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Volumn 11, Issue 20, 2002, Pages 2447-2453

Protecting genomic integrity during DNA replication: Correlation between Werner's and Bloom's syndrome gene products and the MRE11 complex

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYRIBONUCLEASE; DNA; DOUBLE STRANDED DNA; GENE PRODUCT; HELICASE;

EID: 0036797833     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/11.20.2447     Document Type: Review
Times cited : (34)

References (107)
  • 1
    • 0031463889 scopus 로고    scopus 로고
    • Disorders of DNA replication and repair
    • Auerbach, A.D. and Verlander, P.C. (1997) Disorders of DNA replication and repair. Curr. Opin. Pediatr, 9, 600-616.
    • (1997) Curr. Opin. Pediatr , vol.9 , pp. 600-616
    • Auerbach, A.D.1    Verlander, P.C.2
  • 4
    • 0035075342 scopus 로고    scopus 로고
    • Functional and dysfunctional roles of quadruplex DNA in cells
    • Arthanari, H. and Bolton, P.H. (2001) Functional and dysfunctional roles of quadruplex DNA in cells. Chem. Biol., 8, 221-230.
    • (2001) Chem. Biol , vol.8 , pp. 221-230
    • Arthanari, H.1    Bolton, P.H.2
  • 5
    • 0033960606 scopus 로고    scopus 로고
    • Palindromes as substrates for multiple pathways of recombination in Escherichia coli
    • Cromie, G.A., Millar, C.B., Schmidt, K.H. and Leach, D.R. (2000) Palindromes as substrates for multiple pathways of recombination in Escherichia coli. Genetics, 154, 513-522.
    • (2000) Genetics , vol.154 , pp. 513-522
    • Cromie, G.A.1    Millar, C.B.2    Schmidt, K.H.3    Leach, D.R.4
  • 6
    • 0030725454 scopus 로고    scopus 로고
    • Trinucleotide repeats affect DNA replication in vivo
    • Samadashwily, G.M., Raca, G. and Mirkin, S.M. (1997) Trinucleotide repeats affect DNA replication in vivo. Nat. Genet., 17, 298-304.
    • (1997) Nat. Genet , vol.17 , pp. 298-304
    • Samadashwily, G.M.1    Raca, G.2    Mirkin, S.M.3
  • 7
    • 0034638924 scopus 로고    scopus 로고
    • DNA polymerase stalling, sister chromatid recombination and the BRCA genes
    • Scully, R., Puget, N. and Vlasakova, K. (2000) DNA polymerase stalling, sister chromatid recombination and the BRCA genes. Oncogene, 19, 6176-6183.
    • (2000) Oncogene , vol.19 , pp. 6176-6183
    • Scully, R.1    Puget, N.2    Vlasakova, K.3
  • 8
    • 0031025093 scopus 로고    scopus 로고
    • DNA double-strand breaks caused by replication arrest
    • Michel, B., Ehrlich, S.D. and Uzest, M. (1997) DNA double-strand breaks caused by replication arrest. EMBO J., 16, 430-438.
    • (1997) EMBO J , vol.16 , pp. 430-438
    • Michel, B.1    Ehrlich, S.D.2    Uzest, M.3
  • 9
    • 0033168376 scopus 로고    scopus 로고
    • DNA recombination: The replication connection
    • Haber, J.E. (1999) DNA recombination: the replication connection. Trends Biochem. Sci., 24, 271-275.
    • (1999) Trends Biochem. Sci , vol.24 , pp. 271-275
    • Haber, J.E.1
  • 10
    • 0036480427 scopus 로고    scopus 로고
    • Double-strand breaks and translocations in cancer
    • Elliott, B. and Jasin, M. (2002) Double-strand breaks and translocations in cancer. Cell. Mol. Life Sci., 59, 373-385.
    • (2002) Cell. Mol. Life Sci , vol.59 , pp. 373-385
    • Elliott, B.1    Jasin, M.2
  • 11
    • 0035093737 scopus 로고    scopus 로고
    • DNA double-strand breaks: Signaling, repair and the cancer connection
    • Khanna, K.K. and Jackson S.P. (2001) DNA double-strand breaks: signaling, repair and the cancer connection. Nat. Genet., 27, 247-254.
    • (2001) Nat. Genet , vol.27 , pp. 247-254
    • Khanna, K.K.1    Jackson, S.P.2
  • 13
    • 0035916365 scopus 로고    scopus 로고
    • Replication checkpoint: Preventing mitotic catastrophe
    • Canman, C.E. (2001) Replication checkpoint: preventing mitotic catastrophe. Curr. Biol., 11, R121-R124.
    • (2001) Curr. Biol , vol.11
    • Canman, C.E.1
  • 14
    • 0030861685 scopus 로고    scopus 로고
    • DNA helicases in inherited human disorders
    • Ellis, N.A. (1997) DNA helicases in inherited human disorders. Curr. Opin. Genet. Dev, 7, 354 363.
    • (1997) Curr. Opin. Genet. Dev , vol.7 , pp. 354-363
    • Ellis, N.A.1
  • 15
    • 0028568315 scopus 로고
    • Cell cycle control and cancer
    • Hartwell, L.H. and Kastan, M.B. (1994) Cell cycle control and cancer. Science, 266, 1821-1828.
