-
1
-
-
0034818446
-
Post-translational modifications and activation of p53 by genotoxic stresses
-
Appella, E., and C. W. Anderson. 2001. Post-translational modifications and activation of p53 by genotoxic stresses Eur. J. Biochem. 268:2764-2772.
-
(2001)
Eur. J. Biochem.
, vol.268
, pp. 2764-2772
-
-
Appella, E.1
Anderson, C.W.2
-
2
-
-
0034003005
-
Stress signals utilize multiple pathways to stabilize p53
-
Ashcroft, M., Y. Taya, and K. H. Vousden. 2000. Stress signals utilize multiple pathways to stabilize p53. Mol. Cell. Biol. 20:3224-3233.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 3224-3233
-
-
Ashcroft, M.1
Taya, Y.2
Vousden, K.H.3
-
3
-
-
0035694469
-
Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases
-
Barley, N. A., L. Liu, N. H. Chehab, K. Mansfield, K. G. Harris, T. D. Halazonetis, and S. L. Berger. 2001. Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases. Mol. Cell 8:1243-1254.
-
(2001)
Mol. Cell
, vol.8
, pp. 1243-1254
-
-
Barley, N.A.1
Liu, L.2
Chehab, N.H.3
Mansfield, K.4
Harris, K.G.5
Halazonetis, T.D.6
Berger, S.L.7
-
4
-
-
0023147228
-
Selection of DNA binding sites by regulatory proteins. Statistical-mechanical theory and application to operators and promoters
-
Berg, O. G., and P. H. von Hippel. 1987. Selection of DNA binding sites by regulatory proteins. Statistical-mechanical theory and application to operators and promoters. J. Mol. Biol. 193:723-750.
-
(1987)
J. Mol. Biol.
, vol.193
, pp. 723-750
-
-
Berg, O.G.1
Von Hippel, P.H.2
-
5
-
-
0034928858
-
To bind or not to bind
-
Biggin, M. D. 2001. To bind or not to bind. Nat. Genet. 28:303-304.
-
(2001)
Nat. Genet.
, vol.28
, pp. 303-304
-
-
Biggin, M.D.1
-
6
-
-
0033522143
-
DNA damage induced p53 stabilization: No indication for an involvement of p53 phosphorylation
-
Blattner, C., E. Tobiasch, M. Litfen, H. J. Rahmsdorf, and P. Herrlich. 1999. DNA damage induced p53 stabilization: No indication for an involvement of p53 phosphorylation. Oncogene 18:1723-1732.
-
(1999)
Oncogene
, vol.18
, pp. 1723-1732
-
-
Blattner, C.1
Tobiasch, E.2
Litfen, M.3
Rahmsdorf, H.J.4
Herrlich, P.5
-
7
-
-
0031026001
-
Further characterisation of the p53 responsive element - Identification of new candidate genes for trans-activation by p53
-
Bourdon, J. C., V. Deguin-Chambon, J. C. Lelong, P. Dessen, P. May, B. Debuire, and E. May. 1997. Further characterisation of the p53 responsive element - Identification of new candidate genes for trans-activation by p53. Oncogene 14:85-94.
-
(1997)
Oncogene
, vol.14
, pp. 85-94
-
-
Bourdon, J.C.1
Deguin-Chambon, V.2
Lelong, J.C.3
Dessen, P.4
May, P.5
Debuire, B.6
May, E.7
-
8
-
-
0029911703
-
Dominant-negative p53 mutations selected in yeast hit cancer hot spots
-
Brachmann, R. K., M. Vidal, and J. D. Boeke. 1996. Dominant-negative p53 mutations selected in yeast hit cancer hot spots. Proc. Natl. Acad. Sci. USA 93:4091-4095.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 4091-4095
-
-
Brachmann, R.K.1
Vidal, M.2
Boeke, J.D.3
-
9
-
-
0032055501
-
Genetic selection of intragenic suppressor mutations that reverse the effect of common p53 cancer mutations
-
Brachmann, R. K., K. Yu, Y. Eby, N. P. Pavletich, and J. D. Boeke. 1998. Genetic selection of intragenic suppressor mutations that reverse the effect of common p53 cancer mutations. EMBO J. 17:1847-1859.
-
(1998)
EMBO J.
, vol.17
, pp. 1847-1859
-
-
Brachmann, R.K.1
Yu, K.2
Eby, Y.3
Pavletich, N.P.4
Boeke, J.D.5
-
10
-
-
0034594995
-
Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: Definition of mutant states for rescue in cancer therapy
-
Bullock, A. N., J. Henckel, and A. R. Fersht. 2000. Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: Definition of mutant states for rescue in cancer therapy. Oncogene 19:1245-1256.
-
(2000)
Oncogene
, vol.19
, pp. 1245-1256
-
-
Bullock, A.N.1
Henckel, J.2
Fersht, A.R.3
-
11
-
-
0035858984
-
p53 mutants can often transactivate promoters containing a p21 but not Bax or PIG3 responsive elements
-
Campomenosi, P., P. Monti, A. Aprile, A. Abbondandolo, T. Frebourg, B. Gold, T. Crook, A. Inga, M. A. Resnick, R. Iggo, and G. Fronza. 2001. p53 mutants can often transactivate promoters containing a p21 but not Bax or PIG3 responsive elements. Oncogene 20:3573-3579.
-
(2001)
Oncogene
, vol.20
, pp. 3573-3579
-
-
Campomenosi, P.1
Monti, P.2
Aprile, A.3
Abbondandolo, A.4
Frebourg, T.5
Gold, B.6
Crook, T.7
Inga, A.8
Resnick, M.A.9
Iggo, R.10
Fronza, G.11
-
12
-
-
0030864137
-
Two tandem and independent sub-activation domains in the amino terminus of p53 require the adaptor complex for activity
-
Candau, R., D. M. Scolnick, P. Darpino, C. Y. Ying, T. D. Halazonetis, and S. L. Berger. 1997. Two tandem and independent sub-activation domains in the amino terminus of p53 require the adaptor complex for activity. Oncogene 15:807-816.
