Genes potentially involved in plaque rupture

Current Opinion in Lipidology

Volumn 13, Issue 5, 2002, Pages 545-552

  Faber, Birgit C G ^a   Heeneman, Sylvia ^a   Daemen, Mat J A P ^a,b   Cleutjens, Kitty B J M ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Atherosclerosis; Gene expression profiles; Plaque rupture

Indexed keywords

COLLAGENASE 3; GELATINASE A; GELATINASE B; INTERSTITIAL COLLAGENASE; MACROPHAGE ELASTASE; MATRILYSIN; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE 14; NEUTROPHIL COLLAGENASE; PROTEIN KINASE C DELTA; PROTEIN P21; PROTEIN P53; RAS PROTEIN; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE;

ANEURYSM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ATHEROGENESIS; ATHEROSCLEROTIC PLAQUE; CONTROLLED STUDY; DIFFERENTIAL DISPLAY; DNA HYBRIDIZATION; DNA MICROARRAY; DNA SYNTHESIS; EXTRACELLULAR MATRIX; GENE EXPRESSION PROFILING; HEART MUSCLE ISCHEMIA; HUMAN; HUMAN TISSUE; INTIMA; LIPID METABOLISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; REVIEW; STROKE; TURNOVER TIME; ANIMAL; CORONARY ARTERY ATHEROSCLEROSIS; GENETIC PREDISPOSITION; GENETICS; METABOLISM; PATHOLOGY; RUPTURE;

ANIMALIA;

ANIMALS; CORONARY ARTERIOSCLEROSIS; EXTRACELLULAR MATRIX; GENE EXPRESSION PROFILING; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LIPID METABOLISM; RUPTURE, SPONTANEOUS;

EID: 0036775899     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041433-200210000-00011     Document Type: Review

References (94)

1. Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med 1999; 340:115-126.
2. Robbie L, Libby P. Inflammation and atherothrombosis. Ann N Y Acad Sci 2001; 947:167-179; discussion 179-180.
3. Virmani R, Kolodgie FD, Burke AP, et al. Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol 2000; 20:1262-1275.
4. Libby P, Geng YJ, Aikawa M, et al. Macrophages and atherosclerotic plaque stability. Curr Opin Lipidol 1996; 7:330-335.
5. Galis ZS, Khatri JJ. Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly. Circ Res 2002; 90:251-262.
6. Herman MP, Sukhova GK, Libby P, et al. Expression of neutrophil collagenase (matrix metalloproteinase-8) in human atheroma: a novel collagenolytic pathway suggested by transcriptional profiling. Circulation 2001; 104:1899-1904.
7. Faia KL, Davis WP, Marone AJ, et al. Matrix metalloproteinases and tissue inhibitors of metalloproteinases in hamster aortic atherosclerosis: correlation with in-situ zymography. Atherosclerosis 2002; 160:325-337.
8. Armstrong PJ, Johanning JM, Calton WC Jr, et al. Differential gene expression in human abdominal aorta: aneur/smal versus occlusive disease. J Vasc Surg 2002; 35:346-355.
9. Tung WS, Lee JK, Thompson RW. Simultaneous analysis of 1176 gene products in normal human aorta and abdominal aortic aneurysms using a membrane-based complementary DNA expression array. J Vasc Surg 2001; 34:143-150.
10. Faber BC, Cleutjens KB, Niessen RL, et al. Identification of genes potentially involved in rupture of human atherosclerotic plaques. Circ Res 2001; 89:547-554.
11. Peters DG, Kassam AB, Feingold E, et al. Molecular anatomy of an intracranial aneurysm: coordinated expression of genes involved in wound healing and tissue remodeling. Stroke 2001; 32:1036-1042.
12. McCaffrey TA, Fu C, Du B, et al. High-level expression of Egr-1 and Egr-1-inducible genes in mouse and human atherosclerosis. J Clin Invest 2000; 105:653-662.
13. Zohlnhofer D, Klein CA, Richter T, et al. Gene expression profiling of human stent-induced neointima by cDNA array analysis of microscopic specimens retrieved by helix cutter atherectomy: Detection of FK506-binding protein 12 upregulation. Circulation 2001; 103:1396-1402.
14. Adams LD, Geary RL, McManus B, et al. A comparison of aorta and vena cava medial message expression by cDNA array analysis identifies a set of 68 consistently differentially expressed genes, all in aortic media. Circ Res 2000; 87:623-631.
15. Tai JT, Brooks EE, Liang S, et al. Determination of temporal expression patterns for multiple genes in the rat carotid artery injury model. Arterioscler Thromb Vasc Biol 2000; 20:2184-2191.
16. Wuttge, DM, Sirsjo A, Eriksson P, et al. Gene expression in atherosclerotic lesion of ApoE deficient mice. Mol Med 2001; 7:383-392.
17. Silence J, Lupu F, Collen D, et al. Persistence of atherosclerotic plaque but reduced aneurysm formation in mice with stromelysin-1 (MMP-3) gene inactivation. Arterioscler Thromb Vasc Biol 2001; 21:1440-1445.
18. Pyo R, Lee JK, Shipley JM, et al. Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms. J Clin Invest 2000; 105:1641-1649.
19. Prescott MF, Sawyer WK, Von Linden-Reed J, et al. Effect of matrix metalloproteinase inhibition on progression of atherosclerosis and aneurysm in LDL receptor-deficient mice overexpressing MMP-3, MMP-12, and MMP-13 and on restenosis in rats after balloon injury. Ann N Y Acad Sci 1999; 878:179-190.
20. Allaire E, Forough R, Clowes M, et al. Local overexpression of TIMP-1 prevents aortic aneurysm degeneration and rupture in a rat model. J Clin Invest 1998; 102:1413-1420.
21. Curci JA, Liao S, Huffman MD, et al. Expression and localization of macrophage elastase (matrix metalloproteinase-12) in abdominal aortic aneurysms. J Clin Invest 1998; 102:1900-1910.
22. Annabi B, Shedid D, Ghosn P, et al. Differential regulation of matrix metalloproteinase activities in abdominal aortic aneurysms. J Vasc Surg 2002; 35:539-546.
23. Yamashita A, Noma T, Nakazawa A, et al. Enhanced expression of matrix metalloproteinase-9 in abdominal aortic aneurysms. World J Surg 2001; 25:259-265.
24. Zhang B, Ye S, Herrmann SM, et al. Functional polymorphism in the regulatory region of gelatinase B gene in relation to severity of coronary atherosclerosis. Circulation 1999; 99:1788-1794.