    • (1994) Science , vol.266 , pp. 1821-1828
    • Hartwell, L.H.1    Kastan, M.B.2
  • 16
    • 0034578446 scopus 로고    scopus 로고
    • DNA helicases, genomic instability, and human genetic disease
    • van Brabant, A.J., Stan, R. and Ellis, N.A. (2000) DNA helicases, genomic instability, and human genetic disease. Annu. Rev. Genom. Hum. Genet., 1, 409-459.
    • (2000) Annu. Rev. Genom. Hum. Genet , vol.1 , pp. 409-459
    • van Brabant, A.J.1    Stan, R.2    Ellis, N.A.3
  • 17
    • 0036276388 scopus 로고    scopus 로고
    • The Mre 11 complex: At the crossroads of dna repair and checkpoint signalling
    • D'Amours, D. and Jackson, S.P. (2002) The Mre 11 complex: at the crossroads of dna repair and checkpoint signalling. Nat. Rev. Mol. Cell. Biol., 3, 317-327.
    • (2002) Nat. Rev. Mol. Cell. Biol , vol.3 , pp. 317-327
    • D'Amours, D.1    Jackson, S.P.2
  • 19
    • 0020028472 scopus 로고
    • Werner's syndrome with associated malignant neoplasms
    • Hrabko, R.P., Milgrom, H. and Schwartz, R.A. (1982) Werner's syndrome with associated malignant neoplasms. Arch. Dermatol., 118, 106-108.
    • (1982) Arch. Dermatol , vol.118 , pp. 106-108
    • Hrabko, R.P.1    Milgrom, H.2    Schwartz, R.A.3
  • 20
    • 0028831333 scopus 로고
    • Bloom's syndrome
    • German, J. (1995) Bloom's syndrome. Dermatol. Clin., 13, 7-18.
    • (1995) Dermatol. Clin , vol.13 , pp. 7-18
    • German, J.1
  • 21
    • 0026856148 scopus 로고
    • Cancer predisposition in Bloom's syndrome
    • Sullivan, N.F. and Willis, A.E. (1992) Cancer predisposition in Bloom's syndrome. Bioessays, 14, 333-336.
    • (1992) Bioessays , vol.14 , pp. 333-336
    • Sullivan, N.F.1    Willis, A.E.2
  • 22
    • 0021778354 scopus 로고
    • In vitro studies of Werner syndrome cells: Aberrant growth and chromosome behavior
    • Salk, D. (1985) In vitro studies of Werner syndrome cells: aberrant growth and chromosome behavior. Basic Life Sci., 35, 419-426.
    • (1985) Basic Life Sci , vol.35 , pp. 419-426
    • Salk, D.1
  • 23
    • 0037081095 scopus 로고    scopus 로고
    • Lack of WRN results in extensive deletion at nonhomologous joining ends
    • Oshima, J., Huang, S., Pae, C., Campisi, J. and Schiestl, R.H. (2002) Lack of WRN results in extensive deletion at nonhomologous joining ends. Cancer Res., 62, 547-551.
    • (2002) Cancer Res , vol.62 , pp. 547-551
    • Oshima, J.1    Huang, S.2    Pae, C.3    Campisi, J.4    Schiestl, R.H.5
  • 24
    • 0032526483 scopus 로고    scopus 로고
    • Aneuploidy analysis in fibroblasts of human premature aging syndromes by FISH during in vitro cellular aging
    • Mukherjee, A.B. and Costello, C. (1998) Aneuploidy analysis in fibroblasts of human premature aging syndromes by FISH during in vitro cellular aging. Mech. Ageing Dev., 103, 209-222.
    • (1998) Mech. Ageing Dev , vol.103 , pp. 209-222
    • Mukherjee, A.B.1    Costello, C.2
  • 25
    • 0028949455 scopus 로고
    • Cytogenetic aspects of Werner's syndrome lymphocyte cultures
    • Melaragno, M.I., Pagni, D. and Smith, M.A. (1995) Cytogenetic aspects of Werner's syndrome lymphocyte cultures. Mech. Ageing Dev, 78, 117-222.
    • (1995) Mech. Ageing Dev , vol.78 , pp. 117-222
    • Melaragno, M.I.1    Pagni, D.2    Smith, M.A.3
  • 26
    • 0033866655 scopus 로고    scopus 로고
    • Spontaneous and X-ray-induced chromosomal aberrations in Werner syndrome cells detected by FISH using chromosome-specific painting probes
    • Grigorova, M., Balajee, A.S. and Natarajan, A.T. (2000) Spontaneous and X-ray-induced chromosomal aberrations in Werner syndrome cells detected by FISH using chromosome-specific painting probes. Mutagenesis, 15, 303-310.
    • (2000) Mutagenesis , vol.15 , pp. 303-310
    • Grigorova, M.1    Balajee, A.S.2    Natarajan, A.T.3
  • 28
    • 0024465870 scopus 로고
    • Mutator phenotype of Werner syndrome is characterized by extensive deletions
    • Fukuchi, K., Martin, G.M. and Monnat, R.J., Jr (1989) Mutator phenotype of Werner syndrome is characterized by extensive deletions. Proc. Natl Acad. Sci. USA, 86, 5893-5897.