-
(1997)
Oncogene
, vol.15
, pp. 807-816
-
-
Candau, R.1
Scolnick, D.M.2
Darpino, P.3
Ying, C.Y.4
Halazonetis, T.D.5
Berger, S.L.6
-
13
-
-
0034710870
-
Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage
-
Chao, C., S. Saito, C. W. Anderson, E. Appella, and Y. Xu. 2000. Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage. Proc. Natl. Acad. Sci. USA 97:11936-11941.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 11936-11941
-
-
Chao, C.1
Saito, S.2
Anderson, C.W.3
Appella, E.4
Xu, Y.5
-
14
-
-
0032785881
-
Prognostic significance of p53 mutation in breast cancer: Frequent detection of non-missense mutations by yeast functional assay
-
Chappuis, P. O., A. Estreicher, B. Dieterich, H. Bonnefoi, M. Otter, A. P. Sappino, and R. Iggo. 1999. Prognostic significance of p53 mutation in breast cancer: Frequent detection of non-missense mutations by yeast functional assay. Int. J. Cancer 84:587-593.
-
(1999)
Int. J. Cancer
, vol.84
, pp. 587-593
-
-
Chappuis, P.O.1
Estreicher, A.2
Dieterich, B.3
Bonnefoi, H.4
Otter, M.5
Sappino, A.P.6
Iggo, R.7
-
15
-
-
0029802591
-
p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells
-
Chen, X., L. J. Ko, L. Jayaraman, and C. Prives. 1996. p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells. Genes Dev. 10:2438-2451.
-
(1996)
Genes Dev.
, vol.10
, pp. 2438-2451
-
-
Chen, X.1
Ko, L.J.2
Jayaraman, L.3
Prives, C.4
-
16
-
-
0027983669
-
Crystal structure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations
-
Cho, Y., S. Gorina, P. D. Jeffrey, and N. P. Pavletich. 1994. Crystal structure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations. Science 265:346-355.
-
(1994)
Science
, vol.265
, pp. 346-355
-
-
Cho, Y.1
Gorina, S.2
Jeffrey, P.D.3
Pavletich, N.P.4
-
17
-
-
0033617334
-
Ordered recruitment of transcription and chromatin remodeling factors to a cell cycle- and developmentally regulated promoter
-
Cosma, M. P., T. Tanaka, and K. Nasmyth. 1999. Ordered recruitment of transcription and chromatin remodeling factors to a cell cycle- and developmentally regulated promoter. Cell 97:299-311.
-
(1999)
Cell
, vol.97
, pp. 299-311
-
-
Cosma, M.P.1
Tanaka, T.2
Nasmyth, K.3
-
18
-
-
0032516219
-
Human tumor-derived p53 proteins exhibit binding site selectivity and temperature sensitivity for transactivation in a yeast-based assay
-
Di Como, C. J., and C. Prives. 1998. Human tumor-derived p53 proteins exhibit binding site selectivity and temperature sensitivity for transactivation in a yeast-based assay. Oncogene 16:2527-2539.
-
(1998)
Oncogene
, vol.16
, pp. 2527-2539
-
-
Di Como, C.J.1
Prives, C.2
-
19
-
-
0033572746
-
Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2
-
Dumaz, N., and D. W. Meek. 1999. Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2. EMBO J. 18:7002-7010.
-
(1999)
EMBO J.
, vol.18
, pp. 7002-7010
-
-
Dumaz, N.1
Meek, D.W.2
-
20
-
-
0031987277
-
Regulation of p53 downstream genes
-
el-Deiry, W. S. 1998. Regulation of p53 downstream genes. Semin. Cancer Biol. 8:345-357.
-
(1998)
Semin. Cancer Biol.
, vol.8
, pp. 345-357
-
-
El-Deiry, W.S.1
-
21
-
-
0026849821
-
Definition of a consensus binding site for p53
-
el-Deiry, W. S., S. E. Kern, J. A. Pietenpol, K. W. Kinzler, and B. Vogelstein. 1992. Definition of a consensus binding site for p53. Nat. Genet. 1:45-49.
-
(1992)
Nat. Genet.
, vol.1
, pp. 45-49
-
-
El-Deiry, W.S.1
Kern, S.E.2
Pietenpol, J.A.3
Kinzler, K.W.4
Vogelstein, B.5
-
22
-
-
0032956852
-
The c-fos proto-oncogene is a target for transactivation by the p53 tumor suppressor
-
Elkeles, A., T. Juven-Gershon, D. Israeli, S. Wilder, A. Zalcenstein, and M. Oren. 1999. The c-fos proto-oncogene is a target for transactivation by the p53 tumor suppressor. Mol. Cell. Biol. 19:2594-2600.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 2594-2600
-
-
Elkeles, A.1
Juven-Gershon, T.2
Israeli, D.3
Wilder, S.4
Zalcenstein, A.5
Oren, M.6
-
23
-
-
0034881964
-
Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment
-
Espinosa, J. M., and B. M. Emerson. 2001. Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment. Mol. Cell 8:57-69.
