Effect of matrix metalloproteinase inhibition on progression of atherosclerosis and aneurysm in LDL receptor-deficient mice overexpressing MMP-3, MMP-12, and MMP-13 and on restenosis in rats after balloon injury

Annals of the New York Academy of Sciences

Volumn 878, Issue , 1999, Pages 179-190

  Prescott, Margaret Forney ^a   Sawyer, Wilbur K ^a   Von Linden Reed, Jean ^a   Jeune, Michael ^a   Chou, Mary ^a   Caplan, Shari L ^a   Jeng, Arco Y ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CGS 27023A; COLLAGENASE 3; ELASTIN; LOW DENSITY LIPOPROTEIN RECEPTOR; MACROPHAGE ELASTASE; MATRIX METALLOPROTEINASE; STROMELYSIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ANEURYSM; AORTA ATHEROSCLEROSIS; ARTERY INTIMA; ARTERY MEDIA; BALLOON CATHETER; CAROTID ARTERY; CELL MIGRATION; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME INHIBITION; FAT INTAKE; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; RESTENOSIS; SMOOTH MUSCLE FIBER;

ANIMALIA;

EID: 0032863595     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1999.tb07683.x     Document Type: Conference Paper

References (30)

1. 1. Pauly, R.R., A. Passanti, C. Bilato, R. Monticone & L. Cheng et al. 1994. Migration of cultured vascular smooth muscle cells through a basement membrane barrier requires type IV collagenase activity and is inhibited by cellular differentiation. Circ. Res. 75: 41-54.
2. 2. Kenagy, R.D., S. Vergel, E. Mattsson, M. Bendeck, M.A. Reidy & A.W. Clowes. 1996. The role of plasminogen, plasminogen activators, and matrix metalloproteinases in primate arterial smooth muscle cell migration. Arterioscler. Thromb. Vasc. Biol. 16: 1373-1382.
3. 3. Werb, Z., R.M. Hembry, G. Murphy & J. Aggeller. 1986. Commitment to expression of the metalloendopeptidases, collagenase and stromelysin: relationship of inducing events to changes in cytoskeletal architecture. Cell Biol. 102: 697-702.
4. 4. Newman, K.M., J. Jean-Claude, H. Li, J.V. Scholes, Y. Ogata, H. Nagase & M.D. Tilson. 1994. Cellular localization of matrix metalloproteinases in the abdominal aortic aneurysm wall. J. Vasc. Surg. 20: 814-820.
5. 5. Dollery, C.M., J.R. McEwan & A.M. Henney. 1995. Matrix metalloproteinases and cardiovascular disease. Circ. Res. 77: 863-868.
6. 6. Tamarina, N.A., W.D. McMillan, V.P. Shively & W.H. Pearch. 1997. Expression of matrix metalloproteinases and their inhibitors in aneurysms and normal aorta. Surgery 122: 264-271.
7. 7. Curci, J.A., S. Liaq, A.D. Huffman, S.D. Shapiro & R.W. Thompson. 1998. Expression and localization of macrophage elastase (matrix metalloproteinase-12) in abdominal aortic aneurysms. J. Clin. Invest. 102: 1900-1910.
8. 8. Zempo, N., R.D. Kenagy, Y.P. Au, M. Bendeck, M.M. Clowes, M.A. Reidy & A.W. Clowes. 1994. Matrix metalloproteinases of vascular wall cells are increased in balloon-injured rat carotid artery. J. Vasc. Surg. 20: 209-217.
9. 9. Webb, K.E., A.M. Henney, S. Anglin, S.E. Humphries & J.R. McEwan. 1997. Expression of matrix metalloproteinases and their inhibitor TIMP-1 in the rat carotid artery after balloon injury. Arterioscler. Thromb. Vasc. Biol. 17: 1837-1844.
10. 10. Shofuda, K., Y. Nagashima, K. Kawahara, H. Yasumitsu, K. Miki & K. Miyazaki. 1998. Elevated expression of membrane-type 1 and 3 matrix metalloproteinases in rat vascular smooth muscle cells activated by arterial injury. 78: 915-923.
11. 11. Jenkins, G.M., M.T. Crow, C. Bilato, Y. Gluzband, W.S. Ryu, Z. Li, W. Stetler-Stevenson, C. Natler, J.P. Froehlich, E.G. Lakatta & L. Cheng. 1998. Increased expression of membrane-type matrix metalloproteinase and preferential localization of matrix metalloproteinase-2 to the neointima of balloon-injured rat carotid arteries. Circulation 97: 82-90.
12. 12. MacPherson, L.J., E.K. Bayburg, M.P. Caparelli, B.J. Carroll, R. Goldstein, M.R. Justice, L. Zhu, S. Hu, R.A. Melton, L. Fryer, R.L. Goldberg, J.R. Doughty, S. Spirito, V. Blancuzzi, D. Wilson, E.M. O'Byrne, V. Ganu & D.T. Parker. 1997. Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits. J. Med. Chem. 40: 2525-2532.