25. Carrell TW, Burnand KG, Wells GM, et al. Stromelysin-1 (matrix metalloproteinase-3) and tissue inhibitor of metalloproteinase-3 are overexpressed in the wall of abdominal aortic aneurysms. Circulation 2002; 105:477-482.
26. Lemaitre V, O'Byrne TK, Borczuk AC, et al. ApoE knockout mice expressing human matrix metalloproteinase-1 in macrophages have less advanced atherosclerosis. J Clin Invest 2001; 107:1227-1234.
27. Ye S, Watts GF, Mandalia S, et al. Preliminary report: genetic variation in the human stromelysin promoter is associated with progression of coronary atherosclerosis. Br Heart J 1995; 73:209-215.
28. Wang J, Warzecha D, Wilcken D, et al. Polymorphism in the gelatinase B gene and the severity of coronary arterial stenosis. Clin Sci (Lond) 2001; 101:87-92.
29. Silence J, Collen D, Lijnen HR. Reduced atherosclerotic plaque but enhanced aneurysm formation in mice with inactivation of the tissue inhibitor of metalloproteinase-1 (TIMP-1) gene. Circ Res 2002; 90:897-903.
30. Rouis M, Adamy C, Duverger N, et al. Adenovirus-mediated overexpression of tissue inhibitor of metalloproteinase-1 reduces atherosclerotic lesions in apolipoprotein E-deficient mice. Circulation 1999; 100:533-540.
31. Sukhova GK, Shi GP, Simon DI, et al. Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells. J Clin Invest 1998; 102:576-583.
32. Chen J, Tung CH, Mahmood U, et al. In vivo imaging of proteolytic activity in atherosclerosis. Circulation 2002; 105:2766-2771.
33. Tunon J, Ruiz-Ortega M, Egido J. Regulation of matrix proteins and impact on vascular structure. Curr Hypertens Rep 2000; 2:106-113.
34. Mason DP, Kenagy RD, Hasenstab D, et al. Matrix metalloproteinase-9 overexpression enhances vascular smooth muscle cell migration and alters remodeling in the injured rat carotid artery. Circ Res 1999; 85:1179-1185.
35. Bendeck MP, Conte M, Zhang M, et al. Doxycycline modulates smooth muscle cell growth, migration, and matrix remodeling after arterial injury. Am J Pathol 2002; 160:1089-1095.
36. George SJ, Johnson JL, Angelini GD, et al. Adenovirus-mediated gene transfer of the human TIMP-1 gene inhibits smooth muscle cell migration and neointimal formation in human saphenous vein. Hum Gene Ther 1998; 9:867-877.
37. George SJ, Baker AH, Angelini GD, et al. Gene transfer of tissue inhibitor of metalloproteinase-2 inhibits metalloproteinase activity and neointima formation in human saphenous veins. Gene Ther 1998; 5:1552-1560.
38. George SJ, Lloyd CT, Angelini GD, et al. Inhibition of late vein graft neointima formation in human and porcine models by adenovirus-mediated overexpression of tissue inhibitor of metalloproteinase-3. Circulation 2000; 101:296-304.
39. Jormsjo S, Ye S, Moritz J, et al. Allele-specific regulation of matrix metalloproteinase-12 gene activity is associated with coronary artery luminal dimensions in diabetic patients with manifest coronary artery disease. Circ Res 2000; 86:998-1003.
40. Sierevogel MJ, Velema E, de Jaegere PP, et al. Minimal duration of oral matrix metalloproteinase inhibition to prevent constrictive arterial remodeling after balloon dilation in the pig. Radiology 2002; 222:468-473.
41. Mallat Z, Gojova A, Marchiol-Fournigault C, et al. Inhibition of transforming growth factor-beta signaling accelerates atherosclerosis and induces an unstable plaque phenotype in mice. Circ Res 2001; 89:930-934.
42. Lutgens E, Gijbels M, Smook M, et al. Transforming growth factor-beta mediates balance between inflammation and fibrosis during plaque progression. Arterioscler Thromb Vasc Biol 2002; 22:975-982.
43. Guevara NV, Kim HS, Antonova El, et al. The absence of p53 accelerates atherosclerosis by increasing cell proliferation in vivo. Nat Med 1999; 5:335-339.
44. van Vlijmen BJ, Gerritsen G, Franken AL, et al. Macrophage p53 deficiency leads to enhanced atherosclerosis in APOE3*-Leiden transgenic mice. Circ Res 2001; 88:780-786.
45. von der Thusen JH, van Vlijmen BJ, Hoeben RC, et al. Induction of atherosclerotic plaque rupture in apolipoprotein E-/- mice after adenovirus-mediated transfer of p53. Circulation 2002; 105:2064-2070.
46. George SJ, Angelini GD, Capogrossi MC, et al. Wild-type p53 gene transfer inhibits neointima formation in human saphenous vein by modulation of smooth muscle cell migration and induction of apoptosis. Gene Ther 2001; 8:668-676.
