Diabetes and insulin secretion: Whither KATP?

American Journal of Physiology - Endocrinology and Metabolism

Volumn 283, Issue 3 46-3, 2002, Pages

  Nichols, C G ^a   Koster, J C ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

ATP sensitive potassium channels; Kir6.2; Pancreas; SUR1

Indexed keywords

ADENOSINE TRIPHOSPHATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; CONTROLLED STUDY; DIABETES MELLITUS; GENE MUTATION; GENETIC MANIPULATION; GENETIC POLYMORPHISM; GLUCOSE BLOOD LEVEL; HYPERINSULINEMIA; INSULIN RELEASE; MEMBRANE DEPOLARIZATION; METABOLIC REGULATION; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; REVIEW; TRANSGENIC MOUSE;

EID: 0036710407     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00168.2002     Document Type: Review

References (103)

1. Adams TE, Alpert S, and Hanahan D. Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic beta cells. Nature 325: 223-228, 1987.
2. Aguilar-Bryan L, Nichols CG, Wechsler SW, Clement IV JP, Boyd AE III, Gonzalez G, Herrera-Sosa H, Nguy K, Bryan J, and Nelson DA. Cloning of the beta high-affinity sulfonylurea receptor: A regulator of insulin secretion. Science 268: 423-426, 1995.
3. Aizawa T, Komatsu M, Asanuma N, Sato Y, and Sharp GW. Glucose action "beyond ionic events" in the pancreatic beta cell. Trends Pharmacol Sci 19: 496-499, 1998.
4. Allison J, Campbell IL, Morahan G, Mandel TE, Harrison LC, and Miller JF. Diabetes in transgenic mice resulting from over-expression of class I histocompatibility molecules in pancreatic beta cells. Nature 333: 529-533, 1988.
5. Allison J, Malcolm L, Culvenor J, Bartholomeusz RK, Holmberg K, and Miller JF. Overexpression of beta 2-microglobulin in transgenic mouse islet beta cells results in defective insulin secretion. Proc Natl Acad Sci USA 88: 2070-2074, 1991.
6. Ashcroft FM and Rorsman P. ATP-sensitive K+ channels: A link between B-cell metabolism and insulin secretion. Biochem Soc Trans 18: 109-111, 1990.
7. Babenko AP, Aguilar-Bryan L, and Bryan J. A view of sur/KIR6.X, KATP channels. Annu Rev Physiol 60: 667-687, 1998.
8. Bienengraeber M, Alekseev AE, Abraham MR, Carrasco AJ, Moreau C, Vivaudou M, Dzeja PP, and Terzic A. ATPase activity of the sulfonylurea receptor: A catalytic function for the KATP channel complex. FASEB J 14: 1943-1952, 2000.
9. Campbell IL, Hobbs MV, Dockter J, Oldstone MB, and Allison J. Islet inflammation and hyperplasia induced by the pancreatic islet-specific overexpression of interleukin-6 in transgenic mice. Am J Pathol 145: 157-166, 1994.
10. Cook DL, Satin LS, Ashford ML, and Hales CN. ATP-sensitive K+ channels in pancreatic beta-cells. Spare-channel hypothesis. Diabetes 37: 495-498, 1988.
11. D'Alessio DA, Verchere CB, Kahn SE, Hoagland V, Baskin DG, Palmiter RD, and Ensinck JW. Pancreatic expression and secretion of human islet amyloid polypeptide in a transgenic mouse. Diabetes 43: 1457-1461, 1994.
12. Devedjian JC, George M, Casellas A, Pujol A, Visa J, Pelegrin M, Gros L, and Bosch F. Transgenic mice overexpressing insulin-like growth factor-II in beta cells develop type 2 diabetes. J Clin Invest 105: 731-740, 2000.
13. Devedjian JC, Pujol A, Cayla C, George M, Casellas A, Paris H, and Bosch F. Transgenic mice overexpressing alpha2A-adrenoceptors in pancreatic beta-cells show altered regulation of glucose homeostasis. Diabetologia 43: 899-906, 2000.
