Human immunodeficiency virus, type 1 protease substrate specificity is limited by interactions between substrate amino acids bound in adjacent enzyme subsites

Journal of Biological Chemistry

Volumn 271, Issue 9, 1996, Pages 4709-4717

  Ridky, Todd W ^a   Cameron, Craig E ^a   Cameron, John ^a   Leis, Jonathan ^a   Copeland, Terry ^b   Wlodawer, Alexander ^b   Weber, Irene T ^c   Harrison, Robert W ^c  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c THOMAS JEFFERSON UNIVERSITY HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; PROTEINASE; SYNTHETIC PEPTIDE; VIRUS ENZYME;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CONFORMATION; ENZYME BINDING; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; STEREOSPECIFICITY;

AMINO ACID SEQUENCE; AVIAN MYELOBLASTOSIS VIRUS; AVIAN SARCOMA VIRUSES; BINDING SITES; ENDOPEPTIDASES; ESCHERICHIA COLI; HIV PROTEASE; HIV PROTEASE INHIBITORS; HIV-1; HUMANS; KINETICS; MATHEMATICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 0029939026     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.9.4709     Document Type: Article

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