13. 13. O'Byrne, E.O., V. Blancuzzi, H. Singh, L.J. MacPherson, D.T. Parker & E.D. Roberts. 1999. Chrondroprotective activity of a matrix metalloproteinase inhibitor, CGS 27023A in animal models of osteoarthritis. In Advances in Osteoarthritis. S. Tanaka & C. Hamanishi, Eds.: 63-173. Springer-Verlag. Tokyo.
14. 14. Jeng, A.Y., Chou, W.K. Sawyer, S.L. Caplan, J. von Linden-Reed, M. Jeune & M.F. Prescott. 1999. Enhanced expression of matrix metalloproteinase-3, -12, and -13 mRNAs in the aorta of apolipoprotein E-deficient mice with advanced atherosclerosis. Ann. N.Y. Acad. Sci. This volume.
15. 15. Carmeliet, P., L. Moons, R. Lijnen, M. Baes, V. Lemaitre, P. Tipping, A. Drew, Y. Eeckhout, S. Shapiro, F. Lupu & D. Collen. 1997. Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation. Nature Genet. 17: 439-444.
16. 16. Schonbeck, U., F. Mach, G.K. Sukkova, E. Atkinson, E. Levesque, M. Herman, P. Graber, P. Basset & P. Libby. 1999. Expression of stromelysin-3 in atherosclerotic lesions: regulation via CD40-CD40 ligand signaling in vitro and in vivo. J. Exp. Med. 189: 843-853.
17. 17. Sukhova, G., U. Schoenbeck, E. Rabkin, F.J. Schoen, A.R. Poole, R.C. Billinghurst & P. Libby. 1998. Colocalization of interstitial collagenses MMP-1 & MMP-13 with sites of cleaved collagen indicates their role in plaque rupture. Circulation 17: 1-48.
18. 18. Bigatel, D.A., J.R. Elmore, D.J. Carey, G. Cizmeci-Smith, D.P. Franklin & J.R. Youkey. 1999. The matrix metalloproteinase inhibitor BB-94 limits expansion of experimental abdominal aortic aneurysms. J. Vasc. Surg. 29: 130-138.
19. 19. Rao S.K., K.V. Reddy & J.R. Cohen. 1996. Role of serine proteases in aneurysm development. Ann. N.Y. Acad. Sci. 800: 131-137.
20. 20. Gacko, M. & L. Chycaewski. 1997. Activity and localization of cathepsin B, D and G in aortic aneurysm. Int. Surg. 82: 398-402.
21. 21. Gacko, M. & S. Glowinski. 1998. Cathepsin D and cathepsin L activities in aortic aneurysm wall and parietal thrombus. Clin. Chem. Lab. Med. 36: 449-452.
22. 22. Buckmaster, M.J., J.A. Curci, P.R. Murray, S. Liao, B.T. Allen, G.A. Sicard & R.W. Thompson. 1999. Source of elastin-degrading enzymes in mycotic aortic aneurysms: bacteria or host inflammatory response? Cardiovasc. Surg. 7: 16-26.
23. 23. Prescott, M.F., W.K. Sawyer & J. Von Linden-Reed. 1995. Matrix metalloproteinase inhibitor-induced reduction of smooth muscle migration does not inhibit late lesion formation following ballooning. FASEB J. 9: A855.
24. 24. Zempo, N. N. Koyama, R.D. Kenagy, H.J. Lea & W. Clowes. 1996. Regulation of vascular smooth muscle cell migration and proliferation in vitro and in injured rat arteries by a synthetic matrix metalloproteinase inhibitor. Arterioscler. Thromb. Vasc. Biol. 16: 28-32.
25. 25. Bendeck, M.P., C. Irvin & M.A. Reidy. 1996. Inhibition of matrix metalloproteinase activity inhibits smooth muscle cell migration but not neointimal thickening after arterial injury. Circ. Res. 78: 38-43.
26. 26. Clowes, A.W., M.A. Reidy & M.M. Clowes. 1983. Mechanisms of stenosis after arterial injury. Lab. Invest. 49: 208-215.
27. 27. Clowes, A.W. & S.M. Schwartz. 1985. Significance of quiescent smooth muscle migration in the injured rat carotid artery. Circ. Res. 56: 139-145.
28. 28. Tyagi, S.C., L. Meyer, R.A. Schmaltz, H.K. Reddy & D.J. Voelker. 1995. Proteinases and restenosis in the human coronary artery: extracellular matrix production exceeds the expression of proteolytic activity. Atherosclerosis 116: 43-57.
29. 29. Witte, M.B., F.J. Thornton, T. Kiyama, D.T. Efron, G.S. Schultz, L. Moldawer & A. Barbul. 1998. Metalloproteinase inhibitors and wound healing: a novel enhancer of wound strength. Surgery 124: 464-470.
30. 30. Aikawa, M., E. Rabkin, Y. Okada, S.J. Voglic, S.K. Clinton, C.E. Brinckerhoff, G.K. Sukhova & P. Libby. 1998. Lipid lowering by diet reduces metalloproteinase activity and increases collagen content of rabbit atheroma: a potential mechanism of lesion stabilization. Circulation 97: 2433-2444.