ApoE knockout mice expressing human matrix metalloproteinase-1 in macrophages have less advanced atherosclerosis

Journal of Clinical Investigation

Volumn 107, Issue 10, 2001, Pages 1227-1234

  Lemaître, Vincent ^a   O'Byrne, Timothy K ^a   Borczuk, Alain C ^a   Okada, Yasunori ^b   Tall, Alan R ^a   D'Armiento, Jeanine ^a  

^a The New York Presbyterian Hospital   (United States)

^b KEIO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; INTERSTITIAL COLLAGENASE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; INTIMA; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0035019911     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI9626     Document Type: Article

References (50)

1. Atherosclerosis: An inflammatory disease
2. Pathophysiology of plaque rupture and the concept of plaque stabilization
3. Pathophysiology and inflammatory aspects of plaque rupture
4. Molecular bases of the acute coronary syndromes
5. Matrix metalloproteinases: Structures, evolution, and diversification
6. Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques
7. Interstitial collagenase (MMP-1) expression in human carotid atherosclerosis
8. Increased expression of 72-kd type IV collagenase (MMP-2) in human aortic atherosclerotic lesions
9. Identification of 92-kd gelatinase in human coronary atherosclerotic lesions. Association of active enzyme synthesis with unstable angina
10. In situ localization and quantification of mRNA for 92-kd type IV collagenase and its inhibitor in aneurysmal, occlusive, and normal aorta
11. Localization of stromelysin gene expression in atherosclerotic plaques by in situ hybridization
12. Matrilysin is expressed by lipid-laden macrophages at sites of potential rupture in atherosclerotic lesions and localizes to areas of versican deposition, a proteoglycan substrate for the enzyme
13. Evidence for increased collagenolysis by interstitial collagenases- 1 and -3 in vulnerable human atheromatous plaques
14. Membrane type 1 matrix metalloproteinase expression in human atherosclerotic plaques. Evidence for activation by proinflammatory mediators
15. Macrophage foam cells from experimental atheroma constitutively produce matrix-degrading proteinases
16. Interstitial collagenases
17. Collagens in human atherosclerosis. Immunohistochemical analysis using collagen type-specific antibodies
18. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
19. Spontaneous hypercholesterolemia and arteria lesions in mice lacking apolipoprotein E
20. Diet-induced atherosclerosis in mice heterozygous and homozygous for apolipoprotein E gene disruption
21. ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree
22. Mouse models of atherosclerosis
23. Cloning of the gene for interstitial collagenase-3 (matrix metalloproteinase-13) from rabbit synovial fibroblasts: Differential expression with collagenase-1 (matrix metalloproteinase-1)
24. Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation
25. Enhanced expression of matrix metalloproteinase-3, -12, and -13 mRNAs in the aortas of apolipoprotein E-deficient mice with advanced atherosclerosis
26. Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation
27. Macrophage-specific expression of human collagenase (MMP-1) in transgenic mice
28. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
29. Collagenase expression in the lungs of transgenic mice causes pulmonary emphysema
30. 14C]acetylated collagen
31. Detection of collagenase-induced damage of collagen by 9A4, a monoclonal C-terminal neoepitope antibody
32. IFN-gamma potentiates atherosclerosis in apoE knock-out mice
33. Scavenger receptor A gene regulatory elements target gene expression to macrophages and foam cells of atherosclerotic lesions
34. Metalloelastase is required for macrophage-mediated proteolysis and matrix invasion in mice
35. The response-to-retention hypothesis of early atherogenesis
36. Characterization of matrix metalloproteinases produced by rat alveolar macrophages
37. Human monocyte-derived macrophages induce collagen breakdown in fibrous caps of atherosclerotic plaques. Potential role of matrix-degrading metalloproteinases and implications for plaque rupture
38. Role of matrix metalloproteinases in models of macrophage-dependent acute lung injury. Evidence for alveolar macrophage as source of proteinases
39. Extracellular matrix modulates macrophage functions characteristic to atheroma: Collagen type I enhances acquisition of resident macrophage traits by human peripheral blood monocytes in vitro
40. Smooth muscle migration in atherosclerosis and restenosis
41. Evidence for a role of collagen synthesis in arterial smooth muscle cell migration
42. Interaction of native and cell-modified low density lipoprotein with collagen gel
43. Low density lipoproteins bind more to type I and III collagens by negative charge-dependent mechanisms than to type IV and V collagens
44. Progression of coronary atherosclerosis is associated with a common genetic variant of the human stromelysin-1 promoter which results in reduced gene expression
45. Expression of the elastolytic cashepsins S and K in human atheroma and regulation of their production in smooth muscle cells
46. Cystatin C deficiency in human atherosclerosis and aortic aneurysms
47. Pericellular mobilization of the tissue-destructive cysteine proteinases, cathepsins B, L, and S, by human monocyte-derived macrophages
48. Why do plaques rupture?