Optimal subsite occupancy and design of a selective inhibitor of urokinase

Journal of Biological Chemistry

Volumn 272, Issue 33, 1997, Pages 20456-20462

  Ke, Song Hua ^a   Coombs, Gary S ^b   Tachias, Kathy ^a   Corey, David R ^b,c   Madison, Edwin L ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TISSUE PLASMINOGEN ACTIVATOR; UROKINASE;

AMINO ACID SEQUENCE; ARTICLE; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

BACTERIOPHAGES; DRUG DESIGN; HUMANS; PEPTIDES; PLASMINOGEN ACTIVATOR INHIBITOR 1; SERINE PROTEINASE INHIBITORS; URINARY PLASMINOGEN ACTIVATOR;

EID: 0030878999     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.33.20456     Document Type: Article

References (51)

1. Roberts, H. R., and Tabares, A. H. (1995) in Molecular Basis of Thrombosis and Hemostasis (High, K. A., Roberts, H. R., eds) pp. 35-50, Marcel Dekker, New York
2. Castellino, F. J. (1995) in Molecular Basis of Thrombosis and Hemostasis (High, K. A., Roberts, H. R., eds) pp. 495-515, Marcel Dekker, New York
3. Collen, D., and Lijnen, H. R. (1991) Blood 78, 3114-3124
4. Madison, E. L. (1994) Fibrinolysis 8, Suppl. 1, 221-236
5. Carmeliet, P., Schoonjans, L., Kieckens, L., Ream, B., Degen, J., Bronson, R., De Vos, R., van den Oord, J. J., Collen, D., and Mulligan, R. C. (1994) Nature 368, 419-424
6. Carmeliet, P., and Collen, D. (1996) Fibrinolysis 10, 195-213
7. Spraggon, G., Phillips, C., Nowak, U. K., Ponting, C. P., Saunders, D., Dobson, C. M., Stuart, D. I., and Jones, E. Y. (1995) Structure 3, 681-691
8. Lamba, B., Bauer, M., Huber, R., Fischer, S., Rudolph, R., Kohnert, U., and Bode, W. (1996) J. Mol. Biol. 258, 117-135
9. Madison, E. L., Coombs, G. S., and Corey, D. R. (1995) J. Biol. Chem. 270, 7558-7562
10. Coombs, G. S., Dang, A. T., Madison, E. L., and Corey, D. R. (1996) J. Biol. Chem. 271, 4461-4467
11. Ke, S.-H., Coombs, G. S., Tachias, K., Navre, M., Corey, D. R., and Madison, E. L. (1997) J. Biol. Chem. 272, 16603-16609
12. Danø, K., Andreason, P. A., Grondahl-Hansen, J., Kristensen, P., Nielsen, L. S. and Skriver, L. (1985) Adv. Cancer Res. 44, 139-266
13. Tsirka, S. E., Gualandris, A., Amaral, D. G., and Strickland, S. (1995) Nature 377, 340-344
14. Fukudome, K., and Esmon, C. T. (1994) J. Biol. Chem. 269, 26486-26491
15. Min, H. Y., Doyle L. V., Vitt, C. L., Zandonella, C. L., Stratton-Thomas, J. R., Shuman, M. A., and Rosenberg, S. (1996) Cancer Res. 56, 2428-2433
16. Seeds, N. W., Williams, B. L., and Bickford, P. C. (1995) Science 270, 1992-1994
17. Ossowski, L. (1988) Cell 52, 321-328
18. Shapiro, R. L., Duquette, J. G., Roses, D. F., Nunes, I., Harris, M. N., Kamino, H., Wilson, E. L., and Rifkin, D. B. (1996) Cancer Res. 56, 3597-3604
19. Ossowski, L., and Reich, E. (1983) Cell 35, 611-619
20. Hearing, V. J., Law, L. W., Corti, A., Appella, E., and Blasi, F. (1988) Cancer Res. 48, 1270-1278
21. Brünner, N., Høyer-Hansen, G., Rømer, J., Ellis, V., Holst-Hansen, C., Spang-Thomsen, M., and Danø, K. (1992) Proc. Am. Assoc. Cancer Res. 33, 61
