Fusion tyrosine kinases induce drug resistance by stimulation of homology-dependent recombination repair, prolongation of G2/M phase, and protection from apoptosis

Molecular and Cellular Biology

Volumn 22, Issue 12, 2002, Pages 4189-4201

  Slupianek, Artur ^a   Hoser, Grazyna ^a   Majsterek, Ireneusz ^a   Bronisz, Agnieszka ^a   Malecki, Maciej ^a   Blasiak, Janusz ^a   Fishel, Richard ^a   Skorski, Tomasz ^a  

^a TEMPLE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; CYTOSTATIC AGENT; MITOMYCIN; PROTEIN TYROSINE KINASE; STAT5 PROTEIN;

ACUTE LEUKEMIA; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL TRANSFORMATION; CHROMOSOME TRANSLOCATION; CHRONIC LEUKEMIA; DNA DAMAGE; DNA REPAIR; DRUG RESISTANCE; ENZYME ACTIVITY; MOUSE; NONHODGKIN LYMPHOMA; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; APOPTOSIS; BCL-X PROTEIN; CELL TRANSFORMATION, NEOPLASTIC; DNA REPAIR; DNA-BINDING PROTEINS; DRUG RESISTANCE; G2 PHASE; HUMANS; LEUKEMIA; MICE; MICE, INBRED C57BL; MITOSIS; ONCOGENE PROTEINS, FUSION; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-BCL-2; RAD51 RECOMBINASE; RECOMBINATION, GENETIC; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0036261727     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.12.4189-4201.2002     Document Type: Article

References (85)

