Calpain inhibitor entrapped in liposome rescues ischemic neuronal damage

Brain Research

Volumn 819, Issue 1-2, 1999, Pages 8-14

  Yokota, Masayuki ^a   Tani, Eiichi ^a   Tsubuki, Satoshi ^b   Yamaura, Ikuya ^a   Nakagaki, Ikuko ^a   Hori, Seiki ^a   Saido, Takaomi C ^b  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

^b NONE

Author keywords

Calpain; Calpain inhibitor; Hippocampus; Liposome; Transient forebrain cerebral ischemia

Indexed keywords

CALPASTATIN; FLUORESCEIN ISOTHIOCYANATE; FODRIN; LIPOSOME; N ACETYLLEUCYLLEUCYLNORLEUCINAL; PROTEASOME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; CYTOSKELETON; DOSE RESPONSE; ENZYME ACTIVATION; FOREBRAIN; GERBIL; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; INTRAVENOUS DRUG ADMINISTRATION; NERVE CELL DEGENERATION; NERVE CELL LESION; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION;

ANIMALS; BLOOD-BRAIN BARRIER; BLOTTING, WESTERN; CALPAIN; CARRIER PROTEINS; CELL DEATH; CYSTEINE PROTEINASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; FLUORESCEIN-5-ISOTHIOCYANATE; FLUORESCENT DYES; GERBILLINAE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; INJECTIONS, INTRAVENOUS; ISCHEMIC ATTACK, TRANSIENT; LEUPEPTINS; LIPOSOMES; MICROFILAMENT PROTEINS; MICROSCOPY, CONFOCAL; NEURONS; PROSENCEPHALON;

EID: 0033585887     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(98)01334-1     Document Type: Article

References (31)

1. Berridge M.J. Inositol triphosphate and calcium signaling. Nature. 361:1993;315-325.
2. Bi X., Chang V., Siman R., Tocco G., Baudry M. Regional distribution and time-course of calpain activation following kainate-induced seizure activity in adult rat brain. Brain Res. 726:1996;98-108.
3. Blomgren K., Amanda M., Bona E., Saido T.C., Karlsson J.O., Hagberg H. Degradation of fodrin and MAP2 after neonatal cerebral hypoxic-ischemia. Brain Res. 684:1995;136-142.
4. Chen J., Nagayama T., Jin K., Stetler R.A., Zhu R.L., Graham S.T., Simon R.P. Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia. J. Neurosci. 18:1998;4914-4928.
5. Coyle J.T., Puttfarcken P. Oxidative stress, glutamate, and neurodegenerative disorders. Science. 262:1993;670-689.
6. 1 cells. J. Biol. Chem. 270:1995;25115-25120.
7. Ghosh A., Greenberg M.E. Calcium signaling in neurons: molecular mechanisms and cellular consequences. Science. 268:1995;239-247.
8. Hong S.C., Goto Y., Lanzino G., Soleau S., Kassel N.F., Lee K.S. Neuroprotection with a calpain inhibitor in a model of focal transient forebrain cerebral ischemia. Stroke. 25:1994;663-669.
9. Imaizumi S., Woolworth V., Fishman R.A., Chan P.H. Liposome-entrapped superoxide dismutase reduces cerebral infarction in transient forebrain cerebral ischemia in rats. Stroke. 21:1990;1312-1317.
10. Kirino T. Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res. 239:1982;57-69.
11. Kirino T., Tamura A., Sano K. A reversible type of neuronal injury following ischemia in the gerbil hippocampus. Stroke. 17:1986;455-459.
12. Kitagawa K., Matsumoto M., Ohtsuki T., Tagaya M., Okabe T., Hata R., Ueda H., Handa N., Sobue K., Kamada T. The characteristics of blood-brain barrier in three different conditions - infarction, selective neuronal death and selective loss of presynaptic terminals - following transient forebrain cerebral ischemia. Acta Neuropathol. 84:1992;378-386.
13. Lee K.S., Frank S., Vanderklish P., Arai A., Lynch G. Inhibition of proteolysis protects hippocampal neurons from ischemia. Proc. Natl. Acad. Sci. USA. 88:1991;7233-7237.
14. Lipton S.A., Rosenberg P.A. Excitatory amino acids as a final common pathway for neurogenic disorders. N. Engl. J. Med. 330:1994;613-622.
15. Markgraf C.G., Velayo N.L., Johnson M.P., McCarty B.S., Medhi S., Koehl J.R., Chmielewski P.A., Linnik M.D. Six-hour window of opportunity for calpain inhibition in focal ischemia in rats. Stroke. 29:1998;152-158.
16. 2+ elevation induced by in vitro ischemia-like condition in hippocampal slices. Brain Res. 601:1993;103-110.
17. Neumar R.W., Hagle S.M., DeGracia D.J., Krause G.S., White B.C. Brain μ-calpain autolysis during global transient forebrain cerebral ischemia. J. Neurochem. 66:1996;421-424.
18. Pardridge W.M. Drug delivery to the brain. J. Cereb. Blood Flow Metab. 17:1997;713-731.
19. Pettigrew L.C., Holtz M.L., Craddock S.D., Minger S.L., Hall N., Geddes J.W. Microtubular proteolysis in focal transient forebrain cerebral ischemia. J. Cereb. Blood Flow Metab. 16:1996;1189-1202.
20. Rami A., Krieglstein J. Protective effects of calpain inhibitors against neuronal damage caused by cytotoxic hypoxia in vitro and ischemia in vivo. Brain Res. 609:1993;67-70.
21. Saido T.C., Nagao S., Shiramine M., Tsukaguchi M., Sorimachi H., Murofushi H., Tsuchiya T., Ito H., Suzuki K. Autolytic transition of μ-calpain upon activation as resolved by antibodies distinguishing between the pre- and post-autolysis forms. J. Biochem. 111:1992;81-86.
22. Saido T.C., Yokota M., Nagao S., Yamaura I., Tani E., Tsuchiya T., Suzuki K., Kawashima S. Spatial resolution of fodrin proteolysis in postischemic brain. J. Biol. Chem. 268:1993;25239-25243.
23. Saido T.C., Sorimachi H., Suzuki K. Calpain: new perspectives in molecular diversity and physiological-pathological involvement. FASEB J. 8:1994;814-822.
24. Schmidt-Kastner R., Freund T.F. Selective vulnerability of the hippocampus in brain ischemia. Neuroscience. 40:1991;599-636.
25. 2+ stores: activation and function. Trends Neurosci. 18:1995;299-306.
26. Stefanelli C., Bonavita F., Stanic I., Pignatti C., Farruggia G., Masotti L., Guarnieri C., Caldarera C.M. Inhibition of etoposide-induced apoptosis with peptide aldehyde inhibitors of proteasome. Biochem. J. 332:1998;661-665.
27. Szatkowski M., Attwell D. Triggering and execution of neuronal death in brain ischemia: two phases of glutamate release by different mechanisms. Trends Neurosci. 17:1994;359-365.
28. Trump B.F., Berezesky I.K. Calcium-mediated cell injury and cell death. FASEB J. 9:1995;219-228.
29. Wang K.K.W. Developing selective inhibitors of calpain. Trends Pharmacol. Sci. 11:1990;139-142.
30. Yan Y., Winograd E., Viel A., Cronin T., Harrison S.C., Branton D. Crystal structures of the repetitive segment of spectrin. Science. 262:1993;2027-2030.
31. Yokota M., Saido T.C., Tani E., Kawashima S., Suzuki K. Three distinct phases of fodrin proteolysis induced in postischemic hippocampus; involvement of calpain and unidentified protease. Stroke. 26:1995;1901-1907.