The determination and use of optimized protease substrates in drug discovery and development

Current Pharmaceutical Design

Volumn 8, Issue 28, 2002, Pages 2559-2581

  Richardson, Paul L ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Context dependent library; Positional scanning library; Protease assay; Protease inhibitor; Protease phage display; Protease substrate library

Indexed keywords

ACYLTRANSFERASE; ANTICOAGULANT AGENT; ASPARTIC PROTEINASE INHIBITOR; BESTATIN; CATHEPSIN B; CHYMOTRYPSIN; COUMARIN DERIVATIVE; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; DIPEPTIDYL PEPTIDASE IV; DOXORUBICIN; DOXORUBICIN DERIVATIVE; ELASTASE; GELATINASE B; INSULIN; INTERSTITIAL COLLAGENASE; LEUPEPTIN; PEPSTATIN; PEPTIDE LIBRARY; PHENANTHROLINE DERIVATIVE; PLASMIN; PROSTATE SPECIFIC ANTIGEN; PROTEINASE; PROTEINASE INHIBITOR; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR; THROMBIN; TRYPSIN; UNINDEXED DRUG; UROKINASE;

AMINO ACID SYNTHESIS; ANTINEOPLASTIC ACTIVITY; BACTERIOPHAGE; BETA CHAIN; BLOOD CLOT LYSIS; CARBOXY TERMINAL SEQUENCE; CHEMICAL BOND; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG SCREENING; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; HUMAN; HYDROLYSIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOUSE; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN DEGRADATION; RETROVIRUS; REVIEW; SEQUENCE ANALYSIS;

ANIMALS; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DELIVERY SYSTEMS; ENDOPEPTIDASES; HUMANS; PEPTIDE LIBRARY; SEQUENCE ANALYSIS, PROTEIN; SUBSTRATE SPECIFICITY; TECHNOLOGY, PHARMACEUTICAL;

EID: 0036430140     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/1381612023392630     Document Type: Review

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