1. Bcl-2-independent Bcr-Abl-mediated resistance to apoptosis: Protection is correlated with up regulation of Bcl-xL
2. Bcr-Abl exerts its antiapoptotic effect against diverse apoptotic stimuli through blockage of mitochondrial release of cytochrome C and activation of caspase-3
3. DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells
4. 2/M transition after DNA damage: A mechanism of resistance to multiple anticancer agents
5. Homologous recombination as a mechanism of carcinogenesis
6. Oncogenic kinase signalling
7. RecA-mediated strand exchange traverses substitutional heterologies more easily than deletions or insertions
8. 14-3-3sigma is required to prevent mitotic catastrophe after DNA damage
9. 2/M checkpoint
10. Chlorambucil induction of HsRad51 in B-cell chronic lymphocytic leukemia
11. Expression of a distinctive BCR-ABL oncogene in Ph1-positive acute lymphocytic leukemia (ALL)
12. Interleukin 3 protects murine bone marrow cells from apoptosis induced by DNA damaging agents
13. Ribozyme minigene-mediated RAD51 down-regulation increases radiosensitivity of human prostate cancer cells
14. DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis
15. BCR-ABL down-regulates the DNA repair protein DNA-PKcs
16. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
17. BCR-ABL delays apoptosis upstream of procaspase-3 activation
18. Role of oncogenes in resistance and killing by cancer therapeutic agents
19. Molecular genetic advances in chronic myelogenous leukemia
20. Genetic analysis of the DNA-dependent protein kinase reveals an inhibitory role of Ku in late S-G2 phase DNA double-strand break repair
21. BCR/ABL regulates expression of the cyclin-dependent kinase inhibitor p27Kip1 through the phosphatidylinositol 3-Kinase/AKT pathway
22. Modelling the process of drug resistance
23. Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation
24. Oligomerization of the ABL tyrosine kinase by the Ets protein TEL in human leukemia
25. Expression of the oncogenic NPM-ALK chimeric protein in human lymphoid T-cells inhibits drug-induced, but not Fas-induced apoptosis
26. BCL-2 family members and the mitochondria in apoptosis
27. Selection for genome instability by DNA damage in human cells: Unstable microsatellites and their consequences for tumourigenesis
28. Molecular mechanisms of drug resistance in tumours
29. Cooperative and redundant effects of STAT5 and Ras signaling in BCR/ABL transformed hematopoietic cells
30. Blockade of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5-dependent expression of Bcl-xL
31. Bcl-xL inhibits cytochrome c release but not mitochondrial depolarization during the activation of multiple death pathways by tumor necrosis factor-alpha
32. A mitotic spindle requirement for DNA damage-induced apoptosis in Chinese hamster ovary cells
33. Inhibition of pp60c-Src reduces Bcl-XL expression and reverses the transformed phenotype of cells overexpressing EGF and HER-2 receptors
34. DNA double-strand breaks: Signaling, repair and the cancer connection
35. Protein tyrosine kinases and cancer
36. Primary chromosomal rearrangements of leukemia are frequently accompanied by extensive submicroscopic deletions and may lead to altered prognosis
37. A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia
38. Aberrant ALK tyrosine kinase signaling. Different cellular lineages, common oncogenic mechanisms
39. Inactivation of the cyclin-dependent kinase Cdc28 abrogates cell cycle arrest induced by DNA damage and disassembly of mitotic spindles in Saccharomyces cerevisiae
40. A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53
41. Signal transduction and transforming properties of the TEL-TRKC fusions associated with t(12;15) (p13;q25) in congenital fibrosarcoma and acute myelogenous leukemia
42. DNA repair and recombination factor rad51 is overexpressed in human pancreatic adenocarcinoma
43. v-src induces cisplatin resistance by increasing the repair of cisplatin-DNA inter-strand cross-links in human gallbladder adenocarcinoma cells
44. Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma
45. Signal transducer and activator of transcription (STAT)5 activation by BCR/ABL is dependent on intact Src homology (SH)3 and SH2 domains of BCR/ABL and is required for leukemogenesis
46. ts BCR-ABL kinase activation confers increased resistance to genotoxic damage via cell cycle block
47. Cellular responses to DNA damage
48. The tyrosine kinase inhibitor CGP 57148 (ST1 571) induces apoptosis in BCR-ABL-positive cells by down-regulating BCL-X
49. In vitro and in vivo potentiation of radiosensitivity of malignant gliomas by antisense inhibition of the RAD51 gene
50. Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow
51. Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia
52. XRCC3 promotes homology-directed repair of DNA damage in mammalian cells
53. Antibody to HER-2/neu receptor blocks DNA repair after cisplatin in human breast and ovarian cancer cells
54. Signal transduction by wild-type and leukemogenic Abl proteins
55. Bcl-2 family proteins: Regulators of apoptosis and chemoresistance in hematologic malignancies
56. 2-M transition in vertebrates
57. Entry into mitosis in vertebrate somatic cells is guarded by a chromosome damage checkpoint that reverses the cell cycle when triggered during early but not late prophase
58. A novel role for the Bcl-2 protein family: Specific suppression of the RAD51 recombination pathway
59. Versatility of BCR/ABL-expressing leukemic cells in circumventing proapoptotic BAD effects
60. Regulation of Bcl-2 gene expression by BCR-ABL is mediated by Ras
61. Activation of hematopoietic growth factor signal transduction pathways by the human oncogene BCR/ABL
62. Waiting for anaphase: Mad2 and the spindle assembly checkpoint
63. Homologous recombination and the roles of double-strand breaks
64. Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene
65. STAT5 activation contributes to growth and viability in Bcr/Abl-transformed cells
66. A simple technique for quantitation of low levels of DNA damage in individual cells
67. Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway
68. Negative regulation of p120GAP GTPase promoting activity by p210bcr/abl: Implication for RAS-dependent Philadelphia chromosome positive cell growth
69. Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells
70. Leukemia treatment in severe combined immunodeficiency mice by antisense oligodeoxynucleotides targeting cooperating oncogenes
71. bcr/abl tyrosine kinase
72. Role of phosphatidylinositol 3-kinase-Akt pathway in nucleophosmin/anaplastic lymphoma kinase-mediated lymphomagenesis
73. BCR/ABL regulates mammalian recA homologs, resulting in drug resistance
74. -/- mice: A direct role for Stat5 in Bcl-X(L) induction
75. Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death
76. Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells
77. E1A overcomes the apoptosis block in BCR-ABL+ leukemia cells and renders cells susceptible to induction of apoptosis by chemotherapeutic agents
78. Targeted disruption of the Rad51 gene leads to lethality in embryonic mice
79. Overexpression of Rad51 protein stimulates homologous recombination and increases resistance of mammalian cells to ionizing radiation
80. Checkpoint genes required to delay cell division in response to nocodazole respond to impaired kinetochore function in the yeast Saccharomyces cerevisiae
81. Elevated recombination in immortal human cells is mediated by HsRAD51 recombinase
82. Multiple pathways of recombination define cellular responses to cisplatin
83. 2/M transition: Abrupt breakdown of cytoplasmic microtubules at nuclear envelope breakdown and implications for spindle morphogenesis
84. 2/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity
85. Signaling pathways activated by oncogenic forms of Abl tyrosine kinase