Thrombospondin-1 inhibits TCR-mediated T lymphocyte early activation

Journal of Immunology

Volumn 166, Issue 4, 2001, Pages 2427-2436

  Li, Z ^a   He, L ^a   Wilson, K E ^a   Roberts, D D ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD47 ANTIGEN; CD69 ANTIGEN; INTERLEUKIN 2; PHOSPHATASE; PROTEIN KINASE C; PROTEOHEPARAN SULFATE; T LYMPHOCYTE RECEPTOR; THROMBOSPONDIN 1;

ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DNA MICROARRAY; EARLY RESPONSE GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MONONUCLEAR CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; WOUND HEALING;

EID: 0035865337     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.4.2427     Document Type: Article

References (53)

1. CD28/B7 system of T cell costimulation
2. T cell co-stimulatory molecules other than CD28
3. CTLA-4 can function as a negative regulator of T cell activation
4. Molecular basis of T cell inactivation by CTLA-4
5. A negative role for phosphoinositide 3-kinase in T-cell antigen receptor function
6. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b
7. Lymphocyte homing and homeostasis
8. T cell adhesion to endothelial cells and extracellular matrix is modulated upon transendothelial cell migration
9. T lymphocytes adhere to airway smooth muscle cells via integrins and CD44 and induce smooth muscle cell DNA synthesis
10. Adhesion to fibronectin promotes the activation of the p125(FAK)/Zap-70 complex in human T cells
11. 7 co-stimulation of human peripheral blood T cell proliferation
12. + T cells by the interaction of VLA-4 and VLA-5 with fibronectin or VLA-6 with laminin
13. Fibronectin augments anti-CD3-mediated IL-2 receptor (CD25) expression on human peripheral blood lymphocytes
14. The mouse vitronectin receptor is a T cell activation antigen
15. Tenascin suppresses CD3-mediated T cell activation
16. Regulation of tumor growth and metastasis by thrombospondin-1
17. Diversity of function is inherent in matricellular proteins: An appraisal of thrombospondin I
18. Thrombospondin causes activation of latent transforming growth factor-β secreted by endothelial cells by a novel mechanism
19. Thrombospondin-1 is a major activator of TGF-β1 in vivo
20. Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia
21. 1 (VLA-5) integrins
22. 1 integrin- and proteoglycan-mediated stimulation of T lymphoma cell adhesion and mitogen-activated protein kinase signaling by thrombospondin-1 and thrombospondin-1 peptides
23. CD47 ligation selectively down-regulates human interleukin 12 production
24. Costimulation of T cell activation by integrin-associated protein (CD47) is an adhesion-dependent. CD28-independent signaling pathway
25. Central role of thrombospondin-1 in the activation and clonal expansion of inflammatory T cells
26. Coordinate transactivation of the interleukin-2 CD28 response element by c-Rel and ATF-I/CREB2
27. Expression of the early growth response 1 and 2 zinc finger genes during induction of monocytic differentiation
28. Multiparametric flow cytometric analysis of the kinetics of surface molecule expression after polyclonal activation of human peripheral blood T lymphocytes
29. T cell activation via Leu-23 (CD69)
30. Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PACI
31. Immediate-early genes induced by antigen receptor stimulation
32. Stimulation of T cells through the CD3/T-cell receptor complex: Role of cytoplasmic calcium, protein kinase C translocation, and phosphorylation of pp6Oc-src in the activation pathway
33. LAT: The ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation
34. CD47 engagement inhibits cytokine production and maturation of human dendritic cells
35. T cell stimulation via CD47: Agonistic and antagonistic effects of CD47 monoclonal antibody 1/1A4
36. Integrin-associated protein is a receptor for the C-terminal domain of thrombospondin
37. Human signal-regulatory protein is expressed on normal, but not on subsets of leukemic myeloid cells and mediates cellular adhesion involving its counterreceptor CD47
38. Cell spreading distinguishes the mechanism of augmentation of T cell activation by integrin-associated protein/CD47 and CD28
39. Specificities of heparin-binding sites from the amino-terminus and type 1 repeats of thrombospondin-1
40. Thrombospondin-1 is a mediator of the neurotypic differentiation induced by EGF in thymic epithelial cells
41. Regulation of protein kinase cascades by protein phosphatase 2A
42. Rh-related antigen CD47 is the signal-transducer integrin-associated protein
43. 1 integrin in vascular smooth muscle cells
44. (3) integrin ligands to promote melanoma cell spreading and focal adhesion kinase phosphorylation
45. 3(IV) chain of type IV collagen on tumor cells
46. Decreased resistance to bacterial infection and granulocyte defects in IAP-deficient mice
47. Transendothelial migration of neutrophils involves integrin-associated protein (CD47)
48. Integrin-associated protein (CD47) is a comitogenic molecule on CD3-activated human T cells
49. Inhibition of angiogenesis by thrombspondin-1 is mediated by two independent regions within the type 1 repeats
50. Differential roles of protein kinase C and pertussis toxin-sensitive G-binding proteins in modulation of melanoma cell proliferation and motility by thrombospondin-1
51. Modulation of endothelial cell proliferation, adhesion, and motility by recombinant heparin-binding domain and synthetic peptides from the type 1 repeats of thrombospondin
52. Thrombospondin-induced tumor cell migration: Haptotaxis and chemotaxis are mediated by different molecular domains
53. Syndecans, signaling, and cell adhesion