Paradoxical effect on atherosclerosis of hormone-sensitive lipase overexpression in macrophages

Journal of Lipid Research

Volumn 40, Issue 3, 1999, Pages 397-404

  Escary, Jean Louis ^a,b   Choy, Henry A ^a,b   Reue, Karen ^a,b   Wang, Xu Ping ^b   Castellani, Lawrence W ^b   Glass, Christopher K ^d   Lusis, Aldons J ^b,c   Schotz, Michael C ^a,b  

^a VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Acyl CoA:cholesterol acyltransferase; Aortic lesions; Cholesteryl ester hydrolysis; Foam cells; Transgenic mice

Indexed keywords

CHOLESTEROL ACYLTRANSFERASE; TRIACYLGLYCEROL LIPASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROGENESIS; ATHEROGENIC DIET; ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL ESTERIFICATION; CONTROLLED STUDY; DISEASE PREDISPOSITION; ENZYME ACTIVITY; ENZYME ASSAY; FEMALE; HISTOPATHOLOGY; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE SPECIFICITY; TRANSGENIC MOUSE;

ANIMALS; AORTA; ARTERIOSCLEROSIS; CELL LINE; CHOLESTEROL; CHOLESTEROL ESTERASE; CHOLESTEROL ESTERS; DIET, ATHEROGENIC; ENHANCER ELEMENTS (GENETICS); FEMALE; GENE EXPRESSION REGULATION; MACROPHAGES, PERITONEAL; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; PROMOTER REGIONS (GENETICS); RATS; RECEPTORS, IMMUNOLOGIC; RECEPTORS, LIPOPROTEIN; RECEPTORS, SCAVENGER; SCAVENGER RECEPTORS, CLASS B; TRANSFECTION;

