Transglutaminases in disease

Neurochemistry International

Volumn 40, Issue 1, 2002, Pages 85-103

  Kim, Soo Youl ^a,b   Jeitner, Thomas M ^b   Steinert, Peter M ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Alzheimer's disease; Disease; Transglutaminases

Indexed keywords

ACTIN; AUTOANTIBODY; BLOOD CLOTTING FACTOR 13A; CHOLINERGIC RECEPTOR; COLLAGEN; GLIADIN; HISTONE H2B; KERATIN; LIPOCORTIN 1; MYELIN BASIC PROTEIN; MYOSIN; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; REPETITIVE DNA; TROPONIN; TUBULIN;

ALZHEIMER DISEASE; ANTIBODY PRODUCTION; ATHEROSCLEROSIS; AUTOIMMUNITY; CATARACTOGENESIS; CELIAC DISEASE; CONFERENCE PAPER; DEGENERATIVE DISEASE; DISEASE ASSOCIATION; ENZYME ACTIVATION; ENZYME ACTIVITY; GENETIC DISORDER; HEMOPHILIA A; HUMAN; HUNTINGTON CHOREA; INCLUSION BODY MYOSITIS; INFLAMMATION; LAMELLAR ICHTHYOSIS; NEUROTOXICITY; OXIDATIVE STRESS; PARKINSON DISEASE; PATHOGENESIS; PRIORITY JOURNAL; PROGRESSIVE SUPRANUCLEAR PALSY; PROTEIN AGGREGATION;

ARTERIOSCLEROSIS; CATARACT; CELIAC DISEASE; DISEASE; FACTOR XIII DEFICIENCY; HUMANS; ICHTHYOSIS; MYOSITIS, INCLUSION BODY; NEURODEGENERATIVE DISEASES; SUPRANUCLEAR PALSY, PROGRESSIVE; TRANSGLUTAMINASES;

EID: 0036136254     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-0186(01)00064-X     Document Type: Conference Paper

References (219)

