Deciphering the role of Notch signaling in lymphopoiesis

Current Opinion in Immunology

Volumn 14, Issue 2, 2002, Pages 192-199

  Izon, David J ^a   Punt, Jennifer A ^b   Pear, Warren S ^c  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b HAVERFORD COLLEGE   (United States)

^c HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; LIGAND; NOTCH RECEPTOR;

ARTICLE; B LYMPHOCYTE DIFFERENTIATION; CELL FATE; CELL LINEAGE; HUMAN; LYMPHOCYTE FUNCTION; LYMPHOID CELL; LYMPHOPOIESIS; NONHUMAN; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STEM CELL; T CELL LEUKEMIA; T LYMPHOCYTE;

EID: 0036533339     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(02)00321-7     Document Type: Review

References (62)

1. Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling
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3. Notch signal transduction: A real rip and more
4. Notch signaling: From the outside in
5. Notch and presenilin: A proteolytic mechanism emerges
6. HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling
7. Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling
8. Fringe, Notch, and making developmental boundaries
9. Control of daughter cell fates during asymmetric division: Interaction of Numb and Notch
10. CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex
11. SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC to facilitate NotchIC function
12. MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors
13. Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members
14. Suppressor of hairless-independent events in Notch signaling imply novel pathway elements
15. Ligand-induced signaling in the absence of furin processing of Notch1
16. A Notch-independent activity of suppressor of hairless is required for normal mechanoreceptor physiology
17. Notch signaling in lymphocyte development
18. Notch1 expression in early lymphopoiesis influences B versus T lineage determination
19. Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation
20. Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells
21. Deficient T-cell fate specification in mice with an induced inactivation of Notch1
22. Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus
23. Subversion of the T/B lineage decision in the thymus by lunatic fringe-mediated inhibition of Notch-1
24. Fringe modulates Notch-ligand interactions
25. Ectopic expression of Lunatic Fringe leads to downregulation of Serrate-1 in the developing chick neural tube; analysis using in ovo electroporation transfection technique
26. Deltex1 redirects common lymphoid progenitors to the B cell lineage by antagonizing Notch1
27. A genetic analysis of deltex and its interaction with the Notch locus in Drosophila melanogaster
28. Deltex, a locus interacting with the neurogenic genes, Notch, Delta and Mastermind in Drosophila melanogaster
29. Notch inhibition of E47 supports the existence of a novel signaling pathway
30. Human Deltex is a conserved regulator of Notch signalling
31. Murine homologs of Deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis
32. Notch1 deficiency dissociates the intrathymic development of dendritic cells and T-cells
33. Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8 T-cell development
34. Arbiter of differentiation and death: Notch signaling meets apoptosis
35. MHC recognition in thymic development: Distinct, parallel pathways for survival and lineage commitment
36. A role for pref-1 and HES-1 in thymocyte development
37. The bHLH gene Hes1 is essential for expansion of early T-cell precursors
38. Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes
39. Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by Notch1
40. Notch signaling in leukemia
41. Modulated expression of Notch1 during thymocyte development
42. An activated form of Notch influences the choice between CD4 and CD8 T-cell lineages
43. Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength
44. The CD4/CD8 lineage decision: Integration of signalling pathways
45. Signal strength in thymic selection and lineage commitment
46. Lck activity controls CD4/CD8 T-cell lineage commitment
47. Lck transgene reveals a central role for Lck in the differentiation of CD4 SP thymocytes
48. The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate
49. Presenilin-dependent gamma-secretase activity modulates thymocyte development
50. Gamma-secretase inhibitors repress thymocyte development
51. Thymic emigration: Conveyor belts or lucky dips?
52. Notch inhibition of RAS signaling through MAP kinase phosphatase LIP-1 during C. elegans vulval development
53. Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment
54. Developmental regulation of bcl-2 expression in the thymus
55. Serrate1-induced Notch signalling regulates the decision between immunity and tolerance made by peripheral CD4(+) T-cells
56. T-cell regulation of peripheral tolerance and immunity: The potential role for Notch signalling
57. Notch-1 and Notch-2 exhibit unique patterns of expression in human B-lineage cells
58. Notch signaling suppresses IgH gene expression in chicken B cells: Implication in spatially restricted expression of Serrate2/Notch1 in the bursa of Fabricius
59. Cell cycle arrest and apoptosis induced by notch1 in B cells
60. E2A proteins: Essential regulators at multiple stages of B-cell development
61. Mapping precursor movement through the postnatal thymus reveals specific microenvironments supporting defined stages of early lymphoid development
62. Notch ligand-bearing thymic epithelial cells initiate and sustain Notch signaling in thymocytes independently of T cell receptor signaling