-
(2001)
Mol. Cell
, vol.8
, pp. 57-69
-
-
Espinosa, J.M.1
Emerson, B.M.2
-
24
-
-
0029043805
-
A simple p53 functional assay for screening cell lines, blood, and tumors
-
Flaman, J. M., T. Frebourg, V. Moreau, F. Charbonnier, C. Martin, P. Chappuis, A. P. Sappino, I. M. Limacher, L. Bron, J. Benhattar, M. Tada, E. G. Van Meir, A. Estreicher, and R. D. Iggo. 1995. A simple p53 functional assay for screening cell lines, blood, and tumors. Proc. Natl. Acad. Sci. USA 92:3963-3967.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 3963-3967
-
-
Flaman, J.M.1
Frebourg, T.2
Moreau, V.3
Charbonnier, F.4
Martin, C.5
Chappuis, P.6
Sappino, A.P.7
Limacher, I.M.8
Bron, L.9
Benhattar, J.10
Tada, M.11
Van Meir, E.G.12
Estreicher, A.13
Iggo, R.D.14
-
25
-
-
0034256962
-
p53-dependent expression of PIG3 during proliferation, genotoxic stress, and reversible growth arrest
-
Flatt, P. M., K. Polyak, L. J. Tang, C. D. Scatena, M. D. Westfall, L. A. Rubinstein, J. Yu, K. W. Kinzler, B. Vogelstein, D. E. Hill, and J. A. Pietenpol. 2000. p53-dependent expression of PIG3 during proliferation, genotoxic stress, and reversible growth arrest. Cancer Lett. 156:63-72.
-
(2000)
Cancer Lett.
, vol.156
, pp. 63-72
-
-
Flatt, P.M.1
Polyak, K.2
Tang, L.J.3
Scatena, C.D.4
Westfall, M.D.5
Rubinstein, L.A.6
Yu, J.7
Kinzler, K.W.8
Vogelstein, B.9
Hill, D.E.10
Pietenpol, J.A.11
-
26
-
-
0037041392
-
p63 and p73 are required for p53-dependent apoptosis in response to DNA damage
-
Flores, E. R., K. Y. Tsai, D. Crowley, S. Sengupta, A. Yang, F. McKeon, and T. Jacks. 2002. p63 and p73 are required for p53-dependent apoptosis in response to DNA damage. Nature 416:560-564.
-
(2002)
Nature
, vol.416
, pp. 560-564
-
-
Flores, E.R.1
Tsai, K.Y.2
Crowley, D.3
Sengupta, S.4
Yang, A.5
McKeon, F.6
Jacks, T.7
-
27
-
-
0034669124
-
Regulation of p53 activity in nuclear bodies by a specific PML isoform
-
Fogal, V., M. Gostissa, P. Sandy, P. Zacchi, T. Sternsdorf, K. Jensen, P. P. Pandolfi, H. Will, C. Schneider, and G. Del Sal. 2000. Regulation of p53 activity in nuclear bodies by a specific PML isoform. EMBO J. 19:6185-6195.
-
(2000)
EMBO J.
, vol.19
, pp. 6185-6195
-
-
Fogal, V.1
Gostissa, M.2
Sandy, P.3
Zacchi, P.4
Sternsdorf, T.5
Jensen, K.6
Pandolfi, P.P.7
Will, H.8
Schneider, C.9
Del Sal, G.10
-
28
-
-
0029783722
-
A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis
-
Friedlander, P., Y. Haupt, C. Prives, and M. Oren. 1996. A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis. Mol. Cell. Biol. 16:4961-4971.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 4961-4971
-
-
Friedlander, P.1
Haupt, Y.2
Prives, C.3
Oren, M.4
-
29
-
-
0028954118
-
Studies on the transformation of intact yeast cells by the LiAc/SS-DNA/PEG procedure
-
Gietz, R. D., R. H. Schiestl, A. R. Willems, and R. A. Woods. 1995. Studies on the transformation of intact yeast cells by the LiAc/SS-DNA/PEG procedure. Yeast 11:355-360.
-
(1995)
Yeast
, vol.11
, pp. 355-360
-
-
Gietz, R.D.1
Schiestl, R.H.2
Willems, A.R.3
Woods, R.A.4
-
30
-
-
0035872462
-
TP53 mutations in breast cancer associated with BRCA1 or BRCA2 germ-line mutations: Distinctive spectrum and structural distribution
-
Greenblatt, M. S., P. O. Chappuis, J. P. Bond, N. Hamel, and W. D. Foulkes. 2001. TP53 mutations in breast cancer associated with BRCA1 or BRCA2 germ-line mutations: Distinctive spectrum and structural distribution. Cancer Res. 61:4092-4097.
-
(2001)
Cancer Res.
, vol.61
, pp. 4092-4097
-
-
Greenblatt, M.S.1
Chappuis, P.O.2
Bond, J.P.3
Hamel, N.4
Foulkes, W.D.5
-
31
-
-
0030905284
-
Mdm2 promotes the rapid degradation of p53
-
Haupt, Y., R. Maya, A. Kazaz, and M. Oren. 1997. Mdm2 promotes the rapid degradation of p53. Nature 387:296-299.
-
(1997)
Nature
, vol.387
, pp. 296-299
-
-
Haupt, Y.1
Maya, R.2
Kazaz, A.3
Oren, M.4
-
32
-
-
0031310665
-
14-3-3 Sigma is a p53-regulated inhibitor of G2/M progression
-
Hermeking, H., C. Lengauer, K. Polyak, T. C. He, L. Zhang, S. Thiagalingam, K. W. Kinzler, and B. Vogelstein. 1997. 14-3-3 Sigma is a p53-regulated inhibitor of G2/M progression. Mol. Cell 1:3-11.