    • (1989) Proc. Natl Acad. Sci. USA , vol.86 , pp. 5893-5897
    • Fukuchi, K.1    Martin, G.M.2    Monnat R.J. Jr3
  • 29
    • 0019440557 scopus 로고
    • Cytogenetics of Werner's syndrome cultured skin fibroblasts: Variegated translocation mosaicism
    • Salk, D., Au, K., Hoehn, H. and Martin, G.M. (1981) Cytogenetics of Werner's syndrome cultured skin fibroblasts: variegated translocation mosaicism. Cytogenet. Cell Genet., 30, 92-107.
    • (1981) Cytogenet. Cell Genet , vol.30 , pp. 92-107
    • Salk, D.1    Au, K.2    Hoehn, H.3    Martin, G.M.4
  • 30
    • 0030671254 scopus 로고    scopus 로고
    • Abnormal telomere dynamics of B-lymphoblastoid cell strains from Warner's syndrome patients transformed by Epstein Barr virus
    • Tahara, H., Tokutake, Y., Maeda, S., Kataoka, H., Watanabe, T., Satoh, M., Matsumoto, T., Sugawara, M., Ide, T., Goto, M. et al. (1997) Abnormal telomere dynamics of B-lymphoblastoid cell strains from Warner's syndrome patients transformed by Epstein Barr virus. Oncogene, 15, 1911-1920.
    • (1997) Oncogene , vol.15 , pp. 1911-1920
    • Tahara, H.1    Tokutake, Y.2    Maeda, S.3    Kataoka, H.4    Watanabe, T.5    Satoh, M.6    Matsumoto, T.7    Sugawara, M.8    Ide, T.9    Goto, M.10
  • 31
    • 0026702210 scopus 로고
    • Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines
    • Poot, M., Hoehn, H., Runger, T.M. and Martin, G.M. (1992) Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines. Exp. Cell. Res., 202, 267-273.
    • (1992) Exp. Cell. Res , vol.202 , pp. 267-273
    • Poot, M.1    Hoehn, H.2    Runger, T.M.3    Martin, G.M.4
  • 33
    • 0033010781 scopus 로고    scopus 로고
    • Werner syndrome lymphoblastoid cells are sensitive to camptothecin-induced apoptosis in S-phase
    • Poot, M., Gollahon, K.A. and Rabinovitch, P.S. (1999) Werner syndrome lymphoblastoid cells are sensitive to camptothecin-induced apoptosis in S-phase. Hum. Genet., 104, 10-14.
    • (1999) Hum. Genet , vol.104 , pp. 10-14
    • Poot, M.1    Gollahon, K.A.2    Rabinovitch, P.S.3
  • 34
    • 0034689364 scopus 로고    scopus 로고
    • Werner's syndrome lymphoblastoid cells are hypersensitive to topoisomerase II inhibitors in the G2 phase of the cell cycle
    • Pichierri, P., Franchitto, A., Mosesso, P., Proietti de Santis, L., Balajee, A.S. and Palitti, F. (2000) Werner's syndrome lymphoblastoid cells are hypersensitive to topoisomerase II inhibitors in the G2 phase of the cell cycle. Mutat. Res., 459, 123-133.
    • (2000) Mutat. Res , vol.459 , pp. 123-133
    • Pichierri, P.1    Franchitto, A.2    Mosesso, P.3    Proietti de Santis, L.4    Balajee, A.S.5    Palitti, F.6
  • 36
    • 0034231844 scopus 로고    scopus 로고
    • Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest
    • Constantinou, A., Tarsounas, M., Karow, J.K., Brosh, R.M., Bohr, V.A., Hickson, I.D. and West, S.C. (2000) Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest. EMBO Rep., 1, 80-84.
    • (2000) EMBO Rep , vol.1 , pp. 80-84
    • Constantinou, A.1    Tarsounas, M.2    Karow, J.K.3    Brosh, R.M.4    Bohr, V.A.5    Hickson, I.D.6    West, S.C.7
  • 37
    • 0034712726 scopus 로고    scopus 로고
    • Functional interaction between the Werner syndrome protein and DNA polymerase δ
    • Kamath-Loeb, A.S., Johansson, E., Burgers, P.M. and Loeb, L.A. (2000) Functional interaction between the Werner syndrome protein and DNA polymerase δ. Proc. Natl Acad. Sci. USA, 97, 4603-4608.
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 4603-4608
    • Kamath-Loeb, A.S.1    Johansson, E.2    Burgers, P.M.3    Loeb, L.A.4
  • 38
    • 0033621354 scopus 로고    scopus 로고
    • The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I
    • Lebel, M., Spillare, E.A., Harris, C.C. and Leder, P. (1999) The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I. J. Biol. Chem., 274, 37795-37799.
