Virulence factors and the pathogenesis of disease caused by Streptococcus pneumoniae

Research in Microbiology

Volumn 151, Issue 6, 2000, Pages 413-419

  Mitchell, Tim J ^a  

^a Inst Biomed Life Sci Dept M   (United Kingdom)

Author keywords

Pathogenesis; Streptococcus pneumoniae; Virulence factors

Indexed keywords

AUTOLYSIN; CHOLINE BINDING PROTEIN A; HYALURONIDASE; PNEUMOCOCCAL SURFACE ADHESIN A; PNEUMOCOCCUS SURFACE PROTEIN A; PNEUMOLYSIN; SIALIDASE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

BACTERIAL VIRULENCE; CONFERENCE PAPER; PATHOGENESIS; PATHOGENICITY; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STREPTOCOCCUS PNEUMONIAE;

EID: 0033866076     PISSN: 09232508     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0923-2508(00)00175-3     Document Type: Conference Paper

References (46)

1. Lee C.-J., Banks S.D., Lee J.P. Virulence, immunity, and vaccine related to Streptococcus pneumoniae. Crit. Rev. Microbiol. 18:(2):1991;89-114.
2. Austrian R. Pneumococcal infections. Germanier R. Bacterial Vaccines. 1984;257-288 Academic Press, London.
3. Spika J.S., Facklam R.R., Pikaytis B.D., Oxtoby M.J., Party P.S.W. Antimicrobial resistance of Streptococcus pneumoniae in the United States, 1979-1987. J. Infect. Dis. 163:1991;1273-1278.
4. Nesin M., Ramirez M., Tomasz A. Capsular transformation of a multidrug-resistant Streptococcus pneumoniae in vivo. J. Infect. Dis. 177:1998;707-713.
5. Paton J.C., Andrew P.W., Boulnois G.J., Mitchell T.J. Molecular analysis of the pathogenicity of Streptococcus pneumoniae: The role of pneumococcal proteins. Annu. Rev. Microbiol. 47:1993;89-115.
6. Walker J.A., Allen R.L., Falmagne P., Johnson M.K., Boulnois G.J. Molecular cloning, characterization, and complete nucleotide sequence of the gene for pneumolysin, the sulfhydryl-activated toxin of Streptococcus pneumoniae. Infect. Immun. 55:1987;1184-1189.
7. Paton J.C., Berry A.M., Lock R.A., Hansman D., Manning P.A. Cloning and expression in Escherichia coli of the Streptococcus pneumoniae gene encoding pneumolysin. Infect. Immun. 54:(1):1986;50-55.
8. Alexander J.E., Berry A.M., Paton J.C., Rubins J.B., Andrew P.W., Mitchell T.J. Amino acid changes affecting the activity of pneumolysin alter the behaviour of pneumococci in pneumonia. Microb. Pathog. 24:(3):1998;167-174.
9. Berry A.M., Yother J., Briles D.E., Hansman D., Paton J.C. Reduced virulence of a defined pneumolysin-negative mutant of Streptococcus pneumoniae. Infect. Immun. 57:(7):1989;2037-2042.
10. Berry A.M., Alexander J.E., Mitchell T.J., Andrew P.W., Hansman D., Paton J.C. Effect of defined point mutations in the pneumolysin gene on the virulence of Streptococcus pneumoniae. Infect. Immun. 63:1995;1969-1974.
11. Rossjohn J., Gilbert R.J.C., Crane D., Morgan P.J., Mitchell T.J., Rowe A.J., Andrew P.W., Paton J.C., Tweten R.K., Parker M.W. The molecular mechanism of pneumolysin, a virulence factor from Streptococcus pneumoniae. J. Mol. Biol. 284:1998;449-461.
12. Berry A.M., Ogunniyi A.D., Miller D.C., Paton J.C. Comparative virulence of Streptococcus pneumoniae strains with insertion-duplication, point, and deletion mutations in the pneumolysin gene. Infect. Immun. 67:(2):1999;981-985.
13. Camara M., Boulnois G.J., Andrew P.W., Mitchell T.J. A neuraminidase from Streptococcus pneumoniae has the features of a surface protein. Infect. Immun. 62:1994;3688-3695.
14. McDaniel L.S., Yother J., Vijayakumar M., Mcgarry L., Guild W.R., Briles D.E. Use of insertional inactivation to facilitate studies of biological properties of pneumococcal surface protein-a (pspa). J. Exp. M. 165:1987;381-394.