-
(1997)
Mol. Cell
, vol.1
, pp. 3-11
-
-
Hermeking, H.1
Lengauer, C.2
Polyak, K.3
He, T.C.4
Zhang, L.5
Thiagalingam, S.6
Kinzler, K.W.7
Vogelstein, B.8
-
33
-
-
0037173059
-
The p53MH algorithm and its application in detecting p53-responsive genes
-
Hoh, J., S. Jin, T. Parrado, J. Edington, A. J. Levine, and J. Ott. 2002. The p53MH algorithm and its application in detecting p53-responsive genes. Proc. Natl. Acad. Sci. USA 99:8467-8472.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 8467-8472
-
-
Hoh, J.1
Jin, S.2
Parrado, T.3
Edington, J.4
Levine, A.J.5
Ott, J.6
-
34
-
-
0024440559
-
Galactose as a gratuitous inducer of GAL gene expression in yeasts growing on glucose
-
Hovland, P., J. Flick, M. Johnston, and R. A. Sclafani. 1989. Galactose as a gratuitous inducer of GAL gene expression in yeasts growing on glucose. Gene 83:57-64.
-
(1989)
Gene
, vol.83
, pp. 57-64
-
-
Hovland, P.1
Flick, J.2
Johnston, M.3
Sclafani, R.A.4
-
35
-
-
0028519273
-
Allosteric activation of latent p53 tetramers
-
Hupp, T. R., and D. P. Lane. 1994. Allosteric activation of latent p53 tetramers. Curr. Biol. 4:865-875.
-
(1994)
Curr. Biol.
, vol.4
, pp. 865-875
-
-
Hupp, T.R.1
Lane, D.P.2
-
36
-
-
0035945659
-
p53 mutants exhibiting enhanced transcriptional activation and altered promoter selectivity are revealed using a sensitive, yeast-based functional assay
-
Inga, A., P. Monti, G. Fronza, T. Darden, and M. A. Resnick. 2001. p53 mutants exhibiting enhanced transcriptional activation and altered promoter selectivity are revealed using a sensitive, yeast-based functional assay. Oncogene 20:501-513.
-
(2001)
Oncogene
, vol.20
, pp. 501-513
-
-
Inga, A.1
Monti, P.2
Fronza, G.3
Darden, T.4
Resnick, M.A.5
-
37
-
-
0035821734
-
Novel human p53 mutations that are toxic to yeast can enhance transactivation of specific promoters and reactivate tumor p53 mutants
-
Inga, A., and M. A. Resnick. 2001. Novel human p53 mutations that are toxic to yeast can enhance transactivation of specific promoters and reactivate tumor p53 mutants. Oncogene 20:3409-3419.
-
(2001)
Oncogene
, vol.20
, pp. 3409-3419
-
-
Inga, A.1
Resnick, M.A.2
-
38
-
-
0029028352
-
Mutational analysis of the carboxy-terminal portion of p53 using both yeast and mammalian cell assays in vivo
-
Ishioka, C., C. Englert, P. Winge, Y. X. Yan, M. Engelstein, and S. H. Friend. 1995. Mutational analysis of the carboxy-terminal portion of p53 using both yeast and mammalian cell assays in vivo. Oncogene 10:1485-1492.
-
(1995)
Oncogene
, vol.10
, pp. 1485-1492
-
-
Ishioka, C.1
Englert, C.2
Winge, P.3
Yan, Y.X.4
Engelstein, M.5
Friend, S.H.6
-
39
-
-
0037039319
-
Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo
-
Kaeser, M. D., and R. D. Iggo. 2002. Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo. Proc. Natl. Acad. Sci. USA 99:95-100.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 95-100
-
-
Kaeser, M.D.1
Iggo, R.D.2
-
40
-
-
0035953394
-
DNA microarray identification of primary and secondary target genes regulated by p53
-
Kannan, K., N. Amariglio, G. Rechavi, J. Jakob-Hirsch, I. Kela, N. Kaminski, G. Getz, E. Domany, and D. Givol. 2001. DNA microarray identification of primary and secondary target genes regulated by p53. Oncogene 20:2225-2234.
-
(2001)
Oncogene
, vol.20
, pp. 2225-2234
-
-
Kannan, K.1
Amariglio, N.2
Rechavi, G.3
Jakob-Hirsch, J.4
Kela, I.5
Kaminski, N.6
Getz, G.7
Domany, E.8
Givol, D.9
-
41
-
-
0035821652
-
DNA microarray analysis of genes involved in p53 mediated apoptosis: Activation of Apaf-1
-
Kannan, K., N. Kaminski, G. Rechavi, J. Jakob-Hirsch, N. Amariglio, and D. Givol. 2001. DNA microarray analysis of genes involved in p53 mediated apoptosis: Activation of Apaf-1. Oncogene 20:3449-3455.
-
(2001)
Oncogene
, vol.20
, pp. 3449-3455
-
-
Kannan, K.1
Kaminski, N.2
Rechavi, G.3
Jakob-Hirsch, J.4
Amariglio, N.5
Givol, D.6
-
42
-
-
0026496885
-
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxiatelangiectasia
-
Kastan, M. B., Q. Zhan, W. S. el-Deiry, F. Carrier, T. Jacks, W. V. Walsh, B. S. Plunkett, B. Vogelstein, and A. J. Fornace, Jr. 1992. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxiatelangiectasia. Cell 71:587-597.
-
(1992)
Cell
, vol.71
, pp. 587-597
-
-
Kastan, M.B.1
Zhan, Q.2
El-Deiry, W.S.3
Carrier, F.4
Jacks, T.5
Walsh, W.V.6
Plunkett, B.S.7
Vogelstein, B.8
Fornace A.J., Jr.9
-
43
-
-
0029972806
-
p53: Puzzle and paradigm
-
Ko, L. J., and C. Prives. 1996. p53: Puzzle and paradigm. Genes Dev. 10:1054-1072.
-
(1996)
Genes Dev.
, vol.10
, pp. 1054-1072
-
-
Ko, L.J.1
Prives, C.2
-
44
-
-
0035499826
-
How cells choose to die
-
Lane, D. 2001. How cells choose to die. Nature 414:25-27.