    • (1999) J. Biol. Chem , vol.274 , pp. 37795-37799
    • Lebel, M.1    Spillare, E.A.2    Harris, C.C.3    Leder, P.4
  • 39
    • 0026732784 scopus 로고
    • Elevated sister chromatid exchange phenotype of Bloom syndrome cells is complemented by human chromosome 15
    • McDaniel, L.D. and Schultz, R.A. (1992) Elevated sister chromatid exchange phenotype of Bloom syndrome cells is complemented by human chromosome 15. Proc. Natl Acad. Sci. USA, 89, 7968-7972.
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 7968-7972
    • McDaniel, L.D.1    Schultz, R.A.2
  • 40
    • 0025302748 scopus 로고
    • An abnormal profile of DNA replication intermediates in Bloom's syndrome
    • Lonn, U., Lonn, S., Nylen, U., Winblad, G. and German, J. (1990) An abnormal profile of DNA replication intermediates in Bloom's syndrome. Cancer Res., 50, 3141-3145.
    • (1990) Cancer Res , vol.50 , pp. 3141-3145
    • Lonn, U.1    Lonn, S.2    Nylen, U.3    Winblad, G.4    German, J.5
  • 41
    • 0034655991 scopus 로고    scopus 로고
    • BASC, a super complex of BRCA 1-associated proteins involved in the recognition and repair of aberrant DNA structures
    • Wang, Y, Cortez, D., Yazdi, P, Neff, N., Elledge, S.J. and Qin, J. (2000) BASC, a super complex of BRCA 1-associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev., 14, 927-939.
    • (2000) Genes Dev , vol.14 , pp. 927-939
    • Wang, Y.1    Cortez, D.2    Yazdi, P.3    Neff, N.4    Elledge, S.J.5    Qin, J.6
  • 45
  • 48
    • 0343985351 scopus 로고    scopus 로고
    • Cloning the gene for Werner syndrome: A disease with many symptoms of premature aging
    • Lombard, D.B. and Guarente, L. (1996) Cloning the gene for Werner syndrome: a disease with many symptoms of premature aging. Trends Genet., 12, 283-286.
    • (1996) Trends Genet , vol.12 , pp. 283-286
    • Lombard, D.B.1    Guarente, L.2
  • 50
    • 0030686496 scopus 로고    scopus 로고
    • The Bloom's syndrome gene product is a 3′-5′ DNA helicase
    • Karow, J.K., Chakraverty, R.K. and Hickson, I.D. (1997) The Bloom's syndrome gene product is a 3′-5′ DNA helicase. J. Biol. Chem., 272, 30611-30614.
    • (1997) J. Biol. Chem , vol.272 , pp. 30611-30614
    • Karow, J.K.1    Chakraverty, R.K.2    Hickson, I.D.3
  • 51
    • 0033573075 scopus 로고    scopus 로고
    • The three-dimensional structure of the HRDC domain and implications for the Werner and Bloom syndrome proteins
    • Liu, Z., Macias, M.J., Bottomley, M.J., Stier, G., Linge, J.P., Nilges, M., Bork, P. and Sattler, M. (1999) The three-dimensional structure of the HRDC domain and implications for the Werner and Bloom syndrome proteins. Structure Fold Des., 7, 1557-1566.
    • (1999) Structure Fold Des , vol.7 , pp. 1557-1566
    • Liu, Z.1    Macias, M.J.2    Bottomley, M.J.3    Stier, G.4    Linge, J.P.5    Nilges, M.6    Bork, P.7    Sattler, M.8
  • 52
    • 0032545515 scopus 로고    scopus 로고
    • Werner syndrome protein. I. DNA helicase and DNA exonuclease reside on the same polypeptide
    • Shen, J.C., Gray, M.D., Oshima, J., Kamath-Loeb, A.S., Fry, M. and Loeb, L.A. (1998) Werner syndrome protein. I. DNA helicase and DNA exonuclease reside on the same polypeptide. J. Biol. Chem., 273, 34139-34144.
    • (1998) J. Biol. Chem , vol.273 , pp. 34139-34144
    • Shen, J.C.1    Gray, M.D.2    Oshima, J.3    Kamath-Loeb, A.S.4    Fry, M.5    Loeb, L.A.6
  • 53
    • 0032545423 scopus 로고    scopus 로고
    • Werner syndrome protein. II. Characterization of the integral 3′→5′ DNA exonuclease
    • Kamath-Loeb, A.S., Shen, J.C., Loeb, L.A. and Fry, M. (1998) Werner syndrome protein. II. Characterization of the integral 3′→5′ DNA exonuclease. J. Biol. Chem., 273, 34145-34150.
    • (1998) J. Biol. Chem , vol.273 , pp. 34145-34150
    • Kamath-Loeb, A.S.1    Shen, J.C.2    Loeb, L.A.3    Fry, M.4
  • 54
    • 0031686571 scopus 로고    scopus 로고
    • The premature ageing syndrome protein, WRN, is a 3′→5′ exonuclease
    • Huang, S., Li, B., Gray, M.D., Oshima, J., Mian, I.S. and Campisi, J. (1998) The premature ageing syndrome protein, WRN, is a 3′→5′ exonuclease. Nat. Genet., 20, 114-116.
