Werner syndrome protein: Biochemical properties and functional interactions

Experimental Gerontology

Volumn 35, Issue 6-7, 2000, Pages 695-702

  Bohr, V A ^a   Cooper, M ^a   Orren, D ^a   Machwe, A ^a   Piotrowski, J ^a   Sommers, J ^a   Karmakar, P ^a   Brosh, R ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

DNA repair; Replication protein; Werner syndrome protein

Indexed keywords

4 NITROQUINOLINE 1 OXIDE; ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; CYCLINE; DNA; EXONUCLEASE; HELICASE; KU ANTIGEN; REPLICATION PROTEIN A; UNCLASSIFIED DRUG; WERNER PROTEIN;

CONFERENCE PAPER; DNA DAMAGE; DNA REPAIR; GENE MUTATION; HUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; WERNER SYNDROME;

DNA DAMAGE; DNA HELICASES; DNA REPAIR; DNA-BINDING PROTEINS; HUMAN; NUCLEAR PROTEINS; WERNER SYNDROME;

EID: 0033792458     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(00)00145-5     Document Type: Conference Paper

References (22)

1. The Werner Syndrome Protein is involved in RNA polymerase II transcription
2. Functional and physical interaction between WRN helicase and human replication protein A
3. The Werner's Syndrome Protein (WRN) translocates Holliday Junctions in vitro and co-localizes with RPA upon replication arrest
4. Ku complex interacts with and stimulates the Werner protein
5. Ku, a DNA repair protein with multiple cellular functions?
6. Mutator phenotype of Werner syndrome is characterized by extensive deletions
7. The Werner syndrome protein is a DNA helicase
8. RecQ DNA helicase is a suppressor of illegitimate recombination in Escherichia coli
9. The premature ageing syndrome protein, WRN, is a 3-5 exonuclease
10. Functional interaction between the Werner Syndrome Protein and DNA polymerase delta
11. Werner Syndrome Protein. II. Characterization of the integral 3' → 5' DNA exonuclease
12. The Werner Syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I
13. An apoptosis-inducing genotoxin differentiates heterozygotic carriers for Werner helicase mutations from wild-type and homozygous mutants
14. Enzymatic and DNA binding properties of purified WRN protein: High affinity binding to single-stranded DNA but not to DNA damage induced by 4NQO
15. Post-replicative base excision repair in replication foci
16. Impaired S-phase transit of Werner Syndrome cells expressed in lymphoblastoid cells
17. Werner Syndrome Protein. I. DNA helicase and DNA exonuclease reside on the same polypeptide
18. p53-Mediated apoptosis is attenuated in Werner Syndrome cells
19. DNA helicase activity in Werner's Syndrome gene product synthesized in a baculovirus system
20. Deletion of Ku86 causes early onset of senescence in mice
21. DNA repair fine structure in Werner's Syndrome cell lines
22. Positional cloning of the Werner's Syndrome gene