Anoxia-induced neuronal injury: Role of Na+ entry and Na+-dependent transport

Experimental Neurology

Volumn 146, Issue 2, 1997, Pages 403-413

  Chidekel, Aaron S ^a   Friedman, Jonathan E ^a   Haddad, Gabriel G ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMILORIDE; ION CHANNEL; SODIUM ION;

ANIMAL CELL; ANOXIA; ARTICLE; CONTROLLED STUDY; EMBRYO; NERVE CELL LESION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; SODIUM TRANSPORT;

EID: 0031214873     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1997.6544     Document Type: Article

References (40)

1. 1. Allen, D. G., and C. H. Orchard. 1987. Myocardial contractile function during ischemia and hypoxia. Circ. Res. 60: 153-168.
2. 2. Amoroso, S., S. Sensi, G. di Renzo, and L. Annunziato. 1993. Inhibition of the Na(+)-Ca++ exchanger enhances anoxia and glucopenia-induced [3H] aspartate release in hippocampal slices. J. Pharmacol. Exp. Ther. 264: 5-520.
3. 3. Anderson, S. E., E. Murphy, C. Steenbergen, R. London, and P. Cala. 1990. Na-H exchange in myocardium: Effects of hypoxia and acidification on Na and Ca. Am. J. Physiol. 259: C940-C948.
4. 4. Bastiaanse, E. M., D. E. Atsma, M. M. Kuijpers, and A. Van der Laarse. 1994. Simvastatin-sodium delays cell death of anoxic cardiomyocytes by inhibition of Na+/Ca2+ exchanger. FEBS Lett. 343: 151-154.
5. 5. Benveniste, H., J. Drejer, A. Schousboe, and N. H. Diemer. 1984. Elevation of extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J. Neurochem. 43: 1369-1374.
6. 6. Boening, J. A., I. S. Kass, J. E. Cottrell, and G. Chambers. 1989. The effect of blocking sodium influx on anoxic damage in the rat hippocampal slice. Neuroscience 33: 263-268.
7. 7. Brewer, G. J. et al. 1993. Optimized survival of hippocampal neurons in B27 supplemented Neurobasal, a new serum-free medium combination. J. Neurosci. Res. 35: 567-576.
8. 8. Cheng, P. M., and D. F. Donnelly. 1995. Relationship between changes of glomus cell current and neural response of rat carotid body. J. Neurophysiol. 74: 2077-2085.
9. +-dependent exchangers in anoxia-induced injury in rat neocortical neuronal culture. Am. J. Resp. Crit. Care Med. 512: A639.
10. 10. Choi, D. W. Ionic dependence of glutamate neurotoxicity in cortical cell culture. 1987. J. Neurosci. 7: 369-379.
11. 11. Choi, D. W., and S. M. Rothman. 1990. The role of Glutamate neurotoxicity in hypoxic-ischemic neuronal death. Annu. Rev. Neurosci. 13: 171-182.
12. 12. Cummins, T., C. Jiang, and G. G. Haddad. 1993. Human neocortical excitability is decreased during anoxia via sodium channel modulation. J. Clin. Invest. 91: 608-615.
13. 13. Cummins, T. R., D. Donnelly, and G. G. Haddad. 1991. Effect of metabolic inhibitors on the excitability of isolated hippocampal CA1 neurons: Developmental aspects. J. Neurophysiol. 66: 1471-1482.
14. 14. Dubinsky, J. M., and S. M. Rothman. 1991. Intracellular calcium concentrations during 'chemical hypoxia' and excitotoxic neuronal injury. J. Neurosci. 11: 2545-2551.
15. 15. Friedman, J. E., and G. G. Haddad. 1994a. Anoxia induces an increase in intracellular sodium in rat central neurons in vitro. Brain Res. 663: 329-334.
16. +. J. Neurosci. 13: 63-72.
17. 17. Friedman, J. E., and G. G. Haddad. 1994b. Removal of extracellular sodium prevents anoxia-induced injury in freshly dissociated rat CA1 hippocampal neurons. Brain Res. 641: 57-64.
18. 18. Friedman, J. E., A. S. Chidekel, E. J. Chow, and G. G. Haddad. 1995. Differential effects of anoxia and glutamate on cultured neocortical neurons. Soc. Neurosci. Abstr. 20: A7001.