14. Drain P, Li L, and Wang J. KATP channel inhibition by ATP requires distinct functional domains of the cytoplasmic C terminus of the pore-forming subunit. Proc Natl Acad Sci USA 95: 13953-13958, 1998.
15. Efrat S, Fleischer N, and Hanahan D. Diabetes induced in male transgenic mice by expression of human H-ras oncoprotein in pancreatic beta cells. Mol Cell Biol 10: 1779-1783, 1990.
16. Ellard S, Beards F, Allen LI, Shepherd M, Ballantyne E, Harvey R, and Hattersley AT. A high prevalence of glucokinase mutations in gestational diabetic subjects selected by clinical criteria. Diabetologia 43: 250-253, 2000.
17. Elliott EA and Flavell RA. Transgenic mice expressing constitutive levels of IL-2 in islet beta cells develop diabetes. Int Immunol 6: 1629-1637, 1994.
18. Enkvetchakul D, Loussouarn G, Makhina E, Shyng SL, and Nichols CG. The kinetic and physical basis of K(ATP) channel gating: Toward a unified molecular understanding. Biophys J 78: 2334-2348, 2000.
19. Epstein PN, Boschero AC, Atwater I, Cai X, and Overbeek PA. Expression of yeast hexokinase in pancreatic beta cells of transgenic mice reduces blood glucose, enhances insulin secretion, and decreases diabetes. Proc Natl Acad Sci USA 89: 12038-12042, 1992.
20. Epstein PN, Overbeek PA, and Means AR. Calmodulin-induced early-onset diabetes in transgenic mice. Cell 58: 1067-1073, 1989.
21. Epstein PN, Ribar TJ, Decker GL, Yaney G, and Means AR. Elevated beta-cell calmodulin produces a unique insulin secretory defect in transgenic mice. Endocrinology 130: 1387-1393, 1992.
22. Froguel P, Vaxillaire M, Sun F, Velho G, Zouali H, Butel MO, Lesage S, Vionnet N, Clement K, and Fougerousse F. Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus. Nature 356: 162-164, 1992.
23. Glaser B, Kesavan P, Heyman M, Davis E, Cuesta A, Buchs A, Stanley CA, Thornton PS, Permutt MA, Matschinsky FM, and Herold KC. Familial hyperinsulinism caused by an activating glucokinase mutation. N Engl J Med 338:226-230, 1998.
24. Gloyn AL, Hashim Y, Ashcroft SJ, Ashfield R, Wiltshire S, and Turner RC. Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with type 2 diabetes mellitus (UKPDS 53). Diabet Med 18: 206-212, 2001.
25. Gribble FM, Tucker SJ, and Ashcroft FM. The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide. EMBO J 16: 1145-1152, 1997.
26. Grimberg A, Ferry RJ Jr, Kelly A, Koo-McCoy S, Polonsky K, Glaser B, Permutt MA, Aguilar-Bryan L, Stafford D, Thornton PS, Baker L, and Stanley CA. Dysregulation of insulin secretion in children with congenital hyperinsulinism due to sulfonylurea receptor mutations. Diabetes 50: 322-328, 2001.
27. Grupe A, Hultgren B, Ryan A, Ma YH, Bauer M, and Stewart TA. Transgenic knockouts reveal a critical requirement for pancreatic beta cell glucokinase in maintaining glucose homeostasis. Cell 83: 69-78, 1995.
28. Gu D, Arnush M, Sawyer SP, and Sarvetnick N. Transgenic mice expressing IFN-γ in pancreatic β-cells are resistant to streptozotocin-induced diabetes. Am J Physiol Endocrinol Metab 269: E1089-E1094, 1995.
29. Guazzini B, Gaffi D, Mainieri D, Multari G, Cordera R, Bertolini S, Pozza G, Meschi F, and Barbetti F. Three novel missense mutations in the glucokinase gene (G80S; E221K; G227C) in Italian subjects with maturity-onset diabetes of the young (MODY). Mutations in brief no. 162. Online. Hum Mutat 12: 136, 1998.
30. Guillam MT, Dupraz P, and Thorens B. Glucose uptake, utilization, and signaling in GLUT2-null islets. Diabetes 49: 1485-1491, 2000.