1. Characterization of autoantibody in sera anti-DNA antibody and circulating immune complexes from 12 systemic lupus erythematous patients
2. Tansglutaminases: Protein cross-linking enzymes in body fluids
3. Protein crosslinking in assembly and remodeling of extracellular matrices: The role of transglutaminases
4. Transglutaminase-catalyzed matrix cross-linking in differentiating cartilage: Identification of osteonectin as a major glutaminyl substrate
5. Alternative excitotoxic hypotheses
6. Calcium-dependent proteolysis in rabbit lens epithelium after oxidative stress
7. Calpain activates two transglutaminases from porcine skin
8. Calcium-induced intracellular cross-linking of lipocortin I by tissue transglutaminase in A431 cells. Augmentation by membrane phospholipids
9. The intestinal T cell response to alpha-gliadin in adult celiac disease is focused on a single deamidated glutamine targeted by tissue transglutaminase
10. The association of tissue transglutaminase with human recombinant tau results in the formation of insoluble filamentous structures
11. Localization of transglutaminase in hippocampal neurons: Implications for Alzheimer's disease
12. Immunoelectron-microscopic demonstration of NACP/α-synuclein-epitopes on the filamentous component of Lewy bodies in Parkinson's disease and in dementia with Lewy bodies
13. Amyloid precursor epitopes in muscle fibers of inclusion body myositis
14. Insulin-dependent diabetes mellitus as an autoimmune disease
15. Congenital recessive ichthyosis unlinked to loci for epidermal transglutaminases
16. Core histones are glutaminyl substrates for tissue transglutaminase
17. One third of HLA DQ2 homozygous patients with type 1 diabetes express celiac disease associated transglutaminase autoantibodies
18. Huntington's disease, energy, and excitotoxicity
19. Mitochondria, free radicals, and neurodegeneration
20. Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid
21. Intranuclear neuronal inclusions in Huntington's disease and DRPLA
22. Transglutaminase-catalyzed polymerization of troponin in vitro
23. Lipoprotein (a) is a substrate for factor XIIIa and tissue transglutaminase
24. Protein oxidation and lens opacity in humans
25. Effects of chronic MPTP and 3-nitropropionic acid in nonhuman primates
26. Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates
27. Oxidative damage and metabolic dysfunction in Huntington's disease: Selective vulnerability of the basal ganglia
28. The Goodpasture autoantigen. Identification of multiple cryptic epitopes on the NC1 domain of the alpha3(IV) collagen chain
29. Identification of a substrate site for liver transglutaminase on the aminopropeptide of type III collagen
30. Transglutaminase-catalysed cross-linking: A potential mechanism for the interaction of fibrinogen, low density lipoprotein and arterial type III procollagen
31. Trinucleotide repeat length and clinical progression in Huntington's disease
32. Human jejunal transglutaminase: Demonstration of activity, enzyme kinetics and substrate specificity with special relation to gliadin and coeliac disease
33. Keratin cross-linking and epidermal transglutaminase. A review with observations on the histochemical and immunochemical localization of the enzyme
34. Transglutaminase 1 mutations in lamellar ichthyosis. Loss of activity due to failure of activation by proteolytic processing
35. Evidence for an antigen-driven selection process in human auto-antibodies against acetylcholine receptor
36. Inclusion body myositis, a review
37. Coeliac disease in the year 2000: Exploring the iceberg
38. Transient formation of superoxide radicals in polyunsaturated fatty acid-induced brain swelling
39. Cross-linking sites in human and bovine fibrin
40. The neurochemical and behavioral effects of b-amyloid peptide
41. Bullous pemphigoid of childhood: Autoantibodies target the same epitopes within the NC16A domain of BP180 as autoantibodies in bullous pemphigoid of adulthood
42. Sporadic inclusion body myositis correlates with increased expression and cross-linking by transglutaminases 1 and 2
43. Bullous pemphigoid and amyotrophic lateral sclerosis: A new clue for understanding the bullous disease?
44. Mutation causing coagulation factor XIII subunit A deficiency: Characterization of the mutant proteins after expression in yeast
45. Polyglutamine domains are substrates of tissue transglutaminase: Does transglutaminase play a role in expanded CAG/poly-Q neurodegenerative diseases?
46. Transglutaminase-catalyzed inactivation of glyceraldehyde 3-phosphate dehydrogenase and alpha-ketoglutarate dehydrogenase complex by polyglutamine domains of pathological length
47. Transglutaminase-catalyzed incorporation of polyamines into phospholipase A2
48. Serological screening of coeliac disease: Choosing the optimal procedure according to various prevalence values
49. A potential role for apoptosis in neurodegeneration and Alzheimer's disease
50. Amino acid sequence studies on the alpha chain of human fibrinogen. Exact location of cross-linking acceptor sites
51. Cloning of the SCA7 gene reveals a highly unstable CAG repeat expansion
52. Alzheimer neuropathologic alterations in aged cognitively normal subjects
53. Gene disruption of tissue transglutaminase
54. Alzheimer's disease: Tau proteins, the promoting factors of microtubule assembly, are major components of paired helical filaments
