B-lymphocyte quiescence, tolerance and activation as viewed by global gene expression profiling on microarrays

Immunological Reviews

Volumn 176, Issue , 2000, Pages 216-246

  Glynne, R ^a   Ghandour, G ^a   Rayner, J ^a   Mack, D H ^a   Goodnow, C C ^a  

^a Australian National University   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; CD27 ANTIGEN; CHEMOKINE; CYCLIN D2; DNA BINDING PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; NEUROGRANIN;

B LYMPHOCYTE ACTIVATION; B LYMPHOCYTE DIFFERENTIATION; CELL FATE; CELL MATURATION; CLONAL ANERGY; EFFECTOR CELL; GENE EXPRESSION; IMMUNOLOGICAL TOLERANCE; ONCOGENE C MYC; PLASMA CELL; PRIORITY JOURNAL; RECEPTOR BINDING; REVIEW; SIGNAL TRANSDUCTION; SPLEEN CELL;

EID: 0033817046     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-065X.2000.00614.x     Document Type: Review

References (154)

1. Self-tolerance checkpoints in B lymphocyte development
2. Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45
3. Rajewsky K. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death
4. Frequency of B lymphocytes responsive to anti-immunoglobulin
5. Immunoglobulin signal transduction guides the specificity of B cell T cell interactions and is blocked in tolerant self-reactive B cells
6. Expansion or elimination of B cells in vivo: Dual roles for CD40- and Fas (CD95)-ligands modulated by the B cell antigen receptor
7. The immunogenicity of soluble haptenated polymers is determined by molecular mass and hapten valence
8. 4+ T cells
9. Abortive proliferation of rare T cells induced by direct or indirect antigen presentation by rare B cells in vivo
10. Breakdown of self-tolerance in anergic B lymphocytes
11. Quantitative and qualitative control of antigen receptor signaling in tolerant B lymphocytes
12. Growing up on the streets: Why B-cell development differs from T-cell development
13. Different nuclear signals are activated by the B cell receptor during positive versus negative signaling
14. B lymphocytes differentially use the Rel and nuclear factor κB1 (NF-κB1) transcription factors to regulate cell cycle progression and apoptosis in quiescent and mitogen-activated cells
15. Entry of B cell receptor into signaling domains is inhibited in tolerant B cells
16. 2+ response amplitude and duration
17. How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis
18. Amplified RNA synthesized from limited quantities of heterogeneous cDNA
19. Gene expression profiles of laser-captured adjacent neuronal subtypes
20. Expression monitoring by hybridization to high-density oligonucleotide arrays
21. Quantitative monitoring of gene expression patterns with a complementary DNA microarray
22. Genome-wide expression monitoring in Saccharomyces cerevisiae
23. What's wrong with Bonferroni adjustments
24. Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyteproliferation humoral immunityand interleukin-2 expression
25. Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection
26. Induction of self-tolerance in mature peripheral B lymphocytes
27. The molecular biology of immunoglobulin D
28. A selective defect in IgM antigen receptor synthesis and transport causes loss of cell surface IgM expression on tolerant B lymphocytes
29. IgD expression on B cells is more efficient than IgM but both receptors are functionally equivalent in up-regulation CD80/CD86 costimulatory molecules
30. Immunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor function for IgD in antigen-mediated recruitment of B cells
31. Parnes CD72-deficient mice reveal nonredundant roles of CD72 in B cell development and activation
32. The B cell surface protein CD72 recruits the tyrosine phosphatase SHP-1 upon tyrosine phosphorylation
33. Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection
34. Identification and characterization of transcripts from the neurofibromatosis 1 region: The sequence and genomic structure of EVI2 and mapping of other transcripts
35. Evi-2, a common integration site involved in routine myeloid leukemogenesis
36. Autoantigen 1 of the guinea pig sperm acrosome is the homologue of mouse Tpx-1 and human TPX1 and is a member of the cysteine-rich secretory protein (CRISP) family
37. Isolation and characterization of the androgen-dependent mouse cysteine-rich secretory protein-3 (CRISP-3) gene
38. Structure comparison of human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein P14a indicates a functional link between the human immune system and a plant defense system
39. CRISP-3, a protein with homology to plant defense proteins is expressed in mouse B cells under the control of Oct2
40. A novel cell-surface molecule expressed by human interdigitating reticulum cells and activated lymphocytes is a new member of the Ig superfamily
41. TAP transcription and phosphatidylinositol linkage mutants are defective in activation through the T cell receptor
42. Intracellular formation and cell surface expression of a complex of an intact lysosomal protein and MHC class molecules
43. Suppression of lymphocyte activation by plasma lipoproteins
44. Apolipoprotein E is a biologically active constituent of the normal immunoregulatory lipoprotein LDL-In
45. Identification of CD36 as the first gene dependent on the B-cell differentiation factor Oct-2
46. Phorbol ester induces abnormal chronic lymphocytic leukemia cells to express features of hairy cell leukemia
