Intrathecal ciliary neurotrophic factor delivery for treatment of amyotrophic lateral sclerosis (phase I trial)

Neurosurgery

Volumn 40, Issue 1, 1997, Pages 94-100

  Penn, Richard D ^a   Kroin, Jeffrey S ^a   York, Michelle M ^a   Cedarbaum, Jesse M ^b  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b REGENERON PHARMACEUTICALS INC   (United States)

Author keywords

ALS; Ciliary neurotrophic factor; Drug pump; Human trial; Intrathecal; Pharmacokinetics

Indexed keywords

CILIARY NEUROTROPHIC FACTOR;

ADULT; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CASE REPORT; CLINICAL TRIAL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG SAFETY; HUMAN; INFUSION PUMP; INTRATHECAL DRUG ADMINISTRATION; MOTONEURON; NEUROMUSCULAR SYNAPSE; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; SUBARACHNOID SPACE;

ACTIVITIES OF DAILY LIVING; AMYOTROPHIC LATERAL SCLEROSIS; CILIARY NEUROTROPHIC FACTOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; HUMANS; INFUSION PUMPS, IMPLANTABLE; INJECTIONS, SPINAL; METABOLIC CLEARANCE RATE; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS; RECOMBINANT PROTEINS;

EID: 0031028248     PISSN: 0148396X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006123-199701000-00021     Document Type: Article

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