Metal ion chelation in neurodegenerative disorders

Drug Development Research

Volumn 56, Issue 3, 2002, Pages 300-309

  Angel, Itzchak ^a   Bar, Adina ^a   Horovitz, Tammy ^a   Taler, Galia ^a   Krakovsky, Michael ^a   Resnitsky, Dalia ^a   Rosenberg, Gilad ^a   Striem, Sarina ^a   Friedman, Jonathan E ^a   Kozak, Alex ^a  

^a D Pharm Ltd   (Israel)

Author keywords

Alzheimer disease; BAPTA; Brain ischaemia; Calcium; Chelation therapy; Parkinson disease

Indexed keywords

ALPHA SYNUCLEIN; AMYLOID BETA PROTEIN; CALCIUM ION; CALPAIN; CHELATING AGENT; CLIOQUINOL; COPPER ION; COPPER ZINC SUPEROXIDE DISMUTASE; DEFEROXAMINE; DP 109; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; ETHYLENEGLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID BIS(2 OCTYLOXYETHYL) ESTER; FREE RADICAL; GELATINASE A; GELATINASE B; IRON; METAL ION; PBT 1; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; ZINC ION;

ALZHEIMER DISEASE; BRAIN ISCHEMIA; CHELATION; CLINICAL TRIAL; DEGENERATIVE DISEASE; ENDOPLASMIC RETICULUM; HOMEOSTASIS; HUMAN; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; PROTEIN AGGREGATION; REVIEW;

EID: 0036660458     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/ddr.10083     Document Type: Review

References (67)

