Transcript profiling of human dendritic cells maturation-induced under defined culture conditions: Comparison of the effects of tumour necrosis factor alpha, soluble CD40 ligand trimer and interferon gamma

British Journal of Haematology

Volumn 114, Issue 2, 2001, Pages 444-457

  Moschella, Federica ^a   Maffei, Antonella ^b   Catanzaro, Richard P ^a   Papadopoulos, Kyriakos P ^a   Skerrett, Donna ^b   Hesdorffer, Charles S ^a   Harris, Paul E ^a,c  

^a Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain   (United States)

^b INSTITUTE OF GENETICS AND BIOPHYSICS ADRIANO BUZZATI TRAVERSO   (Italy)

^c Black Building BB 20 13 ^*  (United States)

Author keywords

BCL 6; cDNA arrays; Dendritic cells; GMP; Maturation induction

Indexed keywords

ALPHA2 INTEGRIN; CD37 ANTIGEN; CD44H ANTIGEN; CELL ADHESION MOLECULE; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CXCR5; CYTOKINE; GAMMA INTERFERON; GLYCOPROTEIN GP 39; PROTEIN BCL 6; RANTES; RANTES R; TRANSCRIPTION FACTOR REL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADHERENT CELL; AMINO ACID SEQUENCE; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL MATURATION; CULTURE MEDIUM; CYTOKINE PRODUCTION; DENDRITIC CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEQUENCE ANALYSIS; TRANSCRIPTION REGULATION;

BASE SEQUENCE; CD40 LIGAND; CELL DIFFERENTIATION; CELLS, CULTURED; CYTOKINES; DENDRITIC CELLS; DNA, COMPLEMENTARY; GENE EXPRESSION PROFILING; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; INTERFERON TYPE II; INTERLEUKIN-4; INTERLEUKIN-7; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RECEPTORS, CELL SURFACE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034883271     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2001.02953.x     Document Type: Article

References (69)

1. A chemokine-driven positive feedback loop organizes lymphoid follicles
2. Immunobiology of dendritic cells
3. Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood
4. Generation of immunostimulatory dendritic cells from human CD34+ hematopoietic progenitor cells of the bone marrow and peripheral blood
5. HLA-DR-mediated apoptosis susceptibility discriminates differentiation stages of dendritic/monocytic APC
6. Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s
7. Isolation of human blood monocytes with Nycodenz, a new non-ionic iodinated gradient medium
8. Melanoma vaccines
9. Activation of human dendritic cells through CD40 cross-linking
10. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation
11. Rapid generation of broad T-cell immunity in humans after a single injection of mature dendritic cells
12. Mature dendritic cells boost functionally superior CD8 (+) T-cell in humans without foreign helper epitopes
13. Production of IL-12 by human monocyte-derived dendritic cells is optimal when the stimulus is given at the onset of maturation, and is further enhanced by IL-4
14. Cluster analysis and display of genome-wide expression patterns
15. Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B- lymphocytes
16. Pattern of expression of tetraspanin antigen genes in Burkitt lymphoma cell lines
17. CD30 ligand (CD30L) -expressing acute myeloid leukemias: A new model of paracrine interactions for the regulation of blast cells proliferation
18. Collection of mononuclear cells in the Spectra for the generation of dendritic cells
19. Early events in dendritic cell maturation induced by LPS
20. Molecular, structural, and biological characteristics of the tumor necrosis factor ligand superfamily
21. CpG DNA: A potent signal for growth, activation, and maturation of human dendritic cells
22. Serial analysis of gene expression in human monocyte-derived dendritic cells
23. Identification of genes specifically expressed in human activated and mature dendritic cells through serial analysis of gene expression
24. Expression and function of the gamma c subunit of the IL-2, IL-4, and IL-7 receptors. Distinct interaction of gamma c in the IL-4 receptor
25. Direct comparison of GeneChip and SAGE on the quantitative accuracy in transcript profiling analysis
26. Dendritic cells, obtained from peripheral blood precursors in the presence of PGE2, promote Th2 responses
27. IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells
28. T-cell priming by type-1 and type-2 polarized dendritic cells: The concept of a third signal
29. The concept of type 1 and type 2 antigen-presenting cells
30. Targeted inactivation of the tetraspanin CD37 impairs T-cell-dependent B-cell response under suboptimal costimulatory conditions
31. Antigen processing in populations of mature murine dendritic cells is caused by subsets of incompletely matured cells
32. Phenotypic and functional maturation of dendritic cells mediated by heparan sulfate
33. Kinetics of dendritic cell activation: Impact on priming of TH1, TH2 and nonpolarized T cells
34. Dendritic cell maturation and generation of immune responses
35. Requirement of mature dendritic cells for efficient activation of influenza A-specific memory CD8+ T cells
36. B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5
37. Effect of interleukin-7 on the in vitro development and maturation of monocyte derived human dendritic cells
38. A1, a Bcl-2 family member prolongs cell survival and permits myeloid differentiation
39. Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells
40. A novel closed system utilizing styrene copolymer bead adherence for the production of human dendritic cells
41. Antigen processing for amateurs and professionals
42. Generation of dendritic cells in vitro from peripheral blood mononuclear cells with granulocyte-macrophage-colony-stimulating factor, interleukin-4, and tumor necrosis factor-alpha for use in cancer immunotherapy
43. Differential expression of Rel/NF-kappaB and octamer factors is a hallmark of the generation and maturation of dendritic cells
44. Fractalkine, a CX3C chemokine, is expressed by dendritic cells and is up-regulated upon dendritic cell maturation
45. The role of CCR7 in TH1 and TH2 cell localization and delivery of B cell help in vivo
46. Coordinated events during bacteria-induced DC maturation
47. Th1 cells induce and Th2 inhibit antigen-dependent IL-12 secretion by dendritic cells
48. Mature dendritic cells induce T-helper type-1-dominant immune responses in patients with metastatic renal cell carcinoma
49. Generation of mature dendritic cells from human blood. An improved method with special regard to clinical applicability
50. Modulation of TCR-mediated signaling pathway by thymic shared antigen-1 (TSA-1)/stem cell antigen-2 (Sca-2)
51. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha
52. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: Downregulation by cytokines and bacterial products
53. Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation
54. Distinct patterns and kinetics of chemokine production regulate dendritic cell function
55. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
56. The B cell-associated CD37 antigen (gp40-52). Structure and subcellular expression of an extensively glycosylated glycoprotein
57. Massive ex vivo generation of functional dendritic cells from mobilized CD34+ blood progenitors for anticancer therapy
58. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells
59. Dendritic cells generated from human blood in granulocyte macrophage-colony stimulating factor and interleukin-7
60. Human monocyte-derived dendritic cells induce naive T cell differentiation into T helper cell type 2 (Th2) or Th1/Th2 effectors. Role of stimulator/responder ratio
61. Human peripheral blood dendritic cell subsets. Isolation and characterization of precursor and mature antigen-presenting cells
62. Generation of large numbers of fully mature and stable dendritic cells from leukapheresis products for clinical application
63. Development of dendritic-cell based prostate cancer vaccine
64. BCL-6 regulates chemokine gene transcription in macrophages
65. Development of Th1-inducing capacity in myeloid dendritic cells requires environmental instruction
66. In vitro expansion and characterization of dendritic cells derived from human bone marrow CD34+ cells
67. CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells
68. Eradication of established murine tumors using a novel cell-free vaccine: Dendritic cell-derived exosomes