Ribozyme minigene-mediated RAD51 down-regulation increases radiosensitivity of human prostate cancer cells

Nucleic Acids Research

Volumn 29, Issue 7, 2001, Pages 1534-1538

  Collis, S J ^a   Tighe, A ^a,b   Scott, S D ^a,c   Roberts, S A ^a   Hendry, J H ^a   Margison, G P ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c MOUNT VERNON HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC G 418; DNA; NEOMYCIN; OLIGONUCLEOTIDE; RAD51 PROTEIN; RIBOZYME; TRANSFERASE;

ARTICLE; CANCER CELL CULTURE; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; CYTOMEGALOVIRUS; DNA STRAND; DNA VECTOR; DOWN REGULATION; ENHANCER REGION; GAMMA IRRADIATION; GENE CONSTRUCT; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC RECOMBINATION; GENETIC STABILITY; GENETIC TRANSFECTION; GENOTOXICITY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IONIZING RADIATION; PRIORITY JOURNAL; PROMOTER REGION; PROSTATE CANCER; PROTEIN ANALYSIS; RADIATION DOSE; RADIOSENSITIVITY; RADIOSENSITIZATION; REPORTER GENE;

CYTOMEGALOVIRUS;

EID: 0035312501     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/29.7.1534     Document Type: Article

References (16)

1. The role of DNA double strand breaks in ionising radiation-induced killing of eukaryotic cells
2. The contribution of homologous recombination in preserving genome integrity in mammalian cells
3. Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein
4. Purification and characterization of the human Rad51 protein, an analogue of E. coli RecA
5. Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death
6. Cell cycle-dependent protein expression of mammalian homologs of yeast DNA double-strand break repair genes Rad51 and Rad52
7. Ribozyme-mediated reversal of the multidrug-resistant phenotype
8. Tissue-specific expression of an anti-ras ribozyme inhibits proliferation of human malignant melanoma cells
9. A recombinant defective adnoviral agent expressing anti-bcl-2 ribozyme promotes apoptosis of bcl-2-expressing human prostate cancer cells
10. Expression of ribozymes in gene transfer systems to modulate target RNA levels
11. Development of synthetic promoters for radiation-mediated gene therapy
12. Dual-color flow cytometric detection of fluorescent proteins using single-laser (488-nm) excitation
13. Overexpression of Rad51 protein stimulates homologous recombination and increases resistance of mammalian cells to ionizing radiation
14. Antisense inhibition of the RAD51 enhances radiosensitivity
15. In vitro and in vivo potentiation of radiosensitivity of malignant gliomas by antisense inhibition of the RAD51 gene
16. Simple RNA enzymes with new and highly specific endoribonuclease activities