31. Guillam MT, Hummler E, Schaerer E, Yeh JI, Birnbaum MJ, Beermann F, Schmidt A, Deriaz N, Thorens B, and Wu JY. Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2. Nat Genet 17: 327-330, 1997.
32. Hanahan D. Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature 315: 115-122, 1985.
33. Hani EH, Boutin P, Durand E, Inoue H, Permutt MA, Velho G, and Froguel P. Missense mutations in the pancreatic islet beta cell inwardly rectifying K+ channel gene (KIR6.2/BIR): A meta-analysis suggests a role in the polygenic basis of type II diabetes mellitus in Caucasians. Diabetologia 41: 1511-1515, 1998.
34. Hani EH, Clement K, Velho G, Vionnet N, Hager J, Philippi A, Dina C, Inoue H, Permutt MA, Basdevant A, North M, Demenais F, Guy-Grand B, and Froguel P. Genetic studies of the sulfonylurea receptor gene locus in NIDDM and in morbid obesity among French Caucasians. Diabetes 46: 688-694, 1997.
35. Hansen L, Echwald SM, Hansen T, Urhammer SA, Clausen JO, and Pedersen O. Amino acid polymorphisms in the ATP-regulatable inward rectifier Kir6.2 and their relationships to glucose- and tolbutamide-induced insulin secretion, the insulin sensitivity index, and NIDDM. Diabetes 46: 508-512, 1997.
36. Hansen T, Echwald SM, Hansen L, Moller AM, Almind K, Clausen JO, Urhammer SA, Inoue H, Ferrer J, Bryan J, Aguilar-Bryan L, Permutt MA, and Pedersen O. Decreased tolbutamide-stimulated insulin secretion in healthy subjects with sequence variants in the high-affinity sulfonylurea receptor gene. Diabetes 47: 598-605, 1998.
37. Harrigan RA, Nathan MS, and Beattie P. Oral agents for the treatment of type 2 diabetes mellitus: Pharmacology, toxicity, and treatment. Ann Emerg Med 38: 68-78, 2001.
38. Hart LM, de Knijff P, Dekker JM, Stolk RP, Nijpels G, van der Does FE, Ruige JB, Grobbee DE, Heine RJ, and Maassen JA. Variants in the sulphonylurea receptor gene: Association of the exon 16-3t variant with type II diabetes mellitus in Dutch Caucasians. Diabetologia 42: 617-620, 1999.
39. Higgins CF. The ABC of channel regulation. Cell 82: 693-696, 1995.
40. Huopio H, Reimann F, Ashfield R, Komulainen J, Lenko HL, Rahier J, Vauhkonen I, Kere J, Laakso M, Ashcroft F, and Otonkoski T. Dominantly inherited hyperinsulinism caused by a mutation in the sulfonylurea receptor type 1. J Clin Invest 106: 897-906, 2000.
41. Huopio H, Shyng SL, Otonkoski T, and Nichols CG. KATP channels and insulin secretion disorders. Am J Physiol Endocrinol Metab 283: E207-E216, 2002.
42. Inoue H, Ferrer J, Warren-Perry M, Zhang Y, Millns H, Turner RC, Elbein SC, Hampe CL, Suarez BK, Inagaki N, Seino S, and Permutt MA. Sequence variants in the pancreatic islet beta-cell inwardly rectifying K+ channel Kir6.2 (Bir) gene: Identification and lack of role in Caucasian patients with NIDDM. Diabetes 46: 502-507, 1997.
43. Inoue H, Ferrer J, Welling CM, Elbein SC, Hoffman M, Mayorga R, Warren-Perry M, Zhang Y, Millns H, Turner R, Province M, Bryan J, Permutt MA, and Aguilar-Bryan L. Sequence variants in the sulfonylurea receptor (SUR) gene are associated with NIDDM in Caucasians. Diabetes 45: 825-831, 1996.
44. Ishihara H, Tashiro F, Ikuta K, Asano T, Katagiri H, Inukai K, Kikuchi M, Yazaki Y, Oka Y, and Miyazaki J. Inhibition of pancreatic beta-cell glucokinase by antisense RNA expression in transgenic mice: Mouse strain-dependent alteration of glucose tolerance. FEBS Lett 371: 329-332, 1995.