47. Development and follicular localization of tolerant B lymphocytes in lysozyme/anti-lysozyme IgM/IgD transgenic mice
48. Association between B-lymphocyte membrane immunoglobulin and multiple members of the Src family of protein tyrosine kinases
49. Examination of B lymphoid cell lines for membrane immunoglobulin-stimulated tyrosine phosphorylation and src-family tyrosine kinase mRNA expression
50. RC3/neurogranin, a postsynaptic calpacitin for setting the response threshold to calcium influxes
51. Camstatins are peptide antagonists of calmodulin based upon a conserved structural motif in PEP- 19, neurogranin and neuromodulin
52. Cytoskeletal polarity in mammalian lymphocytes in situ
53. Vimentin gene: Expression in human lymphocytes and in Burkitt's lymphoma cells
54. The chaperonin containing TCP-1 (CCT) displays a single-ring mediated disassembly and reassembly cycle
55. Induction of the early growth response (Egr) family of transcription factors during thymic selection
56. + distinguished in the early growth response (Egr)-1 transgenic mice with a recombinase-activating gene-deficient background
57. Methylation of an immediate-early inducible gene as a mechanism for B cell tolerance induction
58. The transcription factor early growth response 1 (Egr-1) advances differentiation of pre-B and immature B cells
59. Unimpaired macrophage differentiation and activation in mice lacking the zinc finger transplantation factor NGFI-A (EGR 1)
60. FcγRII cross-linking inhibits anti-Ig-induced erg-1 and erg-2 expression in BCL1
61. Sequential involvement of NFAT and Egr transcription factors in FasL regulation
62. B cell early response gene expression coupled to B cell receptor CD40 and interleukin-4 receptor costimulation: Evidence for a role of the egr-2/krox 20 transcription factor in B cell proliferation
63. Lupski Functional consequences of mutations in the early growth response 2 gene (EGR2) correlate with severity of human myelinopathies
64. Nab proteins mediate a negative feedback loop controlling Krox-20 activity in the developing hindbrain
65. Novel mutants of NAB corepressors enhance activation by Egr transactivators
66. Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins
67. Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation
68. Neuronal activity-dependent cell survival mediated by transcription factor MEF2
69. +-induced release of the transcription factor MEF2
70. Myocyte enhancer factor-related B-MEF2 is developmentally expressed in B cells and regulates the immunoglobulin J chain promoter
71. Smad transcriptional corepressor
72. The matrix attachment region-binding protein SATB1 participates in negative regulation of tissue-specific gene expression
73. The C elegans gene pag-3 is homologous to the zinc finger proto-oncogene gfi-1
74. The Gfi-1 protooncoprotein represses Bax expression and inhibits T-cell death
75. Zinc finger protein GFI-1 has low oncogenic potential but cooperates strongly with pim and myc genes in T-cell lymphomagenesis
76. Induction of cell cycle regulatory proteins in anti-immunoglobulin-stimulated mature B lymphocytes
77. Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent sets of genes
78. Antigen receptor engagement selectively induces macrophage inflammatory protein-1α (MIP-1α) and MIP-1β chemokine production in human B cells
79. Requirement of MIP-1α for an inflammatory response to viral infection
80. Characterization of an Epstein-Barr virus receptor on human epithelial cells
81. Synthesis degradation and subcellular localization of proteins encoded by the primary response genes TIS7/PC4 and TIS21/PC3
82. Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family
83. Class- and splice variant-specific association of CD98 with integrin beta cytoplasmic domains
84. Spleen-specific expression of the malaria-inducible intronless mouse gene imap38
85. Complex asparagine-linked oligosaccharides are required for morphogenic events during post-implantation development
86. Mice lacking N-acetylglucosaminyltransferase I activity die at mid-gestation revealing an essential role for complex or hybrid N-linked carbohydrates
87. Mature follicular dendritic cell networks depend on expression of lymphotoxin-β receptor by radioresistant stromal cells and of lymphotoxin-β and tumor necrosis factor by B cells
88. Stearoyl-CoA desaturase gene expression in lymphocytes
89. Targeted disruption of the IFN-γ receptor 2 gene results in severe immune defects in mice
90. Urokinase receptor (CD87) regulates leukocyte recruitment via β2 integrins in vivo
91. RP105 a novel B cell surface molecule implicated in B cell activation is a member of the leucine-rich repeat protein family
92. Bacterial lipopolysaccharide causes rapid shedding followed by inhibition of mRNA expression of the IL- 1 type II receptor, with concomitant up-regulation of the type I receptor and induction of incompletely spliced transcripts
93. A novel gene, G7e, resembling a viral envelope gene III is located at the recombinational hot spot in the class region of the mouse MHC
94. Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis
95. The prosurvival Bc1-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-κB that blocks TNF-α-induced apoptosis
96. A1 expression is stimulated by CD40 in B cells and rescues WEHI 231 cells from anti-IgM-induced cell death
97. Regulation of chemotactic and proadhesive responses to chemoattractant receptors by RGS (regulator of G-protein signaling) family members