1. Atwood CS, Scarpa RC, Huang X, Moir RD, Jones WD, Fairlie DP, Tanzi RE, Bush AI. 2000. Characterization of copper interactions with alzheimer amyloid beta peptides: identification of an attomolar-affinity copper binding site on amyloid beta1-42. J Neurochem 75:1219-1233.
2. Barone FC, Clark RK, Price WJ, White RF, Feuerstein GZ, Storer BL, Ohlstein EH. 1993. Neuron-specific enolase increases in cerebral and sytemic circulation following focal ischemia. Brain Res 623:77-82.
3. Berg D, Gerlach M, Youdim MB, Double KL, Zecca L, Riederer P, Becker G. 2001. Brain iron pathways and their relevance to Parkinson's disease. J Neurochem 79:225-236.
4. Berridge MJ, Lipp P, Bootman MD. 2000. The versatility and universatity of calcium signalling. Nat Rev Mol Cell Biol 1:11-21.
5. Bode W, Fernandez-Catalan C, Tschesche H, Grams F, Nagase H, Maskos K. 1999. Structural properties of matrix metalloproteinases. Cell Mol Life Sci 55:639-652.
6. Brown DR. 2001. Copper and prion disease. Brain Res Bull 55:165-173.
7. Bruijn LI, Houseweart MK, Kato S, Anderson KL, Anderson SD, Ohama E, Reaume AG, Scott RW, Cleveland DW. 1998. Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1. Science 281:1851-1854.
8. Bryce SM, Rosenberg G. 1998. Matrix Metalloproteinases in Cerebrovascular Disease. J Cereb Blood Flow Metab 18:1163-1172.
9. Bush AI. 2000. Metals and neuroscience. Curr Opin Chem Biol 4:184-191.
10. Bush AI, Pettingell WH, Multhaup G, Paradis M, Vonsattel JP, Gusella JF, Beyreuther K, Masters CL, Tanzi RE. 1994. Rapid induction of Alzheimer A beta amyloid formation by zinc. Science 265:1464-1467.
11. Carafoli E, Santella L, Branca D, Brini M. 2001. Generation, control, and processing of cellular calcium signals. Crit Rev Biochem Mol Biol 36:107-260.
12. Cherny RA, Atwood CS, Xilinas ME, Gray DN, Jones WD, McLean CA, Barnham KJ, Volitakis I, Fraser FW, Kim Y, Huang X, Goldstein LE, Moir RD, Lim JT, Beyreuther K, Zheng H, Tanzi RE, Masters CL, Bush AI. 2001. Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron 30:665-676.
13. Chidekel AS, Friedman JE, Haddad GG. 1997. Anoxia-induced neuronal injury; role of Na+ entry and Na+-dependent transport. Exp Neurol 146:403-413.
14. Choi DW, Koh JY. 1998. Zinc and brain injury. Annu Rev Neurosci 21:347-375.
15. Donkor IO. 2000. A survey of calpain inhibitors. Curr Med Chem 7:1171-1188.
16. Duda JE, Lee VM, Trojanowski JQ. 2000. Neuropathology of synuclein aggregates. J Neurosci Res 61:121-127.
17. Emmi A, Rajabi H, Stewart J. 1996. Behavioral and neurochemical recovery from partial 6-hydroxydopamine lesions of the substantia nigra is blocked by daily treatment with glutamate receptor antagonists MK-801 and CPP. J Neurosei 16.
18. Frederickson CJ, Suh SW, Silva D, Thompson RB. 2000. Importance of zinc in the central nervous system: the zinc-containing neuron. J Nutr 130:1471S-1483S.
19. Griffith WH, Jasek MC, Bain SH, Murchison D. 2000. Modification of ion channels and calcium homeostasis of basal forebrain neurons during aging. Behav Brain Res 115:219-233.
20. Hagen TM, Ingersoll BT, Lykkesfeldt J, Liu J, Wehr CM, Vinarsky V, Bartholomew JC, Ames AB. 1999. (R)-alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and metabolic rate. Faseb J 13:411-418.
21. Hershfinkel M, Moran A, Grossman N, Sekler I. 2001. A zinc-sensing receptor triggers the release of intracellular Ca2+ and regulates ion transport. Proc Natl Acad Sci USA 98:11749-11754.
22. Hong SC, Goto Y, Lanzino G, Soleau S, Kassell NF, Lee KS. 1994. Neuroprotection with a calpain inhibitor in a model of focal cerebral ischemia. Stroke 25:663-669.
23. Huang X, Atwood CS, Hartshorn MA, Multhaup G, Goldstein LE, Scarpa RC, Cuajungco MP, Gray DN, Lim J, Moir RD, Tanzi RE, Bush AI. 1999. The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction. Biochemistry 38:7609-7616.