45. Iwasaki N, Kawamura M, Yamagata K, Cox NJ, Karibe S, Ohgawara H, Inagaki N, Seino S, Bell GI, and Omori Y. Identification of microsatellite markers near the human genes encoding the beta-cell ATP-sensitive K+ channel and linkage studies with NIDDM in Japanese. Diabetes 45: 267-269, 1996.
46. Janson J, Soeller WC, Roche PC, Nelson RT, Torchia AJ, Kreutter DK, and Butler PC. Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide. Proc Natl Acad Sci USA 93: 7283-7288, 1996.
47. Kane C, Shepherd RM, Squires PE, Johnson PR, James RF, Milla PJ, Aynsley-Green A, Lindley KJ, and Dunne MJ. Loss of functional KATP channels in pancreatic beta-cells causes persistent hyperinsulinemic hypoglycemia of infancy. Nat Med 2: 1344-1347, 1996.
48. Kato I, Suzuki Y, Akabane A, Yonekura H, Tanaka O, Kondo H, Takasawa S, Yoshimoto T, and Okamoto H. Transgenic mice overexpressing human vasoactive intestinal peptide (VIP) gene in pancreatic beta cells. Evidence for improved glucose tolerance and enhanced insulin secretion by VIP and PHM-27 in vivo. J Biol Chem 269: 21223-21228, 1994.
49. Khachatryan A, Guerder S, Palluault F, Cote G, Solimena M, Valentijn K, Millet I, Flavell RA, and Vignery A. Targeted expression of the neuropeptide calcitonin gene-related peptide to beta cells prevents diabetes in NOD mice. J Immunol 158: 1409-1416, 1997.
50. Kinard TA, de Vries G, Sherman A, and Satin LS. Modulation of the bursting properties of single mouse pancreatic beta-cells by artificial conductances. Biophys J 76: 1423-1435, 1999.
51. Knobler H, Weiss Y, Peled M, and Groner Y. Impaired glucose-induced insulin response in transgenic mice overexpressing the L-phosphofructokinase gene. Diabetes 46: 1414-1418, 1997.
52. Koster JC, Marshall BA, Ensor N, Corbett JA, and Nichols CG. Targeted overactivity of beta cell K(ATP) channels induces profound neonatal diabetes. Cell 100: 645-654, 2000.
53. Koster JC, Marshall BA, Ensor N, Corbett JA, and Nichols CG. Diet-induced glucose intolerance in mice expressing ATP-insensitive KATP channels in pancreatic beta cells (Abstract). Diabetes 51, Suppl 2: A370, 2002.
54. Krakowski ML, Kritzik MR, Jones EM, Krahl T, Lee J, Arnush M, Gu D, Mroczkowski B, and Sarvetnick N. Transgenic expression of epidermal growth factor and keratinocyte growth factor in beta-cells results in substantial morphological changes. J Endocrinol 162: 167-175, 1999.
55. Kubisch HM, Wang J, Bray TM, and Phillips JP. Targeted overexpression of Cu/Zn superoxide dismutase protects pancreatic beta-cells against oxidative stress. Diabetes 46: 1563-1566, 1997.
56. Leibowitz G, Glaser B, Higazi AA, Salameh M, Cerasi E, and Landau H. Hyperinsulinemic hypoglycemia of infancy (nesidioblastosis) in clinical remission: High incidence of diabetes mellitus and persistent beta-cell dysfunction at long-term follow-up. J Clin Endocrinol Metab 80: 386-392, 1995.
57. Li L, Wang J, and Drain P. The I182 region of k(ir)6.2 is closely associated with ligand binding in K(ATP) channel inhibition by ATP. Biophys J 79: 841-852, 2000.
58. Martin L, Keller GA, Liggitt D, Oakley H, Pitts-Meek SL, Siegel MW, Terrell T, and Stewart TA. Male-specific beta-cell dysfunction and diabetes resulting from increased expression of a syngeneic MHC class I protein in the pancreata of transgenic mice. New Biol 2: 1101-1110, 1990.