47. Condorelli G, Aycock JK, Frati G, et al. Mutated p21/WAF/CIP transgene overexpression reduces smooth muscle cell proliferation, macrophage deposition, oxidation-sensitive mechanisms, and restenosis in hypercholesterolemic apolipoprotein E knockout mice. Faseb J 2001; 15:2162-2170.
48. Leitges M, Mayr M, Braun U, et al. Exacerbated vein graft arteriosclerosis in protein kinase Cdelta-null mice. J Clin Invest 2001; 108:1505-1512.
49. George J, Afek A, Keren P, et al. Functional inhibition of Ras by S-trans,transfarnesyl thiosalicylic acid attenuates atherosclerosis in apolipoprotein E knockout mice. Circulation 2002; 105:2416-2422.
50. Lutgens E, Garcia de Frutos P, Apericio C, et al. -/-/ApoE-/- Mice develop a collagen-rich, disorganized plaque phenotype, prone to intraplaque hemorrhage. Circulation 2000, 102:1138 abstract 170.
51. Auld GC, Ritchie H, Robbie LA, et al. Thrombin upregulates tissue transglutaminase in endothelial cells: a potential role for tissue transglutaminase in stability of atherosclerotic plaque. Arterioscler Thromb Vasc Biol 2001; 21:1689-1694.
52. Sumi Y, Inoue N, Azumi H, et al. Expression of tissue transglutaminase and elafin in human coronary artery: implication for plaque instability. Atherosclerosis 2002; 160:31-39.
53. Kockx MM, Herman AG. Apoptosis in atherosclerosis: beneficial or detrimental? Cardiovasc Res 2000; 45:736-746.
54. Lutgens E, de Muinck ED, Kitslaar PJ, et al. Biphasic pattern of cell turnover characterizes the progression from fatty streaks to ruptured human atherosclerotic plaques. Cardiovasc Res 1999; 41:473-479.
55. Kolodgie FD, Narula J, Burke AP, et al. Localization of apoptotic macrophages at the site of plaque rupture in sudden coronary death. Am J Pathol 2000; 157:1259-1268.
56. Mallat Z, Benamer H, Hugel B, et al. Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes. Circulation 2000; 101:841-843.
57. Bennett MR, Macdonald K, Chan SW, et al. Cooperative interactions between RB and p53 regulate cell proliferation, cell senescence, and apoptosis in human vascular smooth muscle cells from atherosclerotic plaques. Circ Res 1998; 82:704-712.
58. Huber J, Vales A, Mitulovic G, et al. Oxidized membrane vesicles and blebs from apoptotic cells contain biologically active oxidized phospholipids that induce monocyte-endothelial interactions. Arterioscler Thromb Vasc Biol 2002; 22:101-107.
59. Mallat Z and Tedgui A. Current perspective on the role of apoptosis in atherothrombotic disease. Circ Res 2001; 88:998-1003.
60. Kolodgie FD, Narula J, Haider N, et al. Apoptosis in atherosclerosis. Does it contribute to plaque instability? Cardiol Clin 2001; 19:127-139.
61. Mallat Z, Hugel B, Ohan J, et al. Shed membrane microparticles with procoagulant potential in human atherosclerotic plaques: a role for apoptosis in plaque thrombogenicity. Circulation 1999; 99:348-353.
62. Martinet W, Kockx MM. Apoptosis in atherosclerosis: focus on oxidized lipids and inflammation. Curr Opin Lipidol 2001; 12:535-541.
63. Rossig L, Dimmeler S, Zeiher AM. Apoptosis in the vascular wall and atherosclerosis. Basic Res Cardiol 2001; 96:11-22.
64. Lee T, Chau L. Fas/Fas ligand-mediated death pathway is involved in oxLDL-induced apoptosis in vascular smooth muscle cells. Am J Physiol Cell Physiol 2001; 280:C709-C718.
65. Martinet W, Knaapen MW, De Meyer GR, et al. Oxidative DNA damage and repair in experimental atherosclerosis are reversed by dietary lipid lowering. Circ Res 2001; 88:733-739.
66. Ueno H, Yamamoto H, Ito S, et al. Adenovirus-mediated transfer of a dominant-negative H-ras suppresses neointimal formation in balloon-injured arteries in vivo. Arterioscler Thromb Vasc Biol 1997; 17:898-904.
67. Sousa JE, Costa MA, Abizaid AC, et al. Sustained suppression of neointimal proliferation by sirolimus-eluting stents: one-year angiographic and intravascular ultrasound follow-up. Circulation 2001; 104:2007-2011.
68. Lee RT. Plaque stabilization: the role of lipid lowering. Int J Cardiol 2000; 74 (Suppl 1):S11-S15.
69. Rosenfeld ME, Polinsky P, Virmani R, et al. Advanced atherosclerotic lesions in the innominate artery of the ApoE knockout mouse. Arterioscler Thromb Vasc Biol 2000; 20:2587-2592.
70. Johnson JL, Jackson CL. Atherosclerotic plaque rupture in the apolipoprotein E knockout mouse. Atherosclerosis 2001; 154:399-406.