24. Jacob C, Maret W, Vallee BL. 1998. Control of zinc transfer between thionein, metallothionein, and zinc proteins. Proc Natl Acad Sci USA 95:3489-3494.
25. Kienzl E, Puchinger L, Jellinger K, Linert W, Stachelberger H, Jameson RF. 1995. The role of transition metals in the pathogenesis of Parkinson's disease. J Neurol Sci 134 Suppl.:69-78.
26. Koh JY, Suh SW, Gwag BJ, He YY, Hsu CY, Choi DW. 1996. The role of zinc in selective neuronal death after transient global cerebral ischemia. Science 272:1013-1016.
27. Korkotian E, Segal M. 1997. Calcium-containing organelles display unique reactivity to chemical stimulation in cultured hippocampal neurons. J Neurosci 17:1670-1682.
28. Krakovsky M, Beit-Yannai E, Angel I, Shemesh T, Kozak A. 2000. In: Pharmacology of cerebral ischemia. DP-b99 improves the neurological and histological outcome following occlusion of the middle cerebral artery in rats. Abstract. Marburg, Germany.
29. Krakovsky M, Polyak M, Angel I, Kozak A. 2001. A novel membrane targeted compound active against global and focal ischemia. In: Gjedde SH, Kundsen GM, Paulson OB, editors. Physiological Imaging of the Brain with PET. New York: Academic Press. p 347-352
30. Kreiss DS, Mastropietro CW, Rawji SS, Walters J. 1997. The response of subthalamic nucleus neurons to dopamine receptor stimulation in a rodent model of Parkinson's disease. J Neurosci 17.
31. Lee JM, Zipfel GJ, Choi DW. 1999. The changing landscape of ischaemic brain injury mechanisms. Nature 399:A7-14.
32. Lee KS, Frank S, Vanderldish P, Arai A, Lynch G. 1991. Inhibition of proteolysis protects hippocampal neurons from ischemia. Proc Natl Acad Sci USA 88:7233-7237.
33. Lee MS, Kwon YT, Li M, Peng J, Friedlander RM, Tsai LH. 2000. Neurotoxicity induces cleavage of p35 to p25 by calpain. Nature 405:360-364.
34. Lovell MA, Robertson JD, Teesdale WJ, Campbell JL, Markesbery WR. 1998. Copper, iron and zinc in Alzheimer's disease senile plaques. J Neurol Sci 158:47-52.
35. Lukes A, Mun-Bryce S, Lukes M, Rosenberg GA. 1999. Extracellular matrix degradation by metalloproteinases and central nervous system diseases. Mol Neurobiol 19:267-284.
36. Mattson MP, LaFerla FM, Chan SL, Leissring MA, Sbepel PN, Geiger JD. 2000. Calcium signaling in the ER: its role in neuronal plasticity and neurodegenerative disorders. Trends Neurosci 23:222-229.
37. McLachlan JC. 1991. Transcutaneous electrical nerve stimulation. Lancet 337:742.
38. Montero M, Alonso MT, Carnicero E, Cuchillo-Ibanez I, Albillos A, Garcia AG, Garcia-Sancho J, Alvarez J. 2000. Chromaffin-cell stimulation triggers fast millimolar mitochondrial Ca2+ transients that modulate secretion. Nat Cell Biol 2:57-61.
39. Ostrerova-Golts N, Petrucelli L, Hardy J, Lee JM, Farer M, Wolozin B. 2000. The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity. J Neurosci 20:6048-6054.
40. Outten CE, O'Halloran TV. 2001. Femtomolar sensitivity of metalloregulatory proteins controlling zinc homeostasis. Science 29:2488-2492.
41. Pasehen W, Doutheil J. 1999. Disturbances of the functioning of endoplasmic reticulum: a key mechanism underlying neuronal cell injury? J Cereb Blood Flow Metab 19:1-18.
42. Rami A, Ferger D, Krieglstein J, 1997. Blockade of calpain proteolytic activity rescues neurons from glutamate excitotoxicity. Neurosci Res 27:93-97.
43. Regland B, Lehmann W, Abedini I, Blennow K, Jonsson M, Karlsson I, Sjogren M, Wallin A, Xilinas M, Gottfries CG. 2001. Treatment of Alzheimer's disease with clioquinol. Dement Geriatr Cogn Disord 12:408-414.
44. Reverter D, Sorimachi H, Bode W. 2001. The structure of calcium-free human m-calpain: implications for calcium activation and function. Trends Cardiovasc Med 11:222-229.