55. Human collagen II peptide 256-271 preferentially binds to HLA-DR molecules associated with susceptibility to rheumatoid arthritis
56. Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain
57. Identification of tissue transglutaminase as the autoantigen of celiac disease
58. Antibodies to tissue transglutaminase as serologic markers in patients with dermatitis herpetiformis
59. Transglutaminase catalyzes the formation of sodium dodecyl sulfate-insoluble, Alz-50-reactive polymers of tau
60. Transglutaminase facilitates the formation of polymers of the beta-amyloid peptide
61. Transglutaminase-induced cross-linking between subdomain 2 of G-actin and the 636-642 lysine-rich loop of myosin subfragment 1
62. Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments
63. Transglutaminase-catalyzed protein cross-linking in the molecular program of apoptosis and its relationship to neuronal processes
64. Two new loci for autosomal recessive ichthyosis on chromosomes 3p21 and 19p12-q12 and evidence for further genetic heterogeneity
65. Abnormal tau proteins in progressive supranuclear palsy
66. The ε-(γ-glutamyl)lysine cross-link and the catalytic role of transglutaminases
67. Alpha-synuclein and Parkinson's disease: Selective neurodegenerative effect of alpha-synuclein fragment on dopaminergic neurons in vitro and in vivo
68. Transglutaminase activity in serum and cerebrospinal fluid in sporadic amyotrophic lateral sclerosis: A possible use as an indicator of extent of the motor neuron loss
69. Tissue transglutaminase-catalyzed formation of high-molecular-weight aggregates in vitro is favored with long polyglutamine domains: A possible mechanism contributing to CAG-triplet diseases
70. The α-ketoglutarate dehydrogenase complex in neurodegeneration
71. Calcium stores in cultured fibroblasts and their changes with Alzheimer's disease
72. Juvenile Huntington chorea: Clinical, ultrastructural, and biochemical studies
73. The alpha 5 chain of type IV collagen is the target of IgG autoantibodies in a novel autoimmune disease with subepidermal blisters and renal insufficiency
74. Progressive supranuclear palsy
75. Prevalence and natural history of progressive supranuclear palsy
76. Prevalence and natural history of progressive supranuclear palsy
77. Biochemical detection of Abeta isoforms: Implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease
78. Transglutaminase activity in rat brain: Characterization, distribution, and changes with age
79. Tau proteins of Alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms
80. Human genetic diseases due to codon reiteration: Relationship to an evolutionary mechanism
81. Exposure of beta H-crystallin to hydroxyl radicals enhances the transglutaminase-susceptibility of its existing amine-donor and amine-acceptor sites
82. Thrombin cleavage-independent deposition of fibrinogen in extracellular matrices
83. Molecular genetics of Huntington's disease
84. Nuclear and neuropil aggregates in Huntington's disease: Relationship to neuropathology
85. Stabilization of collagen-tailed acetylcholinesterase in muscle cells through extracellular anchorage by transglutaminase-catalyzed cross-linking
86. Increased natural autoantibody activity to cytoskeleton proteins in sera from patients with necrobiosis lipoidica, with or without insulin-dependent diabetes mellitus
87. Two genetic defects in a patient with complete deficiency of the a-subunit for coagulation factor XIII
88. Natural autoantibodies are involved in the haemolytic anaemia of NZB mice
89. Two adjacent N-terminal glutamines of BM-40 (osteonectin, SPARC) act as amine acceptor sites in transglutaminase C-catalyzed modification
90. Cross-linking of beta-amyloid protein precursor catalyzed by tissue transglutaminase
91. 2+-dependent inactivation of acetylcholine receptors by an endogenous transglutaminase
92. Mutations of keratinocyte transglutaminase in lamellar ichthyosis
93. Amino acid sequence of a subunit of human factor XIII
94. Amino acid sequence of the β subunit of human factor XIIIa, a protein composed of ten repetitive segments
95. The presence of autoantibody to lipocortin-I in autoimmune-prone MRL mice
96. Cross-linking of a synthetic partial-length (1±28) peptide of the Alzheimer beta/A4 amyloid protein by transglutaminase
97. 2+ mobilization is altered in fibroblasts from patients with Alzheimer disease
98. A sensitive fluorescent assay for tissue transglutaminase
99. Residues in the synuclein consensus motif of the alpha-synuclein fragment, NAC, participate in transglutaminase-catalysed cross-linking to Alzheimer-disease amyloid beta A4 peptide
100. Transglutaminase activity is increased in Alzheimer's disease brain
101. Binding of peptides from the N-terminal region of alpha-gliadin to the celiac disease-associated HLA-DQ2 molecule assessed in biochemical and T cell assays
102. Identification of a putative motif for binding of peptides to HLA-DQ2
103. Peptides containing glutamine repeats as substrates for transglutaminase-catalyzed cross-linking: Relevance to diseases of the nervous system
104. Primary structure of microbial transglutaminase from Streptoverticillium sp. strain s-8112
105. Transglutaminase aggregates huntingtin into nonamyloidogenic polymers, and its enzymatic activity increases in Huntington's disease brain nuclei
