A high prevalence of glucokinase mutations in gestational diabetic subjects selected by clinical criteria

Diabetologia

Volumn 43, Issue 2, 2000, Pages 250-253

  Ellard, S ^a   Beards, F ^a   Allen, L I S ^a   Shepherd, M ^a   Ballantyne, E ^a   Harvey, R ^b   Hattersley, A T ^a,c  

^a UNIVERSITY OF EXETER   (United Kingdom)

^b NHS GRAMPIAN   (United Kingdom)

^c School of Postgraduate Medicine and Health Sciences   (United Kingdom)

Author keywords

Gestational diabetes; Glucokinase; Maturity onset diabetes of the young; Mutation analysis; Phenotype selection

Indexed keywords

GLUCOKINASE;

ARTICLE; CAUCASIAN; CLINICAL ARTICLE; GENE MUTATION; GENE SEQUENCE; GENETIC ANALYSIS; GLUCOSE BLOOD LEVEL; HUMAN; HYPERGLYCEMIA; HYPOTHESIS; MATURITY ONSET DIABETES MELLITUS; NON INSULIN DEPENDENT DIABETES MELLITUS; ORAL GLUCOSE TOLERANCE TEST; PATIENT SELECTION; PHENOTYPE; PREGNANCY DIABETES MELLITUS; PREVALENCE; PRIORITY JOURNAL; UNITED KINGDOM;

EID: 0034000635     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250050038     Document Type: Article

References (10)

1. 1. Froguel P, Zouali H, Vionnet N et al. (1993) Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus. N Engl J Med 328: 697-702
2. 2. Page RC, Hattersley AT, Levy JC et al. (1995) Clinical characteristics of subjects with a missense mutation in glucokinase. Diabet Med 12: 209-217
3. 3. O'Rahilly S, Hattersley A, Vaag A, Gray H (1994) Insulin resistance as the major cause of impaired glucose tolerance: a self-fulfilling prophesy? Lancet 344: 585-589
4. 4. Hattersley AT (1996) Glucokinase mutations and Type 2 diabetes. In: Lightman S (ed) Horizons in medicine. Blackwell Science, Bristol, pp 440-449
5. 5. Stoffel M, Bell KL, Blackburn CL et al. (1993) Identification of glucokinase mutations in subjects with gestational diabetes mellitus. Diabetes 42: 937-940
6. 6. Zouali H, Vaxillaire M, Lesage S et al. (1993) Linkage analysis and molecular scanning of glucokinase gene in NIDDM families. Diabetes 42: 1238-1245
7. 7. Saker PJ, Hattersley AT, Barrow B et al. (1996) High prevalence of a missense mutation of the glucokinase gene in gestational diabetic patients due to a founder-effect in a local population. Diabetologia 39: 1325-1328
8. 8. Chiu KC, Go RC, Aoki M et al. (1994) Glucokinse gene in gestational diabetes mellitus: population association study and molecular scanning. Diabetologia 37: 104-110
9. 9. Allen CJ, Argyropoulos G, Bowker M et al. (1997) Gestational diabetes mellitus and gene mutations which affect insulin secretion. Diabetes Res Clin Pract 36: 135-141
10. 10. Zaidi FK, Wareham NJ, McCarthy MI et al. (1997) Homozygosity for a common polymorphism in the islet-specific promoter of the glucokinase gene is associated with a reduced early insulin response to oral glucose in pregnant women. Diabet Med 14: 228-234