45. Roberts-Lewis JM, Savage MJ, Marcy VR, Pinsker LR, Siman R. 1994. Immunolocalization of calpain I-mediated spectrin degradation to vulnerable neurons in the ischemic gerbil brain. J Neurosci 14:3934-3944.
46. Rose CR, Konnerth A. 2001. Stores not just for storage intracellular calcium release and synaptic plasticity. Neuron 31:519-522.
47. Saatman KE, Murai H, Bartus RT, Smith DH, Hayward NJ, Perri BR, McIntosh TK. 1996. Calpain inhibitor AK295 attenuates motor and cognitive deficits following experimental brain injury in the rat. Proc Natl Acad Sci USA 93:3428-3433.
48. Saito K, Elce JS, Hamos JE, Nixon RA. 1993. Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration. Proc Natl Acad Sci USA 90:2628-2632.
49. Sattler R, Charlton MP, Hafner M, Tymianski M. 1998. Distinct influx pathways, not calcium load, determine neuronal vulnerability to calcium neurotoxicity. J Neurochem 71:2349-2364.
50. Sattler R, Tymianski M. 2000. Molecular mechanisms of calcium-dependent excitotoxicity. J Mol Med 78:3-13.
51. Seubert P, Lee K, Lynch G. 1989. Ischemia triggers NMDA receptor-linked cytoskeletal proteolysis in hippocampus. Brain Res 492:366-370.
52. Spigelman I, Tymianski M, Wallace CM, Carlen PL, Velumian AA. 1996. Modulation of hippocampal synaptic transmission by low concentrations of cell-permeant Ca2+ chelators: effects of Ca2+ affinity, chelator structure and binding kinetics. Neuroscience 75:559-572.
53. Squier MK, Miller AC, Malkinson AM, Cohen JJ. 1994. Calpain activation in apoptosis. J Cell Physiol 159:229-237.
54. Sternlicht MD, Werb Z. 2001. How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol 17:463-516.
55. Suh SW, Jensen KB, Jensen MS, Silva DS, Kesslak PJ, Danscher G, Frederickson C. Histochemically-reactive zinc in amyloid plaques, angiopath, and degenerating neurons of Alzheimer's diseased brains. J 2000. Brain Res 852:274-278.
56. Tolmasov M, Krakovsky M, Angel I, Kozak A. 1999. In E.A.C.P.T DP-b99: A novel membrane-targeted compound with a strong neuroprotective action in cerebral ischemia. (Abstract. Eilat, Israel.
57. Trowbridge JP, Walker M. 1991. The healing powers of chelation therapy. New Way of Life, Inc., CT.
58. Tsien RY. 1980. New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. Biochemistry 19:2396-2404.
59. Tsien RY. 1981. A non-disruptive technique for loading calcium buffers and indicators into cells. Nature 290:527-528.
60. Tymianski M, Wallace MC, Spigelman I, Uno M, Carlen PL, Tator CH, Charlton MP. 1993. Cell-permeant Ca2+ chelators reduce early excitotoxic and ischemic neuronal injury in vitro and in vivo. Neuron 11:221-235.
61. Ungersstedt U, Avemo A, Avemo E, Ljungber T, Rouge C. 1973. Animal models of Parkinsonism. Adv Biochem Psycopharmacol 9.
62. Viles JH, Cohen FE, Prusiner SB, Goodin DB, Wright PE, Dyson HJ. 1999. Copper binding to the prion protein: structural implications of four identical cooperative binding sites. Proc Natl Acad Sci USA 96:2042-2047.
63. Weiss JH, Sensi SL. 2000. Ca2+ permeable AMPA or kainate channels and selective neurodegeneration. Trends Neurosei 23:365-371.
64. Weiss JH, Sensi SL, Koh JY. 2000. Zn(2+): a novel ionic mediator of neural injury in brain disease. Trends Pharmacol Sci 21:395-401.
65. West AE, Chen WG, Dalva MB, Dolmetsch RE, Kornhauser JM, Shaywitz AJ, Takasu MA, Tao X, Greenberg ME. 2001. Calcium regulation of neuronal gene expression. Proc Natl Acad Sci USA 98:11024-11031.
66. White BC, Sullivan JM, DeGracia DJ, O'Neil BJ, Neumar RW, Grossman LI, Rafols JA, Krause GS. 2000. Brain ischemia and reperfusion: molecular mechanisms of neuronal injury. J Neurol Sci 179:1-33.
67. Yokota M, Tani E, Tsubuki S, Yamaura I, Nakagaki I, Hori S, Saido TC. 1999. Calpain inhibitor entrapped in liposome rescues ischemic neuronal damage. Brain Res 819:8-14.