α5β1 Integrin controls cyclin D1 expression by sustaining mitogen- activated protein kinase activity in growth factor-treated cells

Molecular Biology of the Cell

Volumn 10, Issue 10, 1999, Pages 3197-3204

  Roovers, Kristin ^a   Davey, Gabriela ^a,b   Zhu, Xiaoyun ^c   Bottazzi, Maria Elena ^a   Assoian, Richard K ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; INTEGRIN; MITOGEN ACTIVATED PROTEIN KINASE; FIBRONECTIN; FIBRONECTIN RECEPTOR; GROWTH PROMOTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN TYROSINE KINASE;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL SUSPENSION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REGULATION; MONOLAYER CULTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANIMAL; CELL CYCLE; CELL DIVISION; CELL STRAIN 3T3; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; FLUORESCENT ANTIBODY TECHNIQUE; GENETIC TRANSFECTION; HUMAN; METABOLISM; MOUSE; PHOSPHORYLATION;

ANIMALIA;

3T3 CELLS; ANIMALS; CELL ADHESION; CELL CYCLE; CELL DIVISION; CYCLIN D1; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; FIBRONECTINS; FLUORESCENT ANTIBODY TECHNIQUE; GROWTH SUBSTANCES; HUMANS; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; PHOSPHORYLATION; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, FIBRONECTIN; TRANSFECTION;

EID: 0032589393     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.10.10.3197     Document Type: Article

References (33)

1. ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions. J. Biol. Chem. 270, 23589-23597.
2. Aplin, E.A., and Juliano, R.L. (1999). Integrin and cytoskeletal regulation of growth factor signaling to the MAP kinase pathway. J. Cell Sci. 112, 695-706.
3. Böhmer, R.M., Scharf E., and Assoian R.K. (1996). Cytoskeletal integrity is required throughout the mitogen stimulation phase of the cell cycle and mediates the anchorage-dependent expression of cyclin D1. Mo1. Biol. Cell 7, 101-111.
4. Brugarolas, J., Bronson, R.T., and Jacks, T. (1998). p21 is a critical CDK2 regulator essential for proliferation control in Rb-deficient cells. J. Cell Sci. 141, 503-514.
5. Day, M.L., Foster, R.G., Day, K.C., Zhao, X., Humphrey, P., Swanson, P., Postigo, A.A., Zhang, S.H., and Dean, D.C. (1997). Cell anchorage regulates apoptosis through the retinoblastoma tumor suppressor/E2F pathway. J. Biol. Chem. 272, 8125-8128.
6. Eliceiri, B.P., Klemke, R., Stromblad, S., and Cheresh, D.A. (1998). Integrin αvβ3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis. J. Cell Biol. 140, 1255-1263.
7. Giancotti, F.G. (1997). Integrin signaling: specificity and control of cell survival and cell cycle progression. Curr. Opin. Cell Biol. 9, 691-700.
8. Howe, A., Aplin, A.E., Alahari, S.K., and Juliano, R.L. (1998). Integrin signaling and cell growth control. Curr. Opin. Cell Biol. 10, 220-231.
9. Kip1, and cell cycle progression in human capillary endothelial cells by cell shape and cytoskeletal tension. Mol. Biol. Cell 9, 3179-3193.
10. Hunter, T., and Pines, J. (1994). Cyclins and cancer II: cyclin D and CDK inhibitors come of age. Cell 79, 573-582.
11. Kerkhoff, E., and Rapp, U.R. (1997). Induction of cell proliferation in quiescent NIH-3T3 cells by oncogenic c-Raf-1. Mol. Cell. Biol. 17, 2576-2586.
12. MAPK pathway. J. Biol. Chem. 272, 20608-20616.
13. Le Gall, M., Grall, D., Chambard, J.-C., Pouysségur, J., and Van Obberghen-Schilling, E. (1998). An anchorage-dependent signal distinct from P42/44 MAP kinase activation is required for cell cycle progression. Oncogene 17, 1271-1277.
14. Lin, T.H., Chen, Q., Howe, A., and Juliano, R.L. (1997). Cell anchorage permits efficient signal transduction between Ras and its downstream kinases. J. Biol. Chem. 272, 8849-8852.
15. Ohtsubo, M., Theodoras, A.M., Schumacher, J., Roberts, J.M., and Pagano, M. (1995). Human cyclin E, a nuclear protein essential for G1-to-S phase transition. Mol. Cell. Biol. 35, 2612-2624.
16. mapk (ERK1) by growth factors: correlation between late phase activation and mitogenicity. Mol. Endocrinol. 6, 845-854.
17. Miyamoto S., Teramoto, H., Gutkind, J.S., and Yamada, K.M. (1996). Integrins can collaborate with growth factors for phosphorylarion of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors. J. Cell Biol. 135, 1633-1642.
18. Moro, L., Venturino, M., Bozzo, C., Silengo, L., Altruda, F., Beguinot, L., Tarone, G., and Defilippi, P. (1998). Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion-dependent cell survival. EMBO J. 17, 6622-6632.
19. Radeva, G., Petrocelli, T., Behrend, E., Leung-Hagesteijn, C., Filmus, J., Slingerland, J., and Dedhar, S. (1997). Overexpression of the integrin-linked kinase promotes anchorage-independent cell cycle progression. J. Biol. Chem. 272, 13937-13944.
20. Renshaw, M.W., Ren, X.-D., and Schwartz, M.A. (1997). Growth factor activation of MAP kinase requires cell adhesion. EMBO J. 16, 5592-5599.
21. Resnitzky, D. (1997). Ectopic expression of cyclin D1 but not cyclin E induces anchorage-independent cell cycle progression. Mol. Cell Biol. 17, 5640-5647.
22. Schlaepfer, D.D., and Hunter, T. (1998). Integrin signaling and tyrosine phosphorylation: just the FAKs? Trends Cell Biol. 8, 151-157.
23. Schwartz, M.A., Schaller, M.D., and Ginsberg, M.H. (1995). Integrins: emerging paradigms of signal transduction. Annu. Rev. Cell Dev. Biol. 11, 549-599.
24. Cip1. Mol. Cell. Biol. 17, 5588-5597.
25. Sherr, C.J. (1994). G1 phase progression: cycling on cue. Cell 79, 551-555.
26. Sherr, C.J., and Roberts, J.R. (1995). Inhibitors of mammalian cyclin-dependent kinases. Genes & Dev. 9, 1149-1163.
27. Short, S.M., Talbott, G.A., and Juliano, R.L. (1998). Integrin-mediated signaling events in human endothelial cells. Mol. Biol. Cell 9, 1969-1980.
28. Weber, J.D., Raben, D.M., Phillips, P.J., and Baldassare, J.J. (1997). Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase. Biochem. J. 326, 61-68.
29. Weinberg, R. (1995). The retinoblastoma protein and cell cycle control. Cell 81, 323-330.
30. Cip1. Mol. Cell. Biol. 17, 5598-5611.
31. Zhu, X., and Assoian, R.K. (1995). Integrin-dependent activation of MAP kinase: a link to shape-dependent cell proliferation. Mol. Biol. Cell 6, 273-282.
32. Zhu X., Ohtsubo, M., Böhmer, R.M., Roberts, J.M., and Assoian, R.K. (1996). Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein. J. Cell Biol. 133, 391-403.
33. Zhu, X., Roovers, K., Davey, G., and Assoian, R.K. (1999). Methods for analysis of adhesion-dependent cell cycle progression. In: Signaling through Cell Adhesion Molecules, ed. J.-L. Guan, Boca Raton, FL: CRC Press, 129-140.