    • (1998) Nat. Genet , vol.20 , pp. 114-116
    • Huang, S.1    Li, B.2    Gray, M.D.3    Oshima, J.4    Mian, I.S.5    Campisi, J.6
  • 55
    • 0035393720 scopus 로고    scopus 로고
    • The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases
    • Mohaghegh, P, Karow, J.K., Brosh, R.M., Jr, Bohr, V.A. and Hickson, I.D. (2001) The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases. Nucleic Acids Res., 29, 2843-2849.
    • (2001) Nucleic Acids Res , vol.29 , pp. 2843-2849
    • Mohaghegh, P.1    Karow, J.K.2    Brosh R.M., Jr.3    Bohr, V.A.4    Hickson, I.D.5
  • 58
    • 0033617316 scopus 로고    scopus 로고
    • Human werner syndrome DNA helicase unwinds tetrahelical structures of the fragile X syndrome repeat sequence d(CGG)n
    • Fry, M. and Loeb, L.A. (1999) Human werner syndrome DNA helicase unwinds tetrahelical structures of the fragile X syndrome repeat sequence d(CGG)n. J. Biol. Chem., 274, 12797-12802.
    • (1999) J. Biol. Chem , vol.274 , pp. 12797-12802
    • Fry, M.1    Loeb, L.A.2
  • 59
    • 0035844242 scopus 로고    scopus 로고
    • Interactions between the Werner syndrome helicase and DNA polymerase δ specifically facilitate copying of tetraplex and hairpin structures of the d(CGG)n trinucleotide repeat sequence
    • Kamath-Loeb, A.S., Loeb, L.A., Johansson, E., Burgers, P.M. and Fry, M. (2001) Interactions between the Werner syndrome helicase and DNA polymerase δ specifically facilitate copying of tetraplex and hairpin structures of the d(CGG)n trinucleotide repeat sequence. J. Biol. Chem., 276, 16439-16446.
    • (2001) J. Biol. Chem , vol.276 , pp. 16439-16446
    • Kamath-Loeb, A.S.1    Loeb, L.A.2    Johansson, E.3    Burgers, P.M.4    Fry, M.5
  • 60
    • 0035902573 scopus 로고    scopus 로고
    • Formation of Holliday junctions by regression of nascent DNA in intermediates containing stalled replication forks: RecG stimulates regression even when the DNA is negatively supercoiled
    • McGlynn, R, Lloyd, R.G. and Marians, K.J. (2001) Formation of Holliday junctions by regression of nascent DNA in intermediates containing stalled replication forks: RecG stimulates regression even when the DNA is negatively supercoiled. Proc. Natl Acad. Sci. USA, 98, 8235-8240.
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 8235-8240
    • McGlynn, R.1    Lloyd, R.G.2    Marians, K.J.3
  • 61
    • 0032526583 scopus 로고    scopus 로고
    • Characterization of Werner syndrome protein DNA helicase activity: Directionality, substrate dependence and stimulation by replication protein A
    • Shen, J.C., Gray, M.D., Oshima, J. and Loeb, L.A. (1998) Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein A, Nucleic Acids Res., 26, 2879-2885.
    • (1998) Nucleic Acids Res , vol.26 , pp. 2879-2885
    • Shen, J.C.1    Gray, M.D.2    Oshima, J.3    Loeb, L.A.4
  • 62
    • 0034283889 scopus 로고    scopus 로고
    • Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA
    • Shen, J.C. and Loeb, L.A. (2000) Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA. Nucleic Acids Res., 28, 3260-3268.
    • (2000) Nucleic Acids Res , vol.28 , pp. 3260-3268
    • Shen, J.C.1    Loeb, L.A.2
  • 63
    • 0032538453 scopus 로고    scopus 로고
    • The Bloom's syndrome helicase unwinds G4 DNA
    • Sun, H., Karow, J.K., Hickson, I.D. and Maizels, N. (1998) The Bloom's syndrome helicase unwinds G4 DNA. J. Biol. Chem., 273, 27587-27592.
    • (1998) J. Biol. Chem , vol.273 , pp. 27587-27592
    • Sun, H.1    Karow, J.K.2    Hickson, I.D.3    Maizels, N.4
  • 65
    • 0032567041 scopus 로고    scopus 로고
    • The many interfaces of Mre1 1
    • Haber, J.E. (1998) The many interfaces of Mre1 1. Cell, 95, 583-586.
    • (1998) Cell , vol.95 , pp. 583-586
    • Haber, J.E.1
  • 66
    • 0029742576 scopus 로고    scopus 로고
    • Human Rad50 is physically associated with human Mre11: Identification of a conserved multiprotein complex implicated in recombinational DNA repair
    • Dolganov, G.M., Maser, R.S., Novikov, A., Tosto, L., Chong, S., Bressan, D.A. and Petrini, J.H. (1996) Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair. Mol. Cell Biol., 16, 4832-4841.
    • (1996) Mol. Cell Biol , vol.16 , pp. 4832-4841
    • Dolganov, G.M.1    Maser, R.S.2    Novikov, A.3    Tosto, L.4    Chong, S.5    Bressan, D.A.6    Petrini, J.H.7
  • 67
    • 0033773501 scopus 로고    scopus 로고
    • Closing the gaps among a web of DNA repair disorders
    • Michelson, R.J. and Weinert, T. (2000) Closing the gaps among a web of DNA repair disorders. Bioessays, 22, 966-969.