-
(2001)
Nature
, vol.414
, pp. 25-27
-
-
Lane, D.1
-
45
-
-
0034633702
-
Generation of oscillations by the p53-Mdm2 feedback loop: A theoretical and experimental study
-
Lev Bar-Or, R., R. Maya, L. A. Segel, U. Alon, A. J. Levine, and M. Oren. 2000. Generation of oscillations by the p53-Mdm2 feedback loop: A theoretical and experimental study. Proc. Natl. Acad. Sci. USA 97:11250-11255.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 11250-11255
-
-
Lev Bar-Or, R.1
Maya, R.2
Segel, L.A.3
Alon, U.4
Levine, A.J.5
Oren, M.6
-
46
-
-
0030941458
-
p53, the cellular gatekeeper for growth and division
-
Levine, A. J. 1997. p53, the cellular gatekeeper for growth and division. Cell. 88:323-331.
-
(1997)
Cell
, vol.88
, pp. 323-331
-
-
Levine, A.J.1
-
47
-
-
0034934774
-
Promoter-specific binding of Rapl revealed by genome-wide maps of protein-DNA association
-
Lieb, J. D., X. Liu, D. Botstein, and P. O. Brown. 2001. Promoter-specific binding of Rapl revealed by genome-wide maps of protein-DNA association. Nat. Genet. 28:327-334.
-
(2001)
Nat. Genet.
, vol.28
, pp. 327-334
-
-
Lieb, J.D.1
Liu, X.2
Botstein, D.3
Brown, P.O.4
-
48
-
-
0029742781
-
Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function
-
Ludwig, R. L., S. Bates, and K. H. Vousden. 1996. Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function. Mol. Cell. Biol. 16:4952-4960.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 4952-4960
-
-
Ludwig, R.L.1
Bates, S.2
Vousden, K.H.3
-
49
-
-
0035913911
-
Negative control of p53 by Sir2alpha promotes cell survival under stress
-
Luo, J., A. Y. Nikolaev, S. Imai, D. Chen, F. Su, A. Shiloh, L. Guarente, and W. Gu. 2001. Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 107:137-148.
-
(2001)
Cell
, vol.107
, pp. 137-148
-
-
Luo, J.1
Nikolaev, A.Y.2
Imai, S.3
Chen, D.4
Su, F.5
Shiloh, A.6
Guarente, L.7
Gu, W.8
-
50
-
-
0032526426
-
How p53 binds DNA as a tetramer
-
McLure, K. G., and P. W. Lee. 1998. How p53 binds DNA as a tetramer. EMBO J. 17:3342-3350.
-
(1998)
EMBO J.
, vol.17
, pp. 3342-3350
-
-
McLure, K.G.1
Lee, P.W.2
-
52
-
-
0030816303
-
Protein interactions at the carboxyl terminus of p53 result in the induction of its in vitro transactivation potential
-
Mundt, M., T. Hupp, M. Fritsche, C. Merkle, S. Hansen, D. Lane, and B. Groner. 1997. Protein interactions at the carboxyl terminus of p53 result in the induction of its in vitro transactivation potential. Oncogene 15:237-244.
-
(1997)
Oncogene
, vol.15
, pp. 237-244
-
-
Mundt, M.1
Hupp, T.2
Fritsche, M.3
Merkle, C.4
Hansen, S.5
Lane, D.6
Groner, B.7
-
53
-
-
0034635373
-
Human and mouse Fas (APO-1/CD95) death receptor genes each contain a p53-responsive element that is activated by p53 mutants unable to induce apoptosis
-
Munsch, D., R. Watanabe-Fukunaga, J. C. Bourdon, S. Nagata, E. May, E. Yonish-Rouach, and P. Reisdorf. 2000. Human and mouse Fas (APO-1/CD95) death receptor genes each contain a p53-responsive element that is activated by p53 mutants unable to induce apoptosis. J. Biol. Chem. 275:3867-3872.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 3867-3872
-
-
Munsch, D.1
Watanabe-Fukunaga, R.2
Bourdon, J.C.3
Nagata, S.4
May, E.5
Yonish-Rouach, E.6
Reisdorf, P.7
-
54
-
-
0030951978
-
DNA bending is essential for the site-specific recognition of DNA response elements by the DNA binding domain of the tumor suppressor protein p53
-
Nagaich, A. K., E. Appella, and R. E. Harrington. 1997. DNA bending is essential for the site-specific recognition of DNA response elements by the DNA binding domain of the tumor suppressor protein p53. J. Biol. Chem. 272:14842-14849.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 14842-14849
-
-
Nagaich, A.K.1
Appella, E.2
Harrington, R.E.3
-
55
-
-
0028200990
-
CA/TG sequence at the 5′ end of oligo(A)-tracts strongly modulates DNA curvature
-
Nagaich, A. K., D. Bhattacharyya, S. K. Brahmachari, and M. Bansal. 1994. CA/TG sequence at the 5′ end of oligo(A)-tracts strongly modulates DNA curvature. J. Biol. Chem. 269:7824-7833.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 7824-7833
-
-
Nagaich, A.K.1
Bhattacharyya, D.2
Brahmachari, S.K.3
Bansal, M.4
-
56
-
-
0034640281
-
Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
-
Oda, E., R. Ohki, H. Murasawa, J. Nemoto, T. Shibue, T. Yamashita, T. Tokino, T. Taniguchi, and N. Tanaka. 2000. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science 288:1053-1058.
-
(2000)
Science
, vol.288
, pp. 1053-1058
-
-
Oda, E.1
Ohki, R.2
Murasawa, H.3
Nemoto, J.4
Shibue, T.5
Yamashita, T.6
Tokino, T.7
Taniguchi, T.8
Tanaka, N.9
-
57
-
-
0034664733
-
p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser46-phosphorylated p53
-
Oda, K., H. Arakawa, T. Tanaka, K. Matsuda, C. Tanikawa, T. Mori, H. Nishimori, K. Tamai, T. Tokino, Y. Nakamura, and Y. Taya. 2000. p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser46-phosphorylated p53. Cell 102:849-862.
