conference Paper

References (103)

1. STAUDT, L.M. 2001. Gene expression physiology and pathophysiology of the immune system. Trends Immunol. 22: 35-40.
2. ALIZADEH, A.A. & L.M. STAUDT. 2000. Genomic-scale gene expression profiling of normal and malignant immune cells. Curr. Opin. Immunol. 12: 219-225.
3. GRANUCCI, F., P.R. CASTAGNOLI, L. ROGGE & F. SINIGAGLIA. 2001. Gene expression profiling in immune cells using microarray. Int. Arch. Allergy Immunol. 126: 257-266.
4. LOY, A.L. & C.C. GOODNOW. 2002. Novel approaches for identifying genes regulating lymphocyte development and function. Curr. Opin. Immunol. 14: 260-265.
5. MAAS, K., S. CHAN, J. PARKER, et al. 2002. Cutting edge: molecular portrait of human autoimmune disease. J. Immunol. 169: 5-9.
6. STAUDT, L.M. & P.O. BROWN. 2000. Genomic views of the immune system. Annu. Rev. Immunol. 18: 829-859.
7. SHAFFER, A.L., A. ROSENWALD, E.M. HURT, et al. 2001. Signatures of the immune response. Immunity 15: 375-385.
8. GLYNNE, R., S. AKKARAJU, J.I. HEALY, et al. 2000. How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis. Nature 403: 672-676.
9. GLYNNE, R., G. GHANDOUR, J. RAYNER, et al. 2000. B-lymphocyte quiescence, tolerance and activation as viewed by global gene expression profiling on microarrays. Immunol. Rev. 176: 216-246.
10. TEAGUE, T.K., D. HILDEMAN, R.M. KEDL, et al. 1999. Activation changes the spectrum but not the diversity of genes expressed by T cells. Proc. Natl. Acad. Sci. USA 96: 12691-12696.
11. BONECCHI, R., G. BIANCHI, P.P. BORDIGNON, et al. 1998. Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J. Exp. Med. 187: 129-134.
12. GRANUCCI, F., C. VIZZARDELLI, N. PAVELKA, et al. 2001. Inducible IL-2 production by dendritic cells revealed by global gene expression analysis. Nat. Immunol. 2: 882-888.
13. HUANG, Q., D. LIU, P. MAJEWSKI, et al. 2001. The plasticity of dendritic cell responses to pathogens and their components. Science 294: 870-875.
14. BARANZINI, S.E., C. ELFSTROM, S.Y. CHANG, et al. 2000. Transcriptional analysis of multiple sclerosis brain lesions reveals a complex pattern of cytokine expression. J. Immunol. 165: 6576-6582.
15. LOCK, C., G. HERMANS, R. PEDOTTI, et al. 2002. Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat. Med. 8: 500-508.
16. EAVES, I.A., L.S. WICKER, G. GHANDOUR, et al. 2002. Combining mouse congenic strains and microarray gene expression analyses to study a complex trait: the NOD model of type 1 diabetes. Genome Res. 12: 232-243.
17. AZUMA, T., M. TAKEI, T. YOSHIKAWA, et al. 2002. Identification of candidate genes for Sjogren's syndrome using MRL/lpr mouse model of Sjogren's syndrome and cDNA microarray analysis. Immunol. Lett. 81: 171-176.
18. CARROLL, J.M., K.J. MCELWEE, E. KING, et al. 2002. Gene array profiling and immunomodulation studies define a cell-mediated immune response underlying the pathogenesis of alopecia areata in a mouse model and humans. J. Invest. Dermatol. 119: 392-402.
19. BECHER, B., B.G. DURELL & R.J. NOELLE. 2002. Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12. J. Clin. Invest. 110: 493-497.
20. LYONS, P. 2002. Gene-expression profiling and the genetic dissection of complex disease. Curr. Opin. Immunol. 14: 627.
