Oxidized membrane vesicles and blebs from apoptotic cells contain biologically active oxidized phospholipids that induce monocyte-endothelial interactions

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 22, Issue 1, 2002, Pages 101-107

  Huber, Joakim ^a   Vales, Anja ^a   Mitulovic, Goran ^a   Blumer, Michael ^a   Schmid, Rainer ^a   Witztum, Joseph L ^a   Binder, Bernd R ^a   Leitinger, Norbert ^a  

^a UNIVERSITY OF VIENNA   (Austria)

Author keywords

Apoptotic blebs; Atherosclerosis; Endothelial cells; Membrane vesicles; Oxidized phospholipids

Indexed keywords

2 OLEOYL 1 PALMITOYLPHOSPHATIDYLCHOLINE; APOLIPOPROTEIN E; CALCIUM IONOPHORE; PHOSPHOLIPID; TERT BUTYL HYDROPEROXIDE; THROMBOCYTE ACTIVATING FACTOR; THROMBOCYTE ACTIVATING FACTOR ANTAGONIST;

APOPTOSIS; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CELL ACTIVATION; CELL INTERACTION; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; INFLAMMATION; MEMBRANE VESICLE; MOLECULAR RECOGNITION; MONOCYTE; MOUSE; NONHUMAN; PEROXIDATION; PRIORITY JOURNAL; VASCULAR DISEASE;

APOPTOSIS; ARTERIOSCLEROSIS; CELL ADHESION; CYTOPLASMIC VESICLES; ENDOTHELIUM, VASCULAR; HUMANS; MONOCYTES; OXIDATION-REDUCTION; PHOSPHOLIPID ETHERS; PLATELET MEMBRANE GLYCOPROTEINS; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; TERT-BUTYLHYDROPEROXIDE; UMBILICAL VEINS;

EID: 0036141870     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/hq0102.101525     Document Type: Article

References (44)

1. Complement proteins C5b-9 induce vesiculation of the endothelial plasma membrane and expose catalytic surface for assembly of the prothrombinase enzyme complex
2. Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells
3. In vitro generation of endothelial microparticles and possible prothrombotic activity in patients with lupus anticoagulant
4. Novel leukocyte agonists are released by endothelial cells exposed to peroxide
5. Pathophysiologic implications of membrane phospholipid asymmetry in blood cells
6. Calpain activation in plasma membrane bleb formation during tert-butyl hydroperoxide-induced rat hepatocyte injury
7. Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I
8. Current perspective on the role of apoptosis in atherothrombotic disease
9. Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death
10. Transcellular activation of platelets and endothelial cells by bioactive lipids in platelet microparticles
11. Modulation of monocyte-endothelial cell interactions by platelet microparticles
12. Leukocyte microparticles stimulate endothelial cell cytokine release and tissue factor induction in a JNK1 signaling pathway
13. Leukocyte-leukocyte interactions mediated by platelet microparticles under flow
14. Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes
15. Platelet-derived microparticles may influence the development of atherosclerosis in diabetes mellitus
16. Cell-derived microparticles generated in patients during cardiopulmonary bypass are highly procoagulant
17. Shed membrane microparticles with procoagulant potential in human atherosclerotic plaques: A role for apoptosis in plaque thrombogenicity
18. Demonstration of platelet-derived microvesicles in blood from patients with activated coagulation and fibrinolysis using a filtration technique and Western blotting
19. Elevated levels of circulating procoagulant microparticles in patients with paroxysmal nocturnal hemoglobinuria and aplastic anemia
20. Sera from patients with heparin-induced thrombocytopenia generate platelet-derived microparticles with procoagulant activity: An explanation for the thrombotic complications of heparin-induced thrombocytopenia
21. Apoptosis in vascular disease
22. Structural identification by mass spectrometry of oxidized phospholipids in minimally oxidized low density lipoprotein that induce monocyte/endothelial interactions and evidence for their presence in vivo
23. Determination of lipid ester ozonides and core aldehydes by high-performance liquid chromatography with on-line mass spectrometry
24. Human fibroblasts downregulate plasminogen activator inhibitor type-1 in cultured human macrovascular and microvascular endothelial cells
25. Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells
26. Nuclear factor (NF)-kappaB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor alpha-induced apoptosis
27. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: Inhibition by overexpression of Bc1-2 and Ab1
28. Improved procedures for the determination of lipid phosphorus by malachite green
29. A rapid method of total lipid extraction and purification
30. Electrospray ionization mass spectroscopic analysis of human erythrocyte plasma membrane phospholipids
31. 2 in atherosclerosis, 2: Potential involvement of biologically active oxidized phospholipids
32. Alterations in individual molecular species of human platelet phospholipids during thrombin stimulation: Electrospray ionization mass spectrometry-facilitated identification of the boundary conditions for the magnitude and selectivity of thrombin-induced platelet phospholipid hydrolysis
33. Minimally modified low density lipoprotein stimulates monocyte endothelial interactions
34. Protease dependent activation of endothelial cells by peritoneal dialysis effluents
35. Peroxide-induced membrane blebbing in endothelial cells associated with glutathione oxidation but not apoptosis
36. Monocyte binding to endothelial cells induced by oxidized phospholipids present in minimally oxidized low density lipoprotein is inhibited by a platelet activating factor receptor antagonist
37. Evidence that phospholipid oxidation products and/or platelet-activating factor play an important role in early atherogenesis: In vitro and in vivo inhibition by WEB 2086
38. Structural identification of a novel pro-inflammatory epoxyisoprostane phospholipid in mildly oxidized low density lipoprotein
39. Monoclonal antibodies against oxidized low-density lipoprotein bind to apoptotic cells and inhibit their phagocytosis by elicited macrophages: Evidence that oxidation-specific epitopes mediate macrophage recognition
40. Protective effect of high density lipoprotein associated paraoxonase: Inhibition of the biological activity of minimally oxidized low density lipoprotein
41. Oxidized lipids in atherogenesis: Formation, destruction and action
42. Structurally similar oxidized phospholipids differentially regulate endothelial binding of monocytes and neutrophils
43. Cloning of monoclonal autoantibodies to epitopes of oxidized lipoproteins from apolipoprotein E-deficient mice: Demonstration of epitopes of oxidized low density lipoprotein in human plasma
44. Monoclonal autoantibodies specific for oxidized phospholipids or oxidized phospholipid-protein adducts inhibit macrophage uptake of oxidized low-density lipoproteins