-
(2000)
Cell
, vol.102
, pp. 849-862
-
-
Oda, K.1
Arakawa, H.2
Tanaka, T.3
Matsuda, K.4
Tanikawa, C.5
Mori, T.6
Nishimori, H.7
Tamai, K.8
Tokino, T.9
Nakamura, Y.10
Taya, Y.11
-
58
-
-
0033579412
-
Regulation of the p53 tumor suppressor protein
-
Oren, M. 1999. Regulation of the p53 tumor suppressor protein. J. Biol. Chem. 274:36031-36034.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 36031-36034
-
-
Oren, M.1
-
59
-
-
0035966316
-
Why is p53 acetylated?
-
Prives, C., and J. L. Manley. 2001. Why is p53 acetylated? Cell 107:815-818.
-
(2001)
Cell
, vol.107
, pp. 815-818
-
-
Prives, C.1
Manley, J.L.2
-
60
-
-
0030960672
-
Transcriptional activation by recruitment
-
Ptashne, M., and A. Gann. 1997. Transcriptional activation by recruitment. Nature 386:569-577.
-
(1997)
Nature
, vol.386
, pp. 569-577
-
-
Ptashne, M.1
Gann, A.2
-
61
-
-
0034704248
-
Genome-wide location and function of DNA binding proteins
-
Ren, B., F. Robert, J. J. Wyrick, O. Aparicio, E. G. Jennings, I. Simon, J. Zeitlinger, J. Schreiber, N. Hannett, E. Kanin, T. L. Volkert, C. J. Wilson, S. P. Bell, and R. A. Young. 2000. Genome-wide location and function of DNA binding proteins. Science 290:2306-2309.
-
(2000)
Science
, vol.290
, pp. 2306-2309
-
-
Ren, B.1
Robert, F.2
Wyrick, J.J.3
Aparicio, O.4
Jennings, E.G.5
Simon, I.6
Zeitlinger, J.7
Schreiber, J.8
Hannett, N.9
Kanin, E.10
Volkert, T.L.11
Wilson, C.J.12
Bell, S.P.13
Young, R.A.14
-
62
-
-
0032528245
-
Identification of a novel class of genomic DNA-binding sites suggests a mechanism for selectivity in target gene activation by the tumor suppressor protein p53
-
Resnick-Silverman, L., S. St. Clair, M. Maurer, K. Zhao, and J. J. Manfredi. 1998. Identification of a novel class of genomic DNA-binding sites suggests a mechanism for selectivity in target gene activation by the tumor suppressor protein p53. Genes Dev. 12:2102-2107.
-
(1998)
Genes Dev.
, vol.12
, pp. 2102-2107
-
-
Resnick-Silverman, L.1
St. Clair, S.2
Maurer, M.3
Zhao, K.4
Manfredi, J.J.5
-
63
-
-
0030031757
-
Induction of HL-60 cells to undergo apoptosis is determined by high levels of wild-type p53 protein whereas differentiation of the cells is mediated by lower p53 levels
-
Ronen, D., D. Schwartz, Y. Teitz, N. Goldfinger, and V. Rotter. 1996. Induction of HL-60 cells to undergo apoptosis is determined by high levels of wild-type p53 protein whereas differentiation of the cells is mediated by lower p53 levels. Cell Growth Differ. 7:21-30.
-
(1996)
Cell Growth Differ.
, vol.7
, pp. 21-30
-
-
Ronen, D.1
Schwartz, D.2
Teitz, Y.3
Goldfinger, N.4
Rotter, V.5
-
64
-
-
0033575732
-
Increased apoptosis induction by 121F mutant p53
-
Saller, E., E. Tom, M. Brunori, M. Otter, A. Estreicher, D. H. Mack, and R.Iggo. 1999. Increased apoptosis induction by 121F mutant p53. EMBO J. 18:442-4437.
-
(1999)
EMBO J.
, vol.18
, pp. 442-4437
-
-
Saller, E.1
Tom, E.2
Brunori, M.3
Otter, M.4
Estreicher, A.5
Mack, D.H.6
Iggo, R.7
-
65
-
-
17944379798
-
ASPP proteins specifically stimulate the apoptotic function of p53
-
Samuels-Lev, Y., D. J. O'Connor, D. Bergamaschi, G. Trigiante, J. K. Hsieh, S. Zhong, I. Campargue, L. Naumovski, T. Crook, and X. Lu. 2001. ASPP proteins specifically stimulate the apoptotic function of p53. Mol. Cell 8:781-794.
-
(2001)
Mol. Cell
, vol.8
, pp. 781-794
-
-
Samuels-Lev, Y.1
O'Connor, D.J.2
Bergamaschi, D.3
Trigiante, G.4
Hsieh, J.K.5
Zhong, S.6
Campargue, I.7
Naumovski, L.8
Crook, T.9
Lu, X.10
-
66
-
-
0026577060
-
Mammalian p53 can function as a transcription factor in yeast
-
Scharer, E., and R. Iggo. 1992. Mammalian p53 can function as a transcription factor in yeast. Nucleic Acids Res. 20:1539-1545.
-
(1992)
Nucleic Acids Res.
, vol.20
, pp. 1539-1545
-
-
Scharer, E.1
Iggo, R.2
-
67
-
-
0033561618
-
Novel p53 mutants selected in BRCA-associated tumours which dissociate transformation suppression from other wild-type p53 functions
-
Smith, P. D., S. Crossland, G. Parker, P. Osin, L. Brooks, J. Waller, E. Philp, M. R. Crompton, B. A. Gusterson, M. J. Allday, and T. Crook. 1999. Novel p53 mutants selected in BRCA-associated tumours which dissociate transformation suppression from other wild-type p53 functions. Oncogene 18:2451-2459.