21. HELLER, R.A., M. SCHENA, A. CHAI, et al. 1997. Discovery and analysis of inflammatory disease-related genes using cDNA microarrays. Proc. Natl. Acad. Sci. USA 94: 2150-2155.
22. LAWRANCE, I.C., C. FIOCCHI & S. CHAKRAVARTI. 2001. Ulcerative colitis and Crohn's disease: distinctive gene expression profiles and novel susceptibility candidate genes. Hum. Mol. Genet. 10: 445-456.
23. OESTREICHER, J.L., I.B. WALTERS, T. KIKUCHI, et al. 2001. Molecular classification of psoriasis disease-associated genes through pharmacogenomic expression profiling. Pharmacogenomics J. 1: 272-287.
24. BOWCOCK, A.M., W. SHANNON, F. DU, et al. 2001. Insights into psoriasis and other inflammatory diseases from large-scale gene expression studies. Hum. Mol. Genet. 10: 1793-1805.
25. HOFFMANN, K.F., T.C. MCCARTY, D.H. SEGAL, et al. 2001. Disease fingerprinting with cDNA microarrays reveals distinct gene expression profiles in lethal type 1 and type 2 cytokine-mediated inflammatory reactions. FASEB J. 15: 2545-2547.
26. STAUDT, L.M. 2002. Gene expression profiling of lymphoid malignancies. Annu. Rev. Med. 53: 303-318.
27. HANASH, S.M. 2001. Global profiling of gene expression in cancer using genomics and proteomics. Curr. Opin. Mol. Ther. 3: 538-545.
28. ALIZADEH, A.A., M.B. EISEN, R.E. DAVIS, et al. 2000. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 403: 503-511.
29. ZHU, H., J.P. CONG, G. MAMTORA, et al. 1998. Cellular gene expression altered by human cytomegalovirus: global monitoring with oligonucleotide arrays. Proc. Natl. Acad. Sci. USA 95: 14470-14475.
30. POOLE, L.J., Y. YU, P.S. KIM, et al. 2002. Altered patterns of cellular gene expression in dermal microvascular endothelial cells infected with Kaposi's sarcoma-associated herpesvirus. J. Virol. 76: 3395-3420.
31. MOSES, A.V., M.A. JARVIS, C. RAGGO, et al. 2002. Kaposi's sarcoma-associated herpesvirus-induced upregulation of the c-kit proto-oncogene, as identified by gene expression profiling, is essential for the transformation of endothelial cells. J. Virol. 76: 8383-8399.
32. MANGER, I.D. & D.A. RELMAN. 2000. How the host 'sees' pathogens: global gene expression responses to infection. Curr. Opin. Immunol. 12: 215-218.
33. BOLDRICK, J.C., A.A. ALIZADEH, M. DIEHN, et al. 2002. Stereotyped and specific gene expression programs in human innate immune responses to bacteria. Proc. Natl. Acad. Sci. USA 99: 972-977.
34. PIZZA, M., V. SCARLATO, V. MASIGNANI, et al. 2000. Identification of vaccine candidates against serogroup B meningococcus by whole-genome sequencing. Science 287: 1816-1820.
35. PUSKAS, L.G., A. ZVARA, L. HACKLER, JR. 8,: P. VAN HUMMELEN. 2002. RNA amplification results in reproducible microarray data with slight ratio bias. Biotechniques 32: 1330-1340.
36. PRITCHARD, C.C., L. HSU, J. DELROW & P.S. NELSON. 2001. Project normal: defining normal variance in mouse gene expression. Proc. Natl. Acad. Sci. USA 98: 13266-13271.
37. CARUCCI, D.J. 2001. Functional genomic technologies applied to the control of the human malaria parasite, Plasmodium falciparum. Pharmacogenomics 2: 137-142.
38. SPELLMAN, P.T., M. MILLER, J. STEWART, et al. 2002. Design and implementation of microarray gene expression markup language (MAGE-ML). Genome Biol. 3: RESEARCH0046-1-0046.9.