59. Meirhaeghe A, Helbecque N, Cottel D, Arveiler D, Ruidavets JB, Haas B, Ferrieres J, Tauber JP, Bingham A, and Amouyel P. Impact of sulfonylurea receptor 1 genetic variability on non-insulin-dependent diabetes mellitus prevalence and treatment: A population study. Am J Med Genet 101: 4-8, 2001.
60. Miki T, Nagashima K, Tashiro F, Kotake K, Yoshitomi H, Tamamoto A, Gonoi T, Iwanaga T, Miyazaki J, and Seino S. Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice. Proc Natl Acad Sci USA 95: 10402-10406, 1998.
61. Miki T, Tashiro F, Iwanaga T, Nagashima K, Yoshitomi H, Aihara H, Nitta Y, Gonoi T, Inagaki N, Miyazaki J, and Seino S. Abnormalities of pancreatic islets by targeted expression of a dominant-negative KATP channel. Proc Natl Acad Sci USA 94: 11969-11973, 1997.
62. Misler S, Barnett DW, Gillis KD, and Pressel DM. Electrophysiology of stimulus -secretion coupling in human beta-cells. Diabetes 41: 1221-1228, 1992.
63. Mueller R, Krahl T, and Sarvetnick N. Pancreatic expression of interleukin-4 abrogates insulitis and autoimmune diabetes in nonobese diabetic (NOD) mice. J Exp Med 184: 1093-1099, 1996.
64. Nadal A, Quesada I, and Soria B. Homologous and heterologous asynchronicity between identified alpha-, beta- and delta-cells within intact islets of Langerhans in the mouse. J Physiol 517: 85-93, 1999.
65. Nestorowicz A, Glaser B, Wilson BA, Shyng SL, Nichols CG, Stanley CA, Thornton PS, and Permutt MA. Genetic heterogeneity in familial hyperinsulinism. Hum Mol Genet 7: 1119-1128, 1998.
66. Nichols CG, Shyng SL, Nestorowicz A, Glaser B, Clement JP, Gonzalez G, Aguilarbryan L, Permutt MA, and Bryan J. Adenosine diphosphate as an intracellular regulator of insulin secretion. Science 272: 1785-1787, 1996.
67. Ohta Y, Tanizawa Y, Inoue H, Hosaka T, Ueda K, Matsutani A, Repunte VP, Yamada M, Kurachi Y, Bryan J, Aguilar-Bryan L, Permutt MA, and Oka Y. Identification and functional analysis of sulfonylurea receptor 1 variants in Japanese patients with NIDDM. Diabetes 47: 476-481, 1998.
68. Page R, Hattersley A, and Turner R. Beta-cell secretory defect caused by mutations in glucokinase gene. Lancet 340: 1162-1163, 1992.
69. Philipson LH, Rosenberg MP, Kuznetsov A, Lancaster ME, Worley JF III, Roe MW, and Dukes ID. Delayed rectifier K+ channel overexpression in transgenic islets and beta-cells associated with impaired glucose responsiveness. J Biol Chem 269: 27787-27790, 1994.
70. Picarella DE, Kratz A, Li CB, Ruddle NH, and Flavell RA. Insulitis in transgenic mice expressing tumor necrosis factor beta (lymphotoxin) in the pancreas. Proc Natl Acad Sci USA 89: 10036-10040, 1992.
71. Picarella DE, Kratz A, Li CB, Ruddle NH, and Flavell RA. Transgenic tumor necrosis factor (TNF)-alpha production in pancreatic islets leads to insulitis, not diabetes. Distinct patterns of inflammation in TNF-alpha and TNF-beta transgenic mice. J Immunol 150: 4136-4150, 1993.
72. Porter SE, Sorenson RL, Dann P, Garcia-Ocana A, Stewart AF, and Vasavada RC. Progressive pancreatic islet hyperplasia in the islet-targeted, parathyroid hormone-related protein-overexpressing mouse. Endocrinology 139: 3743-3751, 1998.
73. Postic C and Magnuson MA. Role of glucokinase (GK) in the maintenance of glucose homeostasis. Specific disruption of the gene by the Cre-loxP technique. J Annu Diabetol Hotel Dieu: 115-124, 1999.