15. Crain M.J., II W.D.W., Turner J.S., Yother J., Talkington D.F., McDaniel L.S., Gray B.M., Briles D.E. Pneumococcal surface protein A (PspA) is serologically highly variable and is expressed by all clinically important capsular serotypes of Streptococcus pneumoniae. Infect Immun. 58:1990;3293-3299.
16. Hammerschmidt S., Bethe G., Remane P.H., Chhatwal G.S. Identification of pneumococcal surface protein A as a lactoferrin-binding protein of Streptococcus pneumoniae. Infect. Immun. 67:1999;1683-1687.
17. Tu A.-H.T., Fulgram R.L., McCrory M.A., Briles D.E., Szalai A.J. Pneumococcal surface protein A inhibits complement activation by Streptococcus pneumoniae. Infect. Immun. 67 67:1999;4720-4724.
18. Tart R.C., McDaniel L.S., Ralph B.A., Briles D.E. Truncated streptococcus-pneumoniae pspa molecules elicit cross-protective immunity against pneumococcal challenge in mice. J. Infect. Dis. 173:1996;380-386.
19. Rosenow C., Ryan P., Weiser J.N., Johnson S., Fontan P., Ortqvist A., Masure H.R. Contribution of novel choline-binding proteins to adherence, colonization and immunogenicity of Streptococcus pneumoniae. Mol. Microbiol. 25:1997;819-829.
20. Hammerschmidt S., Talay S.R., Brandtzaeg P., Chhatwal G.S. SpsA, a novel pneumococcal surface protein with specific binding to secretory Immunoglobulin A and secretory component. Mol. Microbiol. 25:1997;1113-1124.
21. Sampson J.S., O'Connor S.P., Stinson A.R., Tharpe J.A., Russell H. Cloning and nucleotide sequence analysis of psaA, the Streptococcus pneumoniae gene encoding a 37-kilodalton protein holologous to previously reported Streptococcus sp. adhesins. Infect. Immun. 62:1994;319-324.
22. Berry A.M., Paton J.C. Sequence heterogeneity of psaa, a 37-kilodalton putative adhesin essential for virulence of streptococcus-pneumoniae. Infect. Immun. 64:1996;5255-5262.
23. Dintilhac A., Alloing G., Granadel C., Claverys J.P. Competence and virulence of Streptococcus pneumoniae: Adc and PsaA mutants exhibit a requirement for Zn and Mn resulting from inactivation of putative ABC metal permeases. Mol. Microbiol. 25:1997;727-739.
24. Lawrence M.C., Pilling P.A., Epa V.C., Berry A.M., Ogunniyi A.D., Paton J.C. The crytal structure of pneumococcal surface antigen PsaA reveals a metal-binding site and a novel structure for a putative ABC-type binding protein. Structure. 6:1998;1553-1561.
25. Berry A.M., Lock R.A., Hansman D., Paton J.C. Contribution of autolysin to virulence ofStreptococcus pneumoniae. Infect. Immun. 57:(8):1989;2324-2330.
26. Berry A.M., Paton J.C., Hansman D. Effect of insertional inactivation of the genes encoding pneumolysin and autolysin on the virulence of Streptococcus pneumoniae type 3. Microb. Pathog. 12:1992;87-93.
27. Canvin J.R., Marvin A.P., Sivakumaran M., Paton J.C., Boulnois G.J., Andrew P.W., Mitchell T.J. The role of pneumolysin and autolysin in the pathology of pneumonia and septicemia in mice infected with a type 2 pneumococcus. J. Infect. Dis. 172:1995;119-123.
28. Kelly R., Greiff D. Toxicity of pneumococcal neuraminidase. Infect. Immun. 2:(1):1970;115-117.
29. O'Toole R.D., Goode L., Howe C. Neuraminidase activity in bacterial meningitis. J. Clin. Invest. 50:1971;979-985.
30. Berry A.M., Lock R.A., Paton J.C. Cloning and characterization on nanB, a second Streptococcus pneumoniae neuraminidase gene, and purification of the nanB enzyme from recombinant Escherichia coli. J. Bacteriol. 178:1996;4854-4860.
31. Winter A.J., Comis S.D., Osborne M.P., Tarlow M.J., Stephen J., Andrew P.W., Hill J., Mitchell T.J. A role for pneumolysin but not neuraminidase in the hearing loss and cochlear damage induced by experimental pneumococcal meningitis in guinea pigs. Infect. Immun. 65:1997;4411-4418.