    • (2000) Bioessays , vol.22 , pp. 966-969
    • Michelson, R.J.1    Weinert, T.2
  • 69
    • 0033358610 scopus 로고    scopus 로고
    • The mammalian Mre11-Rad50-nbs1 protein complex: Integration of functions in the cellular DNA-damage response
    • Petrini, J.H. (1999) The mammalian Mre11-Rad50-nbs1 protein complex: integration of functions in the cellular DNA-damage response. Am. J. Hum. Genet., 64, 1264-1269.
    • (1999) Am. J. Hum. Genet , vol.64 , pp. 1264-1269
    • Petrini, J.H.1
  • 70
    • 0032076248 scopus 로고    scopus 로고
    • The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: Linkage of double-strand break repair to the cellular DNA damage response
    • Carney J.P., Maser, R.S., Olivares, H., Davis, E.M., Le Beau, M., Yates, JR., 3rd, Hays, L., Morgan, W.F. and Petrini, J.H. (1998) The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response. Cell, 93, 477-486.
    • (1998) Cell , vol.93 , pp. 477-486
    • Carney, J.P.1    Maser, R.S.2    Olivares, H.3    Davis, E.M.4    Le Beau, M.5    Yates J.R. III6    Hays, L.7    Morgan, W.F.8    Petrini, J.H.9
  • 72
    • 0034020464 scopus 로고    scopus 로고
    • The Mre11 complex and ATM: Collaborating to navigate S phase
    • Petrini, J.H. (2000) The Mre11 complex and ATM: collaborating to navigate S phase. Curr. Opin. Cell Biol., 12, 293-296.
    • (2000) Curr. Opin. Cell Biol , vol.12 , pp. 293-296
    • Petrini, J.H.1
  • 75
    • 0033594904 scopus 로고    scopus 로고
    • Disruption of mRad50 causes embryonic stem cell lethality; abnormal embryonic development, and sensitivity to ionizing radiation
    • Luo, G., Yao, M.S., Bender, C.F., Mills, M., Bladl, A.R., Bradley, A. and Petrini, J.H. (1999) Disruption of mRad50 causes embryonic stem cell lethality; abnormal embryonic development, and sensitivity to ionizing radiation. Proc. Natl Acad. Sci. USA, 96, 7376-7381.
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 7376-7381
    • Luo, G.1    Yao, M.S.2    Bender, C.F.3    Mills, M.4    Bladl, A.R.5    Bradley, A.6    Petrini, J.H.7
  • 77
    • 0037086702 scopus 로고    scopus 로고
    • Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair
    • Kang, J., Bronson, R.T. and Xu, Y. (2002) Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair. EMBO J, 21, 1447-1455.
    • (2002) EMBO J , vol.21 , pp. 1447-1455
    • Kang, J.1    Bronson, R.T.2    Xu, Y.3
  • 78
    • 0035869155 scopus 로고    scopus 로고
    • DNA-binding and strand-annealing activities of human Mre11: Implications for its roles in DNA double-strand break repair pathways
    • de Jager, M., Dronkert, M.L., Modesti, M., Beerens, C.E., Kanaar, R. and van Gent, D.C. (2001) DNA-binding and strand-annealing activities of human Mre11: implications for its roles in DNA double-strand break repair pathways. Nucleic Acids Res., 29, 1317-1325.
    • (2001) Nucleic Acids Res , vol.29 , pp. 1317-1325
    • de Jager, M.1    Dronkert, M.L.2    Modesti, M.3    Beerens, C.E.4    Kanaar, R.5    van Gent, D.C.6
  • 79
    • 0033563229 scopus 로고    scopus 로고
    • Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex
    • Paull, T.T. and Gellert, M. (1999) Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex. Genes Dev, 13, 1276-1288.
    • (1999) Genes Dev , vol.13 , pp. 1276-1288
    • Paull, T.T.1    Gellert, M.2
  • 80
    • 0032555480 scopus 로고    scopus 로고
    • Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95
    • Trujillo, K.M., Yuan, S.S., Lee, E.Y. and Sung, P. (1998) Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95. J. Biol. Chem., 273, 21447-21450.
    • (1998) J. Biol. Chem , vol.273 , pp. 21447-21450
    • Trujillo, K.M.1    Yuan, S.S.2    Lee, E.Y.3    Sung, P.4
  • 81
    • 0035929667 scopus 로고    scopus 로고
    • DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50*Mre11 complex
    • Trujillo, K.M. and Sung, P. (2001) DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50*Mre11 complex. J. Biol. Chem., 276, 35458-35464.
    • (2001) J. Biol. Chem , vol.276 , pp. 35458-35464
    • Trujillo, K.M.1    Sung, P.2
  • 82
    • 0033167929 scopus 로고    scopus 로고
    • Structural maintenance of chromosomes (SMC) proteins: Conserved molecular properties for multiple biological functions
    • Strunnikov, A.V. and Jessberger, R. (1999) Structural maintenance of chromosomes (SMC) proteins: conserved molecular properties for multiple biological functions. Eur. J. Biochem., 263, 6-13.