106. Cystamine, a competitor for transglutaminase, slows the progression of Huntington's disease in a transgenic mouse model without altering the formation of nuclear inclusions
107. Calpain inhibitors reduce the cornified cell envelope formation by inhibiting proteolytic processing of transglutaminase 1
108. The structure of the transglutaminase 1 enzyme Deletion cloning reveals domains that regulate its specific activity and substrate specificity
109. Expression of transglutaminase 1 in human epidermis
110. Differential expression of multiple transglutaminases in human brain. Increased expression and cross-linking by transglutaminases 1 and 2 in AD
111. Transglutaminase-catalyzed cross-linking of fibrils of collagen V/XI in A204 rhabdomyosarcoma cells
112. HLA allele distribution distinguishes sporadic inclusion body myositis from hereditary inclusion body myopathies
113. Requirement for transglutaminase in the activation of latent transforming growth factor-beta in bovine endothelial cells
114. Microtubule-associated protein τ (tau) is a major antigenic component of paired helical filaments in Alzheimer disease
115. Huntington aggregates may not predict neuronal death in Huntington's disease
116. Human alpha-lactalbumin and bovine beta-lactoglobulin absorption in infants
117. HLA-DQB1 codon 57 is critical for peptide binding and recognition
118. Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy
119. Antibodies to tissue TGase C in type I diabetes
120. Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ
121. Activated immune system in patients with Huntington's disease
122. A68: A major subunit of paired helical filaments and derivatized forms of normal Tau
123. Evidence of T-lymphocyte functional impairment in Huntington's disease
124. Tissue transglutaminase is increased in Huntington's disease brain
125. Impaired mitochondrial function results in increased tissue transglutaminase activity in situ
126. Formation of a 55,000-weight cross-linked β-crystallin dimer in the calcium treated lens. A model for cataract
127. Novel inhibitors against the transglutaminase-catalyzed cross-linking of lens proteins
128. A new approach to the classification of idiopathic inflammatory myopathy: Myositis-specific autoantibodies define useful homogeneous patient groups
129. Inflammation, Aβ deposition, and neurofibrillary tangle formation as correlates of Alzheimer's disease neurodegeneration
130. Analysis of cytokine expression in muscle in inflammatory myopathies, Duchenne dystrophy, and non-weak control
131. Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice
132. Gluten, major histocompatibility complex, and the small intestine: A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue')
133. Cortical glucose metabolism in Huntington's disease
134. Amyloid plaque core protein in Alzheimer disease and Down syndrome
135. 'Tissue' transglutaminase in cell death: A downstream or a multifunctional upstream effector?
136. Huntingtin is required for normal hematopoiesis
137. Alpha synuclein in neurodegenerative disorders: Murderer or accomplice?
138. Transglutaminase and the neuronal cytoskeleton in Alzheimer's disease
139. Lymphocyte activation markers in idiopathic myositis: Changes with disease activity and differences among clinical and autoantibody subgroups
140. Transglutaminase cross-linking of the tau protein
141. A role for tissue transglutaminase in hepatic injury and fibrogenesis and its regulation by NF-kappaB
142. HLA restriction patterns of gliadin- and astrovirus-specific CD4+ T cells isolated in parallel from the small intestine of celiac disease patients
143. Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease
144. Is Alzheimer's disease inevitable with age?: Lessons from clinicopathologic studies of healthy aging and very mild Alzheimer's disease
145. Assembly of fibronectin into extracellular matrix
146. Cross-linking of fibronectin to collagenous proteins
147. A novel pathway for secretary proteins?
148. Cross-linking sites of the human tau protein, probed by reactions with human transglutaminase
149. Coeliac disease in the West of IRL
150. Elastase inhibitor elafin is a new type of proteinase inhibitor which has a transglutaminase-mediated anchoring sequence termed 'cementoin'
151. Bricks and mortar of the epidermal barrier
152. Identification of cytoplasmic actin as an abundant glutaminyl substrate for tissue transglutaminase in HL-60 and U937 cells undergoing apoptosis
153. A novel function for the transglutaminase 1 enzyme: Attachment of long chain ω-hydroxyceramides to involucrin by ester bond formation
154. Gluten induces an intestinal cytokine response strongly dominated by interferon gamma in patients with celiac disease
155. Celiac disease risk in the USA: High prevalence of antiendomysium antibodies in healthy blood donors
156. Expansion of an unstable trinucleotide CAG repeat in spinocerebellar ataxia type 1
157. Actin is a target antigen of anti-neutrophil cytoplasmic antibodies (ANCA) in autoimmune hepatitis type-1
158. Mapping of a second locus for lamellar ichthyosis to chromosome 2q33-35
159. Bacterial pro-transglutaminase from Streptoverticillium mobaraense-purification, characterisation and sequence of the zymogen
160. Alterations in calcium content and biochemical processes in cultured skin fibroblasts from aged and Alzheimer donors
161. Three novel point mutations in the keratinocyte transglutaminase (TGK) gene in lamellar ichthyosis: Significance for mutant transcript level, TGK immunodetection and activity
