Targeted Expression of the Neuropeptide Calcitonin Gene-Related Peptide to β Cells Prevents Diabetes in NOD Mice

Journal of Immunology

Volumn 158, Issue 3, 1997, Pages 1409-1416

  Khachatryan, Armen ^a   Guerder, Sylvie ^a   Palluault, François ^a   Cote, Gilbert ^b   Solimena, Michele ^a   Valentijn, Karine ^a   Millet, Isabelle ^a   Flavell, Richard A ^a   Vignery, Agnès ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; IMMUNOSUPPRESSIVE AGENT; INSULIN;

ANIMAL; ARTICLE; B LYMPHOCYTE; BIOSYNTHESIS; CELL LINE; FEMALE; GENE EXPRESSION; IMMUNOLOGY; INSULIN DEPENDENT DIABETES MELLITUS; MALE; METABOLISM; MOUSE; NONOBESE DIABETIC MOUSE; PANCREAS ISLET; PATHOLOGY; PHYSIOLOGY; T LYMPHOCYTE; TRANSGENIC MOUSE;

ANIMALS; B-LYMPHOCYTES; CALCITONIN GENE-RELATED PEPTIDE; CELL LINE; DIABETES MELLITUS, TYPE 1; FEMALE; GENE EXPRESSION; IMMUNOSUPPRESSIVE AGENTS; INSULIN; ISLETS OF LANGERHANS; MALE; MICE; MICE, INBRED NOD; MICE, TRANSGENIC; T-LYMPHOCYTES;