22. Duffy, M. J., O'Grady, P., Devaney, D., O'Siorain, L., Fennelly, J. J., and Lijnen, H. J. (1988) Cancer 62, 531-533
23. Jänicke, F., Schmitt, M., Hafter, R., Hollrieder, A., Babic, R., Ulm, K., Gössner, W., and Graeff, H. (1990) Fibrinolysis 4, 69-78
24. Duffy, M. J. (1993) Fibrinolysis 7, 295-302
25. Matthews D. J., and Wells, J. A. (1993) Science 260, 1113-1117
26. Smith, M. M., Shi, L., and Navre, M. (1995) J. Biol. Chem. 270, 6440-6449
27. Loskutoff, D. J. (1993) J. Clin. Invest. 92, 2563
28. van Meijer M., and Pannekoek, H. (1995) Fibrinolysis 9, 263-276
29. Jameson, G. W., Roberts, D. V., Adams, R. W., Kyle, S. A., and Ellmore, D. T. (1973) Biochem. J. 131, 107-117
30. Urano, T., Urano, S., and Castellino, F. J. (1988) Biochem. Biophys. Res. Commun. 150, 45-51
31. Ding, L., Coombs, G. S., Strandberg, L., Navre, M., Corey, D. R., and Madison, E. L. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 7627-7631
32. Alpert, A. J. (1990) J. Chromatogr. 499, 177-196
33. Taylor, J. R. (1982) An Introduction to Error Analysis: The Study of Uncertainties in Physical Measurements, University Science Books, Mill Valley, CA
34. Tucker, H. M., Mottonen, J., Goldsmith, E. J., and Gerard, R. D. (1995) Nat. Struct. Biol. 2, 442-445
35. Zoller, M. J., and Smith, M. (1984) DNA 3, 479-488
36. Kunkel, T. A. (1985) Proc. Natl. Acad. Sci. U. S. A. 82, 488-492
37. Sancho, E., Tonge, D. W., Hockney, R. C., and Booth, N. A. (1994) Eur. J. Biochem. 224, 125-134
38. Chase, T., and Shaw, E. (1967) Biochem. Biophys. Res. Commun. 29, 508-514
39. Olson S. T., Bock, P. E., Kvassman, J., Shore, J. D., Lawrence, D. A., Ginsburg, D., and Björk, I. (1995) J. Biol. Chem. 270, 30007-30017
40. Holmes, W. E., Lijnen, H. R., and Collen, D. (1987) Biochemistry 26, 5133-5140
41. Beatty, K., Bieth, J., and Travis, J. (1980) J. Biol. Chem. 255, 3931-3934
42. Madison, E. L., Goldsmith, E. J., Gerard, R. D., Gething, M. J., Sambrook, J. F., and Bassel-Duby, R. S. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 3530-3533
43. Madison, E. L., and Sambrook, J. F. (1993) Methods Enzymol. 223, 249-271
44. Bode, W., Turk, D., and Karshikov, A. (1992) Protein Sci. 1, 426-471
45. Huber, R., and Bode, W. (1978) Acc. Chem. Res. 11, 114-122
46. Freer, S. T., Kraut, J., Robertus, J. D., Wright, H. T., and Xuong, N. H. (1970) Biochemistry 9, 1997-2009
47. Fehlhammer, H., Bode, W., and Huber, R. (1977) J. Mol. Biol. 111, 415-438
48. Madison, E. L., Goldsmith, E. J., Gerard, R. D., Gething, M.-J., and Sambrook, J. F. (1989) Nature 339, 721-724
49. Madison, E. L., Goldsmith, E. J., Gething, M. J., Sambrook, J. F., and Gerard, R. D. (1990) J. Biol. Chem. 265, 21423-21426
50. Adams, D. S., Griffin, L. A., Nachajko, W. R., Reddy, V. B., and Wei, C.-M. (1991) J. Biol. Chem. 266, 8476-8482
51. Baggio, R., Shi, Y.-Q., Wu, Y.-Q., and Abeles, R. H. (1996) Biochemistry 35, 3551-3553