19. 19. Haddad, G. G., and C. Jiang. 1993b. Mechanisms of anoxia-induced depolarization in brainstem neurons: in-vitro current and voltage clamp studies in the adult rat. Brain Res. 625: 261-268.
20. 2 deprivation in the central nervous system: On mechanisms of neuronal response, differential sensitivity and injury. Prog. Neurobiol. 40: 277-318.
21. + homeostasis in hypoglossal neurons during anoxia: intracellular and extracellular in-vitro studies. J. Physiol. 448: 697-708.
22. 22. Kay, A., and R. Wong. 1986. Isolation of neurons suitable for patch-clamping from adult mammalian central nervous systems. J. Neurosci. Methods 16: 227-238.
23. 23. Kleyman, T. R., and E. J. Cragoe. 1988. Amiloride and Its Analogs as Tools in the Study of Ion Transport. J. Membr. Biol. 105: 1-21.
24. 24. Macklis, J. D., and R. D. Madison. 1990. Progressive Incorporation of propidium iodide in cultured mouse neurons correlates with declining electrophysiologic status: A fluorescence scale of membrane integrity. J. Neurosci. Methods 31: 43-46.
25. 25. Martin, R. L., H. G. E. Lloyd, and A. I. Cowan. 1994. The early events of oxygen and glucose deprivation: Setting the scene for neuronal death? Trends Neurosci. 17: 251-257.
26. 26. Murphy, E., M. Perlman, R. E. London, and C. Steenbergen. 1991. Amiloride delays the ischemia-induced rise in cytosolic free calcium. Circ. Res. 68: 1250-1258.
27. 27. Piper, H., B. Siegmund, Y. Ladilov, and K. Schluter. 1993. Calcium and sodium control in hypoxic-reoxygenated cardiomyocytes. Basic Res. Cardiol. 88: 471-482.
28. + exchanger. J. Biol. Chem. 266: 2739-2745.
29. 29. Sasaki, D. T., S. E. Dumas, and E. G. Engleman. 1987. Discrimination of viable and non-viable cells using propidium iodide in two color immunofluorescence. Cytometry 8: 413-420.
30. i during metabolic inhibition. Am. J. Physiol. 268: H1239-H1248.
31. 31. Siesjo, B. Cell damage in the brain: A speculative synthesis. 1981. J. Cereb. Blood Flow Metab. 1: 155-185.
32. 32. Siesjo, B., and F. Bengtsson. 1989. Calcium fluxes, calcium antagonists, and calcium related pathology in brain ischemia, hypoglycemia and spreading depression: A unifying hypothesis. J. Cereb. Blood Flow Metab. 9: 127-140.
33. 33. Silver, I., and M. Erecinska. 1990. Intracellular and extracellular changes of [Ca2+] in hypoxia and ischemia in rat brain in vivo. J. Gen. Physiol. 95: 837-866.
34. 34. Spitzer, N. C., E. Olson, and X. Gu. 1995. Spontaneous calcium transients regulate neuronal plasticity in developing neurons. J. Neurobiol. 26: 316-324.
35. 35. Steenbergen, C., E. Murphy, L. Levy, and R. E. London. 1987. Elevation of cytosolic free calcium concentration early in myocardial ischemia in perfused rat heart. Circ. Res. 60: 700-707.
36. + channels and Na(+)-Ca2+ exchanger. J. Neurosci. 12: 430-439.
37. 37. Stys, P. K., S. G. Waxman, and B. R. Ransom. 1991a. Na(+)-Ca2+ exchanger mediates Ca2+ influx during anoxia in mammalian central nervous system white matter. Ann. Neural. 30: 375-380.
38. 38. Stys, P. K., S. G. Waxman, and B. R. Ransom. 1991b. Reverse operation of the Na(+)-Ca2+ exchanger mediates Ca2+ influx during anoxia in Mammalian CNS white matter. Ann. N.Y. Acad. Sci. 639: 328-332.
39. 2+-mediated injury in CNS white matter. Trends Neurosci. 14: 461-468.
40. 40. Young, R. S. K., M. J. During, D. F. Donnelly, W. J. Aquila, V. L. Perry, and G. G. Haddad. 1993. Effect of anoxia on excitatory amino acids in brain slices of rats and turtles: in vitro microdialysis. Am. J. Physiol 264: R716-R719.