74. Ribar TJ, Epstein PN, Overbeek PA, and Means AR. Targeted overexpression of an inactive calmodulin that binds Ca2+ to the mouse pancreatic beta-cell results in impaired secretion and chronic hyperglycemia. Endocrinology 136: 106-115, 1995.
75. Ribar TJ, Jan CR, Augustine GJ, and Means AR. Defective glycolysis and calcium signaling underlie impaired insulin secretion in a transgenic mouse. J Biol Chem 270: 28688-28695, 1995.
76. Rissanen J, Markkanen A, Karkkainen P, Pihlajamaki J, Kekalainen P, Mykkanen L, Kuusisto J, Karhapaa P, Niskanen L, and Laakso M. Sulfonylurea receptor 1 gene variants are associated with gestational diabetes and type 2 diabetes but not with altered secretion of insulin. Diabetes Care 23: 70-73, 2000.
77. Sakura H, Ashcroft SJ, Terauchi Y, Kadowaki T, and Ashcroft FM. Glucose modulation of ATP-sensitive K-currents in wild-type, homozygous and heterozygous glucokinase knockout mice. Diabetologia 41: 654-659, 1998.
78. Sakura H, Eto K, Kadowaki H, Simokawa K, Ueno H, Koda N, Fukushima Y, Akanuma Y, Yazaki Y, and Kadowaki T. Structure of the human glucokinase gene and identification of a missense mutation in a Japanese patient with early-onset non-insulin-dependent diabetes mellitus. J Clin Endocrinol Metab 75: 1571-1573, 1992.
79. Sakura H, Wat N, Horton V, Millns H, Turner RC, and Ashcroft FM. Sequence variations in the human Kir6.2 gene, a subunit of the beta-cell ATP-sensitive K-channel: No association with NIDDM in white Caucasian subjects or evidence of abnormal function when expressed in vitro. Diabetologia 39: 1233-1236, 1996.
80. Sarvetnick N, Liggitt D, Pitts SL, Hansen SE, and Stewart TA. Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma. Cell 52: 773-782, 1988.
81. Sarvetnick N, Shizuru J, Liggitt D, Martin L, McIntyre B, Gregory A, Parslow T, and Stewart T. Loss of pancreatic islet tolerance induced by beta-cell expression of interferon-gamma. Nature 346: 844-847, 1990.
82. Schwanstecher C, Meyer U, and Schwanstecher M. K(IR)6.2 polymorphism predisposes to type 2 diabetes by inducing overactivity of pancreatic beta-cell ATP-sensitive K(+) channels. Diabetes 51: 875-879, 2002.
83. Seghers V, Nakazaki M, DeMayo F, Aguilar-Bryan L, and Bryan J. Surl knockout mice. A model for K(ATP) channel-independent regulation of insulin secretion. J Biol Chem 275: 9270-9277, 2000.
84. Sharma N, Crane A, Gonzalez G, Bryan J, and Aguilar-Bryan L. Familial hyperinsulinism and pancreatic beta-cell ATP-sensitive potassium channels. Kidney Int 57: 803-808, 2000.
85. Shyng S, Ferrigni T, and Nichols CG. Control of rectification and gating of cloned KATP channels by the Kir6.2 subunit. J Gen Physiol 110: 141-153, 1997.
86. Shyng S, Ferrigni T, and Nichols CG. Regulation of KATP channel activity by diazoxide and MgADP. Distinct functions of the two nucleotide binding folds of the sulfonylurea receptor. J Gen Physiol 110: 643-654, 1997.
87. Shyng SL, Cukras CA, Harwood J, and Nichols CG. Structural determinants of PIP(2) regulation of inward rectifier K(ATP) channels. J Gen Physiol 116: 599-608, 2000.
88. Stewart TA, Hultgren B, Huang X, Pitts-Meek S, Hully J, and MacLachlan NJ. Induction of type I diabetes by interferon-alpha in transgenic mice. Science 260: 1942-1946, 1993.
89. Stirling B, Cox NJ, Bell GI, Hanis CL, Spielman RS, and Concannon P. Identification of microsatellite markers near the human ob gene and linkage studies in NIDDM-affected sib pairs. Diabetes 44: 999-1001, 1995.
