Deoxysugar methylation during biosynthesis of the antitumor polyketide elloramycin by Streptomyces olivaceus: Characterization of three methyltransferase genes

Journal of Biological Chemistry

Volumn 276, Issue 22, 2001, Pages 18765-18774

  Patallo, Eugenio P ^a   Blanco, Gloria ^a   Fischer, Carsten ^b   Braña, Alfredo F ^a   Rohr, Jürgen ^b   Méndez, Carmen ^a   Salas, José A ^a  

^a DEPARTAMENTO DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR   (Spain)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; DRUG PRODUCTS; ENZYME KINETICS; GENES; SUBSTRATES; SUGAR (SUCROSE); TUMORS;

ANTITUMOR ACTIVITY;

BIOCHEMISTRY;

AMINO ACID; DEOXYSUGAR; ELLORAMYCIN; HYDROXYL GROUP; METHYLTRANSFERASE; NUCLEOTIDE; POLYKETIDE; RHAMNOSE; S ADENOSYLMETHIONINE; UNCLASSIFIED DRUG; 2 METHOXYRHAMNOSYLTETRACENOMYCIN C; 2-METHOXYRHAMNOSYLTETRACENOMYCIN C; ANTHRAQUINONE DERIVATIVE; ANTIINFECTIVE AGENT; DNA; GLYCOSIDE; NAPHTHACENE DERIVATIVE; RECOMBINANT PROTEIN; RHAMNOSYLTETRACENOMYCIN C; S ADENOSYLMETHIONINE DEPENDENT PHOSPHATE METHYLTRANSFERASE; S-ADENOSYLMETHIONINE-DEPENDENT PHOSPHATE METHYLTRANSFERASE; TETRACENOMYCIN C;

AMINO ACID SEQUENCE; ANTIBACTERIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOSYNTHESIS; CARBON NUCLEAR MAGNETIC RESONANCE; ENZYME ACTIVITY; GENE; GENE CLUSTER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METHYLATION; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; STREPTOMYCES; STREPTOMYCES OLIVACEUS; THIN LAYER CHROMATOGRAPHY; BIOLOGICAL MODEL; CELL FREE SYSTEM; CHEMICAL MODEL; CHEMISTRY; COSMID; GENETICS; GLYCOSYLATION; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; SEQUENCE HOMOLOGY; TIME;

POSIBACTERIA; STREPTOMYCES; STREPTOMYCES ALBUS; STREPTOMYCES OLIVACEUS;

AMINO ACID SEQUENCE; ANTHRAQUINONES; ANTI-BACTERIAL AGENTS; CELL-FREE SYSTEM; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, THIN LAYER; CLONING, MOLECULAR; COSMIDS; DNA; GLYCOSIDES; GLYCOSYLATION; METHYLATION; METHYLTRANSFERASES; MODELS, CHEMICAL; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; NAPHTHACENES; RECOMBINANT PROTEINS; RHAMNOSE; SEQUENCE HOMOLOGY, AMINO ACID; STREPTOMYCES; TIME FACTORS;

EID: 0035377584     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M101225200     Document Type: Article

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