71. Williams H, Johnson JL, Carson KG, et al. Characteristics of intact and ruptured atherosclerotic plaques in brachiocephalic arteries of apolipoprotein E knockout mice. Arterioscler Thromb Vasc Biol 2002; 22:788-792.
72. de Winther MP, Hofker MH. New mouse models for lipoprotein metabolism and atherosclerosis. Curr Opin Lipidol 2002; 13:191-197.
73. Linton MF, Fazio S. Class A scavenger receptors, macrophages, and atherosclerosis. Curr Opin Lipidol 2001; 12:489-495.
74. Sakaguchi H, Takeya M, Suzuki H, et al. Role of macrophage scavenger receptors in diet-induced atherosclerosis in mice. Lab Invest 1998; 78:423-434.
75. Febbraio M, Podrez EA, Smith JD, et al. Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice. J Clin Invest 2000; 105:1049-1056.
76. de Winther MP, Gijbels MJ, van Dijk KW, et al. Scavenger receptor deficiency leads to more complex atherosclerotic lesions in APOE3Leiden transgenic mice. Atherosclerosis 1999; 144:315-321.
77. Accad M, Smith SJ, Newland DL, et al. Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1. J Clin Invest 2000; 105:711-719.
78. Yagyu H, Kitamine T, Osuga J, et al. Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemia. J Biol Chem 2000; 275:21324-21330.
79. Kusunoki J, Hansoty DK, Aragane K, et al. Acyl-CoA:cholesterol acyltransferase inhibition reduces atherosclerosis in apolipoprotein E-deficient mice. Circulation 2001; 103:2604-2609.
80. Fazio S, Major AS, Swift LL, et al. Increased atherosclerosis in LDL receptornull mice lacking ACAT1 in macrophages. J Clin Invest 2001; 107:163-171.
81. Escary JL, Choy HA, Reue K, et al. Paradoxical effect on atherosclerosis of hormone-sensitive lipase overexpression in macrophages. J Lipid Res 1999; 40:397-404.
82. Gao J, Serrero G. Adipose differentiation related protein (ADRP) expressed in transfected COS-7 cells selectively stimulates long chain fatty acid uptake. J Biol Chem 1999; 274:16825-16830.
83. Wang X, Reape TJ, Li X, et al. Induced expression of adipophilin mRNA in human macrophages stimulated with oxidized low-density lipoprotein and in atherosclerotic lesions. FEBS Lett 1999; 462:145-150.
84. Souza SC, Muliro KV, Liscum L, et al. Modulation of hormone-sensitive lipase and protein kinase A-mediated lipolysis by perilipin A in an adenoviral reconstituted system. J Biol Chem 2002; 277:8267-8272.
85. Contreras JA. Hormone-sensitive lipase is not required for cholesteryl ester hydrolysis in macrophages. Biochem Biophys Res Commun 2002; 292:900-903.
86. Faber B, Cleutjens K, Boon W, et al. Ruptured plaque specific gene expression: a role for Perilipin ADRP and HSL mediated lipolysis? Circulation; 2001; 104:1110 abstract 42.
87. Rust S, Rosier M, Funke H, et al. Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1. Nat Genet 1999; 22:352-355.
88. Chinetti G, Lestavel S, Bocher V, et al. PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway. Nat Med 2001; 7:53-58.
89. von Eckardstein A, Nofer JR, Assmann G. High density lipoproteins and arteriosclerosis. Role of cholesterol efflux and reverse cholesterol transport. Arterioscler Thromb Vasc Biol 2001; 21:13-27.
90. Ishiguro H, Yoshida H, Major AS, et al. Retrovirus-mediated expression of apolipoprotein A-I in the macrophage protects against atherosclerosis in vivo. J Biol Chem 2001; 276:36742-36748.
91. Major AS, Dove DE, Ishiguro H, et al. Increased cholesterol efflux in apolipoprotein AI (ApoAI)-producing macrophages as a mechanism for reduced atherosclerosis in ApoAI((-/-)) mice. Arterioscler Thromb Vasc Biol 2001; 21:1790-1795.
92. Shah PK, Yano J, Reyes O, et al. High-dose recombinant apolipoprotein AI(milano) mobilizes tissue cholesterol and rapidly reduces plaque lipid and macrophage content in apolipoprotein e-deficient mice. Potential implications for acute plaque stabilization. Circulation 2001; 103:3047-3050.
93. Braun A, Trigatti BL, Post MJ, et al. Loss of SR-BI expression leads to the early onset of occlusive atherosclerotic coronary artery disease, spontaneous myocardial infarctions, severe cardiac dysfunction, and premature death in apolipoprotein E-deficient mice. Circ Res 2002; 90:270-276.
94. Takemoto M, Liao JK. Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors. Arterioscler Thromb Vasc Biol 2001; 21:1712-1719.