90. Takamura T, Kato I, Kimura N, Nakazawa T, Yonekura H, Takasawa S, and Okamoto H. Transgenic mice overexpressing type 2 nitric-oxide synthase in pancreatic beta cells develop insulin-dependent diabetes without insulitis. J Biol Chem 273: 2493-2496, 1998.
91. Terauchi Y, Sakura H, Yasuda K, Iwamoto K, Takahashi N, Ito K, Kasai H, Suzuki H, Ueda O, and Kamada N. Pancreatic beta-cell-specific targeted disruption of glucokinase gene. Diabetes mellitus due to defective insulin secretion to glucose. J Biol Chem 270: 30253-30256, 1995.
92. Thomas PM, Cote GJ, Wohllk N, Haddad B, Mathew PM, Rabl W, Aguilar-Bryan L, Gagel RF, and Bryan J. Mutations in the sulfonylurea receptor gene in familial persistent hyperinsulinemic hypoglycemia of infancy. Science 268: 426-429, 1995.
93. Thorens B, Guillam MT, Beermann F, Burcelin R, and Jaquet M. Transgenic reexpression of GLUT1 or GLUT2 in pancreatic beta cells rescues GLUT2-null mice from early death and restores normal glucose-stimulated insulin secretion. J Biol Chem 275: 23751-23758, 2000.
94. Trapp S, Tucker SJ, and Ashcroft FM. Activation and inhibition of K-ATP currents by guanine nucleotides is mediated by different channel subunits. Proc Natl Acad Sci USA 94: 8872-8877, 1997.
95. Tucker SJ, Gribble FM, Proks P, Trapp S, Ryder TJ, Haug T, Reimann F, and Ashcroft FM. Molecular determinants of KATP channel inhibition by ATP. EMBO J 17: 3290-3296, 1998.
96. Tucker SJ, Gribble FM, Zhao C, Trapp S, and Ashcroft FM. Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor. Nature 387: 179-183, 1997.
97. Ueda K, Komine J, Matsuo M, Seino S, and Amachi T. Cooperative binding of ATP and MgADP in the sulfonylurea receptor is modulated by glibenclamide. Proc Natl Acad Sci USA 96: 1268-1272, 1999.
98. Valera A, Solanes G, Fernandez-Alvarez J, Pujol A, Ferrer J, Asins G, Gomis R, and Bosch F. Expression of GLUT-2 antisense RNA in beta cells of transgenic mice leads to diabetes. J Biol Chem 269: 28543-28546, 1994.
99. Vasavada RC, Garcia-Ocana A, Zawalich WS, Sorenson RL, Dann P, Syed M, Ogren L, Talamantes F, and Stewart AF. Targeted expression of placental lactogen in the beta cells of transgenic mice results in beta cell proliferation, islet mass augmentation, and hypoglycemia. J Biol Chem 275: 15399-15406, 2000.
100. Velho G, Froguel P, Clement K, Pueyo ME, Rakotoambinina B, Zouali H, Passa P, Cohen D, and Robert JJ. Primary pancreatic beta-cell secretory defect caused by mutations in glucokinase gene in kindreds of maturity onset diabetes of the young. Lancet 340: 444-448, 1992.
101. Vionnet N, Stoffel M, Takeda J, Yasuda K, Bell GI, Zouali H, Lesage S, Velho G, Iris F, and Passa P. Nonsense mutation in the glucokinase gene causes early-onset non-insulinc-dependent diabetes mellitus. Nature 356: 721-722, 1992.
102. Wogensen L, Ma YH, Grodsky GM, Robertson RP, Burton F, Sutcliffe JG, and Sarvetnick N. Functional effects of transgenic expression of cholera toxin in pancreatic beta-cells. Mol Cell Endocrinol 98: 33-42, 1993.
103. Zhang Y, Warren-Perry M, Sakura H, Adelman J, Stoffel M, Bell GI, Ashcroft FM, and Turner RC. No evidence for mutations in a putative beta-cell ATP-sensitive K+ channel subunit in MODY, NIDDM, or GDM. Diabetes 44: 597-600, 1995.