메뉴 건너뛰기




Volumn 8, Issue 4, 2002, Pages 179-186

Caretaker tumour suppressor genes that defend genome integrity

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; UBIQUITIN;

EID: 0036220630     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4914(02)02298-0     Document Type: Review
Times cited : (84)

References (62)
  • 4
    • 0035425350 scopus 로고    scopus 로고
    • Increased frequency of ATM mutations in breast carcinoma patients with early onset disease and positive family history
    • (2001) Cancer , vol.92 , pp. 479-487
    • Teraoka, S.N.1
  • 5
    • 0035887491 scopus 로고    scopus 로고
    • Spectrum of ATM gene mutations in a hospital-based series of unselected breast cancer patients
    • (2001) Cancer Res. , vol.61 , pp. 7608-7615
    • Dork, T.1
  • 7
    • 0032167446 scopus 로고    scopus 로고
    • A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination
    • (1998) Immunity , vol.9 , pp. 367-376
    • Gao, Y.1
  • 8
    • 0033544724 scopus 로고    scopus 로고
    • The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder
    • (1999) Cell , vol.99 , pp. 577-587
    • Stewart, G.S.1
  • 11
    • 0034141562 scopus 로고    scopus 로고
    • The controlling role of ATM in homologous recombinational repair of DNA damage
    • (2000) EMBO J. , vol.19 , pp. 463-471
    • Morrison, C.1
  • 12
    • 0033617368 scopus 로고    scopus 로고
    • Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl
    • (1999) J. Biol. Chem. , vol.274 , pp. 12748-12752
    • Chen, G.1
  • 15
    • 0032508504 scopus 로고    scopus 로고
    • Enhanced phosphorylation of p53 by ATM in response to DNA damage
    • (1998) Science , vol.281 , pp. 1674-1677
    • Banin, S.1
  • 16
    • 0032508608 scopus 로고    scopus 로고
    • Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
    • (1998) Science , vol.281 , pp. 1677-1679
    • Canman, C.E.1
  • 17
    • 0034142034 scopus 로고    scopus 로고
    • The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
    • (2000) Genes Dev. , vol.14 , pp. 289-300
    • Shieh, S.Y.1
  • 18
    • 0035887213 scopus 로고    scopus 로고
    • Critical roles for the serine 20, but not the serine 15, phosphorylation site and for the polyproline domain in regulating p53 turnover
    • (2001) Biochem. J. , vol.359 , pp. 459-464
    • Dumaz, N.1
  • 20
    • 0033601346 scopus 로고    scopus 로고
    • Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome
    • (1999) Science , vol.286 , pp. 2528-2531
    • Bell, D.W.1
  • 21
    • 0034611728 scopus 로고    scopus 로고
    • ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
    • (2000) Nature , vol.404 , pp. 613-617
    • Lim, D.S.1
  • 22
    • 0034713393 scopus 로고    scopus 로고
    • Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products
    • (2000) Nature , vol.405 , pp. 473-477
    • Zhao, S.1
  • 25
    • 0034655991 scopus 로고    scopus 로고
    • BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures
    • (2000) Genes Dev. , vol.14 , pp. 927-939
    • Wang, Y.1
  • 31
    • 0030850047 scopus 로고    scopus 로고
    • Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage
    • (1997) Cell , vol.90 , pp. 425-435
    • Scully, R.1
  • 32
    • 0033618621 scopus 로고    scopus 로고
    • Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response
    • (1999) Science , vol.285 , pp. 747-750
    • Zhong, Q.1
  • 33
    • 0030764691 scopus 로고    scopus 로고
    • hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 6087-6096
    • Maser, R.S.1
  • 34
    • 0343280013 scopus 로고    scopus 로고
    • A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
    • (2000) Curr. Biol. , vol.10 , pp. 886-895
    • Paull, T.T.1
  • 36
    • 0035105291 scopus 로고    scopus 로고
    • Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway
    • (2001) Mol. Cell , vol.7 , pp. 249-262
    • Garcia-Higuera, I.1
  • 39
    • 0033106326 scopus 로고    scopus 로고
    • Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells
    • (1999) Mol. Cell , vol.3 , pp. 389-395
    • Xu, X.1
  • 40
    • 0035854674 scopus 로고    scopus 로고
    • BRCA1 is a selective co-activator of 14-3-3 sigma gene transcription in mouse embryonic stem cells
    • (2001) J. Biol. Chem. , vol.276 , pp. 25647-25650
    • Aprelikova, O.1
  • 41
    • 0034624718 scopus 로고    scopus 로고
    • hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response
    • (2000) Nature , vol.404 , pp. 201-204
    • Lee, J.S.1
  • 42
    • 0033574543 scopus 로고    scopus 로고
    • Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage
    • (1999) J. Biol. Chem. , vol.274 , pp. 11334-11338
    • Li, S.1
  • 44
    • 0035942190 scopus 로고    scopus 로고
    • Cancer-predisposing mutations within the RING domain of BRCA1: Loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 5134-5139
    • Ruffner, H.1
  • 45
    • 0035805582 scopus 로고    scopus 로고
    • The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation
    • (2001) J. Biol. Chem. , vol.276 , pp. 14537-14540
    • Hashizume, R.1
  • 47
    • 0035105999 scopus 로고    scopus 로고
    • Role of BRCA2 in control of the RAD51 recombination and DNA repair protein
    • (2001) Mol. Cell , vol.7 , pp. 273-282
    • Davies, A.A.1
  • 48
    • 0035099044 scopus 로고    scopus 로고
    • BRCA2 is required for homology-directed repair chromosomal breaks
    • (2001) Mol. Cell , vol.7 , pp. 263-272
    • Moynahan, M.E.1
  • 49
    • 0035902551 scopus 로고    scopus 로고
    • Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 8644-8649
    • Xia, F.1
  • 50
    • 0035951405 scopus 로고    scopus 로고
    • A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression
    • (2001) Cell , vol.104 , pp. 247-257
    • Marmorstein, L.Y.1
  • 52
    • 0032736140 scopus 로고    scopus 로고
    • Rothmund-thomson syndrome responsible gene, RECQL4: Genomic structure and products
    • (1999) Genomics , vol.61 , pp. 268-276
    • Kitao, S.1
  • 53
    • 0034737004 scopus 로고    scopus 로고
    • Rothmund-Thomson syndrome due to RECQ4 helicase mutations: Report and clinical and molecular comparisons with Bloom syndrome and Werner syndrome
    • (2000) Am. J. Med. Genet. , vol.90 , pp. 223-228
    • Lindor, N.M.1
  • 54
    • 0035934019 scopus 로고    scopus 로고
    • Clinical manifestations in a cohort of 41 Rothmund-Thomson syndrome patients
    • (2001) Am. J. Med. Genet. , vol.102 , pp. 11-17
    • Wang, L.L.1
  • 56
    • 0034231844 scopus 로고    scopus 로고
    • Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest
    • (2000) EMBO Rep. , vol.1 , pp. 80-84
    • Constantinou, A.1
  • 57
    • 0035839467 scopus 로고    scopus 로고
    • The Bloom's syndrome protein (BLM) interacts with MLH1 but is not required for DNA mismatch repair
    • (2001) J. Biol. Chem. , vol.276 , pp. 30031-30035
    • Langland, G.1
  • 58
    • 0035504589 scopus 로고    scopus 로고
    • Direct association of Bloom's syndrome gene product with the human mismatch repair protein MLH1
    • (2001) Nucleic Acids Res. , vol.29 , pp. 4378-4386
    • Pedrazzi, G.1
  • 59
    • 0035377356 scopus 로고    scopus 로고
    • Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51
    • (2001) J. Biol. Chem. , vol.276 , pp. 19375-19381
    • Wu, L.1
  • 60
    • 0032832195 scopus 로고    scopus 로고
    • Physical and functional interaction between p53 and the Werner's syndrome protein
    • (1999) J. Biol. Chem. , vol.274 , pp. 29463-29469
    • Blander, G.1
  • 61
    • 0035980070 scopus 로고    scopus 로고
    • Functional interaction of p53 and BLM DNA helicase in apoptosis
    • (2001) J. Biol. Chem. , vol.276 , pp. 32948-32955
    • Wang, X.W.1
  • 62
    • 0033151615 scopus 로고    scopus 로고
    • p53-mediated apoptosis is attenuated in Werner syndrome cells
    • (1999) Genes Dev. , vol.13 , pp. 1355-1360
    • Spillare, E.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.