162. Identification of 'tissue' transglutaminase binding proteins in neural cells committed to apoptosis
163. Mutation in the a-synuclein gene identified in families with Parkinson's disease
164. Cereal dietary proteins with sites for cross-linking by transglutaminase
165. Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2
166. Osteopontin, a substrate for transglutaminase and factor XIII activity
167. Cross-linking of the dermo-epidermal junction of skin regenerating from keratinocyte autografts. Anchoring fibrils are a target for tissue transglutaminase
168. Identification of glutamine and lysine residues in Alzheimer amyloid beta A4 peptide responsible for transglutaminase-catalyzed homopolymerization and cross-linking to alpha 2M receptor
169. Diseases associated with dermatitis herpetiformis
170. Clinical, serologic, and immunogenetic features of familial idiopathic inflammatory myopathy
171. Genetic dissection of familial Parkinson's disease
172. Cross-linking of plasminogen activator inhibitor 2 and alpha 2-antiplasmin to fibrin
173. Factor XIIIa cross-links lipoprotein(a) with fibrinogen and is present in human atherosclerotic lesions
174. Participation of transglutaminase in the activation of latent transforming growth factor beta 1 in aging articular cartilage
175. Mutations in the gene for transglutaminase 1 in autosomal recessive lamellar ichthyosis
176. Occurrence of IgA and IgG autoantibodies to calreticulin in coeliac disease and various autoimmune diseases
177. ++-induced protein loss, vimentin cleavage and opacification
178. The incidence of endemic sprue/celiac disease in Berlin (West). A prospective study with short discussion of a case
179. Vitronectin is a substrate for transglutaminases
180. Hutingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions
181. Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization
182. Identification of the autoantigen of coeliac disease
183. Brain transglutaminase: In vitro crosslinking of human neurofilament proteins into insoluble polymers
184. Splice-site mutation in TGM1 in congenital recessive ichthyosis in American families: Molecular, genetic, genealogic, and clinical studies
185. Identification of a gliadin T-cell epitope in coeliac disease: General importance of gliadin deamidation for intestinal T-cell recognition
186. Alpha-synuclein in Lewy bodies
187. Localization of transglutaminase-reactive glutamine residues in bovine osteopontin
188. A founder effect is proposed for factor XIII B subunit deficiency caused by the insertion of triplet AAC in exon III encoding the second sushi domain
189. The complexity and redundancy of epithelial barrier function
190. Initiation of assembly of the cell envelope barrier structure of stratified squamous epithelia
191. Biochemical evidence that small proline rich proteins and trichohyalin function in epithelia to modulate the biomechanical properties of their cornified cell envelopes
192. Screening for proteins with polyglutamine expansions in autosomal dominant cerebellar ataxias
193. Correlation between the onset age of Huntington's disease and length of the trinucleotide repeat in IT-15
194. Molecular mechanism of type II factor XIII deficiency: Novel G562R mutation and C-terminal truncation of the A subunit cause factor XIII deficiency as characterized in a mammalian expression system
195. Cross-linking of alpha 2-plasmin inhibitor and fibronectin to fibrin by fibrin-stabilizing factor
196. Differential pattern in tissue-specific somatic mosaicism of expanded CAG trinucleotide repeats in dentatorubral-pallidoluysian atrophy, Machado-Joseph disease, and X-linked recessive spinal and bulbar muscular atrophy
197. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's Disease chromosomes
198. Celiac sprue
199. Epidermal transglutaminase in the ichthyoses
200. Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity
201. The unstable trinucleotide repeat story of major psychosis
202. Huntington disease
203. CSF antibodies to myelin basic protein and to myelin-associated glycoprotein in multiple sclerosis. Evidence of the intrathecal production of antibodies
204. Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells
205. Extravascular fibrin formation and dissolution in synovial tissue of patients with osteoarthritis and rheumatoid arthritis
206. Homozygotes for Huntington's disease
207. Degradation of tryptophan in neurodegenerative disorders
208. Increased transglutaminase in the aortas of cholesterol-fed rabbits: Occurrence of buffer soluble and insoluble forms and an inhibitor
209. Lewy body variant of Alzheimer's disease: Alpha-synuclein in dystrophic neurites of A beta plaques
210. Tissue transglutaminase is an in situ substrate of calpain: Regulation of activity
211. Modulation of the in situ activity of tissue transglutaminase by calcium and GTP
212. Differentiation and programmed cell death-related intermediate biomarkers for the development of non-small cell lung cancer:A pilot study
213. Transglutaminase-induced cross-linking of tau proteins in progressive supranuclear palsy
214. Expression of the transglutaminase enzymes in progressive supranuclear palsy
215. Autosomal dominant cerebellar ataxia (SCA6) associated with small polyglutamine expansions in the alpha 1A-voltage-dependent calcium channel