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Volumn 191, Issue 11, 2000, Pages 1819-1828

Assessment of caspase activities in intact apoptotic thymocytes using cell-permeable fluorogenic caspase substrates

Author keywords

Apoptosis; Caspase; Lymphocyte; PhiPhiLux(TM); Thymocyte

Indexed keywords

CASPASE; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; INTERLEUKIN 1BETA CONVERTING ENZYME;

EID: 0034608386     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.191.11.1819     Document Type: Article
Times cited : (143)

References (36)
  • 1
    • 0027525104 scopus 로고
    • The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme
    • Yuan, J., S. Shaham, S. Ledoux, H.M. Ellis, and H.R. Horvitz. 1993. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme. Cell. 75:641-652.
    • (1993) Cell , vol.75 , pp. 641-652
    • Yuan, J.1    Shaham, S.2    Ledoux, S.3    Ellis, H.M.4    Horvitz, H.R.5
  • 3
    • 0033573020 scopus 로고    scopus 로고
    • Caspase-9 and APAF-1 form an active holoenzyme
    • Rodriguez, J., and Y. Lazebnik. 1999. Caspase-9 and APAF-1 form an active holoenzyme. Genes Dev. 13:3179-3184.
    • (1999) Genes Dev. , vol.13 , pp. 3179-3184
    • Rodriguez, J.1    Lazebnik, Y.2
  • 4
    • 0029787268 scopus 로고    scopus 로고
    • Molecular ordering of apoptotic mammalian CED-3/ ICE-like proteases
    • Orth, K., K. O'Rourke, G.S. Salvesen, and V.M. Dixit. 1996. Molecular ordering of apoptotic mammalian CED-3/ ICE-like proteases. J. Biol. Chem. 271:20977-20980.
    • (1996) J. Biol. Chem. , vol.271 , pp. 20977-20980
    • Orth, K.1    O'Rourke, K.2    Salvesen, G.S.3    Dixit, V.M.4
  • 6
    • 0032536519 scopus 로고    scopus 로고
    • Caspases are activated in a branched protease cascade and control distinct downstream processes in fas-induced apoptosis
    • Hirata, H., A. Takahashi, S. Kobayashi, S. Yonehara, H. Sawai, T. Okazaki, K. Yamamoto, and M. Sasada. 1998. Caspases are activated in a branched protease cascade and control distinct downstream processes in fas-induced apoptosis. J. Exp. Med. 187:587-600.
    • (1998) J. Exp. Med. , vol.187 , pp. 587-600
    • Hirata, H.1    Takahashi, A.2    Kobayashi, S.3    Yonehara, S.4    Sawai, H.5    Okazaki, T.6    Yamamoto, K.7    Sasada, M.8
  • 8
    • 0032472329 scopus 로고    scopus 로고
    • Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization
    • Bossy-Wetzel, E., D.D. Newmeyer, and D.R. Green. 1998. Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization. EMBO (Eur. Mol. Biol. Organ.) J. 17:37-49.
    • (1998) EMBO (Eur. Mol. Biol. Organ.) J. , vol.17 , pp. 37-49
    • Bossy-Wetzel, E.1    Newmeyer, D.D.2    Green, D.R.3
  • 12
    • 0033522391 scopus 로고    scopus 로고
    • Conformation of the Bax C-terminus regulates subcellular location and cell death
    • Nechushtan, A., C.L. Smith, Y.T. Hsu, and R.J. Youle. 1999. Conformation of the Bax C-terminus regulates subcellular location and cell death. EMBO (Eur. Mol. Biol. Organ.) J. 18:2330-2341.
    • (1999) EMBO (Eur. Mol. Biol. Organ.) J. , vol.18 , pp. 2330-2341
    • Nechushtan, A.1    Smith, C.L.2    Hsu, Y.T.3    Youle, R.J.4
  • 13
    • 0030918305 scopus 로고    scopus 로고
    • Design of profluorescent protease substrates guided by exciton theory
    • Packard, B.Z., D.D. Toptygin, A. Komoriya, and L. Brand. 1997. Design of profluorescent protease substrates guided by exciton theory. Methods Enzymol. 278:15-23.
