Inhibition of membrane-type 1 matrix metalloproteinase by hydroxamate inhibitors: An examination of the subsite pocket

Journal of Medicinal Chemistry

Volumn 41, Issue 8, 1998, Pages 1209-1217

  Yamamoto, Minoru ^a   Tsujishita, Hideki ^a   Hori, Noriyuki ^a   Ohishi, Yuichi ^a   Inoue, Shintaro ^a   Ikeda, Shoji ^a   Okada, Yasunori ^b  

^a KANEBO LTD   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BATIMASTAT; COLLAGENASE; COLLAGENASE INHIBITOR; GELATINASE A; GELATINASE B; HYDROXAMIC ACID DERIVATIVE; ILOMASTAT; MARIMASTAT; MATRIX METALLOPROTEINASE INHIBITOR; N1 [2,2 DIMETHYL 1 [(METHYLAMINO)CARBONYL]PROPYL] N4 HYDROXY 2 (2 METHYLPROPYL)BUTANEDIAMIDE; STROMELYSIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME INHIBITION; EXTRACELLULAR MATRIX; GLIOBLASTOMA; HUMAN; HUMAN CELL; METASTASIS INHIBITION; PROTEIN DOMAIN; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; DIPEPTIDES; HUMANS; HYDROXAMIC ACIDS; LIGANDS; MATRIX METALLOPROTEINASES, MEMBRANE-ASSOCIATED; METALLOENDOPEPTIDASES; MODELS, MOLECULAR; MUTATION; PHENYLALANINE; PROTEASE INHIBITORS; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 0032499266     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970404a     Document Type: Article

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