EID: 0033008605     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Beisiegel, U., and R. W. St. Clair. 1996. An emerging understanding of the interactions of plasma lipoproteins with the arterial wall that leads to the development of atherosclerosis. Curr. Opin. Lipidol. 7: 265-268.
2. Bulkley, B. H., L. M. Buja, V. J. Ferrans, G. B. Bulkley, and W. C. Roberts. 1975. Tuberous xanthoma in homozygous type II hyperlipoproteinemia: a histologic, histochemical, and electron microscopical study. Arch. Pathol. 99: 293-300.
3. Brown, M. S., Y. K. Ho, and J. L. Goldstein. 1980. The cholesteryl ester cycle in macrophage foam cells: continual hydrolysis and reesterification of cytoplasmic cholesteryl esters. J. Biol. Chem. 255: 9344-9352.
4. Ho, Y. K., M. S. Brown, and J. L. Goldstein. 1980. Hydrolysis and excretion of cytoplasmic cholesteryl esters by macrophages: stimulation by high density lipoprotein and other agents. J. Lipid Res. 21: 391-398.
5. von Eckardstein, A. 1996. Cholesterol efflux from macrophages and other cells. Curr. Opin. Lipidol. 7: 308-319.
6. Libby, P., Y.J. Geng, M. Aikawa, U. Schoenbeck, F. Mach, S. K. Clinton, G. K. Sukhova, and R. T. Lee. 1996. Macrophages and atherosclerotic plaque stability, Curr. Opin. Lipidol. 7: 330-335.
7. Cheng, D., C. C. Y. Chang, X. M. Qu, and T. Y. Chang. 1995. Activation of acyl-coenzyme A:cholesterol acyltransferase by cholesterol or by oxysterol in a cell-free system. J. Biol. Chem. 270: 685-695.
8. Uelmen, P. J., K. Oka, M. Sullivan, C. C. Y. Chang, T. Y. Chang, and L. Chan. 1995. Tissue-specific expression and cholesterol regulation of acylcoenzyme A:cholesterol acyltransferase (ACAT) in mice. Molecular cloning of mouse ACAT cDNA, chromosomal localization, and regulation of ACAT in vivo and in vitro. J. Biol. Chem. 270: 26192-26201.
9. Kellner-Weibel, G., W. G. Jerome, D. M. Small, G. J. Warner, J. K. Stoltenborg, M. A. Kearney, M. H. Corjay, M. C. Phillips, and G. H. Rothblat. 1998. Effects of intracellular free cholesterol accumulation on macrophage viability. A model for foam cell death. Arterioscler. Thromb. Vasc. Biol. 18: 423-431.
10. Bernard, D. W., A. Rodriguez, G. H. Rothblat, and J. M. Glick. 1991. cAMP stimulates cholesteryl ester clearance to high density lipoproteins in J774 macrophages. J. Biol. Chem. 266: 710-716.
11. Khoo, J. C., E. M. Mahoney, and D. Steinberg. 1981. Neutral cholesterol esterase activity in macrophages and its enhancement by cAMP-dependent protein kinase. J. Biol. Chem. 256: 12659-12661.
12. Small, C. A., J. A. Goodacre, and S. J. Yeaman. 1989. Hormone-sensitive lipase is responsible for the neutral cholesterol ester hydrolase activity in macrophages. FEBS Lett. 247: 205-208.
13. Small, C. A., M. P. Rogers, J. A. Goodacre, and S. J. Yeaman. 1991. Phosphorylation and activation of hormone-sensitive lipase in isolated macrophages. FEBS Lett. 279: 323-326.
14. Escary, J.-L., H. A. Choy, K. Reue, and M. C. Schotz. 1998. Hormone-sensitive lipase overexpression increases cholesteryl ester hydrolysis in macrophage foam cells. Arterioscler. Thromb. Vasc. Biol. 18: 991-998.
15. Bocan, T. M., S. B. Mueller, P. D. Uhlendorf, R. S. Newton, and B. R. Krause. 1991. Comparison of CI-976, an ACAT inhibitor, and selected lipid-lowering agents for antiatherosclerotic activity in iliac-femoral and thoracic aortic lesions. A biochemical, morphological, and morphometric evaluation. Arterioscler. Thromb. 11: 1830-1843.
16. Krause, B. R., M. Anderson, C. L. Bisgaier, T. Bocan, R. Bousley, P. DeHart, A. Essenburg, K. Hamelehle, R. Human, K. Kieft, W. McNally, R. Stanfield, and R. S. Newton. 1993. In vivo evidence that the lipid-regulating activity of the ACAT inhibitor CI-976 in rats is due to inhibition of both intestinal and liver ACAT. J. Lipid Res. 34: 279-294.
17. Horvai, A., W. Palinski, H. Wu, K. S. Moulton, K. Kalla, and C. K. Glass. 1995. Scavenger receptor A gene regulatory elements target gene expression to macrophages and to foam cells of atherosclerotic lesions. Proc. Natl. Acad. Sci. USA. 92: 5391-5395.
18. Conrad, R. E. 1981. Induction and collection of peritoneal exudate macrophages. In Manual of Macrophage Methodology. H. B. Herscowitz, H. T. Holden, J. A. Bellanti, and A. Ghaffar, editors. Marcel Dekker, Inc., New York. 5-11.
19. Kraemer, F. B., S. Patel, M. S. Saedi, and C. Sztalryd. 1993. Detection of hormone-sensitive lipase in various tissues. I. Expression of an HSL/bacterial fusion protein and generation of anti-HSL antibodies. J. Lipid Res. 34: 663-671.
20. Qiao, J-H., P-Z. Xie, M. C. Fishbein, J. Kreuzer, T. A. Drake, L. L. Demer, and A. J. Lusis. 1994. Pathology of atheromatous lesions in inbred and genetically engineered mice: genetic determination of arterial calcification. Arterioscler. Thromb. 14: 1480-1497.
21. Hedrick, C. C., L. W. Castellani, C. H. Warden, D. L. Puppione, and A. J. Lusis. 1993. Influence of mouse apolipoprotein A-II on plasma lipoproteins in transgenic mice. J. Biol. Chem. 269: 20676-20682.
22. Kraal, G., M. Rep, and M. Janse. 1987. Macrophages in T and B cell compartments and other tissue macrophages recognized by monoclonal antibody MOMA-2. An immunohistochemical study. Scand. J. Immunol. 26: 653-661.
23. Khoo, J. C., K. Reue, D. Steinberg, and M. C. Schotz. 1993. Expression of hormone-sensitive lipase mRNA in macrophages. J. Lipid Res. 34: 1969-1974.
24. Holm, C., P. Belfrage, and G. Fredrikson. 1987. Immunological evidence for the presence of hormone-sensitive lipase in rat tissues other than adipose tissue. Biochem. Biophys. Res. Commun. 148: 99-105.
25. LeBoeuf, R. C., M. H. Doolittle, A. Montcalm, D. C. Martin, K. Reue, and A. J. Lusis. 1990. Phenotypic characterization of the Ath-I gene controlling high density lipoprotein levels and susceptibility to atherosclerosis. J. Lipid Res. 31: 91-101.
26. de Villiers, W. J. S., J. D. Smith, M. Miyata, H. M. Dansky, E. Darley, and S. Gordon. 1998. Macrophage phenotype in mice deficient in both macrophage-colony-stimulating factor (Op) and apolipoprotein E. Arterioscler. Thromb. Vasc. Biol. 18: 631-640.
27. Wang, H., S. J. Germain, P. P. Benfield, and P. J. Gillies. 1996. Gene expression of acyl-coenzyme-A:cholesterol-acyltransferase is upregulated in human monocytes during differentiation and foam cell formation. Arterioscler. Thromb. Vasc. Biol. 16: 809-814.