39. KUO, W.P., T.K. JENSSEN, A.J. BUTTE, et al. 2002. Analysis of matched mRNA measurements from two different microarray technologies. Bioinformatics 18: 405-412.
40. GRIFANTINI, R., E. BARTOLINI, A. MUZZI, et al. 2002. Previously unrecognized vaccine candidates against group B meningococcus identified by DNA microarrays. Nat. Biotechnol. 20: 914-921.
41. DHIMAN, N., R. BONILLA, D.J. O'KANE & G.A. POLAND. 2001. Gene expression microarrays: a 21st century tool for directed vaccine design. Vaccine 20: 22-30.
42. MITCHELL, T.C., D. HILDEMAN, R.M. KEDL, et al. 2001. Immunological adjuvants promote activated T cell survival via induction of Bcl-3. Nat. Immunol. 2: 397-402.
43. LE NAOUR, F., L. HOHENKIRK, A. GROLLEAU, et al. 2001. Profiling changes in gene expression during differentiation and maturation of monocyte-derived dendritic cells using both oligonucleotide microarrays and proteomics. J. Biol. Chem. 276: 17920-17931.
44. GRANUCCI, F., C. VIZZARDELLI, E. VIRZI, et al. 2001. Transcriptional reprogramming of dendritic cells by differentiation stimuli. Eur. J. Immunol. 31: 2539-2546.
45. LAPTEVA, N., M. NIEDA, Y. ANDO, et al. 2001. Gene expression analysis in human monocytes, monocyte-derived dendritic cells, and alpha-galactosylceramide-pulsed monocyte-derived dendritic cells. Biochem. Biophys. Res. Commun. 289: 531-538.
46. LAPTEVA, N., Y. ANDO, M. NIEDA, et al. 2001. Profiling of genes expressed in human monocytes and monocyte-derived dendritic cells using cDNA expression array. Br. J. Haematol. 114: 191-197.
47. CHEN, Z., J.R. GORDON, X. ZHANG & J. XIANG. 2002. Analysis of the gene expression profiles of immature versus mature bone marrow-derived dendritic cells using DNA arrays. Biochem. Biophys. Res. Commun. 290: 66-72.
48. CHEN, Z., S. DEHM, K. BONHAM, et al. 2001. DNA array and biological characterization of the impact of the maturation status of mouse dendritic cells on their phenotype and antitumor vaccination efficacy. Cell Immunol. 214: 60-71.
49. SUCIU-FOCA, C.N., F. PIAZZA, E. HO, et al. 2001. Distinct mRNA microarray profiles of tolerogenic dendritic cells. Hum. Immunol. 62: 1065-1072.
50. MOSCHELLA, F., A. MAFFEI, R.P. CATANZARO, et al. 2001. Transcript profiling of human dendritic cells maturation-induced under defined culture conditions: comparison of the effects of tumour necrosis factor alpha, soluble CD40 ligand trimer and interferon gamma. Br. J. Haematol. 114: 444-457.
51. BALTATHAKIS, I., O. ALCANTARA & D.H. BOLDT. 2001. Expression of different NF-kappaB pathway genes in dendritic cells (DCs) or macrophages assessed by gene expression profiling. J. Cell. Biochem. 83: 281-290.
52. ROGGE, L., E. BIANCHI, M. BIFFI, et al. 2000. Transcript imaging of the development of human T helper cells using oligonucleotide arrays. Nat. Genet. 25: 96-101.
53. HAMALAINEN, H., H. ZHOU, W. CHOU, et al. 2001. Distinct gene expression profiles of human type 1 and type 2 T helper cells. Genome Biol. 2: RESEARCH0022.1-0022.11
54. CHTANOVA, T., R.A. KEMP, A.P. SUTHERLAND, et al. 2001. Gene microarrays reveal extensive differential gene expression in both CD4(+) and CDS(+) type 1 and type 2 T cells. J. Immunol. 167: 3057-3063.
55. LI, X. D., D.M. ESSAYAN, M.C. LIU, et al. 2001. Profiling of differential gene expression in activated, allergen-specific human Th2 cells. Genes Immun. 2: 88-98.