    • (1997) Methods Enzymol. , vol.278 , pp. 15-23
    • Packard, B.Z.1    Toptygin, D.D.2    Komoriya, A.3    Brand, L.4
  • 14
    • 0029910914 scopus 로고    scopus 로고
    • Profluorescent protease substrates: Intramolecular dimers described by the exciton model
    • Packard, B.Z., D.D. Toptygin, A. Komoriya, and L. Brand. 1996. Profluorescent protease substrates: intramolecular dimers described by the exciton model. Proc. Natl. Acad. Sci. USA. 93:11640-11645.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 11640-11645
    • Packard, B.Z.1    Toptygin, D.D.2    Komoriya, A.3    Brand, L.4
  • 15
    • 0030773630 scopus 로고    scopus 로고
    • Characterization of fluorescence quenching in bifluorophoric protease substrates
    • Packard, B.Z., D.D. Toptygin, A. Komoriya, and L. Brand. 1997. Characterization of fluorescence quenching in bifluorophoric protease substrates. Biophys. Chem. 67:167-176.
    • (1997) Biophys. Chem. , vol.67 , pp. 167-176
    • Packard, B.Z.1    Toptygin, D.D.2    Komoriya, A.3    Brand, L.4
  • 16
    • 0031673049 scopus 로고    scopus 로고
    • Intramolecular resonance dipole-dipole interactions in a protease substrate
    • Packard, B.Z., D.D. Toptygin, A. Komoriya, and L. Brand. 1998. Intramolecular resonance dipole-dipole interactions in a protease substrate. J. Phys. Chem. B. 102:752-758.
    • (1998) J. Phys. Chem. B. , vol.102 , pp. 752-758
    • Packard, B.Z.1    Toptygin, D.D.2    Komoriya, A.3    Brand, L.4
  • 19
    • 0032546387 scopus 로고    scopus 로고
    • Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1
    • Zhang, J., D. Cado, A. Chen, N.H. Kabra, and A. Winoto. 1998. Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1. Nature. 392:296-300.
    • (1998) Nature , vol.392 , pp. 296-300
    • Zhang, J.1    Cado, D.2    Chen, A.3    Kabra, N.H.4    Winoto, A.5
  • 21
    • 0029853199 scopus 로고    scopus 로고
    • Systemic injection of a tripeptide inhibits the intracellular activation of CPP32-like proteases in vivo and fully protects mice against Fas-mediated fulminant liver destruction and death
    • Rodriguez, I., K. Matsuura, C. Ody, S. Nagata, and P. Vassalli. 1996. Systemic injection of a tripeptide inhibits the intracellular activation of CPP32-like proteases in vivo and fully protects mice against Fas-mediated fulminant liver destruction and death. J. Exp. Med. 184:2067-2072.
    • (1996) J. Exp. Med. , vol.184 , pp. 2067-2072
    • Rodriguez, I.1    Matsuura, K.2    Ody, C.3    Nagata, S.4    Vassalli, P.5
  • 23
    • 0029978182 scopus 로고    scopus 로고
    • Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis
    • Enari, M., R.V. Talanian, W.W. Wong, and S. Nagata. 1996. Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis. Nature. 380:723-726.
    • (1996) Nature , vol.380 , pp. 723-726
    • Enari, M.1    Talanian, R.V.2    Wong, W.W.3    Nagata, S.4
  • 25
    • 0028891783 scopus 로고
    • Apoptosis, oncosis, and necrosis. An overview of cell death
    • Majno, G., and I. Joris. 1995. Apoptosis, oncosis, and necrosis. An overview of cell death. Am. J. Pathol. 146:3-15.
    • (1995) Am. J. Pathol. , vol.146 , pp. 3-15
    • Majno, G.1    Joris, I.2
  • 26
    • 0030472889 scopus 로고    scopus 로고
    • Different ICE-family protease requirements for the apoptotic death of T lymphocytes triggered by diverse stimuli
