Impaired mitochondrial function results in increased tissue transglutaminase activity in situ

Journal of Neurochemistry

Volumn 75, Issue 5, 2000, Pages 1951-1961

  Lesort, M ^a   Tucholski, J ^a   Zhang, J ^a   Johnson, G V W ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

3 Nitropropionic acid; GTP; Huntington's disease; Mitochondria; Oxidative stress; Tissue transglutaminase

Indexed keywords

3 NITROPROPIONIC ACID; ANTIOXIDANT; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; SUCCINATE DEHYDROGENASE;

AMIDATION; ARTICLE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVITY; ENZYME LOCALIZATION; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; NEUROBLASTOMA CELL; OXIDATIVE STRESS; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATE; ANTIOXIDANTS; CALCIUM; DOSE-RESPONSE RELATIONSHIP, DRUG; GTP-BINDING PROTEINS; GUANOSINE TRIPHOSPHATE; HUMAN; HUNTINGTON DISEASE; MARINE TOXINS; MITOCHONDRIA; NEUROBLASTOMA; OXIDATIVE STRESS; PROPIONIC ACIDS; SUCCINATE DEHYDROGENASE; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANSFECTION; TRANSGLUTAMINASES; TUMOR CELLS, CULTURED;

EID: 0033794508     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0751951.x     Document Type: Article

References (57)

1. Identification of a guanosine triphosphate-binding site on guinea pig liver transglutaminase. Role of GTP and calcium ions in modulating activity
2. 3-Nitropropionate, the toxic substance of Indigofera, is a suicide inactivator of succinate dehydrogenase
3. Huntington's disease, energy, and excitotoxicity
4. Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid
5. 3-Nitropropionic acid neurotoxicity is attenuated in copper/zinc superoxide dismutase transgenic mice
6. 3-Nitropropionic acid induces apoptosis in cultured striatal and cortical neurons
7. Covalent incorporation of polyamines as gamma-glutamyl derivatives into CHO cell protein
8. GTP modulates calcium binding and cation-induced conformational changes in erythrocyte transglutaminase
9. Increased vulnerability to 3-nitropropionic acid in an animal model of Huntington's disease
10. Increased susceptibility to transglutaminase of eye lens proteins exposed to activated oxygen species produced in the glucose-glucose oxidase reaction
11. Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates
12. Oxidative damage and metabolic dysfunction in Huntington's disease: Selective vulnerability of the basal ganglia
13. Oxidative stress in Huntington's disease
14. Two types of transglutaminase in the PC12 pheochromocytoma cell line. Stimulation by sodium butyrate
15. Colocalization of tissue transglutaminase and stress fibers in human vascular smooth muscle cells and human umbilical vein endothelial cells
16. Inactivation of succinate dehydrogenase by 3-nitropropionate
17. Pathogenesis of inclusion bodies in (CAG)(n)/Q(n)-expansion diseases with special reference to the role of tissue transglutaminase and to selective vulnerability
18. Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation
19. A quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor necrosis factor (TNF) activity
20. Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain
21. 2+ overload induced by a mitochondrial toxin, 3-nitropropionic acid
22. Expression of tissue transglutaminase in Balb-C 3T3 fibroblasts: Effects on cellular morphology and adhesion
23. Tissue transglutaminase-catalyzed formation of high-molecular-weight aggregates in vitro is favored with long polyglutamine domains: A possible mechanism contributing to CAG-triplet diseases
24. Human genetic diseases due to codon reiteration: Relationship to an evolutionary mechanism
25. Transglutaminases: Multifunctional cross-linking enzymes that stabilize tissues
26. Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine)
27. Exposure of beta H-crystallin to hydroxyl radicals enhances the transglutaminase susceptibility of its existing amine donor and amine acceptor sites
28. 2+ indicators with greatly improved fluorescence properties
29. Oxidation inhibits substrate proteolysis by calpain I but not autolysis
30. Activation of transglutaminase at calcium levels consistent with a role for this enzyme as a calcium receptor protein
31. Activity and distribution of tissue transglutaminase in association with nerve-muscle synapses
32. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group
33. Identification of amine acceptor protein substrates of transglutaminase in liver extracts: Use of 5-(biotinamido) pentylamine as a probe
34. Transglutaminase activity is increased in Alzheimer's disease brain
35. Transglutaminase action imitates Huntington's disease: Selective polymerization of huntingtin containing expanded polyglutamine
36. Transglutaminase aggregates huntingtin into nonamyloidogenic polymers, and its enzymatic activity increases in Huntington's disease brain nuclei
37. Mice deficient in cellular glutathione peroxidase show increased vulnerability to malonate, 3-nitropropionic acid, and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine
38. Sphingosylphosphocholine reduces the calcium ion requirement for activating tissue transglutaminase
39. Regulation of human tissue transglutaminase function by magnesium-nucleotide complexes. Identification of distinct binding sites for Mg-GTP and Mg-ATP
40. Biochemical differences among four inosinate dehydrogenase inhibitors, mycophenolic acid, ribavirin, tiazofurin, and selenazofurin, studied in mouse lymphoma cell culture
41. Site-directed mutagenesis of human tissue transglutaminase: Cys-277 is essential for transglutaminase activity but not for GTPase activity
42. Tissue transglutaminase is increased in Huntington's disease brain
43. Mixed-function oxidation of histidine residues
44. Estimation of biomass in growing cell lines by adenosine triphosphate assay
45. Transglutaminase and neuronal differentiation
46. Novel free radical spin traps protect against malonate and MPTP neurotoxicity
47. Reduced cerebral glucose metabolism in asymptomatic subjects at risk for Huntington's disease
48. A procedure for rapid extraction and high-pressure liquid chromatographic separation of the nucleotides and other small molecules from bacterial cells
49. Free and protein-conjugated polyamines in mouse epidermal cells. Effect of high calcium and retinoic acid
50. Phenotype-specific 'tissue' transglutaminase regulation in human neuroblastoma cells in response to retinoic acid: Correlation with cell death by apoptosis
51. Involvement of oxidative stress in 3-nitropropionic acid neurotoxicity
52. Exposure of beta L-crystallin to oxidizing free radicals enhances its susceptibility to transglutaminase activity
53. 2+ and nucleotides
54. Putative nucleotide binding sites of guinea pig liver transglutaminase
55. In vitro polymerization of oxidized tau into filaments
56. Tau is modified by tissue transglutaminase in situ: Possible functional and metabolic effects of polyamination
57. Modulation of the in situ activity of tissue transglutaminase by calcium and GTP