High-dose recombinant apolipoprotein A-IMilano mobilizes tissue cholesterol and rapidly reduces plaque lipid and macrophage content in apolipoprotein E-deficient mice: Potential implications for acute plaque stabilization

Circulation

Volumn 103, Issue 25, 2001, Pages 3047-3050

  Shah, Prediman K ^a,c   Yano, Juliana ^a   Reyes, Odette ^a   Chyu, Kuang Yuh ^a   Kaul, Sanjay ^a   Bisgaier, Charles L ^b   Drake, Sandra ^b   Cercek, Bojan ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Esperion Therapeutics Inc   (United States)

^c CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

Apolipoproteins; Atherosclerosis; Cholesterol

Indexed keywords

APOLIPOPROTEIN A1; CHOLESTEROL; DIPALMITOYLPHOSPHATIDYLCHOLINE; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; AORTA ROOT; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BLOOD SAMPLING; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; HYPERLIPOPROTEINEMIA TYPE 3; IMMUNOHISTOCHEMISTRY; LIPID COMPOSITION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RABBIT;

EID: 0035954267     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/hc2501.092494     Document Type: Article

References (15)

1. A-I Milano apoprotein: Decreased high density lipoprotein cholesterol levels with significant lipoprotein modifications and without clinical atherosclerosis in an Italian family
2. Recombinant apolipoprotein A-I Milano reduces intimal thickening after balloon injury in hypercholesterolemic rabbits
3. Effects of recombinant apolipoprotein A-I(Milano) on aortic atherosclerosis in apolipoprotein E-deficient mice
4. Recombinant apolipoprotein A-I Milano dimer inhibits carotid intimal thickening induced by perivascular manipulation in rabbits
5. A cell culture system for screening human serum for ability to promote cellular cholesterol efflux: Relations between serum components and efflux, esterification, and transfer
6. Pathology of atheromatous lesions in inbred and genetically engineered mice
7. Reverse cholesterol transport: Physiology and pharmacology
8. Rempdelling and shuttling: Mechanisms for the synergistic effects between different acceptor particles in the mobilization of cellular cholesterol
9. Effects of upregulating individual steps in the reverse cholesterol transport pathway on reverse cholesterol transport in normolipidemic mice
10. The yin and yang of oxidation in the development of the fatty streak
11. Acute effects of intravenous infusion of Apo A-I/phosphatdylcholine discs on plasma lipoproteins in humans
12. Stimulation of fecal sterol excretion after infusion of recombinant proapolipoprotein A-I: Potential reverse cholesterol transport in humans
13. Cholesterol mobilization and regression of atheroma in cholesterol-fed rabbits induced by large unilamellar vesicles
14. Pravastatin treatment increases collagen content, and decreases lipid content, inflammation, metalloproteinases, and cell death in human carotid plaques: Implications for plaque stabilization
15. Statins alter smooth muscle cell accumulation and collagen content in established atheroma of Watanabe heritable hyperlipidemic rabbits