    • (1999) Eur. J. Biochem , vol.263 , pp. 6-13
    • Strunnikov, A.V.1    Jessberger, R.2
  • 86
    • 0033954246 scopus 로고    scopus 로고
    • Replication fork pausing and recombination or 'gimme a break'
    • Rothstein, R., Michel, B. and Gangloff, S. (2000) Replication fork pausing and recombination or 'gimme a break'. Genes Dev., 14, 1-10.
    • (2000) Genes Dev , vol.14 , pp. 1-10
    • Rothstein, R.1    Michel, B.2    Gangloff, S.3
  • 87
    • 0034001767 scopus 로고    scopus 로고
    • RecQ family helicases: Roles in cancer and aging
    • Karow, J.K., Wu, L. and Hickson, I.D. (2000) RecQ family helicases: roles in cancer and aging. Curr. Opin. Genet. Dev., 10, 32-38.
    • (2000) Curr. Opin. Genet. Dev , vol.10 , pp. 32-38
    • Karow, J.K.1    Wu, L.2    Hickson, I.D.3
  • 88
    • 0036544565 scopus 로고    scopus 로고
    • Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest
    • Franchitto, A. and Pichierri, P. (2002) Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest. J. Cell Biol., 157, 19-30.
    • (2002) J. Cell Biol , vol.157 , pp. 19-30
    • Franchitto, A.1    Pichierri, P.2
  • 89
    • 0035169035 scopus 로고    scopus 로고
    • Werner's syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of cell cycle
    • Pichierri, P, Franchitto, A., Mosesso, P. and Palitti, F. (2001) Werner's syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of cell cycle. Mol. Biol. Cell, 12, 2412-2421.
    • (2001) Mol. Biol. Cell , vol.12 , pp. 2412-2421
    • Pichierri, P.1    Franchitto, A.2    Mosesso, P.3    Palitti, F.4
  • 90
    • 0030994386 scopus 로고    scopus 로고
    • rqh1+, a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest
    • Stewart, E., Chapman, C.R., Al-Khodairy, F., Carr, A.M. and Enoch, T. (1997) rqh1+, a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest. EMBO J., 16, 2682-2692.
    • (1997) EMBO J , vol.16 , pp. 2682-2692
    • Stewart, E.1    Chapman, C.R.2    Al-Khodairy, F.3    Carr, A.M.4    Enoch, T.5
  • 91
    • 0033957793 scopus 로고    scopus 로고
    • The yeast Sgs1p helicase acts upstream of Rad53p in the DNA replication checkpoint and colocalizes with Rad53p in S-phase-specific foci
    • Frei, C. and Gasser, S.M. (2000) The yeast Sgs1p helicase acts upstream of Rad53p in the DNA replication checkpoint and colocalizes with Rad53p in S-phase-specific foci. Genes Dev., 14, 81-96.
    • (2000) Genes Dev , vol.14 , pp. 81-96
    • Frei, C.1    Gasser, S.M.2
  • 93
    • 0034608750 scopus 로고    scopus 로고
    • Polymerase η deficiency in the xeroderma pigmentosum yariant uncovers an overlap between the S phase checkpoint and double-strand break repair
    • Limoli, C.L., Giedzinski, E., Morgan, W.F. and Cleaver, J.E. (2000) Polymerase η deficiency in the xeroderma pigmentosum yariant uncovers an overlap between the S phase checkpoint and double-strand break repair. Proc. Natl Acad. Sci. USA, 97, 7939-7946.
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 7939-7946
    • Limoli, C.L.1    Giedzinski, E.2    Morgan, W.F.3    Cleaver, J.E.4
  • 96
    • 0036145353 scopus 로고    scopus 로고
    • An antisense construct of full-length human RAD50 cDNA confers sensitivity to ionizing radiation and alkylating agents on human cell lines
    • Kim, Y.C., Koh, J.T., Shin, B.A., Ahn, K.Y., Choi, B.K., Kim, C.G. and Kim, K.K. (2002) An antisense construct of full-length human RAD50 cDNA confers sensitivity to ionizing radiation and alkylating agents on human cell lines. Radiat. Res., 157, 19-25.
    • (2002) Radiat. Res , vol.157 , pp. 19-25
    • Kim, Y.C.1    Koh, J.T.2    Shin, B.A.3    Ahn, K.Y.4    Choi, B.K.5    Kim, C.G.6    Kim, K.K.7
  • 97
    • 0037150227 scopus 로고    scopus 로고
    • Bloom's syndrome protein response to ultraviolet-C radiation and hydroxyurea-mediated DNA synthesis inhibition
    • Ababou, M., Dumaire, V., Lecluse, Y. and Amor-Gueret, M. (2002) Bloom's syndrome protein response to ultraviolet-C radiation and hydroxyurea-mediated DNA synthesis inhibition. Oncogene, 21, 2079-2088.
