The SH2 and SH3 adapter Nck: A two-gene family and a linker between tyrosine kinases and multiple signaling networks

Histology and Histopathology

Volumn 15, Issue 3, 2000, Pages 947-955

  Li, W ^a   She, H ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Adapters; Signal transduction; Src homology domains; Tyrosine kinases

Indexed keywords

ACTIN; BINDING PROTEIN; COMPLEMENTARY DNA; PROTEIN TYROSINE KINASE; RAC PROTEIN; RAS PROTEIN;

CELL COMMUNICATION; GENE EXPRESSION; GENE TARGETING; HUMAN; MAMMAL; MITOGENESIS; MORPHOGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; REVIEW; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

ACTINS; ANIMALS; BINDING SITES; CYTOSKELETON; HUMANS; MITOGENS; ONCOGENE PROTEINS; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS;

MAMMALIA;

EID: 0033913657     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (84)

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2. PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase family members
3. Identification of a mouse p21Cdc42/Rac activated kinase
4. SH2 and SH3-containing adaptor proteins: Redundant or independent mediators of intracellular signal transduction
5. Interaction of the Nck adapter protein with p21-activated kinase (PAK1)
6. Identification of Grb4/Nck, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck
7. Participation of the SH2 and SH3 adapter Nckβ/Grb4/Nck2 in PDGF-stimulated, Rac1-dependent actin polymerization in NIH 3T3 fibroblasts
8. Nck family genes, chromosomal location, expression and signaling specificity
9. The 70kDa S6 kinase: Regulation of a kinase with multiple roles in mitogenic signaling
10. The 70kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac 1
11. A novel ligand for SH3 domains
12. Identification of a mouse p21(cdc42/rac)-activated kinase
13. The SH2 and SH3-containing Nck protein transforms mammalian fibroblasts in the absence of elevated phosphotyrosine levels
14. A Drosophila protein-tyrosine phosphatase associates with an adapter protein required for axonal guidance
15. Cloning and characterization of human protein kinase with homology to Ste20
16. The Drosophila SH2-SH3 adapter protein Dock is expressed in embryonic axons and facilitates synapse formation by the RP3 motoneuron
17. Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways
18. The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase PAK1
19. Drosophila photoreceptor axon guidance and targeting requires the dreadlocks SH2/SH3 adapter protein
20. Rho GTPases and the actin cytoskeleton
21. Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells
22. Binding of NCK to SOS and activation of ras-dependent gene expression
23. Chromosome locations of genes encoding human signal transduction adapter proteins Nck, Shc and Grb2
24. The tyrosine kinase negative regulator c-Cbl as a RING-TYPE, E2-dependent ubiquitin-protein ligase
25. RAC regulation of actin polymerization and proliferation by a pathway distinct from jun kinase
26. Molecular cloning of p125Nap1, a protein that associates with an SH3 domain of Nck
27. Hepatocyte growth factor induces activation of Nck and phospholipase C-γ in lung carcinoma cells
28. Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade
29. The Nck SH2/SH3 adaptor protein is present in the nucleus and associates with the nuclear protein SAM68
30. Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase
31. Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells
32. The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation
33. Nck, a melanoma cDNA encoding a cytoplasmic protein consisting of the src homology units SH2 and SH3
34. c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor
35. The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors
36. Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck
37. A casein kinase I activity is constitutively associated with Nck
38. Molecular cloning of a new member of the p21-Cdc42/Rac-activated kinase (PAK) family
39. A brain serine/threonine protein kinase activated by Cdc42 and Rac1
40. The GRB family of SH2 domain proteins
41. High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains
42. A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20
43. A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs
44. The Nck SH2/SH3 adaptor protein: A regulator of multiple intracellular signal transduction events
45. The SH2/SH3 domain containing protein Nck is recognized by certain anti-phospholipase C-γ1 antibodies, and its phosphorylation on tyrosine is stimula ted by platelet-derived growth factor and epidermal growth factor treatment
46. Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP
47. The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor alpha
48. Cbl-mediated negative regulation of platelet-derived growth factor receptor-dependent cell proliferation. A critical role for Cbl tyrosine kinase-binding domain
49. Activation of p70/p85 S6 kinase by a pathway independent of p21(ras)
50. Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor
51. PAK promotes morphological changes by acting upstream of Rac
52. Cloning, sequencing, and overexpression of SH2/SH3 adaptor protein Nck from mouse thymus
53. Phosphorylation of Nck in response to a variety of receptors, phorbol myristate and cyclic AMP
54. Protein modules and signaling networks
55. SH2 and SH3 domains: Protein modules that determine specificity of protein interaction in signal transduction
56. Isolation of a Nck-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling
57. Domain requirements for the Dock adapter protein in growth cone signaling
58. Abl protein-tyrosine kinase selects the Crk adaptor as a substrate using SH3-binding sites
59. Physical association between Src homology 3 elements and the protein product of the c-cbl proto-oncogene
60. Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains
61. Requirement of phospholipase Cγ, the tyrosine phosphatase syp and the adaptor proteins Shc and Nck for PDGF-induced DNA synthesis, evidence for the existence of Ras-dependent and Ras-independent pathways
62. Nck inhibits NGF and basic FGF induced PC12 cell differentiation via mitogen-activated protein kinase-independent pathway
63. The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly
64. Fibronectin-stimulated signaling from a focal adhesion kinase-c-src complex: Involvement of the Grb2, p130cas, and Nck adaptor proteins
65. Growth factor signaling by receptor tyrosine kinases
66. Human p21-activated kinase (PAK1) regulates actin organization of mammalian cells
67. Wiskott-Aldrich Syndrome protein (WASP) is associated with Grb2 and EGFR in living cells
68. Activation of the Abl tyrosine kinase in vivo by Src homology 3 domains from the Src homology 2/Src homology 3 adaptor Nck
69. SH2 domains recognize specific phosphopeptide sequence
70. Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase
71. NIK is a new Ste20-related kinase that binds Nck and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain
72. Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization
73. Differential inhibition of signaling pathways by dominant-negative SH2/SH3 adapter proteins
74. Expression of mutated Nck SH2/SH3 adaptor respecifies mesodermal cell fate in Xenopus laevis development
75. Induced direct binding of the adaptor protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth factor
76. Nck-2, a novel src homology2/3-containing adapter protein that interact with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways
77. Phospholipase C-y1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal
78. Localization of human AF2 and NCK genes and 13 other Notl-linking clones to chromosome 3 by fluorescence in situ hybridization
79. Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides
80. Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: Crystal structures of the complexed and peptide-free forms
81. The RING finger of c-Cbl mediates desensitization of the epidermal growth factor receptor
82. Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways
83. A Nck-Pak1 signaling module is required for T-cell receptor-mediated activation of NFAT, but not of JNK
84. Actin cytoskeleton: The Arp2/3 complex gets to the point