56. LIU, K., Y. LI, V. PRABHU, et al. 2001. Augmentation in expression of activation-induced genes differentiates memory from naive CD4+ T cells and is a molecular mechanism for enhanced cellular response of memory CD4+ T cells. J. Immunol. 166: 7335-7344.
57. LIU, K., M. CATALFAMO, Y. LI, et al. 2002. IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8+ memory T cells. Proc. Natl. Acad. Sci. USA 99: 6192-6197.
58. DIEHN, M., A.A. ALIZADEH, O.J. RANDO, et al. 2002. Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation. Proc. Natl. Acad. Sci. USA 99: 11796-11801.
59. MUTA, H., L.H. BOISE, L. FANG & E.R. PODACK. 2000. CD30 signals integrate expression of cytotoxic effector molecules, lymphocyte trafficking signals, and signals for proliferation and apoptosis. J. Immunol. 165: 5105-5111.
60. LI, Z., L. HE, K. WILSON & D. ROBERTS. 2001. Thrombospondin-1 inhibits TCR-mediated T lymphocyte early activation. J. Immunol. 166: 2427-2436.
61. SUZUKI, Y., M. RAHMAN & H. MITSUYA. 2001. Diverse transcriptional response of CD4(+) T cells to stromal cell-derived factor (SDF)-1: cell survival promotion and priming effects of SDF-1 on CD4(+) T cells. J. Immunol. 167: 3064-3073.
62. GROLLEAU, A., J. BOWMAN, B. PRADET-BALADE, et al. 2002. Global and specific translational control by rapamycin in T cells uncovered by microarrays and proteomics. J. Biol. Chem. 277: 22175-22184.
63. FESKE, S., J. GILTNANE, R. DOLMETSCH, et al. 2001. Gene regulation mediated by calcium signals in T lymphocytes. Nat. Immunol. 2: 316-324.
64. MCHUGH, R.S., M.J. WHITTERS, C.A. PICCIRILLO, et al. 2002. CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 16: 311-323.
65. WILSON, S.B. & M.C. BYRNE. 2001. Gene expression in NKT cells: defining a functionally distinct CD1d-restricted T cell subset. Curr. Opin. Immunol. 13: 555-561.
66. WILSON, S.B., S.C. KENT, H.F. HORTON, et al. 2000. Multiple differences in gene expression in regulatory Valpha 24Jalpha Q T cells from identical twins discordant for type I diabetes. Proc. Natl. Acad. Sci. USA 97: 7411-7416.
67. FAHRER, A.M., Y. KONIGSHOFER, E.M. KERR, et al. 2001. Attributes of gammadelta intraepithelial lymphocytes as suggested by their transcriptional profile. Proc. Natl. Acad. Sci. USA 98: 10261-10266.
68. HOFFMANN, R., T. SEIDL, M. NEEB, et al. 2002. Changes in gene expression profiles in developing B cells of murine bone marrow. Genome Res. 12: 98-111.
69. HUSSON, H., E.G. CARIDEO, D. NEUBERG, et al. 2002. Gene expression profiling of follicular lymphoma and normal germinal center B cells using cDNA arrays. Blood 99: 282-289.
70. ISLAM, T.C., J. LINDVALL, A. WENNBORG, et al. 2002. Expression profiling in transformed human B cells: influence of Btk mutations and comparison to B cell lymphomas using filter and oligonucleotide arrays. Eur. J. Immunol. 32: 982-993.
71. BRUTSCHE, M.H., I.C. BRUTSCHE, P. WOOD, et al. 2001. B-cell isotype control in atopy and asthma assessed with cDNA array technology. Am. J. Physiol. Lung Cell. Mol. Physiol. 280: L627-L637.
72. DADGOSTAR, H., B. ZARNEGAR, A. HOFFMANN, et al. 2002. Cooperation of multiple signaling pathways in CD40-regulated gene expression in B lymphocytes. Proc. Natl. Acad. Sci. USA 99: 1497-1502.
