hADA3 is required for p53 activity

EMBO Journal

Volumn 20, Issue 22, 2001, Pages 6404-6413

  Wang, Ting ^a   Kobayashi, Takahiko ^a   Takimoto, Rishu ^b   Denes, Alec E ^a   Snyder, Eric L ^a   El Deiry, Wafik S ^b   Brachmann, Rainer K ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Apoptosis; DNA damage; hADA3; Histone acetyltransferase; p53

Indexed keywords

HISTONE ACETYLTRANSFERASE; PROTEIN HADA3; PROTEIN P53; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; GENE ACTIVITY; GENE MUTATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MITOSIS INHIBITION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY;

ACETYLTRANSFERASES; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; CELL LINE; CELLS, CULTURED; DNA; DNA DAMAGE; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; FLOW CYTOMETRY; GENE LIBRARY; GENES, P53; GENES, REPORTER; HELA CELLS; HISTONE ACETYLTRANSFERASES; HUMANS; MODELS, BIOLOGICAL; MUTATION; OLIGONUCLEOTIDES, ANTISENSE; PHOSPHORYLATION; PLASMIDS; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; ULTRAVIOLET RAYS;

EID: 0035890271     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.22.6404     Document Type: Article

References (47)

1. Regulation of p53 stability
2. Recruitment of p300/CBP in p53-dependent signal pathways
3. Suppression of human colorectal carcinoma cell growth by wild-type p53
4. Dominant-negative p53 mutations selected in yeast hit cancer hot spots
5. Genetic selection of intragenic suppressor mutations that reverse the effect of common p53 cancer mutations
6. Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction
7. Structural and functional analysis of yeast putative adaptors. Evidence for an adaptor complex in vivo
8. Two tandem and independent sub-activation domains in the amino terminus of p53 require the adaptor complex for activity
9. p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage
10. Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53
11. Protein interaction cloning in yeast: Identification of mammalian proteins that react with the leucine zipper of Jun
12. Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor
13. WAF1, a potential mediator of p53 tumor suppression
14. The complexity of p53 modulation: Emerging patterns from divergent signals
15. Conjunction dysfunction: CBP/p300 in human disease
16. The SAGA unfolds: Convergence of transcription regulators in chromatin-modifying complexes
17. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
18. Synergistic activation of transcription by CBP and p53
19. Mdm2 promotes the rapid degradation of p53
20. DNA damage-induced activation of p53 by the checkpoint kinase chk2
21. ADA3, a putative transcriptional adaptor, consists of two separable domains and interacts with ADA2 and GCN5 in a trimeric complex
22. p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2
23. Stimulation of p53-mediated transcriptional activation by the p53-binding proteins, 53BP1 and 53BP2
24. Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast
25. A transactivation-deficient mouse model provides insights into trp53 regulation and function
26. Use of a membrane-localized green fluorescent protein allows simultaneous identification of transfected cells and cell cycle analysis by flow cytometry
27. p53: Puzzle and paradigm
28. Acetylation: A regulatory modification to rival phosphorylation?
29. Regulation of p53 stability by Mdm2
30. p53, the cellular gatekeeper for growth and division
31. Binding and modulation of p53 by p300/CBP coactivators
32. Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein
33. p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage
34. p53AIP1, a potential mediator of p53-dependent apoptosis and its regulation by ser-46-phosphorylated p53
35. Histone-like TAFs within the PCAF histone acetylase complex
36. Regulation of the p53 tumor suppressor protein
37. Homozygous deletion of the death receptor DR4 gene in a nasopharyngeal cancer cell line is associated with TRAIL resistance
38. DNA damage activates p53 through a phosphorylation-acetylation cascade
39. The PCAF acetylase complex as a potential tumor suppressor
40. CREB-binding protein and p300/CBP-associated factor are transcriptional coactivators of the p53 tumor suppressor protein
41. The human homologs of checkpoint kinases chk1 and cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
42. Acetylation of histones and transcription-related factors
43. Histone acetylation and transcriptional regulatory mechanisms
44. Reverse two-hybrid and one-hybrid systems to detect dissociation of protein-protein and DNA-protein interactions
45. Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast
46. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A