Secondary structure peptide mimetics: Design, synthesis, and evaluation of β-strand mimetic thrombin inhibitors

Journal of Medicinal Chemistry

Volumn 42, Issue 8, 1999, Pages 1367-1375

  Boatman, P Douglas ^a   Ogbu, Cyprian O ^a   Eguchi, Masakatsu ^a,b   Kim, Hwa Ok ^a   Nakanishi, Hiroshi ^a,b   Cao, Bolong ^a   Shea, J Paul ^a   Kahn, Michael ^a,b  

^a Molecumetics Ltd   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 AMINO N [4 [[AMINO(IMINO)METHYL]AMINO] 1 (1,3 BENZOTHIAZOL 2 YLCARBONYL)BUTYL] 7 BENZYL 8 OXOHEXAHYDRO 1H PYRAZOLO[1,2 A]PYRIDAZINE 1 CARBOXAMIDE; 7 AMINO N [4 [[AMINO(IMINO)METHYL]AMINO] 1 (2 CHLOROACETYL)BUTYL] 7 BENZYL 8 OXOHEXAHYDRO 1H PYRAZOLO[1,2 A]PYRIDAZINE 1 CARBOXAMIDE; THROMBIN INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTICOAGULATION; ARTICLE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CONFORMATION; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; INTESTINE ABSORPTION; NONHUMAN; PROTEIN SECONDARY STRUCTURE; RAT; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION INHIBITION;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CACO-2 CELLS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; INJECTIONS, INTRAVENOUS; MODELS, MOLECULAR; MOLECULAR MIMICRY; PAPIO; PEPTIDES; PROTEIN STRUCTURE, SECONDARY; RATS; SERINE PROTEINASE INHIBITORS; THROMBIN; THROMBOSIS;

EID: 0033594506     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980354p     Document Type: Article

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