73. ZHU, N., L.M. RAMIREZ, R.L. LEE, et al. 2002. CD40 signaling in B cells regulates the expression of the Pim-1 kinase via the NF-kappa B pathway. J. Immunol. 168: 744-754.
74. LOCATI, M., U. DEUSCHLE, M.L. MASSARDI, et al. 2002. Analysis of the gene expression profile activated by the CC chemokine ligand 5/RANTES and by lipopolysaccharide in human monocytes. J. Immunol. 168: 3557-3562.
75. RAVASI, T., C. WELLS, A. FOREST, et al. 2002. Generation of diversity in the innate immune system: macrophage heterogeneity arises from gene-autonomous transcriptional probability of individual inducible genes. J. Immunol. 168: 44-50.
76. ROSENBERGER, C.M., M.G. SCOTT, M.R. GOLD, et al. 2000. Salmonella typhimurium infection and lipopolysaccharide stimulation induce similar changes in macrophage gene expression. J. Immunol. 164: 5894-5904.
77. MIKITA, T., G. PORTER, R.M. LAWN & D. SHIFFMAN. 2001. Oxidized low density lipoprotein exposure alters the transcriptional response of macrophages to inflammatory stimulus. J. Biol. Chem. 276: 45729-45739.
78. SHIFFMAN, D., T. MIKITA, J.T. TAI, et al. 2000. Large scale gene expression analysis of cholesterol-loaded macrophages. J. Biol. Chem. 275: 37324-37332.
79. FESSLER, M.B., K.C. MALCOLM, M.W. DUNCAN & G.S. WORTHEN. 2002. A genomic and proteomic analysis of activation of the human neutrophil by lipopolysaccharide and its mediation by p38 mitogen-activated protein kinase. J. Biol. Chem. 277: 31291-31302.
80. KOBAYASHI, S.D., J.M. VOYICH, C.L. BUHL, et al. 2002. Global changes in gene expression by human polymorphonuclear leukocytes during receptor-mediated phagocytosis: cell fate is regulated at the level of gene expression. Proc. Natl. Acad. Sci. USA 99: 6901-6906.
81. TAYLOR, L.A., C.M. CARTHY, D. YANG, et al. 2000. Host gene regulation during coxsackievirus B3 infection in mice: assessment by microarrays. Circ. Res. 87: 328-334.
82. CHAMBERS, J., A. ANGULO, D. AMARATUNGA, et al. 1999. DNA microarrays of the complex human cytomegalovirus genome: profiling kinetic class with drug sensitivity of viral gene expression. J. Virol. 73: 5757-5766.
83. SIMMEN, K.A., J. SINGH, B.G. LUUKKONEN, et al. 2001. Global modulation of cellular transcription by human cytomegalovirus is initiated by viral glycoprotein B. Proc. Natl. Acad. Sci. USA 98: 7140-7145.
84. GEISS, G.K., R.E. BUMGARNER, M.C. AN, et al. 2000. Large-scale monitoring of host cell gene expression during HIV-1 infection using cDNA microarrays. Virology 266: 8-16.
85. GEISS, G.K., M. SALVATORE, T.M. TUMPEY, et al. 2002. Cellular transcriptional profiling in influenza A virus-infected lung epithelial cells: the role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenza. Proc. Natl. Acad. Sci. USA 99: 10736-10741.
86. PAULOSE-MURPHY, M., N.K. HA, C. XIANG, et al. 2001. Transcription program of human herpesvirus 8 (kaposi's sarcoma-associated herpesvirus). J. Virol. 75: 4843-4853.
87. JENNER, R.G., M.M. ALBA, C. BOSHOFF & P. KELLAM. 2001. Kaposi's sarcoma-associated herpesvirus latent and lyric gene expression as revealed by DNA arrays. J. Virol. 75: 891-902.