    • (2002) Oncogene , vol.21 , pp. 2079-2088
    • Ababou, M.1    Dumaire, V.2    Lecluse, Y.3    Amor-Gueret, M.4
  • 98
    • 0028857690 scopus 로고
    • Structural and functional similarities between the SbcCD proteins of Escherichia coli and the RAD50 and MRE11 (RAD32) recombination and repair proteins of yeast
    • Sharples, G.J. and Leach, D.R. (1995) Structural and functional similarities between the SbcCD proteins of Escherichia coli and the RAD50 and MRE11 (RAD32) recombination and repair proteins of yeast. Mol. Microbiol., 17, 1215-1217.
    • (1995) Mol. Microbiol , vol.17 , pp. 1215-1217
    • Sharples, G.J.1    Leach, D.R.2
  • 99
    • 0037169325 scopus 로고    scopus 로고
    • The Mre11 complex is required for repair of hairpin-capped double-strand breaks and prevention of chromosome rearrangements
    • Lobachev, K.S., Gordenin, D.A. and Resnick, M.A. (2002) The Mre11 complex is required for repair of hairpin-capped double-strand breaks and prevention of chromosome rearrangements. Cell, 108, 183-193.
    • (2002) Cell , vol.108 , pp. 183-193
    • Lobachev, K.S.1    Gordenin, D.A.2    Resnick, M.A.3
  • 100
    • 0035897415 scopus 로고    scopus 로고
    • Regulation and localization of the Bloom syndrome protein in response to DNA damage
    • Bischof, O., Kim, S.H., Irving, J., Beresten, S., Ellis, N.A. and Campisi, J. (2001) Regulation and localization of the Bloom syndrome protein in response to DNA damage. J. Cell Biol., 153, 367-380.
    • (2001) J. Cell Biol , vol.153 , pp. 367-380
    • Bischof, O.1    Kim, S.H.2    Irving, J.3    Beresten, S.4    Ellis, N.A.5    Campisi, J.6
  • 101
    • 0028223554 scopus 로고
    • Increased rate of spontaneous mitotic recombination in T lymphocytes from a Bloom's syndrome patient using a flow-cytometric assay at HLA-A locus
    • Kusunoki, Y., Hayashi, T., Hirai, Y., Kushiro, J., Tatsumi, K., Kurihara, T., Zghal, M., Kamoun, M.R., Takebe, H., Jeffreys, A. et al. (1994) Increased rate of spontaneous mitotic recombination in T lymphocytes from a Bloom's syndrome patient using a flow-cytometric assay at HLA-A locus. Jpn J. Cancer Res., 85, 610-618.
    • (1994) Jpn J. Cancer Res , vol.85 , pp. 610-618
    • Kusunoki, Y.1    Hayashi, T.2    Hirai, Y.3    Kushiro, J.4    Tatsumi, K.5    Kurihara, T.6    Zghal, M.7    Kamoun, M.R.8    Takebe, H.9    Jeffreys, A.10
  • 103
    • 0035377356 scopus 로고    scopus 로고
    • Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51
    • Wu, L., Davies, S.L., Levitt, N.C. and Hickson, I.D. (2001) Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51. J. Biol. Chem., 276, 19375-19381.
    • (2001) J. Biol. Chem , vol.276 , pp. 19375-19381
    • Wu, L.1    Davies, S.L.2    Levitt, N.C.3    Hickson, I.D.4
  • 104
    • 0032999346 scopus 로고    scopus 로고
    • Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells
    • Sonoda, E., Sasaki, M.S., Morrison, C., Yamaguchi-Iwai, Y., Takata, M. and Takeda, S. (1999) Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells. Mol. Cell Biol., 19, 5166-5169.
    • (1999) Mol. Cell Biol , vol.19 , pp. 5166-5169
    • Sonoda, E.1    Sasaki, M.S.2    Morrison, C.3    Yamaguchi-Iwai, Y.4    Takata, M.5    Takeda, S.6
  • 106
    • 85047699856 scopus 로고    scopus 로고
    • Werner and Bloom helicases are involved in DNA repair in a complementary fashion
    • Imamura, O., Fujita, K., Itoh, C., Takeda, S., Furuichi, Y. and Matsumoto, T. (2002) Werner and Bloom helicases are involved in DNA repair in a complementary fashion. Oncogene, 21, 954-963.
    • (2002) Oncogene , vol.21 , pp. 954-963
    • Imamura, O.1    Fujita, K.2    Itoh, C.3    Takeda, S.4    Furuichi, Y.5    Matsumoto, T.6
  • 107
    • 0035009356 scopus 로고    scopus 로고
    • Werner helicase relocates into nuclear foci in response to DNA damaging agents and co-localizes with RPA and Rad51
    • Sakamoto, S., Nishikawa, K., Heo, S.J., Goto, M., Furuichi, Y. and Shimamoto, A. (2001) Werner helicase relocates into nuclear foci in response to DNA damaging agents and co-localizes with RPA and Rad51. Genes Cells, 6, 421-430.
    • (2001) Genes Cells , vol.6 , pp. 421-430
    • Sakamoto, S.1    Nishikawa, K.2    Heo, S.J.3    Goto, M.4    Furuichi, Y.5    Shimamoto, A.6


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