32. Berry A.M., Lock R.A., Thomas S.M., Rajan D.P., Hansman D., Paton J.C. Cloning and nucleotide sequence of the Streptococcus pneumoniae hyaluronidase gene and purification of the enzyme from recombinant Escherichia coli. Infect. Immun. 62:1994;1101-1108.
33. Yesilkaya H., Kadioglu A., Gingles N., Alexander J.E., Mitchell T.J., Andrew P.W. Role of manganese containing superoxide dismutase (MnSOD) in oxidative stress and virulence of Streptococcus pneumoniae. Infect. Immun. 68:2000;2819-2826.
34. Lange R., Wagner C., Saizieu A.D., Flint N., Molnos J., Steiger M., Caspers P., Kamber M., Keck W., Amrein K.E. Domain organisation and molecular characterization of 13 two-component sytems identified by genome sequencing of S. pneumoniae. Gene. 1999.
35. Rayner C, Jackson A.D, Rutman A, Dewar A, Mitchell T.J, Andrew P.W, Cole P.J, Wilson R. Interaction of pneumolysin-sufficient and -deficient isogenic variants ofStreptococcus pneumoniaewith human respiratory mucosa. Infect. Immun. 63:1995;442-447.
36. Benton K.A., Everson M.P., Briles D.E. A pneumolysin-negative mutant of Streptococcus pneumoniae causes chronic bacteremia rather than acute sepsis in mice. Infect. Immun. 63:1995;448-455.
37. Johnson M.K., Hobden J.A., Hagenah M., O'Callaghan R.J., Hill J.M., Chen S. The role of pneumolysin in ocular infections with Streptococcus pneumoniae. Curr. Eye Res. 9:1990;1107-1114.
38. Friedland I.R., Paris M.M., Hickey S., Shelton S., Olsen K., Paton J.C., McCracken G.H. The limited role of pneumolysin in the pathogenesis of pneumococcal meningitis. J. Infect. Dis. 172:1995;805-809.
39. Sato K., Quartey M.K., Liebeler C.L., Le C.T., Giebink G.S. Roles of autolysin and pneumolysin in middle ear inflammation caused by a type 3 Streptococcus pneumoniae strain in the chinchilla otitis media model. Infect. Immun. 64:1996;1140-1145.
40. Rubins J.B., Charboneau D., Fasching C., Berry A.M., Paton J.C., Alexander J.E., Andrew P.W., Mitchell T.J., Janoff E.N. Distinct role for pneumolysin's cytotoxic and complement activities in the pathogenesis of pneumococcal pneumonia. Am. J. Respir. Crit. Care M. 153:1996;1339-1346.
41. Benton K.A, Paton J.C., Briles D.E. The hemolytic and complement-activating properties of pneumolysin do not contribute individually to virulence in a pneumococcal bacteramia model. Microb. Pathog. 23:1997;201-209.
42. Johnson M.K., Callegan M.C., Engel L.S., O'Callaghan R.J., Hill J.M., Hobden J.A., Boulnois G.J., Andrew P.W., Mitchell T.J. Growth and virulence of a complement-activation-negative mutant of Streptococcus pneumoniae in the rabbit cornea. Curr. Eye Res. 14:1995;281-285.
43. Novak R., Cauwels A., Charpentier E., Tuomanen E. Identification of a Streptococcus pneumoniae gene locus encoding proteins of an ABC phosphate transporter and a two-component regulatory system. J. Bacteriol. 181:(4):1999;1126-1133.
44. Guenzi E., Gasc A.M. Sicard M.A., Hackenbeck R., A two-component signal transducing system is involved in competence and penicillin susceptibility in laboratory mutants of Streptococcus pneumoniae. Mol. Microbiol. 12:1994;505-515.
45. Novak R., Braun J.S., Charpentier E., Tuomanen E. Penicillin tolerance genes of Streptococcus pneumoniae: the ABC-type manganese permease complex Psa. Mol. Microbiol. 29:(5):1998;1285-1296.
46. Pestova E.V., Havarstein L.S., Morrison D.A. Regulation of competence for genetic transformation in Streptococcus pneumoniae by an autoinduced peptide pheromone and a two-component regulatory system. Mol. Microbiol. 21:1996;853-862.