88. CHANG, Y.E. & L.A. LAIMINS. 2000. Microarray analysis identifies interferon-inducible genes and Stat-1 as major transcriptional targets of human papillomavirus type 31. J. Virol. 74: 4174-4182.
89. HOBBS, W.E. & N.A. DELUCA. 1999. Perturbation of cell cycle progression and cellular gene expression as a function of herpes simplex virus ICP0. J. Virol. 73: 8245-8255.
90. KHODAREV, N.N., S.J. ADVANI, N. GUPTA, et al. 1999. Accumulation of specific RNAs encoding transcriptional factors and stress response proteins against a background of severe depletion of cellular RNAs in cells infected with herpes simplex virus 1. Proc. Natl. Acad. Sci. USA 96: 12062-12067.
91. STINGLEY, S.W., J.J. RAMIREZ, S.A. AGUILAR, et al. 2000. Global analysis of herpes simplex virus type 1 transcription using an oligonucleotide-based DNA microarray. J. Virol. 74: 9916-9927.
92. BOLT, G., K. BERG & M. BLIXENKRONE-MOLLER. 2002. Measles virus-induced modulation of host-cell gene expression. J. Gen. Virol. 83: 1157-1165.
93. LIANG, F.T., F.K. NELSON & E. FIKRIG. 2002. Molecular adaptation of Borrelia burgdorferi in the murine host. J. Exp. Med. 196: 275-280.
94. COOMBES, B.K. & J.B. MAHONY. 2001. cDNA array analysis of altered gene expression in human endothelial cells in response to Chlamydia pneumoniae infection. Infect. Immun. 69: 1420-1427.
95. ISRAEL, D.A., N. SALAMA, C.N. ARNOLD, et al. 2001. Helicobacter pylori strain-specific differences in genetic content, identified by microarray, influence host inflammatory responses. J. Clin. Invest. 107: 611-620.
96. BJORKHOLM, B.M., J.L. GURUGE, J.D. OH, et al. 2002. Colonization of germ-free transgenic mice with genotyped Helicobacter pylori strains from a case-control study of gastric cancer reveals a correlation between host responses and HsdS components of type I restriction-modification systems. J. Biol. Chem. 277: 34191-34197.
97. COX, J.M., C.L. CLAYTON, T. TOMITA, et al. 2001. cDNA array analysis of cag pathogenicity island-associated Helicobacter pylori epithelial cell response genes. Infect. Immun. 69: 6970-6980.
98. GRIFANTINI, R., O. FINCO, E. BARTOLINI, et al. 1998. Multi-plasmid DNA vaccination avoids antigenic competition and enhances immunogenicity of a poorly immunogenic plasmid. Eur. J. Immunol. 28: 1225-1232.
99. ICHIKAWA, J.K., A. NORRIS, M.G. BANGERA, et al. 2000. Interaction of Pseudomonas aeruginosa with epithelial cells: identification of differentially regulated genes by expression microarray analysis of human cDNAs. Proc. Natl. Acad. Sci. USA 97: 9659-9664.
100. DETWEILER, C.S., D.B. CUNANAN & S. FALKOW. 2001. Host microarray analysis reveals a role for the Salmonella response regulator phoP in human macrophage cell death. Proc. Natl. Acad. Sci. USA 98: 5850-5855.
101. ECKMANN, L., J.R. SMITH, M.P. HOUSLEY, et al. 2000. Analysis by high density cDNA arrays of altered gene expression in human intestinal epithelial cells in response to infection with the invasive enteric bacteria Salmonella. J. Biol. Chem. 275: 14084-14094.
102. BLADER, I.J., I.D. MANGER & J.C. BOOTHROYD. 2001. Microarray analysis reveals previously unknown changes in Toxoplasma gondii-infected human cells. J. Biol. Chem. 276: 24223-24231.
103. DE AVALOS, S.V., I.J. BLADER, M. FISHER, et al. 2002. Immediate/early response to Trypanosoma cruzi infection involves minimal modulation of host cell transcription. J. Biol. Chem. 277: 639-644.