Copper and prion disease

Brain Research Bulletin

Volumn 55, Issue 2, 2001, Pages 165-173

  Brown, David R ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Mouse; Neurodegeneration; Structure; Superoxide dismutase

Indexed keywords

AMYLOID; ANTIOXIDANT; COPPER; CUPRIZONE; MANGANESE; PRION PROTEIN; SUPEROXIDE DISMUTASE;

CELL SURFACE; CONFERENCE PAPER; COPPER METABOLISM; CREUTZFELDT JAKOB DISEASE; DEGENERATIVE DISEASE; FATAL FAMILIAL INSOMNIA; GERSTMANN STRAUSSLER SCHEINKER SYNDROME; HOMEOSTASIS; HUMAN; METAL BINDING; NERVE CELL; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; SCRAPIE; WASTING SYNDROME;

ANIMALS; BRAIN; COPPER; HUMANS; METALLOPROTEINS; NERVE DEGENERATION; OXIDATIVE STRESS; PRION DISEASES; PRIONS; PROTEIN ISOFORMS; SUPEROXIDE DISMUTASE;

EID: 0035872476     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0361-9230(01)00453-1     Document Type: Conference Paper

References (71)

1. Dramatic aggregation of Alzheimer aB by CuII is induced by conditions representing physiological acidosis
2. Identification of a protein that purifies with the scrapie prion
3. Amyloid plaques in spongiform encephalopathy of mule deer
4. Normal host prion protein necessary for scrapie-induced neurotoxicity
5. Mouse cortical cells lacking cellular PrP survive in culture with a neurotoxic PrP fragment
6. Role of microglia and host prion protein in neurotoxicity of a prion protein fragment
7. Different requirements for the neurotoxicity of fragments of PrP and β-amyloid
8. The cellular prion protein binds copper in vivo
9. Expression of prion protein in PC12 is enhanced by exposure to oxidative stress
10. Prion protein-deficient cells show altered response to oxidative stress due to decreased SOD-1 activity
11. Prion protein expression and superoxide dismutase activity
12. Effects of copper on survival of prion protein knockout neurones and glia
13. Prion protein peptide neurotoxicity can be mediated by astrocytes
14. Astrocytic glutamate uptake and prion protein expression
15. Prion protein expression aids cellular uptake and veratridine-induced release of copper
16. Normal prion protein has an activity like that of superoxide dismutase
17. Consequences of manganese replacement of copper for prion protein function and proteinase resistance
18. Functional and structural differences between the prion protein from two alleles prnpa and prnpb of mouse
19. Transmissions to mice indicate that "new variant" CJD is caused by the BSE agent
20. Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
21. Mice devoid of PrP are resistent to scarpie
22. Genetics and polymorphism of the mouse prion gene complex: Control of scrapie incubation time
23. Mass spectrometric identification of amino acid transformations during oxidation of peptides and proteins: Modifications of methionine and tyrosine
24. Pathological conformations of prion proteins
25. Evidence that the β-amyloid plaques of Alzheimer's disease represent the redox-silencing entombment of Aβ by zinc
26. Superoxide dismutases
27. 2, superoxide dismutases, and related matters
28. Prion protein amyloidosis
29. Role of microglia in neuronal cell death in prion disease
30. c at the neuromuscular junction
31. Immunolocalization of scrapie amyloid PrP27-30 in chronic wasting disease of Rocky Mountain elk and hybrids of captive mule deer and white tailed deer
32. The βA4 anyloid precursor protein binds to copper
33. Protease-resistant prion protein produced in vitro lacks detectable infectivity
34. Recombinant full-length murine prion protein mPrP23-231: Purification and spectroscopic characterization
35. Copper binding to the N-terminal tandem repeat regions of mammalian and avian prion protein
36. Copper binding to the N-terminal repeat region of mammalian and avian prion protein: Structural studies using synthetic peptides
37. Cu II potentiation of Alzheimer Aβ neurotoxicity
38. Zinc-induced Alzheimer's Aβ1-40 aggregation is mediated by conformational factors
39. Profiles of brain glycosidase activity in cuprisone-fed Syrian hamsters and in scrapie-affected mice, rats, Chinese hamsters and Syrian hamsters
40. A comparison of the biochemical changes induced in mouse brain by cuprizone toxicity and by scrapie infection
41. The effects of cuprizone toxicity on the incubation period of scrapie in mice
42. Human prion disease
43. Human copper-containing superoxide dismutase of high molecular weight
44. Epidemiological and experimental studies on a new incident of transmissible mink encephalopathy
45. Metal dependent a-helical formation promoted by glycine rich octapeptide region of prion protein
46. Raman spectroscopic study on the copperII binding mode of prion octapeptide and its pH dependence
47. Mice with gene targetted prion protein alterations show that Prnp Sinc and Prni are congruent
48. The amyloid precursor protein of Alzheimer's disease in the reduction of copper II to copper I
49. Evidence for catalytic dismutation of superoxide by cobaltII derivatives of bovine superoxide dismutase in aqueous solution as studied by pulse radiolysis
50. Tissue distribution of immunoreactive mouse extracellular superoxide dismutase
51. Histopathological similarities between scrapie and cuprizone toxicity in mice
52. Clinical and histological observations between cuprizone toxicity and scrapie in mice
53. Novel proteinaceous infectious particles cause scrapie
54. Molecular biology of prion disease
55. Human prion disease
56. Ecosystems supporting clusters of sporadic TSEs demonstrate excesses of the radical generating divalent cation manganese and deficiencies of antioxidant co-factors; Cu, Se, Fe, Zn. Does a foreign cation substitution at PrP's Cu domain initiate TSE?
57. Cellular prion protein localization in rodent and primate brain
58. Cobalt substitution studies on bovine erythrocyte superoxide dismutase: Evidence for a novel cobalt-superoxide dismutase derivative
59. A prion protein cycles between the cell surface and an endocytic compartment in cultured neuroblastoma cells
60. Differential release of cellular and scrapie prion protein from cellular membranes of phosphatidylinositol specific phospholipase C
61. Role of cytosolic copper, metallothionein and glutathione in copper toxicity in rat hepatoma tissue culture cells
62. Prion protein selectively binds copper II ions
63. The Wilson disease gene is a copper transporting ATP-ase with homology to the Menkes disease gene
64. Enzyme activities and sodium, potassium and copper concentrations in mouse brain and liver after cuprizone treatment in vivo
65. Copper binding to the prion protein: Structural implications of four identical cooperative binding sites
66. Strain-specific prion-protein conformation determined by metal ions
67. Paradoxical shortening of scrapie incubation times by expression of prion protein transgenes derived from long incubation period mice
68. Degeneration of skeletal muscle, peripheral nerves and the central nervous system in transgenic mice overexpressing wild-type prion proteins
69. Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice
70. Selective oxidation of methionine residues in prion proteins
71. Histopathology of enzootic ataxia in Sika deer Cervus nippon Temminck