    • Sarin, A., M.-L. Wu, and P.A. Henkart. 1996. Different ICE-family protease requirements for the apoptotic death of T lymphocytes triggered by diverse stimuli. J. Exp. Med. 184: 2445-2450.
    • (1996) J. Exp. Med. , vol.184 , pp. 2445-2450
    • Sarin, A.1    Wu, M.-L.2    Henkart, P.A.3
  • 27
    • 0001582524 scopus 로고    scopus 로고
    • Structural characteristics of fluorophores which form intramolecular H-type dimers ina protease substrate
    • Packard, B.Z., A. Komoriya, D.D. Toptygin, and L. Brand. 1997. Structural characteristics of fluorophores which form intramolecular H-type dimers ina protease substrate. J. Phys. Chem. B. 101:5070-5074.
    • (1997) J. Phys. Chem. B. , vol.101 , pp. 5070-5074
    • Packard, B.Z.1    Komoriya, A.2    Toptygin, D.D.3    Brand, L.4
  • 28
    • 0000958037 scopus 로고    scopus 로고
    • Intramolecular excitonic dimers in protease substrates: Modification of the backbone moiety to probe the H-dimer structure
    • Packard, B.Z., A. Komoriya, V. Nanda, and L. Brand. 1998. Intramolecular excitonic dimers in protease substrates: modification of the backbone moiety to probe the H-dimer structure. J. Phys. Chem. B. 102:1820-1827.
    • (1998) J. Phys. Chem. B. , vol.102 , pp. 1820-1827
    • Packard, B.Z.1    Komoriya, A.2    Nanda, V.3    Brand, L.4
  • 29
    • 0033515888 scopus 로고    scopus 로고
    • Complexity in biological signaling systems
    • Weng, G., U.S. Bhalla, and R. Iyengar. 1999. Complexity in biological signaling systems. Science. 284:92-96.
    • (1999) Science , vol.284 , pp. 92-96
    • Weng, G.1    Bhalla, U.S.2    Iyengar, R.3
  • 30
    • 0028920863 scopus 로고
    • Altered cytokine export and apoptosis in mice deficient in interleukin-1β converting enzyme
    • Kuida, K., J.A. Lippke, G. Ku, M.W. Harding, D.J. Livingston, M.S.S. Su, and R.A. Flavell. 1995. Altered cytokine export and apoptosis in mice deficient in interleukin-1β converting enzyme. Science. 267:2000-2003.
    • (1995) Science , vol.267 , pp. 2000-2003
    • Kuida, K.1    Lippke, J.A.2    Ku, G.3    Harding, M.W.4    Livingston, D.J.5    Su, M.S.S.6    Flavell, R.A.7
  • 32
    • 0032499138 scopus 로고    scopus 로고
    • p53-dependent impairment of T-cell proliferation in FADD dominant-negative transgenic mice
    • Zornig, M., A.O. Hueber, and G. Evan. 1998. p53-dependent impairment of T-cell proliferation in FADD dominant-negative transgenic mice. Curr. Biol. 8:467-170.
    • (1998) Curr. Biol. , vol.8 , pp. 467-1170
    • Zornig, M.1    Hueber, A.O.2    Evan, G.3
  • 33
    • 0031730436 scopus 로고    scopus 로고
    • Caspase 1-independent 1L-1beta release and inflammation induced by the apoptosis inducer Fas ligand
    • Miwa, K., M. Asano, R. Horai, Y. Iwakura, S. Nagata, and T. Suda. 1998. Caspase 1-independent 1L-1beta release and inflammation induced by the apoptosis inducer Fas ligand. Nat. Med. 4:1287-1292.
    • (1998) Nat. Med. , vol.4 , pp. 1287-1292
    • Miwa, K.1    Asano, M.2    Horai, R.3    Iwakura, Y.4    Nagata, S.5    Suda, T.6
  • 36
    • 0030002801 scopus 로고    scopus 로고
    • Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32
    • Slee, E.A., H.J. Zhu, S.C. Chow, M. MacFarlane, D.W. Nicholson, and G.M. Cohen. 1996. Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32. Biochem. J. 315:21-24.
    • (1996) Biochem. J. , vol.315 , pp. 21-24
    • Slee, E.A.1    Zhu, H.J.2    Chow, S.C.3    MacFarlane, M.4    Nicholson, D.W.5    Cohen, G.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.