-
(1999)
Oncogene
, vol.18
, pp. 2451-2459
-
-
Smith, P.D.1
Crossland, S.2
Parker, G.3
Osin, P.4
Brooks, L.5
Waller, J.6
Philp, E.7
Crompton, M.R.8
Gusterson, B.A.9
Allday, M.J.10
Crook, T.11
-
68
-
-
0034903337
-
In vivo site-directed mutagenesis using oligonucleotides
-
Storici, F., L. K. Lewis, and M. A. Resnick. 2001. In vivo site-directed mutagenesis using oligonucleotides. Nat. Biotechnol. 19:773-776.
-
(2001)
Nat. Biotechnol.
, vol.19
, pp. 773-776
-
-
Storici, F.1
Lewis, L.K.2
Resnick, M.A.3
-
69
-
-
0035028599
-
Kinetics of p53 binding to promoter sites in vivo
-
Szak, S. T., D. Mays, and J. A. Pietenpol. 2001. Kinetics of p53 binding to promoter sites in vivo. Mol. Cell. Biol. 21:3375-3386.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 3375-3386
-
-
Szak, S.T.1
Mays, D.2
Pietenpol, J.A.3
-
70
-
-
0034594978
-
A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage
-
Tanaka, H., H. Arakawa, T. Yamaguchi, K. Shiraishi, S. Fukuda, K. Matsui, Y. Takei, and Y. Nakamura. 2000. A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage. Nature 404:42-49.
-
(2000)
Nature
, vol.404
, pp. 42-49
-
-
Tanaka, H.1
Arakawa, H.2
Yamaguchi, T.3
Shiraishi, K.4
Fukuda, S.5
Matsui, K.6
Takei, Y.7
Nakamura, Y.8
-
71
-
-
0033584842
-
One mechanism for cell type-specific regulation of the bax promoter by the tumor suppressor p53 is dictated by the p53 response element
-
Thornborrow, E. C., and J. J. Manfredi. 1999. One mechanism for cell type-specific regulation of the bax promoter by the tumor suppressor p53 is dictated by the p53 response element. J. Biol. Chem. 274:33747-33756.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 33747-33756
-
-
Thornborrow, E.C.1
Manfredi, J.J.2
-
72
-
-
0029157601
-
Discrimination of DNA binding sites by mutant p53 proteins
-
Thukral, S. K., Y. Lu, G. C. Blain, T. S. Harvey, and V. L. Jacobsen. 1995. Discrimination of DNA binding sites by mutant p53 proteins. Mol. Cell. Biol. 15:5196-5202.
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 5196-5202
-
-
Thukral, S.K.1
Lu, Y.2
Blain, G.C.3
Harvey, T.S.4
Jacobsen, V.L.5
-
73
-
-
0028145057
-
p53 tagged sites from human genomic DNA
-
Tokino, T., S. Thiagalingam, W. S. el-Deiry, T. Waldman, K. W. Kinzler, and B. Vogelstein. 1994. p53 tagged sites from human genomic DNA. Hum. Mol. Genet. 3:1537-1542.
-
(1994)
Hum. Mol. Genet.
, vol.3
, pp. 1537-1542
-
-
Tokino, T.1
Thiagalingam, S.2
El-Deiry, W.S.3
Waldman, T.4
Kinzler, K.W.5
Vogelstein, B.6
-
74
-
-
0033119627
-
Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2
-
Unger, T., T. Juven-Gershon, E. Moallem, M. Berger, R. Vogt Sionov, G. Lozano, M. Oren, and Y. Haupt. 1999. Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2. EMBO J. 18:1805-1814.
-
(1999)
EMBO J.
, vol.18
, pp. 1805-1814
-
-
Unger, T.1
Juven-Gershon, T.2
Moallem, E.3
Berger, M.4
Vogt Sionov, R.5
Lozano, G.6
Oren, M.7
Haupt, Y.8
-
75
-
-
0033531264
-
PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes
-
Velasco-Miguel, S., L. Buckbinder, P. Jean, L. Gelbert, R. Talbott, J. Laidlaw, B. Seizinger, and N. Kley. 1999. PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes. Oncogene 18:127-137.
-
(1999)
Oncogene
, vol.18
, pp. 127-137
-
-
Velasco-Miguel, S.1
Buckbinder, L.2
Jean, P.3
Gelbert, L.4
Talbott, R.5
Laidlaw, J.6
Seizinger, B.7
Kley, N.8
-
76
-
-
0032541325
-
The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression
-
Venot, C., M. Maratrat, C. Dureuil, E. Conseiller, L. Bracco, and L. Debussche. 1998. The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression. EMBO J. 17:4668-4679.
-
(1998)
EMBO J.
, vol.17
, pp. 4668-4679
-
-
Venot, C.1
Maratrat, M.2
Dureuil, C.3
Conseiller, E.4
Bracco, L.5
Debussche, L.6
-
78
-
-
0035195557
-
The evolution of diverse biological responses to DNA damage: Insights from yeast and p53
-
Wahl, G. M., and A. M. Carr. 2001. The evolution of diverse biological responses to DNA damage: Insights from yeast and p53. Nat. Cell. Biol. 3:E277-E286.
-
(2001)
Nat. Cell. Biol.
, vol.3
-
-
Wahl, G.M.1
Carr, A.M.2
-
79
-
-
0033531266
-
Evolutionary conservation and somatic mutation hotspot maps of p53: Correlation with p53 protein structural and functional features
-
Walker, D. R., J. P. Bond, R. E. Tarone, C. C. Harris, W. Makalowski, M. S. Boguski, and M. S. Greenblatt. 1999. Evolutionary conservation and somatic mutation hotspot maps of p53: Correlation with p53 protein structural and functional features. Oncogene 18:211-218.