EID: 0031065148     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Wallengren, J., and H. Möller. 1986. The effect of capsaicin on some experimental inflammations in human skin. Acta Derm. Venereol. 66:375.
2. Nilsson, G., and S. Ahlstedt. 1989. Increased delayed-type hypersensitivity reaction in rats neuromanipulated with capsaicin. Int. Arch. Allergy Appl. Immunol. 90:256.
3. Girolomoni, G., and R. E. Tigelaar. 1990. Capsaicin-sensitive primary sensory neurons are potent modulators of murine delayed-type hypersensitivity reactions. J. Immunol. 145:1105.
4. Wallengren, J., R. Ekman, and H. Möller. 1991. Capsaicin enhances allergic contact dermatitis in the guinea pig. Contact Dermatitis 24:30.
5. Kruger, L., J. D. Silverman, P. W. Mantyh, C. Sternini, and N. Brecha. 1989. Peripheral patterns of calcitonin-gene-related peptide general somatic sensory innervation: cutaneous and deep terminations. J. Comp. Neurol. 280:291.
6. Wang, F., I. Millet, K. Bottomly, and A. Vignery. 1992. Calcitonin gene related peptide inhibits IL-2 production by murine T lymphocytes. J. Biol. Chem. 267: 21052.
7. Hosoi, J., G. F. Murphy, C. L. Egan, E. A. Lerner, S. Grabbe, A. Asahina, and R. D. Granstein. 1993. Regulation of Langerhans cell function by nerves containing calcitonin gene-related peptide. Nature 363:159.
8. Asahina, A., J. Hosoi, S. Beissert, A. Stratigos, and D. Granstein. 1995. Inhibition of the induction of delayed-type and contact hypersensitivity by calcitonin gene-related peptide. J. Immunol. 154:3056.
9. Gillardon, F., I. Moll, S. Michel, J. Benrath, E. Weihe, and M. Zimmermann. 1995. Calcitonin gene-related peptide and nitric oxide are involved in ultraviolet radiation-induced immunosuppression. Eur. J. Pharmacol. 293:395.
10. Bach, J. F. 1994. Insulin-dependent diabetes mellitus as an autoimmune disease. Endocr. Rev. 15:516.
11. + T cells in the destruction of islet grafts by spontaneously diabetic mice. Proc. Natl. Acad. Sci. USA 88:527.
12. null mice are diabetes and insulin resistant. Diabetes 43:505.
13. Picarella, D. E., A. Kratz, C. B. Li, N. Ruddle, and R. A. Flavell. 1992. Insulitis in transgenic mice expressing tumor necrosis factor β (lymphotoxin) in the pancreas. Proc. Natl. Acad. Sci. USA 89:10036.
14. Sarvetnick, N., J. Shizuru, D. Liggitt, L. Martin, B. McIntyre, A. Gregory, T. Parslow, and T. Stewart. 1990. Loss of pancreatic islet tolerance induced by β-cell expression of interferon-γ. Nature 346:844.
15. Allison, J., P. McClive, L. Oxbrow, A. Baxter, G. Morahan, and J. F. A. P. Miller. 1994. Genetic requirements for acceleration of diabetes in ono-obese diabetic mice expressing interleukin-2 in islet beta-cells. Eur. J. Immunol. 24:2535.
16. Elliott, E. A., and R. A. Flavell. 1994. Transfgenic mice expressing constitutive levels of IL-2 in islet β cells develop diabetes. Int. Immunol. 6:1629.
17. Cote, G. J., D. T. Stolow, S. Peleg, S. M. Berget, and R. F. Gagel. 1992. Identification of exon sequences and an exon binding protein involved in alternative RNA splicing of calcitonin/CGRP. Nucleic Acids Res. 20:2361.
18. Lou, H., G. J. Cote, and R. F. Gagel. 1994. The calcitonin exon and its flanking intronic sequences are sufficient for the regulation of human calcitonin/calcitonin gene related peptide RNA splicing. Mol. Endocrinol. 8:1618.
19. Hogan, B., F. Constantini, and E. Lacy. 1986. Production of transgenic mice. In Manipulating the Mouse embryo: A Labaratoy Manual. Cold Spring Harbor, Cold Spring Harbor, NY, pp. 217-250.
20. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Extraction purification, and analysis of messenger RNA from eukarystic cells. Ch. 12. In Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, Cold Spring Harbor, NY.
21. DeCamilli P., R. Cameron, and P. Greengard. 1983. Synapsin I (protein I), a nerve terminal-specific phosphoprotein: its general distribution in synapses of the central and peripheral nervous system demonstrated by immunofluorescence in frozen and plastic sections. J. Cell Biol. 96:1337.
22. Lo, D., L. C. Burkly, G. Widera, C. Cowing, R. A. Flavell, R. D. Palmiter, and R. L. Brinster. 1988. Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells. Cell 52:159.
23. Pozzilli, P., A. Signore, A. J. Williams, and P. E. Beales. 1993. NOD mouse colonies around the world: recent facts and figures. Immunol. Today 14:193.
24. Signore, A., P. Pozzilli, E. A. Gale, D. Andreani, and P. C. Beverley. 1989. The natural history of lymphocyte subsets infiltrating the pancreas of NOD mice. Diabetologia 32:282.
25. Kikutani, H., and S. Makino. 1992. The murine autoimmune diabetes model: NOD and related strains. Adv. Immunol. 51:285.
26. Cohen, J. Correlation and multivariate methods. In Statistical Power Analysis for Behavior Sciences, 2nd Ed. Erlbaum Associates, Hillsdale, NJ, pp. 467-530.
27. Umeda, Y., and M. Arisawa. 1989. Inhibition of natural killer activity by calcitonin gene-related peptide. Immunopharmacol. Immunotoxicol. 11:309.
28. Nong, Y. H., R. G. Titus, J. M. Ribeiro, and H. G. Remold. 1989. Peptides encoded by the calcitonin gene inhibit macrophage function. J. Immunol. 143:45.
29. Vignery, A., F. Wang, and M. B. Ganz. 1991. Macrophages express functional receptors for calcitonin gene related peptide J. Cell. Physiol. 149:301.
30. Asahina, A., O. Moro, J. Hosoi, E. A. Lerner, S. Xu, A. Takashima, and R. D. Granstein. 1995. Specific induction of cAMP in Langerhans cells by calcitonin gene related peptide: relevance to functional effects. Proc. Natl. Acad. Sci. USA 92:8323.