Dual stimulation of Ras/Mitogen-activated protein kinase and RhoA by cell adhesion to fibronectin supports growth factor-stimulated cell cycle progression

Journal of Cell Biology

Volumn 151, Issue 7, 2000, Pages 1413-1422

  Danen, Erik H J ^a,b   Sonneveld, Petra ^a   Sonnenberg, Arnoud ^a   Yamada, Kenneth M ^b  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

Author keywords

Cell adhesion; Fibronectin; G1 cell cycle; Integrin; Rho

Indexed keywords

CYCLIN D1; FIBRONECTIN; GROWTH FACTOR; GUANOSINE TRIPHOSPHATASE; INTEGRIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P21; RAS PROTEIN; RHO FACTOR; TRANSCRIPTION FACTOR E2F;

ARTICLE; CELL ADHESION; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL TRANSFORMATION; CYTOSKELETON; ENZYME ACTIVATION; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; REGULATORY MECHANISM;

3T3 CELLS; ACTINS; ANIMALS; CARRIER PROTEINS; CELL ADHESION; CELL CYCLE; CELL CYCLE PROTEINS; CULTURE MEDIA, SERUM-FREE; CYCLIN D1; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; CYTOSKELETON; DNA-BINDING PROTEINS; E2F TRANSCRIPTION FACTORS; ENZYME ACTIVATION; FIBRONECTINS; G1 PHASE; GROWTH SUBSTANCES; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; RAS GTPASE-ACTIVATING PROTEINS; RETINOBLASTOMA PROTEIN; RHOA GTP-BINDING PROTEIN; RNA, MESSENGER; S PHASE; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR DP1; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 0034739844     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.151.7.1413     Document Type: Article

References (62)

1. p21(WAF1/CIP1) is upregulated by the geranylgeranyltransferase I inhibitor GGTI-298 through a transforming growth factor
2. Integrin and cytoskeletal regulation of growth factor signaling to the MAP kinase pathway
3. Anchorage-dependent regulation of the mitogen-activated protein kinase cascade by growth factors is supported by a variety of integrin alpha chains
4. Anchorage-dependent cell cycle progression
5. Requirement for Rho in integrin signalling
6. Cell cycle regulation by the retinoblastoma family of growth inhibitory proteins
7. Cytoskeletal integrity is required throughout the mitogen stimulation phase of the cell cycle and mediates the anchorage-dependent expression of cyclin D1
8. Regulation of p21(cip1) expression by growth factors and the extracellular matrix reveals a role for transient ERK activity in G1 phase
9. Fibronectin matrix regulates activation of RHO and CDC42 GTPases and cell cycle progression
10. Focal adhesions, contractility, and signaling
11. Adhesion-dependent control of cyclin E/cdk2 activity and cell cycle progression in normal cells but not in Ha-ras transformed NRK cells
12. Integrin-mediated cell adhesion activates mitogen-activated protein kinases
13. pRB phosphorylation mutants reveal role of pRB in regulating S phase completion by a mechanism independent of E2F
14. Reduced expression of α5β1 integrin prevents spreading-dependent cell proliferation
15. Dependence of cyclin E-CDK2 kinase activity on cell anchorage
16. Cellular tumorigenicity in nude mice: Correlation with cell growth in semi-solid medium
17. Integrin signaling
18. Rac and Cdc42 are potent stimulators of E2F-dependent transcription capable of promoting retinoblastoma susceptibility gene product hyperphosphorylation
19. Geranylgeranylated Rho small GTPase(s) are essential for the degradation of p27Kip1 and facilitate the progression from G1 to S phase in growth-stimulated rat FRTL-5 cells
20. Integrin signaling and cell growth control
21. RhoA stimulates p27(Kip) degradation through its regulation of cyclin E/CDK2 activity
22. Integrins: Versatility, modulation, and signaling in cell adhesion
23. Coordinate, biphasic activation of p44 mitogen-activated protein kinase and S6 kinase by growth factors in hamster fibroblasts. Evidence for thrombin-induced signals different from phosphoinositide turnover and adenylylcyclase inhibition
24. Ras induces anchorage-independent growth by subverting multiple adhesion-regulated cell cycle events
25. A novel CCAAT-binding prorein necessary for adhesion-dependent cyclin A transcription at the G1/S boundary is sequestered by a retinoblastoma-like protein in G0
26. A temporal and biochemical link between growth factor-activated MAP kinases, cyclin D1 induction and cell cycle entry
27. The guanine nucleotide exchange factor Tiam1 affects neuronal morphology; opposing roles for the small GTPases Rac and Rho
28. Cyclin E-induced S phase without activation of the pRb/E2F pathway
29. Rho GTPases
30. Rapid methods for isolation of human plasma fibronectin
31. Transformation of mammalian cells by constitutively active MAP kinase kinase
32. Cdc42Hs, but not Rac1, inhibits serum-stimulated cell cycle progression at G1/S through a mechanism requiring p38/RK
33. Matrix/integrin interaction activates the mitogen-activated protein kinase, p44erk-1 and p42erk-2
34. An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1
35. Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1
36. Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation
37. G1 events and regulation of cell proliferation
38. Microinjection of recombinant p21Rho induces rapid changes in cell morphology
39. Differential effect of rac and cdc42 on p38 kinase activity and cell cycle progression of nonadherent primary mouse fibroblasts
40. Activation of Rac and Cdc42 by integrins mediates cell spreading
41. A role for Rho in Ras transformation
42. An essential role for Rac in Ras transformation
43. Cdc42 regulates anchorage-independent growth and is necessary for Ras transformation
44. Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton
45. Growth factor activation of MAP kinase requires cell adhesion
46. The small GTP-binding protein RhoA regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
47. α5β1 integrin controls cyclin D1 expression by sustaining mitogen-activated protein kinase activity in growth factor-treated cells
48. A hierarchy of ECM-mediated signalling regulates tissue-specific gene expression
49. Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase
50. Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site
51. Anchorage-dependent transcription of the cyclin A gene
52. Asparagine residue in the RhoA gene product is the modification site for botulinum ADP-ribosyltransferase
53. Dissociation of mitogen-activated protein kinase activation from p125 focal adhesion kinase tyrosine phosphorylation in Swiss 3T3 cells stimulated by bombesin, lysophosphatidic acid, and platelet-derived growth factor
54. Integrins and their ligands
55. Regulation of transcription by MAP kinase cascades
56. Integrin alpha 5 beta 1 expression negatively regulates cell growth: Reversal by attachment to fibronectin
57. Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase
58. Ras-stimulated extracellular signal-related kinase 1 and Rho activities coordinate platelet-derived growth factor-induced G1 progression through the independent regulation of cyclin D1 and p27
59. Integrin signaling
60. Integrin-dependent activation of MAP kinase: A link to shape-dependent cell proliferation
61. Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein