The versatile functions of the transcriptional coactivators p300 and CBP and their roles in disease

Histology and Histopathology

Volumn 17, Issue 2, 2002, Pages 657-668

  Janknecht, Ralf ^a  

^a MAYO GRADUATE SCHOOL   (United States)

Author keywords

CBP; Coactivator; p300; Transcription regulation; Tumor suppressor

Indexed keywords

ACYLTRANSFERASE; ANDROGEN RECEPTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; DACTINOMYCIN; HISTONE; MITOGEN ACTIVATED PROTEIN KINASE; ONCOPROTEIN; POLYGLUTAMINE; PROTEIN C FOS; PROTEIN C JUN; PROTEIN C MYB; PROTEIN KINASE C; PROTEIN P300; PROTEIN P44; PROTEIN P53; SMAD PROTEIN; STEROID RECEPTOR; TAX PROTEIN; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR NF E2; TRANSCRIPTION FACTOR PIT 1; TRANSFORMING GROWTH FACTOR BETA;

ACETYLATION; ALLELE; CANCER INHIBITION; CHROMATIN; CHROMOSOME MUTATION; CHROMOSOME TRANSLOCATION; CYTOTOXICITY; DNA BINDING; EMBRYO DEVELOPMENT; GENETIC TRANSCRIPTION; HEMATOLOGIC DISEASE; HUMAN; MALIGNANT NEOPLASTIC DISEASE; NERVE CELL DEGENERATION; NONHUMAN; NUCLEOSOME; PROTEIN DEFICIENCY; PROTEIN FUNCTION; REVIEW; RUBINSTEIN SYNDROME; SIDE EFFECT; STRESS; TRANSCRIPTION REGULATION; VIRUS INFECTION;

ACETYLTRANSFERASES; ANIMALS; CREB-BINDING PROTEIN; GENE TARGETING; HUMANS; NEURODEGENERATIVE DISEASES; NUCLEAR PROTEINS; PHOSPHORYLATION; TRANS-ACTIVATORS; TRANSLOCATION, GENETIC; TUMOR SUPPRESSOR PROTEINS;

EID: 0036115749     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (137)

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6. The SV40 large T antigen and adenovirus E1a oncoproteins interact with distinct isoforms of the transcriptional co-activator, p300
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10. Variation in microdeletions of the cyclic AMP-responsive element-binding protein gene at chromosome band 16p13.3 in the Rubinstein-Taybi syndrome
11. Plant orthologs of p300/CBP: Conservation of a core domain in metazoan p300/CBP acetyltransferase-related proteins
12. The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein
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15. Regulatory squelching
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17. MOZ is fusef to p300 in an acute monocytic leukemia with t(8;22)
18. Role of CBP/P300 in nuclear receptor signalling
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27. Structure and ligand of a histone acetyltransferase bromodomain
28. Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor
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30. Cell death in polyglutamine diseases
31. The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation
32. p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing hormone-dependent transactivation
33. Mutations truncating the EP300 acetylase in human cancers
34. Detection of CBP rearrangements in acute myelogenous leukemia with t(8;16)
35. Conjunction dysfunction: CBP/p300 in human disease
36. CBP/p300 in cell growth, transformation, and development
37. p300/MDM2 complexes participate in MDM2-mediated p53 degradation
38. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
39. Synergistic activation of transcription by CBP and p53
40. Insulin suppresses transactivation by CAAT/enhancer-binding proteins beta (C/EBPbeta). Signaling to p300/CREB-binding protein by protein kinase B disrupts interaction with the major activation domain of C/EBPbeta
41. Molecular genetics: Unmasking polyglutamine triggers in neurodegenerative disease
42. Regulation of histone acetyltransferases p300 and PCAF by the bHLH protein twist and adenoviral oncoprotein E1A
43. p300 is a component of an estrogen receptor coactivator complex
44. Transcription coactivator p300 binds PCNA and may have a role in DNA repair synthesis
45. Interaction of human immunodeficiency virus type 1 Tat with the transcriptional coactivators p300 and CREB binding protein
46. Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation
47. The Kaposi's sarcoma-associated herpesvirus K8 protein interacts with CREB-binding protein (CBP) and represses CBP-mediated transcription
48. Adenoviral E1A-associated protein p300 is involved in acute myeloid leukemia with t(11;22)(q23;q13)
49. Acetylation of general transcription factors by histone acetyltransferases
50. p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2
51. p300-mediated acetylation facilitates the transfer of histone H2A-H2B dimers from nucleosomes to a histone chaperone
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55. MAP kianse-dependent transcriptional coactivation by Elk-1 and its cofactor CBP
56. Regulation of the c-fos promoter by the ternary complex factor Sap-1a and its coactivator CBP
57. TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300
58. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors
59. Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiation
60. Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells
61. Efficient recruitment of TFIIB and CBP-RNA polymerase II holoenzyme by an interferon-beta enhanceosome in vitro
62. Fusion of MOZ and p300 histone acetyltransferases in acute monocytic leukemia with a t(8;22)(p11;q13) chromosome translocation
63. Phosphorylation of the adenovirus E1A-associated 300 kDa protein in response to retinoic acid and E1A during the differentiation of F9 cells
64. Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP
65. Differential use of CREB binding protein-coactivator complexes
66. Control of cAMP-regulated enhancers by the viral transactivator Tax through CREB and the co-activator CBP
67. Nuclear protein CBP is a coactivator for the transcription factor CREB
68. Chromatin-related properties of CBP fused to MLL generate a myelodysplastic-like syndrome that evolves into myeloid leukemia
69. cAMP response element-binding protein-binding protein binds to human papillomavirus E2 protein and activates E2-dependent transcription
70. The transcriptional activity of cAMP response element-binding protein-binding protein is modulated by the latency associated nuclear antigen of Kaposi's sarcoma-associted herpesvirus
71. HHV-8 encoded vIRF-1 represses the interferon antiviral response by blocking IRF-3 recruitment of the CBP/p300 coactivators
72. p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage
73. Nerve growth factor up-regulates the transcriptional activity of CBP through activation of the p42/p44 (MAPK) cascade
74. CBP associates with the p42/p44 MAPK enzymes and is phosphorylated following NGF treatment
75. Adenoviral E1A-associated protein p300 as a functional homologue of the transcriptional co-activator CBP
76. p300 forms a stable, template-committed complex with chromatin: Role for the bromodomain
77. HIV-1 tat transactivator recruits p300 and CREB-binding protein histone acetyltransferases to the viral promoter
78. CREB-binding proteion sequestration by expanded polyglutamine
79. Recruitment of CBP/p300 by the IFN beta enhanceosome is required for synergistic activation of transcription
80. Tumors in Rubinstein-Taybi syndrome
81. Regulation of E2F transcription by cyclin E-Cdk2 kinase mediated through p300/CBP co-activators
82. p300 gene alterations in colorectal and gastric carcinomas
83. RNA helicase A mediates association of CBP with RNA polymerase II
84. Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300
85. Polyomavirus large T antigen binds the transcriptional coactivator protein p300
86. The transactivation domain within cysteine/histiodine-rich region 1 of CBP comprises two novel zinc-binding modules
87. Induction-independent recruitment of CREB-binding protein to the c-fos serum response element through interactions between the bromodomain and Elk-1
88. Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity
89. The transcriptional coactivators p300 and CBP are histone acetyltransferases
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92. Fusion of the MORF and CBP genes in acute myeloid leukemia with the t(10;16)(q22;p13)
93. Phosphorylation of ETS transcription factor ER81 in a complex with its coactivators CREB-binding protein and p300
94. Developmentally regulated expression of the transcriptional cofactors/histone acetyltransferases CBP and p300 during mouse embryogenesis
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100. CREB-binding protein/p300 activates MyoD by acetylation
101. Interaction between acetylated MyoD and the bromodomain of CBP and/or p300
102. The Ewing's sarcoma gene product functions as a transcriptional activator
103. All patients with the t(11;16)(q23;p13.3) that involves MLL and CBP have treatment-related hematologic disorders
104. Increased affinity of c-Myb for CREB-binding protein (CBP) after CBP-induced acetylation
105. Novel MLL-CBP fusion transcript in therapy-related chronic myelomonocytic leukemia with a t(11;16)(q23;p13) chromosome translocation
106. The hox homeodomain proteins block cbp histone acetyltransferase activity
107. A CBP/p300 homolog specifies multiple differentiation pathways in Caenorhabditis elegans
108. Functional interaction between nucleosome assembly proteins and p300/CREB-binding protein family coactivators
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111. MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3)
112. Acetylation regulates transcription factor activity at multiple levels
113. Transcription factor-dependent regulation of CBP and P/CAF histone acetyltransferase activity
114. Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila
115. The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription
116. Tax protein of HTLV-1 inhibits CBP/p300-mediated transcription by interfering with recruitment of CBP/p300 onto DNA element of E-box or p53 binding site
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118. CREB-binding protein activates transcription through multiple domains
119. The t(11;16)(q23;p13) translocation in myelodysplastic syndrome fuses the MLL gene to the CBP gene
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121. Extensive brain hemorrhage and embryonic lethality in a mouse null mutant of CREB-binding protein
122. CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor beta transcriptional responses in endothelial cells
123. Binding of p53 to the KIX domain of CREB binding protein. A potential link to human T-cell leukemia virus, type I-associated leukemogenesis
124. Physical association between the histone acetyl transferase CBP and a histone methyl transferase
125. CREB-binding protein and p300 in transcriptional regulation
126. Epstein-Barr virus nuclear protein 2 interacts with p300, CBP, and PCAF histone acetyltransferases in activation of the LMP1 promoter
127. Coactivator and corepressor complexes in nuclear receptor function
128. Analysis with specific polyclonal antiserum indicates that the E1A-associated 300-kDa product is a stable nuclear phosphoprotein that undergoes cell cycle phase-specific modification
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132. Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300
133. Phosphorylation of p300 at serine 89 by protein kinase C
134. Human p300 protein is a coactivator for the transcription factor MyoD
135. CREB binding protein recruitment to the transcription complex requires growth factor-dependent phosphorylation of its GF box
136. Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB
137. The human papillomavirus type 16 E6 oncoprotein can down-regulate p53 activity by targeting the transcriptional coactivator CBP/p300