A substrate combinatorial array for caspases

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 12, 1999, Pages 1667-1672

  Lee, Dennis ^a   Adams, Jerry L ^a   Brandt, Martin ^b   DeWolf Jr , Walter E ^b   Keller, Paul M ^b   Levy, Mark A ^b  

^a Department of Medicinal Chemistry ^*  (United States)

^b Molecular Recognition   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; INTERLEUKIN 1BETA CONVERTING ENZYME;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME SUBSTRATE; ENZYME SYNTHESIS;

CASPASE 1; CASPASES; CASPASES, INITIATOR; CATALYSIS; KINETICS; OLIGOPEPTIDES; SUBSTRATE SPECIFICITY;

EID: 0033591721     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00260-7     Document Type: Article

References (16)

1. Advances in Pharmacology; Kaufmann S. H., Ed.; Academic: NY, 1997; Vol. 41.
2. (a) Black, R. A.; Kronheim, S. R.; Sleath, P. R. FEBS Lett. 1989, 247, 386.
3. (b) Kostura, M. J.; Tocci, M. J.; Limjuco, G.; Chin, J.; Cameron, P.; Hillman, A. G.; Chartrain, N. A.; Schmidt, J. A. Proc. Natl. Acad. Sci. U.S.A. 1989, 86, 5227.
4. (c) Nicholson, D. W.; Thornberry, N. A. TIBS 1997, 8, 299.
5. (a) Rano, T. A.; Timkey, T.; Peterson, E. P.; Rotonda, J.; Nicholson, D. W.; Becker, J. W.; Chapman, K. T.; Thornberry, N. A. Chem. Biol. 1997, 4, 149.
6. (b) Thornberry, N. A.; Lazebnik, Y. Science 1998, 281, 1312.
7. Thornberry, N. A.; Rano, T. A.; Peterson, E. P.; Rasper, D. M. Timkey, T.; Garcia-Calvo, M.; Houtzager, V. M.; Nordstrom, P. A.; Roy, S.; Vaillancourt, J. P.; Chapman, K. T.; Nicholson, D. W. J. Biol. Chem. 1997, 272, 17907.
8. A more directed approach toward the evaluation of individual peptide substrates for caspases has been investigated. Talanian, R. V., Quinlan, C., Trautz, S., Hackett, M. C., Mankovich, J. A., Banach, D., Ghayur, T., Brady, K. D., Wong, W. W. J. Biol. Chem. 1997, 272, 9677.
9. Thornberry, N. A.; Bull, H. G.; Calaycay, J. R.; Chapman, K. T ; Howard, A. D.; Kostura, M. J.; Miller, D. K.; Molineaux, S. M.; Weidner, J. R.; Aunins, J.; Elliston, K. O.; Ayala, J. M.; Casana, F. J.; Chin, J.; Ding, G. J.-F.; Egger, L. A.; Gaffney, E. P.; Jimjuco, G.; Palyha, O. C.; Raju, S. M.; Rolando, A. M.; Salley, J. P.; Yamin, T.-T.; Lee, T. D.; Shively, J. E.; MacCross, M.; Mumford, R. A.; Schmidt, J. A.; Tocci, M. J. Nature 1992, 356, 768.
10. Rotonda, J.; Nicholson, D. W.; Fazil, K. M.; Gallant, M.; Gareau, Y.; Labelle, M.; Peterson, E. P.; Rasper, D. M.; Ruel, R.; Vaillancourt, J. P.; Thornberry, N. A.; Becker, J. W. Nature Struct. Biol. 1996, 3, 619.
11. Iijima, H.; Nakahara, Y.; Ogawa, T. Tetrahedron. Lett. 1992, 33, 7907.
12. Kanaoka, Y.; Takahashi, T.; Nakayama, H.; Ueno, T.; Sekine, T. Chem. Pharm. Bull. 1982, 30, 1485.
13. Advanced ChemTech, Inc. Louisville, KY.
14. Yue, T.-L.; Wang, C.; Romanic, A. M.; Kikly, K.; Keller, P.; DeWolf, W. E. Jr.; Hart, T. K.; Thomas, H. C.; Storer, B.; Gu, J.-L.; Wang, X.; Feuerstein, G. Z. J. Mol. Cell Cardiol. 1998, 30, 495.
15. Howard, A. D.; Kostura, M. J.; Thornberry, N.; Ding, G. J. F.; Limjuco, G.; Weidner, J.; Salley, J. P.; Hogquist, K. A.; Chaplin, D. D.; Mumford, R. A.; Schmidt, J. A.; Tocci, M. J. J. Immun. 1991, 147, 2964.
16. m). That was not the case in our study. The source of this discrepancy is unclear. Nevertheless, Ac-WVAD-AMC was identified as an efficiently processed substrate in both studies.