98. Regulator of G protein signaling 1 (RGS1) markedly impairs Gi α signaling responses of B lymphocytes
99. Identification of the basolateral targeting determinant of a peripheral membrane protein in polarized cells
100. MacMARCKS is not essential for phagocytosis in macrophages
101. Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation
102. Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signaling
103. Defects in regulation of apoptosis in caspase-2-deficient mice
104. Genomic structure and assignment of the RhoH/TTF small GTPase gene (ARHH) to 4p13 by in situ hybridization
105. Small GTP-binding proteins in human endothelial cells
106. Gem: An induced immediate early protein belonging to the Ras family
107. Cooperative inhibition of T-cell antigen receptor signaling by a complex between a kinase and a phosphatase
108. Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp
109. Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin
110. Distinct mechanisms for rescue from apoptosis in Ramos human B cells by signaling through CD40 and interleukin-4 receptor: Role for inhibition of an early response gene Berg36
111. Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PAC1
112. Disruption of the erp/mkp-1 gene does not affect mouse development: Normal MAP kinase activity in ERP/MKP-1-deficient fibroblasts
113. + - and integrin-binding protein and are regulated dynamically with synaptic plasticity
114. Mcm2, but not RPA is a component of the mammalian early G1-phase prereplication complex
115. The c-myc oncogene perturbs B lymphocyte development in E-μ-myc transgenic mice
116. Control of cell growth by c-Myc in the absence of cell division
117. c-Myc enhances protein synthesis and cell size during B lymphocyte development
118. c-Myc null cells misregulate cad and gadd45 but not other proposed c-Myc targets
119. Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis
120. Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF
121. mel-18 negatively regulates cell cycle progression upon B cell antigen receptor stimulation through a cascade leading to c-myc/cdc25
122. Transcriptional repression by blimp-1 (PRDI-BF1) involves recruitment of histone deacetylase
123. The herpes simplex virus virulence factor ICP34.5 and the cellular protein MyD116 complex with proliferating cell nuclear antigen through the 63-amino-acid domain conserved in ICP34.5, MyD116 and GADD34
124. Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma
125. ICSAT overexpression is not sufficient to cause adult T-cell leukemia or multiple myeloma
126. Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function
127. Perinatal synthetic lethality and hematopoietic defects in compound mafG:mafK mutant mice
128. Functional redundancy of the Nur77 and Nor- 1 orphan steroid receptors in T-cell apoptosis
129. Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor
130. LKLF: A transcriptional regulator of single-positive T cell quiescence and survival
131. Interaction of short-range repressors with Drosophila CtBP in the embryo
132. Basic Kruppel-like factor functions within a network of interacting haematopoietic transcription factors
133. Klf4 is a transcription factor required for establishing the barrier function of the skin
134. Repression of the immunoglobulin heavy chain 3' enhancer by helix-loop-helix protein Id3 via a functionally important E47/E12 binding site: Implications for developmental control of enhancer function
135. Impaired immune responses and B-cell proliferation in mice lacking the Id3 gene
136. A new dexamethasone-induced gene of the leucine zipper family protects T lymphocytes from TCR/CD3-activated cell death
137. Transforming growth factor-β-stimulated clone-22 is a member of a family of leucine zipper proteins that can homo- and heterodimerize and has transcriptional repressor activity
138. Underdeveloped uterus and reduced estrogen responsiveness in mice with disruption of the estrogen-responsive finger protein gene, which is a direct target of estrogen receptor α
139. Critical roles for the Bc1-3 oncoprotein in T cell-mediated immunity, splenic microarchitecture and germinal center reactions
140. Genomic instability in Gadd45a-deficient mice
141. Deregulated expression of c-fos disturbs proliferative responses of B cells to sIg cross-linking
142. Mice lacking c-los have normal hematopoietic stem cells but exhibit altered B-cell differentiation due to an impaired bone marrow environment
143. ATF3 and stress responses
144. C/EBP β isoform recruits the SWI/SNF complex to activate myeloid genes
145. Inactivation of the IL-6 gene prevents development of multicentric Castleman's disease in C/EBP β-deficient mice
146. Identification of novel stress-induced genes downstream of chop
147. Stra13 expression is associated with growth arrest and represses transcription through histone deacetylase (HDAC)-dependent and HDAC-independent mechanisms
148. STAT1 affects lymphocyte survival and proliferation partially independent of its role downstream of IFN-γ
149. Drug target validation and identification of secondary drug target effects using DNA microarrays
150. Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression
151. Abnormal differentiation of thymocytes in mice treated with cyclosporin A
152. Effects of cyclosporine A on T cell development and clonal deletion
153. Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes
154. Cyclosporine, tolerance, and autoimmunity