The structure of calcium-free human m-calpain: Implications for calcium activation and function

Trends in Cardiovascular Medicine

Volumn 11, Issue 6, 2001, Pages 222-229

  Reverter, David ^a   Sorimachi, Hiroyuki ^a   Bode, Wolfram ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CALPAIN; CYSTEINE PROTEINASE;

APOPTOSIS; BINDING SITE; CALCIUM METABOLISM; CELL DIFFERENTIATION; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME STRUCTURE; GENE EXPRESSION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CALCIUM; CALPAIN; HUMANS; RATS;

EID: 0034769614     PISSN: 10501738     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1050-1738(01)00112-8     Document Type: Review

References (47)

1. Characterization of cDNA clones encoding a novel calcium-activated neutral proteinase from Schistosoma mansoni
2. Alscript; a tool to format multiple sequence alignments
3. Structure of a calpain Ca(2+)-binding domain reveals a novel EF-hand and Ca(2+)-induced conformational changes
4. Calpain; a protease in search of a function?
5. Roles of individual EF-hands in the activation of m-calpain by calcium
6. Autolysis, Ca2+ requirement, and heterodimer stability in m-calpain
7. Is calpain activity regulated by membranes and autolysis or by calcium and calpastatin?
8. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus
9. Calpain mutants with increased Ca2+ sensitivity and implications for the role of the C2-like domain III
10. Crystal structure of calpain reveals the structural basis for Ca(2+)-dependent protease activity and a novel mode of enzyme activation
11. The role of calcium activated neutral protease on myocardial cell injury in hypoxia
12. Molecular cloning of the cDNA for the large subunit of the high-Ca2+-requiring form of human Ca2+-activated neutral protease
13. Structure of papain refined at 1.65 A resolution
14. Calpain is a mediator of preservation-reperfusion injury in rat liver transplantation
15. MOLSCRIPT-A program to produce both detailed and schematic plots of protein structures
16. EF-hands reach out
17. Inhibition of proteolysis protects hippocampal neurons from ischemia
18. Crystal structure of calcium bound domain VI of calpain at 1.9 A resolution and its role in enzyme assembly, regulation, and inhibitor binding
19. Protective effect of the protease inhibitor leupeptin against myocardial stunning
20. Calpain inhibitor I reduces the activation of nuclear factor-κB and organ injury/dysfunction in hemorrhagic shock
21. Raster3D; photorealistic molecular graphics
22. Calcium-binding properties of human erythrocyte calpain
23. Nucleotide sequence of a cDNA coding for the small subunit of human calcium-dependent protease
24. Functional defects of a muscle-specific calpain, p94, caused by mutations associated with limb-girdle muscular dystrophy type 2A
25. Structure and physiology of calpain, an enigmatic protease
26. Role of phospholipids in the activation of Ca2+-dependent neutral proteinase of human erytrocytes
27. Protective effects of calpain inhibitors against neuronal damage caused by cytotoxic hypoxia in vitro and ischemia in vivo
28. Structural basis for possible calcium induced activation mechanisms of calpains
29. Calpainopathy-a survey of mutations and polymorphisms
30. C2-domains, structure and function of a universal Ca2+-binding domain
31. Positive regulation of mu-calpain action by polyphosphoinositides
32. Human low-Mr kininogen contains three copies of a cystatin sequence that are divergent in structure and in inhibitory activity for cysteine proteinases
33. On the size of the active site in proteases
34. Molecular cloning of a novel mammalian calcium-dependent protease distinct from both m- and mu-types. Specific expression of the mRNA in skeletal muscle
35. A novel tissue-specific calpain species expressed predominantly in the stomach comprises two alternative splicing products with and without Ca(2+)-binding domain
36. Structure and physiological function of calpains
37. The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium
38. A novel aspect of calpain activation
39. Calpain; novel family members, activation, and physiologic function
40. Preference of calcium-dependent interactions between calmodulin-like domains of calpain and calpastatin subdomains
41. Domain III of calpain is a Ca(2+) regulated phospholipid-binding domain
42. The pathogenic activation of calpain; a marker and mediator of cellular toxicity and disease states
43. Ca(2+) bridges the C2 membrane-binding domain of protein kinase Cα directly to phosphatidylserine
44. Functional properties of recombinant calpain I and of mutants lacking domains III and IV of the catalytic subunit
45. Calpain and caspase; can you tell me the difference?
46. An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective
47. Calpain inhibitor entrapped in liposome rescues ischemic neuronal damage