-
(1999)
Oncogene
, vol.18
, pp. 211-218
-
-
Walker, D.R.1
Bond, J.P.2
Tarone, R.E.3
Harris, C.C.4
Makalowski, W.5
Boguski, M.S.6
Greenblatt, M.S.7
-
80
-
-
0035941214
-
Analyses of p53 target genes in the human genome by bioinformatic and microarray approaches
-
Wang, L., Q. Wu, P. Qiu, A. Mirza, M. McGuirk, P. Kirschmeier, J. R. Greene, Y. Wang, C. B. Pickett, and S. Liu. 2001. Analyses of p53 target genes in the human genome by bioinformatic and microarray approaches. J. Biol. Chem. 276:43604-43610.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 43604-43610
-
-
Wang, L.1
Wu, Q.2
Qiu, P.3
Mirza, A.4
McGuirk, M.5
Kirschmeier, P.6
Greene, J.R.7
Wang, Y.8
Pickett, C.B.9
Liu, S.10
-
81
-
-
0035890271
-
hADA3 is required for p53 activity
-
Wang, T., T. Kobayashi, R. Takimoto, A. E. Denes, E. L. Snyder, W. S. el-Deiry, and R. K. Brachmann. 2001. hADA3 is required for p53 activity. EMBO. J. 20:6404-6413.
-
(2001)
EMBO. J.
, vol.20
, pp. 6404-6413
-
-
Wang, T.1
Kobayashi, T.2
Takimoto, R.3
Denes, A.E.4
Snyder, E.L.5
El-Deiry, W.S.6
Brachmann, R.K.7
-
82
-
-
0029823529
-
Structure-based rescue of common tumor-derived p53 mutants
-
Wieczorek, A. M., J. L. Waterman, M. J. Waterman, and T. D. Halazonetis. 1996. Structure-based rescue of common tumor-derived p53 mutants. Nat. Med. 2:1143-1146.
-
(1996)
Nat. Med.
, vol.2
, pp. 1143-1146
-
-
Wieczorek, A.M.1
Waterman, J.L.2
Waterman, M.J.3
Halazonetis, T.D.4
-
83
-
-
0032947176
-
p53-mediated regulation of proliferating cell nuclear antigen expression in cells exposed to ionizing radiation
-
Xu, J., and G. F. Morris. 1999. p53-mediated regulation of proliferating cell nuclear antigen expression in cells exposed to ionizing radiation. Mol. Cell. Biol. 19:12-20.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 12-20
-
-
Xu, J.1
Morris, G.F.2
-
84
-
-
0035265823
-
PUMA induces the rapid apoptosis of colorectal cancer cells
-
Yu, J., L. Zhang, P. M. Hwang, K. W. Kinzler, and B. Vogelstein. 2001. PUMA induces the rapid apoptosis of colorectal cancer cells. Mol. Cell 7:673-682.
-
(2001)
Mol. Cell
, vol.7
, pp. 673-682
-
-
Yu, J.1
Zhang, L.2
Hwang, P.M.3
Kinzler, K.W.4
Vogelstein, B.5
-
85
-
-
0033453226
-
Identification and classification of p53-regulated genes
-
Yu, J., L. Zhang, P. M. Hwang, C. Rago, K. W. Kinzler, and B. Vogelstein. 1999. Identification and classification of p53-regulated genes. Proc. Natl. Acad. Sci. USA 96:14517-14522.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 14517-14522
-
-
Yu, J.1
Zhang, L.2
Hwang, P.M.3
Rago, C.4
Kinzler, K.W.5
Vogelstein, B.6
-
86
-
-
0029131447
-
A functional p53-responsive intronic promoter is contained within the human mdm2 gene
-
Zauberman, A., D. Flusberg, Y. Haupt, Y. Barak, and M. Oren. 1995. A functional p53-responsive intronic promoter is contained within the human mdm2 gene. Nucleic Acids Res. 23:2584-2592.
-
(1995)
Nucleic Acids Res.
, vol.23
, pp. 2584-2592
-
-
Zauberman, A.1
Flusberg, D.2
Haupt, Y.3
Barak, Y.4
Oren, M.5
-
87
-
-
0029006743
-
Identification of p53 target genes through immune selection of genomic DNA: The cyclin G gene contains two distinct p53 binding sites
-
Zauberman, A., A. Lupo, and M. Oren. 1995. Identification of p53 target genes through immune selection of genomic DNA: The cyclin G gene contains two distinct p53 binding sites. Oncogene 10:2361-2366.
-
(1995)
Oncogene
, vol.10
, pp. 2361-2366
-
-
Zauberman, A.1
Lupo, A.2
Oren, M.3
-
88
-
-
0034656243
-
Analysis of p53-regulated gene expression patterns using oligonucleotide arrays
-
Zhao, R., K. Gish, M. Murphy, Y. Yin, D. Notterman, W. H. Hoffman, E. Tom, D. H. Mack, and A. J. Levine. 2000. Analysis of p53-regulated gene expression patterns using oligonucleotide arrays. Genes Dev. 14:981-993.
-
(2000)
Genes Dev.
, vol.14
, pp. 981-993
-
-
Zhao, R.1
Gish, K.2
Murphy, M.3
Yin, Y.4
Notterman, D.5
Hoffman, W.H.6
Tom, E.7
Mack, D.H.8
Levine, A.J.9
-
89
-
-
0034704151
-
Definition of the p53 functional domains necessary for inducing apoptosis
-
Zhu, J., S. Zhang, J. Jiang, and X. Chen. 2000. Definition of the p53 functional domains necessary for inducing apoptosis. J. Biol. Chem. 275:39927-39934.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 39927-39934
-
-
Zhu, J.1
Zhang, S.2
Jiang, J.3
Chen, X.4
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